WO2000004382A8 - Arrays of proteins and methods of use thereof - Google Patents

Arrays of proteins and methods of use thereof

Info

Publication number
WO2000004382A8
WO2000004382A8 PCT/US1999/015971 US9915971W WO0004382A8 WO 2000004382 A8 WO2000004382 A8 WO 2000004382A8 US 9915971 W US9915971 W US 9915971W WO 0004382 A8 WO0004382 A8 WO 0004382A8
Authority
WO
WIPO (PCT)
Prior art keywords
arrays
methods
proteins
protein
protein arrays
Prior art date
Application number
PCT/US1999/015971
Other languages
French (fr)
Other versions
WO2000004382A1 (en
Inventor
Peter Wagner
Dana Ault-Riche
Steffen Nock
Christian Itin
Original Assignee
Zyomyx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zyomyx Inc filed Critical Zyomyx Inc
Priority to CA002337654A priority Critical patent/CA2337654A1/en
Priority to EP99935573A priority patent/EP1097380A1/en
Priority to JP2000560449A priority patent/JP2002520618A/en
Priority to AU51025/99A priority patent/AU765508B2/en
Publication of WO2000004382A1 publication Critical patent/WO2000004382A1/en
Publication of WO2000004382A8 publication Critical patent/WO2000004382A8/en
Priority to AU2003262452A priority patent/AU2003262452B2/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061—The surface being organic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00617—Delimitation of the attachment areas by chemical means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00617—Delimitation of the attachment areas by chemical means
    • B01J2219/00619—Delimitation of the attachment areas by chemical means using hydrophilic or hydrophobic regions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00621—Delimitation of the attachment areas by physical means, e.g. trenches, raised areas
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/00626—Covalent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/0063—Other, e.g. van der Waals forces, hydrogen bonding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00635—Introduction of reactive groups to the surface by reactive plasma treatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B01J2219/00641—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being continuous, e.g. porous oxide substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof

Abstract

Protein arrays for the parallel, in vitro screening of biomolecular activity are provided. Methods of using the protein arrays are also disclosed. On the arrays, a plurality of different proteins, such as different members of a single protein family, are immobilized on one or more organic thin films on the substrate surface. The protein arrays are particularly useful in drug development, proteomics, and clinical diagnostics.
PCT/US1999/015971 1998-07-14 1999-07-14 Arrays of proteins and methods of use thereof WO2000004382A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002337654A CA2337654A1 (en) 1998-07-14 1999-07-14 Arrays of proteins and methods of use thereof
EP99935573A EP1097380A1 (en) 1998-07-14 1999-07-14 Arrays of proteins and methods of use thereof
JP2000560449A JP2002520618A (en) 1998-07-14 1999-07-14 Protein arrays and methods of using same
AU51025/99A AU765508B2 (en) 1998-07-14 1999-07-14 Arrays of proteins and methods of use thereof
AU2003262452A AU2003262452B2 (en) 1998-07-14 2003-11-21 Arrays of proteins and methods of use thereof I

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/115,455 1998-07-14
US09/115,455 US6406921B1 (en) 1998-07-14 1998-07-14 Protein arrays for high-throughput screening

Publications (2)

Publication Number Publication Date
WO2000004382A1 WO2000004382A1 (en) 2000-01-27
WO2000004382A8 true WO2000004382A8 (en) 2001-03-15

Family

ID=22361520

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US1999/015971 WO2000004382A1 (en) 1998-07-14 1999-07-14 Arrays of proteins and methods of use thereof
PCT/US1999/015968 WO2000004389A2 (en) 1998-07-14 1999-07-14 Arrays of protein-capture agents and methods of use thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US1999/015968 WO2000004389A2 (en) 1998-07-14 1999-07-14 Arrays of protein-capture agents and methods of use thereof

Country Status (8)

Country Link
US (14) US6406921B1 (en)
EP (2) EP1097380A1 (en)
JP (2) JP2002520618A (en)
AT (1) ATE397752T1 (en)
AU (2) AU773068B2 (en)
CA (2) CA2337075A1 (en)
DE (1) DE69938867D1 (en)
WO (2) WO2000004382A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9290382B2 (en) 2001-09-06 2016-03-22 Rapid Micro Biosystems Rapid detection of replicating cells

Families Citing this family (767)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5776748A (en) * 1993-10-04 1998-07-07 President And Fellows Of Harvard College Method of formation of microstamped patterns on plates for adhesion of cells and other biological materials, devices and uses therefor
CA2242582A1 (en) * 1996-02-16 1997-08-21 Smith & Nephew Endoscopy, Inc. Graft anchor
US7041510B2 (en) * 1996-04-25 2006-05-09 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
CA2255599C (en) 1996-04-25 2006-09-05 Bioarray Solutions, Llc Light-controlled electrokinetic assembly of particles near surfaces
US6750016B2 (en) 1996-07-29 2004-06-15 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6506564B1 (en) 1996-07-29 2003-01-14 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6984491B2 (en) 1996-07-29 2006-01-10 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6582921B2 (en) 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
US7169556B2 (en) 1996-07-29 2007-01-30 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
CA2262018C (en) 1996-07-29 2007-10-02 Nanosphere Llc Nanoparticles having oligonucleotides attached thereto and uses therefor
US7098320B1 (en) 1996-07-29 2006-08-29 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6368877B1 (en) * 1997-06-25 2002-04-09 Massachusetts Institute Of Technology Self-assembling peptide surfaces for cell patterning and interactions
US6974669B2 (en) * 2000-03-28 2005-12-13 Nanosphere, Inc. Bio-barcodes based on oligonucleotide-modified nanoparticles
US20050037397A1 (en) * 2001-03-28 2005-02-17 Nanosphere, Inc. Bio-barcode based detection of target analytes
US20020144905A1 (en) * 1997-12-17 2002-10-10 Christian Schmidt Sample positioning and analysis system
CA2316966C (en) 1997-12-17 2008-04-08 Horst Vogel Positioning and electrophysiological characterization of individual cells and reconstituted membrane systems on microstructured carriers
US7244349B2 (en) 1997-12-17 2007-07-17 Molecular Devices Corporation Multiaperture sample positioning and analysis system
AU740830B2 (en) * 1998-01-29 2001-11-15 Glaucus Proteomics B.V. High density arrays for proteome analysis and methods and compositions therefor
JP2002502977A (en) 1998-02-04 2002-01-29 インビトロジェン コーポレイション Microarrays and their uses
GB9812783D0 (en) 1998-06-12 1998-08-12 Cenes Ltd High throuoghput screen
US6897073B2 (en) * 1998-07-14 2005-05-24 Zyomyx, Inc. Non-specific binding resistant protein arrays and methods for making the same
US20030138973A1 (en) * 1998-07-14 2003-07-24 Peter Wagner Microdevices for screening biomolecules
US6780582B1 (en) 1998-07-14 2004-08-24 Zyomyx, Inc. Arrays of protein-capture agents and methods of use thereof
US6406921B1 (en) * 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US20020119579A1 (en) * 1998-07-14 2002-08-29 Peter Wagner Arrays devices and methods of use thereof
US6576478B1 (en) * 1998-07-14 2003-06-10 Zyomyx, Inc. Microdevices for high-throughput screening of biomolecules
US7132247B1 (en) * 1998-09-17 2006-11-07 Regents Of The University Of Minnesota Composite devices incorporating biological material and methods
US20030190740A1 (en) * 1998-10-13 2003-10-09 The University Of Georgia Research Foundation, Inc Stabilized bioactive peptides and methods of identification, synthesis, and use
EP1121425B1 (en) * 1998-10-13 2005-06-29 The University Of Georgia Research Foundation, Inc. Stabilized bioactive peptides and methods of identification, synthesis and use
EP1133523A1 (en) * 1998-11-16 2001-09-19 Genway Biotech, Inc. Generation of antibodies using polynucleotide vaccination in avian species
US6635311B1 (en) 1999-01-07 2003-10-21 Northwestern University Methods utilizing scanning probe microscope tips and products therefor or products thereby
US6827979B2 (en) 1999-01-07 2004-12-07 Northwestern University Methods utilizing scanning probe microscope tips and products therefor or produced thereby
US7166475B2 (en) * 1999-02-26 2007-01-23 Cyclacel Ltd. Compositions and methods for monitoring the modification state of a pair of polypeptides
EP1159615A2 (en) * 1999-03-10 2001-12-05 National Institutes of Health, as represented by the Secretary, Department of Health and Human Services of the Government Universal protein array system
AU3867400A (en) * 1999-03-19 2000-10-09 Duke University Methods of using bioelastomers
DE19916867A1 (en) * 1999-04-14 2000-10-19 Fraunhofer Ges Forschung Making a molecular array on which molecules are immobilized, using micro-compartments or microcapillary reactors on planar substrates with sensor elements employs microelectronic production techniques
US20040053290A1 (en) * 2000-01-11 2004-03-18 Terbrueggen Robert Henry Devices and methods for biochip multiplexing
US7638464B2 (en) * 1999-04-26 2009-12-29 Biocept, Inc. Three dimensional format biochips
KR20020022653A (en) 1999-04-29 2002-03-27 사이퍼젠 바이오시스템스, 인코오포레이티드 Sample holder with hydrophobic coating for gas phase mass spectrometers
US6690399B1 (en) * 1999-05-07 2004-02-10 Tropix, Inc. Data display software for displaying assay results
JP4493125B2 (en) * 1999-05-07 2010-06-30 独立行政法人理化学研究所 Method for detecting interacting proteins
US6824987B1 (en) * 1999-05-11 2004-11-30 President And Fellows Of Harvard College Small molecule printing
US7932213B2 (en) * 1999-05-11 2011-04-26 President And Fellows Of Harvard College Small molecule printing
US20030073250A1 (en) * 1999-05-21 2003-04-17 Eric Henderson Method and apparatus for solid state molecular analysis
US20020042081A1 (en) * 2000-10-10 2002-04-11 Eric Henderson Evaluating binding affinities by force stratification and force panning
US20030186311A1 (en) * 1999-05-21 2003-10-02 Bioforce Nanosciences, Inc. Parallel analysis of molecular interactions
US6573369B2 (en) * 1999-05-21 2003-06-03 Bioforce Nanosciences, Inc. Method and apparatus for solid state molecular analysis
EP1055925B1 (en) * 1999-05-28 2010-09-08 Yokogawa Electric Corporation Biochip reader
US7179638B2 (en) * 1999-07-30 2007-02-20 Large Scale Biology Corporation Microarrays and their manufacture by slicing
ES2367551T3 (en) * 1999-08-13 2011-11-04 Bayer Technology Services Gmbh DEVICE AND PROCEDURE FOR THE DETERMINATION OF MULTIPLE ANALYTICS.
US8111401B2 (en) * 1999-11-05 2012-02-07 Robert Magnusson Guided-mode resonance sensors employing angular, spectral, modal, and polarization diversity for high-precision sensing in compact formats
US7167615B1 (en) * 1999-11-05 2007-01-23 Board Of Regents, The University Of Texas System Resonant waveguide-grating filters and sensors and methods for making and using same
AU1859201A (en) * 1999-11-29 2001-06-12 Unilever Plc Immobilisation of proteins
US20010039014A1 (en) * 2000-01-11 2001-11-08 Maxygen, Inc. Integrated systems and methods for diversity generation and screening
AU774593C (en) * 2000-01-13 2005-06-23 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US7816098B2 (en) 2000-01-31 2010-10-19 Sense Proteomic Limited Methods of making and using a protein array
DE60142765D1 (en) * 2000-01-31 2010-09-23 Sense Proteomic Ltd METHOD FOR PRODUCING PROTEIN EXPRESSION ARRAYS AND APPLYING THE SAME IN FAST SCREENING
WO2001057198A2 (en) * 2000-01-31 2001-08-09 Sense Proteomic Limited Methods of generating protein expression arrays and the use thereof in rapid screening
US20080280771A1 (en) * 2000-02-08 2008-11-13 Regents Of The University Of Michigan Protein MicroarraySystem
US20050230315A1 (en) * 2003-01-13 2005-10-20 Regents Of The University Of Michigan Protein microarray system
CN1444646A (en) * 2000-02-23 2003-09-24 齐翁米克斯股份有限公司 Chips having elevated sample surfaces
US6897015B2 (en) * 2000-03-07 2005-05-24 Bioforce Nanosciences, Inc. Device and method of use for detection and characterization of pathogens and biological materials
US6686461B1 (en) 2000-03-22 2004-02-03 Solulink Bioscience, Inc. Triphosphate oligonucleotide modification reagents and uses thereof
US7102024B1 (en) 2000-08-01 2006-09-05 Schwartz David A Functional biopolymer modification reagents and uses thereof
US6541071B1 (en) * 2000-03-23 2003-04-01 Corning Incorporated Method for fabricating supported bilayer-lipid membranes
WO2001072458A1 (en) * 2000-03-27 2001-10-04 Zyomyx, Inc. Site-specific, covalent bioconjugation of proteins
US20040094414A1 (en) * 2000-03-30 2004-05-20 Manfred Engelhardt Biosensor, biosensor array, method for producing an electrode of a biosensor , method for producing a biosensor
JP2003530365A (en) * 2000-04-10 2003-10-14 ザ スクリプス リサーチ インスティチュート Proteomic analysis
AU2001255436A1 (en) * 2000-04-17 2001-10-30 Transtech Pharma Protein expression system arrays and use in biological screening
DE10020704B4 (en) * 2000-04-27 2006-09-28 Bioref Gmbh Biochip for archiving and laboratory medical analysis of biological sample material, process for its production and its use in diagnostic procedures
AU5951201A (en) 2000-05-04 2001-11-12 Univ Yale High density protein arrays for screening of protein activity
DE10027397A1 (en) * 2000-06-02 2001-12-13 Graffinity Pharm Design Gmbh Surface for the immobilization of ligands
US7153682B2 (en) * 2000-06-05 2006-12-26 Chiron Corporation Microarrays on mirrored substrates for performing proteomic analyses
EP1297338B1 (en) * 2000-06-05 2007-04-18 Novartis Vaccines and Diagnostics, Inc. Microarrays for performing proteomic analyses
US7148058B2 (en) * 2000-06-05 2006-12-12 Chiron Corporation Protein microarrays on mirrored surfaces for performing proteomic analyses
KR100865664B1 (en) 2000-06-14 2008-10-29 비스타겐 인코포레이티드 Toxicity typing using liver stem cells
AU2001269906A1 (en) * 2000-06-19 2002-01-02 Zyomyx, Inc. Methods for immobilizing polypeptides
US7892854B2 (en) 2000-06-21 2011-02-22 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
US20020115068A1 (en) * 2000-06-23 2002-08-22 Ian Tomlinson Matrix screening method
DE10031587A1 (en) * 2000-06-29 2002-01-10 Basf Ag Dosing of microscale suspensions for the production of material samples in combinatorial materials research and their testing
AU7687001A (en) 2000-07-11 2002-01-21 Nanospherre Inc Method of detection by enhancement of silver staining
US7023547B2 (en) * 2000-07-11 2006-04-04 Maven Technologies, Llc Apparatus including a biochip for imaging of biological samples and method
US7518724B2 (en) * 2000-07-11 2009-04-14 Maven Technologies Image acquisition, processing, and display
EP1301632A2 (en) * 2000-07-19 2003-04-16 Pointilliste, Inc. Nested sorting and high throughput screening
US20020102577A1 (en) * 2000-07-31 2002-08-01 Raillard Sun Ai Nucleotide incorporating enzymes
AU2001277245A1 (en) * 2000-08-03 2002-02-18 Massachusetts Institute Of Technology Microarrays of functional biomolecules, and uses therefor
US7270730B2 (en) 2000-08-04 2007-09-18 Essen Instruments, Inc. High-throughput electrophysiological measurement system
US7067046B2 (en) 2000-08-04 2006-06-27 Essen Instruments, Inc. System for rapid chemical activation in high-throughput electrophysiological measurements
US6977155B2 (en) 2000-08-10 2005-12-20 Corning Incorporated Arrays of biological membranes and methods and use thereof
US7678539B2 (en) 2000-08-10 2010-03-16 Corning Incorporated Arrays of biological membranes and methods and use thereof
US20020048823A1 (en) * 2000-08-11 2002-04-25 Qianjin Hu Methods and universal monoclonal antibody array
US7244598B2 (en) * 2000-08-14 2007-07-17 Surface Logix, Inc. Biomolecule arrays
CA2419490C (en) 2000-08-15 2010-01-26 Discerna Limited Functional protein arrays
WO2002057200A2 (en) * 2000-08-15 2002-07-25 Bioforce Nanosciences, Inc. Nanoscale molecular arrayer
US7094568B2 (en) * 2000-08-17 2006-08-22 Sense Proteomic Ltd. Method for producing proteins tagged at the N- or C-terminus
CN1494589A (en) * 2000-08-17 2004-05-05 �������ɭ Method
EP1184349A1 (en) * 2000-09-01 2002-03-06 A.S.B.L. Facultes Universitaires Notre-Dame De La Paix Method for obtaining a surface activation of a solid support for building biochips microarrays
EP2071481A3 (en) * 2000-09-14 2009-09-02 Reverse Proteomics Research Institute Co., Ltd Method system, apparatus and device for discovering and preparing chemical compounds for medical and other uses
US20040115726A1 (en) * 2001-09-14 2004-06-17 Renpei Nagashima Method, system, apparatus and device for discovering and preparing chemical compounds for medical and other uses.
AU2001290879A1 (en) * 2000-09-15 2002-03-26 California Institute Of Technology Microfabricated crossflow devices and methods
GB0022978D0 (en) * 2000-09-19 2000-11-01 Oxford Glycosciences Uk Ltd Detection of peptides
AU2001292959A1 (en) 2000-09-22 2002-04-02 Clontech Laboratories, Inc. Highly sensitive proteomic analysis methods and kits and systems for practicing the same
EP1195606A1 (en) * 2000-10-03 2002-04-10 VBC-Genomics Forschungsges.m.b.H. Allergen-microarray assay
US7348182B2 (en) * 2000-10-03 2008-03-25 Mirari Biosciences, Inc. Directed microwave chemistry
US20040209303A1 (en) * 2000-10-03 2004-10-21 Martin Mark T. Methods and compositions for directed microwave chemistry
AU2002211317A1 (en) * 2000-10-03 2002-04-15 Mirari Biosciences, Inc. Methods and compositions for directed microwave chemistry
US7887885B2 (en) 2000-10-20 2011-02-15 Northwestern University Nanolithography methods and products therefor and produced thereby
EP1409127A2 (en) 2000-10-24 2004-04-21 Fatemeh Mojtabai Ordered two- and three-dimensional structures of amphiphilic molecules
US20050100951A1 (en) * 2000-10-26 2005-05-12 Biocept, Inc. 3D format biochips and method of use
US20030092075A1 (en) * 2000-10-30 2003-05-15 Sru Biosystems, Llc Aldehyde chemical surface activation processes and test methods for colorimetric resonant sensors
US7175980B2 (en) * 2000-10-30 2007-02-13 Sru Biosystems, Inc. Method of making a plastic colorimetric resonant biosensor device with liquid handling capabilities
US7371562B2 (en) 2000-10-30 2008-05-13 Sru Biosystems, Inc. Guided mode resonant filter biosensor using a linear grating surface structure
US7615339B2 (en) * 2000-10-30 2009-11-10 Sru Biosystems, Inc. Method for producing a colorimetric resonant reflection biosensor on rigid surfaces
US7202076B2 (en) * 2000-10-30 2007-04-10 Sru Biosystems, Inc. Label-free high-throughput optical technique for detecting biomolecular interactions
US7217574B2 (en) * 2000-10-30 2007-05-15 Sru Biosystems, Inc. Method and apparatus for biosensor spectral shift detection
US7023544B2 (en) * 2000-10-30 2006-04-04 Sru Biosystems, Inc. Method and instrument for detecting biomolecular interactions
US7875434B2 (en) * 2000-10-30 2011-01-25 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
US7101660B2 (en) * 2000-10-30 2006-09-05 Sru Biosystems, Inc. Method for producing a colorimetric resonant reflection biosensor on rigid surfaces
US7118710B2 (en) * 2000-10-30 2006-10-10 Sru Biosystems, Inc. Label-free high-throughput optical technique for detecting biomolecular interactions
US7153702B2 (en) * 2000-10-30 2006-12-26 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
US7264973B2 (en) * 2000-10-30 2007-09-04 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant optical biosensor
US7575939B2 (en) 2000-10-30 2009-08-18 Sru Biosystems, Inc. Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements
US7306827B2 (en) * 2000-10-30 2007-12-11 Sru Biosystems, Inc. Method and machine for replicating holographic gratings on a substrate
US7142296B2 (en) * 2000-10-30 2006-11-28 Sru Biosystems, Inc. Method and apparatus for detecting biomolecular interactions
US7300803B2 (en) * 2000-10-30 2007-11-27 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
DE10054055A1 (en) * 2000-10-31 2002-05-23 Nmi Univ Tuebingen Methods for analyzing proteins
US20050084908A1 (en) * 2000-11-06 2005-04-21 Chugai Seiyaku Kabushiki Kaisha Methods for detecting binding of low-molecular-weight compound and its binding partner molecule
US7232109B2 (en) * 2000-11-06 2007-06-19 California Institute Of Technology Electrostatic valves for microfluidic devices
US7374906B2 (en) 2000-11-08 2008-05-20 Surface Logix, Inc. Biological assays using gradients formed in microfluidic systems
US7123764B2 (en) 2000-11-08 2006-10-17 Surface Logix Inc. Image processing method for use in analyzing data of a chemotaxis or haptotaxis assay
US6699665B1 (en) 2000-11-08 2004-03-02 Surface Logix, Inc. Multiple array system for integrating bioarrays
AU2002224831A1 (en) * 2000-11-17 2002-05-27 Zeptosens Ag Kit and method for determining multiple analytes
JP2002153272A (en) * 2000-11-24 2002-05-28 Inst Of Physical & Chemical Res Biomolecule microarray
US6905816B2 (en) 2000-11-27 2005-06-14 Intelligent Medical Devices, Inc. Clinically intelligent diagnostic devices and methods
CA2430110C (en) 2000-11-27 2012-03-27 Intelligent Medical Devices L.L.C. Clinically intelligent diagnostic devices and methods
DK1360207T3 (en) * 2000-12-13 2011-09-05 Bac Ip B V Protein array of variable domains of heavy immunoglobulin chains from camels
FR2818287B1 (en) * 2000-12-14 2003-01-17 Commissariat Energie Atomique SOLID SUPPORT FOR THE IMMOBILIZATION OF OLIGONUCLEOTIDES
EP1344065A2 (en) 2000-12-14 2003-09-17 Paul Stroobant Differential phage capture proteomics
US6798521B2 (en) * 2000-12-29 2004-09-28 Texas Instruments Incorporated Robust integrated surface plasmon resonance sensor
AU2002246978A1 (en) * 2001-01-10 2002-07-24 Symyx Technologies, Inc. Polymer brushes for immobilizing molecules to a surface
US6783672B2 (en) * 2001-01-18 2004-08-31 Kemmons A. Tubbs Integrated high throughput system for the mass spectrometry of biomolecules
WO2002059601A1 (en) * 2001-01-23 2002-08-01 President And Fellows Of Harvard College Nucleic-acid programmable protein arrays
US20020169562A1 (en) * 2001-01-29 2002-11-14 Gregory Stephanopoulos Defining biological states and related genes, proteins and patterns
US7332286B2 (en) 2001-02-02 2008-02-19 University Of Pennsylvania Peptide or protein microassay method and apparatus
WO2002063280A1 (en) * 2001-02-06 2002-08-15 Auburn University Ligand sensor devices and uses thereof
US6913697B2 (en) * 2001-02-14 2005-07-05 Science & Technology Corporation @ Unm Nanostructured separation and analysis devices for biological membranes
JP4797196B2 (en) * 2001-02-14 2011-10-19 株式会社 フューエンス Microchip
US20020165675A1 (en) * 2001-03-03 2002-11-07 Golovlev Valeri V. Method and microelectronic device for multi-site molecule detection
EP1366364A4 (en) * 2001-03-07 2006-05-17 Bio Rad Laboratories Assay system for simultaneous detection and measurement of multiple modified cellular proteins
US20020137106A1 (en) * 2001-03-09 2002-09-26 Ciphergen Biosystems, Inc. Detection of biological pathway components
US7041449B2 (en) * 2001-03-19 2006-05-09 Wisconsin Alumni Research Foundation Methods of screening for compounds that inhibit expression of biomarker sequences differentially expressed with age in mice
WO2002074979A2 (en) * 2001-03-20 2002-09-26 Ortho-Clinical Diagnostics, Inc. Expression profiles and methods of use
US20060040286A1 (en) * 2001-03-28 2006-02-23 Nanosphere, Inc. Bio-barcode based detection of target analytes
US20020142337A1 (en) * 2001-03-29 2002-10-03 Edwards David N. Hybrid gene libraries and uses thereof
US6960437B2 (en) 2001-04-06 2005-11-01 California Institute Of Technology Nucleic acid amplification utilizing microfluidic devices
AU2002258790A1 (en) * 2001-04-10 2002-10-28 The Trustees Of Columbia University In The City Of New York Novel microarrays and methods of use thereof
AU2002303384A1 (en) * 2001-04-17 2002-10-28 William J. Dower Epitope-captured antibody display
US20030077616A1 (en) * 2001-04-19 2003-04-24 Ciphergen Biosystems, Inc. Biomolecule characterization using mass spectrometry and affinity tags
EP1379545A2 (en) * 2001-04-19 2004-01-14 Gesellschaft für biotechnologische Forschung mbH (GBF) Method for producing stable, regeneratable antibody arrays
WO2002086081A2 (en) * 2001-04-20 2002-10-31 Carnegie Mellon University Methods and systems for identifying proteins
WO2002088388A1 (en) * 2001-04-26 2002-11-07 Ruebben Albert A method and a device for quantification of mutation loads
AU2002340641A1 (en) * 2001-05-03 2002-11-18 Sigma-Genosys, Ltd. Methods for assembling protein microarrays
CA2446867C (en) * 2001-05-11 2016-09-20 Yale University Global analysis of protein activities using proteome chips
US9157875B2 (en) * 2001-05-16 2015-10-13 Benjamin P. Warner Drug development and manufacturing
US20080220441A1 (en) * 2001-05-16 2008-09-11 Birnbaum Eva R Advanced drug development and manufacturing
US7238472B2 (en) * 2001-05-25 2007-07-03 Nanosphere, Inc. Non-alloying core shell nanoparticles
US7147687B2 (en) * 2001-05-25 2006-12-12 Nanosphere, Inc. Non-alloying core shell nanoparticles
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
WO2003002712A2 (en) * 2001-06-26 2003-01-09 Wisconsin Alumni Research Foundation Gene expression alterations underlying the retardation of aging by caloric restriction in mammals
US6844028B2 (en) * 2001-06-26 2005-01-18 Accelr8 Technology Corporation Functional surface coating
JP4500540B2 (en) * 2001-06-29 2010-07-14 ヴェリ‐キュー，インコーポレイテッド Methods and compositions for determining the purity of chemically synthesized nucleic acids and purifying chemically synthesized nucleic acids
US20060019235A1 (en) * 2001-07-02 2006-01-26 The Board Of Trustees Of The Leland Stanford Junior University Molecular and functional profiling using a cellular microarray
JP2005514617A (en) * 2001-07-02 2005-05-19 ザ、ボード、オブ、トラスティーズ、オブ、ザ、リーランド、スタンフォード、ジュニア、ユニバーシティ Microarray for cell phenotyping and manipulation
CN100386627C (en) * 2001-07-03 2008-05-07 包刚 Filtration-based microarray chip
EP1421209A4 (en) * 2001-07-06 2006-04-19 Millipore Corp Satterned composite membrane and stenciling method for the manufacture thereof
WO2003006676A2 (en) * 2001-07-13 2003-01-23 Nanosphere, Inc. Method for immobilizing molecules onto surfaces
US20050287560A1 (en) * 2001-07-13 2005-12-29 Nanosphere, Inc. Method for preparing substrates having immobilized molecules and substrates
US7297553B2 (en) 2002-05-28 2007-11-20 Nanosphere, Inc. Method for attachment of silylated molecules to glass surfaces
US20030013208A1 (en) * 2001-07-13 2003-01-16 Milagen, Inc. Information enhanced antibody arrays
WO2003008977A2 (en) * 2001-07-16 2003-01-30 Protein, Forest, Inc. Arrays of buffers for analysing biomolecules by their isoelectric point
DE60230927D1 (en) * 2001-07-16 2009-03-05 Caprotec Bioanalytics Gmbh FISH CONNECTIONS, THEIR ABDUCTION AND METHOD FOR ANALYZING THE PROTEOM AND COMPLEX COMPOSITIONS
US6444318B1 (en) * 2001-07-17 2002-09-03 Surmodics, Inc. Self assembling monolayer compositions
JP4264002B2 (en) * 2001-07-17 2009-05-13 バイオ−ラド ラボラトリーズ インコーポレイテッド Latex-based adsorption chip
US7172804B2 (en) * 2001-07-17 2007-02-06 Northwestern University Film-immobilized capture particles
AU2002329606A1 (en) * 2001-07-17 2003-03-03 Bioforce Nanosciences, Inc. Combined molecular blinding detection through force microscopy and mass spectrometry
US7517496B2 (en) * 2001-07-17 2009-04-14 Bio-Rad Laboratories, Inc. Latex based adsorbent chip
US20030143612A1 (en) * 2001-07-18 2003-07-31 Pointilliste, Inc. Collections of binding proteins and tags and uses thereof for nested sorting and high throughput screening
US6977138B2 (en) 2001-07-24 2005-12-20 Massachusetts Institute Of Technology Reactive polymer coatings
EP1279963A1 (en) * 2001-07-27 2003-01-29 Université de Nantes Protein-target screening method using near-infrared fluorescent dyes
EP1281966A3 (en) * 2001-07-30 2003-06-18 Fuji Photo Film Co., Ltd. Method and apparatus for conducting a receptor-ligand reaction
US6852727B2 (en) * 2001-08-01 2005-02-08 Merck & Co., Inc. Benzimisazo[4,5-f]isoquinolinone derivatives
US7172905B2 (en) * 2001-08-07 2007-02-06 The University Of Chicago Polypeptide immobilization
US20100104631A1 (en) * 2001-08-13 2010-04-29 Lipella Pharmaceuticals Inc. Method of treatment for bladder dysfunction
US20030049626A1 (en) * 2001-08-14 2003-03-13 Milagen, Inc. Antibody-based analysis of matrix protein arrays
US20030040129A1 (en) * 2001-08-20 2003-02-27 Shah Haresh P. Binding assays using magnetically immobilized arrays
US6767731B2 (en) * 2001-08-27 2004-07-27 Intel Corporation Electron induced fluorescent method for nucleic acid sequencing
CA2458844A1 (en) * 2001-08-27 2003-03-06 Surface Logix, Inc. Immobilization of biological molecules onto surfaces coated with monolayers
US7075162B2 (en) * 2001-08-30 2006-07-11 Fluidigm Corporation Electrostatic/electrostrictive actuation of elastomer structures using compliant electrodes
US20030068655A1 (en) * 2001-09-12 2003-04-10 Protiveris, Inc. Microcantilever apparatus and methods for detection of enzymes
DE10145226A1 (en) * 2001-09-13 2003-04-10 Lifebits Ag Manufacture of carrier-bound molecules
DE10145700A1 (en) * 2001-09-17 2003-04-10 Infineon Technologies Ag Biochip arrangement, sensor arrangement and method for operating a biochip arrangement
JP2003099614A (en) * 2001-09-21 2003-04-04 Daiwa Securities Group Inc Holding number inside sale processor, holding number inside sale processing system and program
US7042488B2 (en) 2001-09-27 2006-05-09 Fujinon Corporation Electronic endoscope for highlighting blood vessel
CA2462833C (en) * 2001-10-02 2012-07-03 Northwestern University Protein and peptide nanoarrays
US20030073104A1 (en) * 2001-10-02 2003-04-17 Belcher Angela M. Nanoscaling ordering of hybrid materials using genetically engineered mesoscale virus
WO2003031066A1 (en) * 2001-10-11 2003-04-17 California Institute Of Technology Devices utilizing self-assembled gel and method of manufacture
US8323903B2 (en) * 2001-10-12 2012-12-04 Life Technologies Corporation Antibody complexes and methods for immunolabeling
US20050069962A1 (en) * 2001-10-12 2005-03-31 Archer Robert M Antibody complexes and methods for immunolabeling
KR20040068122A (en) 2001-10-15 2004-07-30 바이오어레이 솔루션스 리미티드 Multiplexed analysis of polymorphic loci by concurrent interrogation and enzyme-mediated detection
US20050153298A1 (en) * 2001-10-23 2005-07-14 Gembitsky Dmitry S. Protein micro-arrays and multi-layered affinity interaction detection
US8440093B1 (en) 2001-10-26 2013-05-14 Fuidigm Corporation Methods and devices for electronic and magnetic sensing of the contents of microfluidic flow channels
DE60228128D1 (en) 2001-11-09 2008-09-18 Nanosphere Inc Bioconjugate NANOPARTICLE PROBES
US20050095646A1 (en) * 2001-11-19 2005-05-05 Sherman Michael I. Method of using a non-antibody protein to detect and measure an analyte
CA2467836A1 (en) * 2001-11-20 2003-09-04 Duke University Interfacial biomaterials
AU2002365404A1 (en) * 2001-11-27 2003-06-10 Compound Therapeutics, Inc. Solid-phase immobilization of proteins and peptides
EP1463796B1 (en) 2001-11-30 2013-01-09 Fluidigm Corporation Microfluidic device and methods of using same
US7361310B1 (en) 2001-11-30 2008-04-22 Northwestern University Direct write nanolithographic deposition of nucleic acids from nanoscopic tips
US6797393B2 (en) 2001-11-30 2004-09-28 Eastman Kodak Company Method for making biochip substrate
US7691333B2 (en) 2001-11-30 2010-04-06 Fluidigm Corporation Microfluidic device and methods of using same
ATE361471T1 (en) * 2001-12-05 2007-05-15 Sense Proteomic Ltd PROTEIN ARRAYS FOR ALLEL VARIANTS AND THEIR USE
US20050112616A1 (en) * 2001-12-10 2005-05-26 William Lee Functionalized materials and libraries thereof
EP1319954A1 (en) * 2001-12-12 2003-06-18 Centre National de Genotypage Methods for protein analysis using protein capture arrays
JP4382339B2 (en) * 2001-12-14 2009-12-09 富士フイルム株式会社 Measuring chip
GB0130318D0 (en) * 2001-12-19 2002-02-06 Univ Leeds Membrane
DE60225593T2 (en) * 2001-12-21 2009-04-16 Ge Healthcare Bio-Sciences Ab IMMOBILIZATION OF BINDING MATERIALS
KR20030057219A (en) * 2001-12-28 2003-07-04 삼성에스디아이 주식회사 Compound forming intermediated layer on matrix, composition for intermediated layer, and biochip using the same
KR100450202B1 (en) * 2002-01-07 2004-09-24 삼성에스디아이 주식회사 A method for forming a pattern of functional group for immobilizing physiological material
AU2003210546A1 (en) * 2002-01-16 2003-09-02 Panomics, Inc. Methods for isolating and characterizing short-lived proteins and arrays derived therefrom
US20060228723A1 (en) * 2002-01-16 2006-10-12 Keith Bradley System and method for electronic sensing of biomolecules
US7056665B2 (en) 2002-01-16 2006-06-06 Panomics, Inc. Screening methods involving the detection of short-lived proteins
US20070178477A1 (en) * 2002-01-16 2007-08-02 Nanomix, Inc. Nanotube sensor devices for DNA detection
US20030134433A1 (en) * 2002-01-16 2003-07-17 Nanomix, Inc. Electronic sensing of chemical and biological agents using functionalized nanostructures
US20040048311A1 (en) * 2002-01-24 2004-03-11 Dana Ault-Riche Use of collections of binding sites for sample profiling and other applications
JP2003222589A (en) * 2002-01-31 2003-08-08 Communication Research Laboratory Dual-wavelength surface plasmon resonance spectroscopic device
SE0200269D0 (en) * 2002-01-31 2002-01-31 Ellem Bioteknik Ab Material for implantation
US20030148362A1 (en) * 2002-02-07 2003-08-07 Eastern Virginia Medical School Of The Medical College Of Hampton Roads Diagnostic microarray and method of use thereof
EP1489167A4 (en) * 2002-03-01 2006-06-07 Nat Inst Of Advanced Ind Scien Immobilized cells and liposomes and method of immobilizing the same
US20050266455A1 (en) * 2002-03-02 2005-12-01 Sci Tec, Inc. Method and microelectronic device for multi-site molecule detection
US6815078B2 (en) 2002-03-06 2004-11-09 Eastman Kodak Company Substrate for protein microarray containing functionalized polymer
CA2478298A1 (en) * 2002-03-07 2003-09-12 Zephyr Proteomix Ltd. Microarrays of cellulose binding chimeric proteins and methods of use thereof
ES2319634T3 (en) * 2002-03-11 2009-05-11 Caprotec Bioanalytics Gmbh COMPOUNDS AND METHODS TO ANALYZE THE PROTEOM.
US6703216B2 (en) 2002-03-14 2004-03-09 The Regents Of The University Of California Methods, compositions and apparatuses for detection of gamma-hydroxybutyric acid (GHB)
US20030228709A1 (en) * 2002-03-25 2003-12-11 Kozlowski Roland Zbignieiw Arrays
WO2003085379A2 (en) 2002-04-01 2003-10-16 Fluidigm Corporation Microfluidic particle-analysis systems
US20030215858A1 (en) * 2002-04-08 2003-11-20 Baylor College Of Medicine Enhanced gene expression system
US20030194709A1 (en) * 2002-04-10 2003-10-16 Xing Yang Hydrophobic zone device
US20040033546A1 (en) * 2002-04-10 2004-02-19 The Trustees Of Columbia University In The City Of New York Novel microarrays and methods of use thereof
US7687256B2 (en) * 2002-04-11 2010-03-30 Spire Corporation Surface activated biochip
WO2003102547A2 (en) * 2002-04-26 2003-12-11 Genencor International, Inc. Methods and articles for high throughput analysis of biomolecular interactions
CN1665790A (en) * 2002-05-03 2005-09-07 莫莱丘莱尔探针公司 Compositions and methods for detection and isolation of phosphorylated molecules
US20040171034A1 (en) * 2002-05-03 2004-09-02 Brian Agnew Compositions and methods for detection and isolation of phosphorylated molecules
US7445894B2 (en) * 2002-05-03 2008-11-04 Molecular Probes, Inc. Compositions and methods for detection and isolation of phosphorylated molecules
US20030211488A1 (en) 2002-05-07 2003-11-13 Northwestern University Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection
US20030211478A1 (en) * 2002-05-08 2003-11-13 Gentel Corporation Transcription factor profiling on a solid surface
US20030208936A1 (en) * 2002-05-09 2003-11-13 Lee Charles Hee Method for manufacturing embroidery decorated cards and envelopes
US7460960B2 (en) * 2002-05-10 2008-12-02 Epitome Biosystems, Inc. Proteome epitope tags and methods of use thereof in protein modification analysis
US20060014212A1 (en) * 2002-05-10 2006-01-19 Epitome Biosystems, Inc. Proteome epitope tags and methods of use thereof in protein modification analysis
JP2006511819A (en) * 2002-05-10 2006-04-06 イピトミ バイオシステムズ インコーポレイテッド Unique recognition sequences and their use in protein analysis
US7618788B2 (en) * 2002-05-10 2009-11-17 Millipore Corporation Proteome epitope tags and methods of use thereof in protein modification analysis
US8273403B2 (en) * 2002-05-10 2012-09-25 Bio-Layer Pty Ltd. Generation of surface coating diversity
AU2003204160B2 (en) * 2002-05-13 2010-05-13 Corning Incorporated Self-aliquoting sample storage plate system
US8785179B2 (en) * 2002-05-22 2014-07-22 Texas Instruments Incorporated Biosensor and method
US20050239193A1 (en) * 2002-05-30 2005-10-27 Bioforce Nanosciences, Inc. Device and method of use for detection and characterization of microorganisms and microparticles
WO2003101394A2 (en) * 2002-05-31 2003-12-11 Ciphergen Biosystems, Inc. Defensins: use as antiviral agents
EP1413886A1 (en) * 2002-10-25 2004-04-28 Interuniversitair Microelektronica Centrum ( Imec) Sensor surface
EP1369692A3 (en) * 2002-06-04 2003-12-17 Interuniversitaire Microelectronica Centrum vzw ( IMEC) Sensor surface
US7135343B2 (en) * 2002-06-17 2006-11-14 Agilent Technologies, Inc. Biomolecule resistant and their methods of use in assays
CA2490522A1 (en) * 2002-06-20 2003-12-31 Paul Stroobant Improved methods for performing differential capture proteomics
US7948041B2 (en) 2005-05-19 2011-05-24 Nanomix, Inc. Sensor having a thin-film inhibition layer
JP2005532456A (en) * 2002-07-02 2005-10-27 ナノスフェアー　インコーポレイテッド Nanoparticle polyanion complex and its use in the detection of analytes
US20040009528A1 (en) * 2002-07-11 2004-01-15 Shyh-Yu Shaw Protein chips
USH2223H1 (en) * 2002-07-11 2008-09-02 The United States Of America As Represented By The Secretary Of The Navy Patterned, micrometer-sized antibody features
US20050008828A1 (en) * 2002-07-25 2005-01-13 Trustees Of Stevens Institute Of Technology Patterned polymer microgel and method of forming same
JP4099822B2 (en) * 2002-07-26 2008-06-11 セイコーエプソン株式会社 Dispensing device, dispensing method, and biological sample-containing solution ejection failure detection method
CA2497273C (en) * 2002-07-29 2014-06-10 Mt Technologies, Inc. Biomimetic membranes
US20040067597A1 (en) * 2002-07-31 2004-04-08 Caliper Technologies Corp. High density reagent array preparation methods
US20050074898A1 (en) * 2002-07-31 2005-04-07 Caliper Technologies Corp. High density reagent array preparation methods
AU2003254216A1 (en) * 2002-08-02 2004-02-23 Applera Corporation Fluorescence polarization assay
AU2003257109A1 (en) * 2002-08-05 2004-02-23 Invitrogen Corporation Compositions and methods for molecular biology
WO2004015393A2 (en) * 2002-08-13 2004-02-19 Discovery Partners International Spotting pattern for placement of compounds in an array
GB2391867A (en) * 2002-08-13 2004-02-18 Smartbead Technologies Ltd Analysis system using coded supports
WO2004016802A2 (en) * 2002-08-15 2004-02-26 Proteoplex, Inc. Methods and apparatus for preparing and assaying biological samples to determine protein concentration
EP2315027A1 (en) * 2002-08-16 2011-04-27 Decision Biomarkers Incorporated Substrates for isolating, reacting and microscopically analyzing materials
CA2496141A1 (en) * 2002-08-16 2004-02-26 Zyomyx, Inc. Methods and reagents for surface functionalization
US20050233473A1 (en) * 2002-08-16 2005-10-20 Zyomyx, Inc. Methods and reagents for surface functionalization
US7384742B2 (en) * 2002-08-16 2008-06-10 Decision Biomarkers, Inc. Substrates for isolating reacting and microscopically analyzing materials
AU2003270004A1 (en) * 2002-08-28 2004-03-19 Mt Technologies, Inc. Microfluidic affinity system using polydimethylsiloxane and a surface modification process
EP1540677A2 (en) * 2002-08-29 2005-06-15 Bioscale Inc. Resonant sensor and sensing system
JP2005537486A (en) * 2002-09-03 2005-12-08 ツェプトゼンス　アクチエンゲゼルシャフト Analytical platform and detection method in which analyte is measured as a specific binding partner immobilized in a sample
US20040043508A1 (en) * 2002-09-03 2004-03-04 Frutos Anthony G. Polymer-coated substrates for binding biological molecules
WO2004023143A2 (en) * 2002-09-03 2004-03-18 Zeptosens Ag Analytical platform and identification method
US7429492B2 (en) * 2002-09-09 2008-09-30 Sru Biosystems, Inc. Multiwell plates with integrated biosensors and membranes
US7927822B2 (en) * 2002-09-09 2011-04-19 Sru Biosystems, Inc. Methods for screening cells and antibodies
EP1548437A4 (en) * 2002-09-17 2006-06-07 Olympus Corp Method and apparatus for arranging liquid reaction components on substrate surface for detecting target substance by reaction among plural reaction components on substrate and article utilized in the method
US20050064508A1 (en) 2003-09-22 2005-03-24 Semzyme Peptide mediated synthesis of metallic and magnetic materials
JP2004105070A (en) * 2002-09-18 2004-04-08 Inst Of Physical & Chemical Res Method for producing ligand-bonded protein using cell-free protein synthetic system and use thereof
AU2003267255A1 (en) * 2002-09-20 2004-04-08 Novus Molecular, Inc. Methods and devices for active bioassay
US7143785B2 (en) 2002-09-25 2006-12-05 California Institute Of Technology Microfluidic large scale integration
JP5695287B2 (en) 2002-10-02 2015-04-01 カリフォルニア インスティテュート オブ テクノロジー Nucleic acid analysis of microfluids
CA2502246A1 (en) * 2002-10-15 2004-04-29 Abmetrix, Inc. Sets of digital antibodies directed against short epitopes, and methods using same
AU2003284227A1 (en) * 2002-10-15 2004-05-04 The Regents Of The University Of Michigan Multidimensional protein separation system
DE10249608A1 (en) * 2002-10-18 2004-05-06 Gkss-Forschungszentrum Geesthacht Gmbh Device and method for structural analysis and detection of complex glycostructures
EP1576374B1 (en) * 2002-10-25 2008-08-06 Sense Proteomic Limited Enzyme array and assay
US20040081969A1 (en) * 2002-10-29 2004-04-29 Ilsley Diane D. Devices and methods for evaulating the quality of a sample for use in an array assay
EP1585806A2 (en) * 2002-10-30 2005-10-19 Pointilliste, Inc. Methods for producing polypeptide-tagged collections and capture systems containing the tagged polypeptides
US20030153013A1 (en) * 2002-11-07 2003-08-14 Ruo-Pan Huang Antibody-based protein array system
CA2545304A1 (en) * 2002-11-08 2004-05-21 University Of Copenhagen Method of immobilising a protein to a zeolite
US7526114B2 (en) 2002-11-15 2009-04-28 Bioarray Solutions Ltd. Analysis, secure access to, and transmission of array images
US20040096914A1 (en) * 2002-11-20 2004-05-20 Ye Fang Substrates with stable surface chemistry for biological membrane arrays and methods for fabricating thereof
EP1578962A4 (en) * 2002-12-11 2007-03-14 New England Biolabs Inc Carrier-ligand fusions and uses thereof
WO2004055198A2 (en) * 2002-12-12 2004-07-01 Chiron Corporation Device and method for in-line blood testing using biochips
ATE534748T1 (en) * 2002-12-12 2011-12-15 Nanosphere Inc DIRECT SNP DETECTION USING NON-AMPLIFIED DNA
EP1573044A4 (en) 2002-12-18 2006-07-05 Ciphergen Biosystems Inc Serum biomarkers in lung cancer
US20040121339A1 (en) * 2002-12-19 2004-06-24 Jizhong Zhou Special film-coated substrate for bio-microarray fabrication and use thereof
EP1583816A4 (en) * 2002-12-22 2007-06-13 Scripps Research Inst Protein arrays
US7785601B2 (en) 2002-12-31 2010-08-31 Sygnis Bioscience Gmbh & Co. Kg Methods of treating neurological conditions with hematopoietic growth factors
US7695723B2 (en) 2002-12-31 2010-04-13 Sygnis Bioscience Gmbh & Co. Kg Methods of treating neurological conditions with hematopoietic growth factors
WO2004060044A2 (en) * 2003-01-02 2004-07-22 Bioforce Nanosciences, Inc. Method and apparatus for molecular analysis in small sample volumes
KR100523212B1 (en) * 2003-01-04 2005-10-24 한국과학기술원 A Protein Chip for Analyzing Interaction Between Protein and Substrate Peptide Therefor
US7736909B2 (en) * 2003-01-09 2010-06-15 Board Of Regents, The University Of Texas System Methods and compositions comprising capture agents
JP5253715B2 (en) * 2003-01-10 2013-07-31 株式会社プロテインクリスタル Protein complex, method for producing the same, and use thereof
US7422865B2 (en) * 2003-01-13 2008-09-09 Agilent Technologies, Inc. Method of identifying peptides in a proteomic sample
US20040137158A1 (en) * 2003-01-15 2004-07-15 Kools Jacques Constant Stefan Method for preparing a noble metal surface
JP4741458B2 (en) * 2003-01-16 2011-08-03 カプロテック・バイオアナリティクス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Method for analyzing capture compounds, collections thereof, and proteomes and composite compositions
KR100994566B1 (en) * 2003-01-20 2010-11-15 삼성전자주식회사 An array device comprising a photoresist film having immobilization regions and a method using the same
AU2003290561A1 (en) * 2003-02-10 2004-09-06 Dana Ault-Riche Self-assembling arrays and uses thereof
US20050008851A1 (en) * 2003-02-18 2005-01-13 Fuji Photo Film Co., Ltd. Biosensor
EP1606215B1 (en) * 2003-02-25 2008-12-17 Yeda Research And Development Co., Ltd. Nanoscopic structure and devices using the same
WO2004075855A2 (en) * 2003-02-26 2004-09-10 Biomed Solutions, Llc Process for in vivo treatment of specific biological targets in bodily fluid
EP1597399A2 (en) * 2003-02-27 2005-11-23 Nanosphere, Inc. Label-free gene expression profiling with universal nanoparticle probes in microarray assay format
CN1514243A (en) * 2003-04-30 2004-07-21 成都夸常科技有限公司 Method of preceeding qualitative and lor quantitative analysis against target substance its device and marker and detecting reagent box
EP2390352A1 (en) 2003-03-18 2011-11-30 Quantum Genetics Ireland Limited Systems and methods for improving protein and milk production of dairy herds
US20040185445A1 (en) * 2003-03-19 2004-09-23 Ye Fang Universal readout for target identification using biological microarrays
US7191068B2 (en) * 2003-03-25 2007-03-13 Proteogenix, Inc. Proteomic analysis of biological fluids
US8068990B2 (en) * 2003-03-25 2011-11-29 Hologic, Inc. Diagnosis of intra-uterine infection by proteomic analysis of cervical-vaginal fluids
US20040248287A1 (en) * 2003-03-28 2004-12-09 Qianjin Hu Multi-array systems and methods of use thereof
US20040197841A1 (en) * 2003-04-02 2004-10-07 Apffel James Alexander Methods and reagents for multiplexed analyses
US20050145496A1 (en) 2003-04-03 2005-07-07 Federico Goodsaid Thermal reaction device and method for using the same
US7476363B2 (en) 2003-04-03 2009-01-13 Fluidigm Corporation Microfluidic devices and methods of using same
US8828663B2 (en) 2005-03-18 2014-09-09 Fluidigm Corporation Thermal reaction device and method for using the same
AU2004228678A1 (en) 2003-04-03 2004-10-21 Fluidigm Corp. Microfluidic devices and methods of using same
US7604965B2 (en) 2003-04-03 2009-10-20 Fluidigm Corporation Thermal reaction device and method for using the same
US20040248205A1 (en) * 2003-04-16 2004-12-09 Stern Lawrence J. Major histocompatibility complex (MHC)-peptide arrays
WO2004094460A2 (en) 2003-04-17 2004-11-04 Ciphergen Biosystems, Inc. Polypeptides related to natriuretic peptides and methods of their identification and use
WO2004094989A2 (en) * 2003-04-22 2004-11-04 Ciphergen Biosystems, Inc. Methods of host cell protein analysis
WO2004097368A2 (en) * 2003-04-28 2004-11-11 Ciphergen Biosystems, Inc. Improved immunoassays
US7425700B2 (en) 2003-05-22 2008-09-16 Stults John T Systems and methods for discovery and analysis of markers
KR100547015B1 (en) * 2003-05-23 2006-01-26 주식회사 올메디쿠스 Biosensor for analyzing quantitatively analyte with a predetermined size and larger than, and manufacturing method thereof
US20050250094A1 (en) * 2003-05-30 2005-11-10 Nanosphere, Inc. Method for detecting analytes based on evanescent illumination and scatter-based detection of nanoparticle probe complexes
US20040248323A1 (en) * 2003-06-09 2004-12-09 Protometrix, Inc. Methods for conducting assays for enzyme activity on protein microarrays
JP4389870B2 (en) * 2003-06-10 2009-12-24 株式会社島津製作所 Cell-free protein synthesis method using mammalian cultured cell extract
WO2004113872A2 (en) * 2003-06-24 2004-12-29 The Trustees Of Columbia University In The City Of New York Covalent methods for immobilization of thiolated biomolecules on siliceous and metallic surfaces
US20040265921A1 (en) * 2003-06-30 2004-12-30 National University Of Singapore Intein-mediated attachment of ligands to proteins for immobilization onto a support
US7794947B2 (en) * 2003-07-10 2010-09-14 Institute For Systems Biology Affinity capture of peptides by microarray and related methods
US9243275B1 (en) * 2003-07-10 2016-01-26 Polytechnic Institute Of New York University Biosensor and method of making same
US20050079520A1 (en) * 2003-07-21 2005-04-14 Jie Wu Multiplexed analyte detection
US20060014003A1 (en) * 2003-07-24 2006-01-19 Libera Matthew R Functional nano-scale gels
US20050059024A1 (en) 2003-07-25 2005-03-17 Ambion, Inc. Methods and compositions for isolating small RNA molecules
CN1878866B (en) 2003-07-25 2012-08-01 安比恩股份有限公司 Methods and compositions for preparing RNA from a fixed sample
CA2534661A1 (en) 2003-08-08 2005-02-17 Genenews Inc. Osteoarthritis biomarkers and uses thereof
WO2005014805A1 (en) * 2003-08-08 2005-02-17 Regents Of The University Of Minnesota A structured material for the production of hydrogen
US7413712B2 (en) 2003-08-11 2008-08-19 California Institute Of Technology Microfluidic rotary flow reactor matrix
US7223609B2 (en) * 2003-08-14 2007-05-29 Agilent Technologies, Inc. Arrays for multiplexed surface plasmon resonance detection of biological molecules
AU2004267802B2 (en) * 2003-08-18 2011-03-17 Tethys Bioscience, Inc. Methods for reducing complexity of a sample using small epitope antibodies
US7754497B2 (en) * 2003-08-29 2010-07-13 Reverse Proteomics Research Institute Co., Ltd. Method for immobilizing proteins
US20070092964A1 (en) 2003-09-03 2007-04-26 Zymoyx, Inc. Ion detection using a pillar chip
US20050176026A1 (en) * 2003-09-05 2005-08-11 Franck Carl P. Liquid mixing reactor for biochemical assays
US20050053949A1 (en) * 2003-09-08 2005-03-10 Silin Vitalii Ivanovich Biochip for proteomics applications
US20050059083A1 (en) * 2003-09-15 2005-03-17 Becton Dickinson And Company High throughput method to identify ligands for cell attachment
WO2005029705A2 (en) 2003-09-18 2005-03-31 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
US7695688B2 (en) * 2003-09-19 2010-04-13 Applied Biosystems, Llc High density plate filler
US9492820B2 (en) 2003-09-19 2016-11-15 Applied Biosystems, Llc High density plate filler
KR100518953B1 (en) * 2003-09-19 2005-10-12 주식회사 제노포커스 Method for Whole Surrounding Surface Display of Target Proteins Using Exosporium of Bacillus cereus Group
US7998435B2 (en) 2003-09-19 2011-08-16 Life Technologies Corporation High density plate filler
US8277760B2 (en) 2003-09-19 2012-10-02 Applied Biosystems, Llc High density plate filler
US7407630B2 (en) 2003-09-19 2008-08-05 Applera Corporation High density plate filler
CA2539824C (en) 2003-09-22 2015-02-03 Xinwen Wang Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules
US8298780B2 (en) * 2003-09-22 2012-10-30 X-Body, Inc. Methods of detection of changes in cells
US20050069949A1 (en) * 2003-09-30 2005-03-31 International Business Machines Corporation Microfabricated Fluidic Structures
US20070017870A1 (en) * 2003-09-30 2007-01-25 Belov Yuri P Multicapillary device for sample preparation
WO2005032688A1 (en) * 2003-09-30 2005-04-14 Chromba, Inc. Multicapillary column for chromatography and sample preparation
US20050069462A1 (en) * 2003-09-30 2005-03-31 International Business Machines Corporation Microfluidics Packaging
US20050079507A1 (en) * 2003-10-09 2005-04-14 Ye Fang Target evaluation using biological membrane arrays
WO2005047851A2 (en) * 2003-10-15 2005-05-26 The Trustees Of Columbia University In The City Of New York Device for measuring nanometer level pattern-dependent binding reactions
US20050084981A1 (en) * 2003-10-16 2005-04-21 Magdalena Ostrowski Method of depositing a bioactive material on a substrate
US20050112650A1 (en) * 2003-10-20 2005-05-26 Ciphergen Biosystems, Inc. Reactive polyurethane-based polymers
WO2005040800A1 (en) * 2003-10-23 2005-05-06 Consejo Superior De Investigaciones Científicas Method for producing and using a new protein array, said protein array and the applications thereof
JP2006514299A (en) * 2003-10-27 2006-04-27 センス プロテオミック リミテッド Enzyme arrays and assays
AU2004286252A1 (en) 2003-10-28 2005-05-12 Bioarray Solutions Ltd. Optimization of gene expression analysis using immobilized capture probes
WO2005045060A2 (en) 2003-10-29 2005-05-19 Bioarray Solutions, Ltd. Multiplexed nucleic acid analysis by fragmentation of double-stranded dna
US20050095648A1 (en) * 2003-10-30 2005-05-05 Mario Geysen Method for designing linear epitopes and algorithm therefor and polypeptide epitopes
US20050214803A1 (en) * 2003-11-06 2005-09-29 Sru Biosystems, Llc High-density amine-functionalized surface
JP4796967B2 (en) 2003-11-07 2011-10-19 ヴァーミリオン インコーポレイテッド Biomarkers for Alzheimer's disease
US20060007515A1 (en) * 2003-11-13 2006-01-12 Dmitri Simonian Surface lubrication in microstructures
US7153896B2 (en) 2003-11-14 2006-12-26 Eastman Kodak Company Element for protein microarrays
US7332355B2 (en) * 2003-11-18 2008-02-19 California Institute Of Technology Method and compositions for the detection of protein glycosylation
CA2545653C (en) 2003-11-21 2014-07-08 Anp Technologies, Inc. Asymmetrically branched polymer conjugates and microarray assays
KR100580631B1 (en) * 2003-11-22 2006-05-16 삼성전자주식회사 A substrate having an oxide layer, method for detecting a target substance using the same and optical sensor containing the same
US20090246889A1 (en) * 2003-11-22 2009-10-01 Samsung Electronics Co., Ltd. Substrate having oxide layer, method for detecting target material using the substrate, and optical sensor including the substrate
US20050109622A1 (en) * 2003-11-26 2005-05-26 Peter Peumans Method for controlling electrodeposition of an entity and devices incorporating the immobilized entity
WO2005055812A2 (en) 2003-12-05 2005-06-23 Ciphergen Biosystems, Inc. Serum biomarkers for chagas disease
AU2004296412B2 (en) * 2003-12-12 2011-03-10 Anteo Technologies Pty Ltd A method for designing surfaces
EP1711819A4 (en) 2003-12-15 2008-04-16 Univ Pennsylvania Ct For Techn Method and devices for running reactions on a target plate for maldi mass spectrometry
US20050170445A1 (en) * 2004-01-07 2005-08-04 Duke University Methods of establishing profiles for use in evaluating wound healing and biocompatibility of implant materials and microarrays useful therefor
US20060018911A1 (en) * 2004-01-12 2006-01-26 Dana Ault-Riche Design of therapeutics and therapeutics
US20050208597A1 (en) * 2004-01-26 2005-09-22 The Board Of Trustees Of The Leland Stanford Junior University Microarray analysis of post-translational modifications
JP2005204609A (en) * 2004-01-26 2005-08-04 Canon Inc Kit for immobilizing organic material, structure in which organic material is immobilized and method for producing the same structure
EP1562046A1 (en) * 2004-02-03 2005-08-10 B.R.A.H.M.S Aktiengesellschaft Method of diagnosing sepsis by detecting selectively the concentration of superoxide dismutase 1 (SOD-1) in samples
WO2005112544A2 (en) 2004-02-19 2005-12-01 The Governors Of The University Of Alberta Leptin promoter polymorphisms and uses thereof
JP2005269902A (en) * 2004-03-22 2005-10-06 Seiko Epson Corp Method for immobilizing cell on solid-phase surface
US7276283B2 (en) * 2004-03-24 2007-10-02 Wisconsin Alumni Research Foundation Plasma-enhanced functionalization of carbon-containing substrates
US7723126B2 (en) * 2004-03-24 2010-05-25 Wisconsin Alumni Research Foundation Plasma-enhanced functionalization of inorganic oxide surfaces
CN100357738C (en) * 2004-03-26 2007-12-26 博奥生物有限公司 Method of detecting small molecule compound and its special biochip
JP2005312425A (en) * 2004-03-31 2005-11-10 Toyo Kohan Co Ltd Method for immobilizing polypeptide and solid support having polypeptide immobilized thereon, method for detection and purification of polypeptide using the same and solid support for immobilizing polypeptide
US7371331B2 (en) * 2004-04-01 2008-05-13 Valerie J Marty Method of creating a patterned monolayer on a surface
JP4451193B2 (en) * 2004-04-12 2010-04-14 大日本印刷株式会社 Method for producing pattern forming body
WO2005108615A2 (en) * 2004-04-14 2005-11-17 President And Fellows Of Harvard College Nucleic-acid programmable protein arrays
EP2207033B1 (en) 2004-04-15 2014-06-18 University of Florida Research Foundation, Inc. Neural proteins as biomarkers for nervous system injury and other neural disorders
WO2005103281A2 (en) 2004-04-26 2005-11-03 Children's Medical Center Corporation Platelet biomarkers for the detection of disease
US20080304068A1 (en) * 2004-04-28 2008-12-11 Tsuneo Urisu Biochip Production Method, Biochip, Biochip Analysis Apparatus, and Biochip Analysis Method
WO2005118810A1 (en) 2004-06-03 2005-12-15 Athlomics Pty Ltd Agents and methods for diagnosing stress
US20060251795A1 (en) * 2005-05-05 2006-11-09 Boris Kobrin Controlled vapor deposition of biocompatible coatings for medical devices
DE102004031258A1 (en) * 2004-06-29 2006-02-09 Jennissen, Herbert P., Prof. Dr. Protein hybrids with polyhydroxyaromatic amino acid epitopes
WO2006002472A1 (en) 2004-07-02 2006-01-12 Bio-Layer Pty Ltd Use of metal complexes
US20060009623A1 (en) * 2004-07-06 2006-01-12 National University Of Singapore C-terminal attachment of ligands to proteins for immobilization onto a support
US20060014155A1 (en) * 2004-07-16 2006-01-19 Wisconsin Alumni Research Foundation Methods for the production of sensor arrays using electrically addressable electrodes
WO2006007664A1 (en) * 2004-07-22 2006-01-26 Genomics Research Partners Pty Ltd Agents and methods for diagnosing osteoarthritis
CA2579790A1 (en) * 2004-07-30 2006-02-09 Mount Sinai School Of Medicine Of New York University Npc1l1 and npc1l1 inhibitors and methods of use thereof
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
WO2006012744A1 (en) * 2004-08-04 2006-02-09 Axela Biosensors Inc. Patterned surfaces with chemical crosslinkers for use in diffraction-based sensing
US20060040377A1 (en) * 2004-08-17 2006-02-23 Biocept, Inc. Protein microarrays
US20130040840A1 (en) * 2004-09-02 2013-02-14 Bioarray Solutions, Ltd. Nucleic acid amplification with integrated multiplex detection
US20060052948A1 (en) * 2004-09-09 2006-03-09 Jorn Gorlach Method of identifying drugs, targeting moieties or diagnostics
US20060051348A1 (en) * 2004-09-09 2006-03-09 Jorn Gorlach Method of producing a plurality of isolated antibodies to a plurality of cognate antigens
CA2591926A1 (en) * 2004-09-20 2006-03-30 Proteogenix, Inc. Diagnosis of fetal aneuploidy
ITVR20040149A1 (en) * 2004-09-22 2004-12-22 Sanitaria Scaligera Spa RAPID MONITORING SYSTEM OF THE BLOOD GROUP AND FOR THE DETECTION OF IMMUNOHEMATOLOGICAL REACTIONS
US7592139B2 (en) 2004-09-24 2009-09-22 Sandia National Laboratories High temperature flow-through device for rapid solubilization and analysis
JP2006095452A (en) * 2004-09-30 2006-04-13 Fuji Photo Film Co Ltd Spin coat film forming method
WO2006041392A1 (en) * 2004-10-13 2006-04-20 Biacore Ab Preparation and use of a reactive solid support surface
SE0402476D0 (en) * 2004-10-13 2004-10-13 Biacore Ab Preparation and use of a reactive solid support surface
WO2006047417A2 (en) 2004-10-21 2006-05-04 University Of Florida Research Foundation, Inc. Detection of cannabinoid receptor biomarkers and uses thereof
WO2006043179A1 (en) * 2004-10-23 2006-04-27 Biosystems International Sas Expression profiling platform technology
US20110077164A1 (en) * 2004-10-23 2011-03-31 Andras Guttman Expression profiling platform technology
WO2006049498A1 (en) * 2004-11-05 2006-05-11 Modiquest B.V. Means and methods for isolating and/or identifying a target molecule
US20060246467A1 (en) * 2004-11-15 2006-11-02 California Institute Of Technology Biomarker sensors and method for multi-color imaging and processing of single-molecule life signatures
US20060223195A1 (en) * 2004-11-16 2006-10-05 Meyer Grant D Stress based removal of nonspecific binding from surfaces
US7745143B2 (en) * 2004-11-19 2010-06-29 Plexera, Llc Plasmon resonance biosensor and method
EP1812714B1 (en) * 2004-11-19 2008-03-26 ebm-papst St. Georgen GmbH & Co. KG Arrangement with a ventilator and a pump
WO2006062427A1 (en) * 2004-11-24 2006-06-15 Institut Molekulyarnoi Biologii Im. V.A.Engelgardta Rossiiskoi Akademii Nauk Method for quantitatively detecting biological toxins
ES2416207T3 (en) * 2004-11-29 2013-07-30 Centre National De La Recherche Scientifique Trichlorosilyl alkyl isocyanate molecule and surface modified mineral substrate
CA2590188A1 (en) * 2004-12-08 2006-06-15 Lyotropic Therapeutics, Inc. Compositions for binding to assay substrata and methods of using
US20080003599A1 (en) * 2004-12-28 2008-01-03 Dary Ekaterina L Biological Microchip for Multiple Parallel Immunoassay of Compounds and Immunoassay Metods Using Said Microchip
WO2006074360A2 (en) * 2005-01-06 2006-07-13 Eastern Virginia Medical School Apolipoprotein a-ii isoform as a biomarker for prostate cancer
JP4736439B2 (en) * 2005-01-25 2011-07-27 東レ株式会社 Nucleic acid immobilization carrier
CA2595377A1 (en) 2005-01-28 2006-08-03 Children's Medical Center Corporation Methods for diagnosis and prognosis of epithelial cancers
US7396689B2 (en) * 2005-02-04 2008-07-08 Decision Biomarkers Incorporated Method of adjusting the working range of a multi-analyte assay
EP2520669A3 (en) 2005-02-07 2013-02-27 GeneNews Inc. Mild osteoathritis biomarkers and uses thereof
JP2006335912A (en) * 2005-06-03 2006-12-14 Fujifilm Holdings Corp Immobilizing agent for physiologically active substance
US20060240478A1 (en) * 2005-02-23 2006-10-26 Fuji Photo Film Co., Ltd. Biosensor
US20060234265A1 (en) * 2005-03-21 2006-10-19 Jim Richey Microarrays having multi-functional, compartmentalized analysis areas and methods of use
JP4435709B2 (en) * 2005-03-22 2010-03-24 富士フイルム株式会社 Biosensor
WO2006110314A2 (en) 2005-03-25 2006-10-19 Ambion, Inc. Methods and compositions for depleting abundant rna transcripts
AU2006232370B2 (en) 2005-04-01 2011-10-06 Banyan Biomarkers Biomakers of liver injury
US8048638B2 (en) 2005-04-01 2011-11-01 University Of Florida Research Foundation, Inc. Biomarkers of liver injury
US20060234269A1 (en) * 2005-04-18 2006-10-19 Matthew Asplund Laser Modification and Functionalization of Substrates
JP5002584B2 (en) * 2005-04-26 2012-08-15 バイエル・テクノロジー・サービシズ・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング Novel apparatus and method for coating a substrate for the detection of an analytical sample by an affinity assay method
US7611908B2 (en) * 2005-05-02 2009-11-03 Bioscale, Inc. Method and apparatus for therapeutic drug monitoring using an acoustic device
US7749445B2 (en) * 2005-05-02 2010-07-06 Bioscale, Inc. Method and apparatus for analyzing bioprocess fluids
WO2006119160A2 (en) 2005-05-02 2006-11-09 Anp Technologies, Inc. Polymer conjugate enhanced bioassays
US7648844B2 (en) * 2005-05-02 2010-01-19 Bioscale, Inc. Method and apparatus for detection of analyte using an acoustic device
US7300631B2 (en) * 2005-05-02 2007-11-27 Bioscale, Inc. Method and apparatus for detection of analyte using a flexural plate wave device and magnetic particles
US20070003954A1 (en) * 2005-05-12 2007-01-04 The Board Of Regents Of The University Of Texas System Protein and antibody profiling using small molecule microarrays
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
US20070021433A1 (en) 2005-06-03 2007-01-25 Jian-Qiang Fan Pharmacological chaperones for treating obesity
RU2596491C2 (en) 2005-06-08 2016-09-10 Дана-Фарбер Кэнсер Инститьют Methods and compositions for treating persistent infections
US20100056392A1 (en) * 2005-06-15 2010-03-04 Matthew Greving Microstructure and microdomain microarrays, methods of making same and uses thereof
WO2007002567A2 (en) * 2005-06-23 2007-01-04 Nanosphere, Inc. Selective isolation and concentration of nucleic acids from complex samples
WO2007002527A2 (en) 2005-06-24 2007-01-04 Ciphergen Biosystems, Inc. BIOMARKERS FOR OVARIAN CANCER: β-2 MICROGLOBULIN
EP2476761A3 (en) 2005-07-07 2012-10-17 Athlomics Pty Ltd Polynucleotide marker genes and their expression, for diagnosis of endotoxemia
WO2007024877A2 (en) 2005-08-22 2007-03-01 Cornell Research Foundation, Inc. Compositions and methods for analyzing protein interactions
US7464580B2 (en) * 2005-09-26 2008-12-16 Oakland University Ionic liquid high temperature gas sensors
US9057046B2 (en) 2005-09-26 2015-06-16 Rapid Micro Biosystems, Inc. Cassette containing growth medium
FR2891279B1 (en) * 2005-09-27 2007-12-14 Centre Nat Rech Scient NEW CHIPS FOR SURFACE PLASMON DETECTION (SPR)
US20070202515A1 (en) * 2005-10-12 2007-08-30 Pathologica, Llc. Promac signature application
US20070141627A1 (en) * 2005-10-19 2007-06-21 Behrens Timothy W Systemic Lupus Erythematosus
ATE518007T1 (en) 2005-10-21 2011-08-15 Genenews Inc METHOD AND APPARATUS FOR CORRELING LEVELS OF BIOMARKER PRODUCTS WITH DISEASES
JP5127718B2 (en) 2005-10-29 2013-01-23 バイエル・テクノロジー・サービシズ・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング Method for measuring one or more analytes in a sample of biological origin having a complex composition and use thereof
FR2893130B1 (en) * 2005-11-08 2008-05-02 Thales Sa IMAGING DEVICE FOR BIOPUCE, AND BIOPUCE THEREFOR
WO2008054398A2 (en) 2005-11-09 2008-05-08 The Trustees Of Columbia University In The City Of New York Photochemical methods and photoactive compounds for modifying surfaces
US7960312B2 (en) * 2005-11-10 2011-06-14 National University Of Corporation Hiroshima University Method and agent for immobilizing protein via protein bound to silicon oxide-containing substance
US8372596B2 (en) * 2005-11-10 2013-02-12 National University Of Corporation Hiroshima University Asbestos detection method, asbestos detection agent, asbestos detection kit, method for screening candidate for agent aiming at preventing or treating disease for which asbestos is causative or worsening factor
EP1951906B1 (en) * 2005-11-10 2010-12-22 Bristol-Myers Squibb Pharma Company Moesin, caveolin 1 and yes associated protein 1 as predictive markers of response to dasatinib in breast cancers
US7889347B2 (en) * 2005-11-21 2011-02-15 Plexera Llc Surface plasmon resonance spectrometer with an actuator driven angle scanning mechanism
US7463358B2 (en) * 2005-12-06 2008-12-09 Lumera Corporation Highly stable surface plasmon resonance plates, microarrays, and methods
WO2007070809A2 (en) * 2005-12-12 2007-06-21 Mcgill University Biomarkers for babesia
US20130172274A1 (en) 2005-12-20 2013-07-04 Duke University Methods and compositions for delivering active agents with enhanced pharmacological properties
WO2007073486A2 (en) 2005-12-20 2007-06-28 Duke University Methods and compositions for delivering active agents with enhanced pharmacological properties
US8841255B2 (en) 2005-12-20 2014-09-23 Duke University Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides
JP2007171003A (en) * 2005-12-22 2007-07-05 Fujifilm Corp Substrate for mass spectrometry, analytical method, and apparatus
US7781203B2 (en) * 2005-12-29 2010-08-24 Corning Incorporated Supports for assaying analytes and methods of making and using thereof
AU2006332457A1 (en) * 2005-12-30 2007-07-12 Bio-Layer Pty Limited Binding of molecules
AU2007277445A1 (en) * 2006-01-03 2008-01-31 Dana-Farber Cancer Institute Small molecule printing
US7709227B2 (en) * 2006-01-04 2010-05-04 Phasebio Pharmaceuticals, Inc. Multimeric ELP fusion constructs
US7648834B2 (en) * 2006-01-17 2010-01-19 Moore Wayne E Plasmon fluorescence augmentation for chemical and biological testing apparatus
US20090011428A1 (en) * 2006-01-18 2009-01-08 The Regents Of The University Of California Fluid Membrane-Based Ligand Display System for Live Cell Assays and Disease Diagnosis Applications
AU2007209980A1 (en) * 2006-01-27 2007-08-09 Eastern Virginia Medical School Proteomic fingerprinting of human IVF-derived embryos: identification of biomarkers of developmental potential
JP4833679B2 (en) * 2006-01-31 2011-12-07 富士通株式会社 Method and apparatus for producing molecular film with adjusted density
US8008067B2 (en) 2006-02-13 2011-08-30 University Of Maryland, Baltimore County Microwave trigger metal-enhanced chemiluminescence (MT MEC) and spatial and temporal control of same
CA2642833A1 (en) 2006-02-17 2007-08-30 Children's Medical Center Corporation Free ngal as a biomarker for cancer
US20070207504A1 (en) * 2006-03-06 2007-09-06 The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Proteomic methods for the identification of differentiated adipose cells and adipose derived adult stem cells
EP1996942A1 (en) * 2006-03-10 2008-12-03 Tethys Bioscience, Inc. Multiplex protein fractionation
WO2007106466A2 (en) 2006-03-11 2007-09-20 The Board Of Trustees Of The Leland Stanford Junior University Beta-2 microglobulin as a biomarker for peripheral artery disease
US7855057B2 (en) * 2006-03-23 2010-12-21 Millipore Corporation Protein splice variant/isoform discrimination and quantitative measurements thereof
US7909928B2 (en) 2006-03-24 2011-03-22 The Regents Of The University Of Michigan Reactive coatings for regioselective surface modification
US8288162B2 (en) * 2006-03-28 2012-10-16 Inanovate, Inc. Nano-particle biochip substrates
US7886577B2 (en) 2006-03-30 2011-02-15 Oakland University Devices with surface bound ionic liquids and method of use thereof
US8375768B2 (en) * 2006-03-30 2013-02-19 Oakland University Ionic liquid thin layer sensor for electrochemical and/or piezoelectric measurements
WO2007115207A2 (en) * 2006-03-31 2007-10-11 Regents Of The University Of Minnesota Irf-5 haplotypes in systemic lupus erythematosus
US20080003694A1 (en) * 2006-04-18 2008-01-03 Swanson Basil I Robust, self-assembled, biocompatible films
US7923054B2 (en) 2006-04-19 2011-04-12 Gore Enterprise Holdings, Inc. Functional porous substrates for attaching biomolecules
US20100216657A1 (en) * 2006-05-16 2010-08-26 Arcxis Biotechnologies, Inc. Pcr-free sample preparation and detection systems for high speed biologic analysis and identification
WO2007140388A2 (en) * 2006-05-31 2007-12-06 The Johns Hopkins University Ablation based laser machining of biomolecule patterns on substrates
US7947148B2 (en) 2006-06-01 2011-05-24 The Regents Of The University Of Michigan Dry adhesion bonding
KR100931027B1 (en) 2006-06-27 2009-12-10 한국생명공학연구원 Cysteine-tagged Protein shock Variant at the N-terminus
WO2008002267A1 (en) * 2006-06-28 2008-01-03 Rgb Technologies Ab A sensor kit and a system for detecting an analyte in a test environment
US8178316B2 (en) * 2006-06-29 2012-05-15 President And Fellows Of Harvard College Evaluating proteins
FR2903590B1 (en) * 2006-07-13 2013-05-10 Commissariat Energie Atomique CELL SENSING DEVICE BY CONTACT
US20100003189A1 (en) 2006-07-14 2010-01-07 The Regents Of The University Of California Cancer biomarkers and methods of use thereof
US8343539B2 (en) * 2006-07-14 2013-01-01 Regents Of The University Of Minnesota Compounds that bind α5β1 integrin and methods of use
KR100813262B1 (en) * 2006-07-25 2008-03-13 삼성전자주식회사 Method for producing a patterned spot microarray using photocatalyst and a microarray produced by the method
CN101501499A (en) * 2006-08-02 2009-08-05 皇家飞利浦电子股份有限公司 A method of determining the concentration of an analyte using analyte sensor molecules coupled to a porous membrane
GB0617429D0 (en) * 2006-09-05 2006-10-18 Electrophoretics Ltd Markers of renal transplant rejection and renal damage
ES2655564T3 (en) 2006-09-07 2018-02-20 Otago Innovation Limited Biomarker for the early detection of acute heart disorders
US8658573B2 (en) * 2006-09-11 2014-02-25 The Trustees Of Columbia University In The City Of New York Photo-generated carbohydrate arrays and the rapid identification of pathogen-specific antigens and antibodies
US8273539B2 (en) 2006-09-25 2012-09-25 Mayo Foundation For Medical Education And Research Extracellular and membrane-associated prostate cancer markers
US20090087925A1 (en) * 2007-10-01 2009-04-02 Zyomyx, Inc. Devices and methods for analysis of samples with depletion of analyte content
US20080085512A1 (en) * 2006-10-05 2008-04-10 D Andrade Petula N Array assay devices and methods for making and using the same
WO2008127291A2 (en) * 2006-10-10 2008-10-23 Los Alamos National Security, Llc Advanced drug development and manufacturing
EP2074230B1 (en) 2006-10-11 2012-11-28 Janssen Pharmaceutica NV Compositions and methods for treating and diagnosing irritable bowel syndrome
US20080167532A1 (en) * 2006-10-13 2008-07-10 Mayo Foundation For Medical Education And Research Assessing cancer treatment responsiveness
JP2008105973A (en) * 2006-10-24 2008-05-08 Toyo Kohan Co Ltd Method of preserving polypeptide immobilized support
CN101646943A (en) * 2006-10-31 2010-02-10 Sru生物系统公司 Method for blocking non-specific protein binding on a functionalized surface
JP2008171800A (en) * 2006-10-31 2008-07-24 Fei Co Protective layer for charged particle beam processing
WO2008058018A2 (en) 2006-11-02 2008-05-15 Mayo Foundation For Medical Education And Research Predicting cancer outcome
EP2089532A4 (en) * 2006-12-01 2010-02-17 Cedars Sinai Medical Center Positive selection of serum proteins for proteomic analysis
US8029902B2 (en) * 2006-12-11 2011-10-04 Wisconsin Alumni Research Foundation Plasma-enhanced functionalization of substrate surfaces with quaternary ammonium and quaternary phosphonium groups
CN101663323A (en) * 2006-12-27 2010-03-03 埃默里大学 The composition and the method that are used for the treatment of transmissible disease and tumour
KR100894419B1 (en) * 2006-12-29 2009-04-24 삼성전자주식회사 Biochip kit and method of testing biological sample
EP2629094A1 (en) 2007-01-24 2013-08-21 Carnegie Mellon University Optical biosensors
US20090053690A1 (en) * 2007-02-02 2009-02-26 California Institute Of Technology Surface chemistry and deposition techniques
US7867783B2 (en) 2007-02-22 2011-01-11 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
TW200837349A (en) * 2007-03-07 2008-09-16 Nat Univ Tsing Hua Biochip and manufacturing method thereof
KR100836206B1 (en) 2007-03-20 2008-06-09 연세대학교 산학협력단 Peg hydrogel for fabrication of micropattern and process thereof
US8399047B2 (en) 2007-03-22 2013-03-19 The Regents Of The Univeristy Of Michigan Multifunctional CVD coatings
JP4850855B2 (en) * 2007-03-22 2012-01-11 信越化学工業株式会社 Manufacturing method of substrate for producing microarray
EP2210099A4 (en) 2007-03-27 2011-03-16 Vermillion Inc Biomarkers for ovarian cancer
JP5656339B2 (en) * 2007-03-28 2015-01-21 Jsr株式会社 Protein-immobilized carrier and method for producing the same
US20080242559A1 (en) * 2007-03-28 2008-10-02 Northwestern University Protein and peptide arrays
US7863037B1 (en) 2007-04-04 2011-01-04 Maven Technologies, Llc Ligand binding assays on microarrays in closed multiwell plates
US8093039B2 (en) 2007-04-10 2012-01-10 The Trustees Of The Stevens Institute Of Technology Surfaces differentially adhesive to eukaryotic cells and non-eukaryotic cells
EP2153203A4 (en) * 2007-04-19 2010-04-21 Sru Biosystems Inc Method for employing a biosensor to detect small molecules that bind directly to immobilized targets
WO2008128333A1 (en) * 2007-04-19 2008-10-30 The Governors Of The University Of Alberta A method to distinguish antibody-mediated tissue rejection from t cell-mediated tissue rejection
US20080274458A1 (en) * 2007-05-01 2008-11-06 Latham Gary J Nucleic acid quantitation methods
EP2162552A4 (en) 2007-05-11 2010-06-30 Univ Johns Hopkins Biomarkers for melanoma
US20090041633A1 (en) * 2007-05-14 2009-02-12 Dultz Shane C Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
WO2008143351A1 (en) * 2007-05-18 2008-11-27 Fujirebio Inc. Chemical surface nanopatterns to increase activity of surface-immobilized biomolecules
US7799558B1 (en) 2007-05-22 2010-09-21 Dultz Shane C Ligand binding assays on microarrays in closed multiwell plates
US20100184110A1 (en) * 2007-06-06 2010-07-22 Siemens Healthcare Diagnostics Inc. Predictive diagnostics for kidney disease
KR100927886B1 (en) * 2007-06-18 2009-11-23 한국생명공학연구원 Protein shock-oligonucleotide conjugates
EP3666284A1 (en) 2007-06-22 2020-06-17 Children's Medical Center, Corp. Methods and uses thereof of a fragment of saposin a
US20100291563A1 (en) * 2007-06-29 2010-11-18 Halloran Philip F Assessing tissue rejection
US9134307B2 (en) * 2007-07-11 2015-09-15 X-Body, Inc. Method for determining ion channel modulating properties of a test reagent
AU2008274978A1 (en) * 2007-07-11 2009-01-15 Sru Biosystems, Inc. Methods of identifying modulators of ion channels
KR20100058496A (en) * 2007-07-20 2010-06-03 더 유니버시티 오브 유타 리서치 파운데이션 Identification and quantification of biomarkers for evaluating the risk of preterm birth
DE102007034993A1 (en) * 2007-07-26 2009-01-29 Hanna Diehl Soluble Cadherin 17 for the diagnosis and risk stratification of colon or colon cancer
US20090060786A1 (en) * 2007-08-29 2009-03-05 Gibum Kim Microfluidic apparatus for wide area microarrays
US8354280B2 (en) 2007-09-06 2013-01-15 Bioscale, Inc. Reusable detection surfaces and methods of using same
EP2548962B1 (en) 2007-09-19 2016-01-13 Applied Biosystems, LLC Sirna sequence-independent modification formats for reducing off-target phenotypic effects in rnai, and stabilized forms thereof
US20090087919A1 (en) 2007-09-28 2009-04-02 Caldera Pharmaceuticals, Inc. Method and Apparatus for Measuring Protein Post-Translational Modification
WO2009058867A2 (en) * 2007-10-29 2009-05-07 Primorigen Biosciences, Llc Affinity measurements using frameless multiplexed microarrays
EP3536336A1 (en) 2007-11-30 2019-09-11 Siemens Healthcare Diagnostics Inc. Adiponectin receptor fragments and methods of use
US8004669B1 (en) 2007-12-18 2011-08-23 Plexera Llc SPR apparatus with a high performance fluid delivery system
US20090181857A1 (en) * 2008-01-15 2009-07-16 Academia Sinica System and method for producing a label-free micro-array biochip
KR100959831B1 (en) 2008-01-18 2010-05-28 포항공과대학교 산학협력단 Pattern-Recognition Type Plate Detecting Multi-Biomolecule
US20090196852A1 (en) * 2008-02-04 2009-08-06 Watkinson D Tobin Compositions and methods for diagnosing and treating immune disorders
DE102008011850A1 (en) * 2008-02-29 2009-09-03 Michael Grzendowski Biomarker for the diagnosis of brain tumor
EP3156925A3 (en) 2008-03-10 2017-06-21 Lineagen, Inc. Copd biomarker signatures
AU2009224114B2 (en) 2008-03-12 2013-02-21 Otago Innovation Limited Biomarkers
CA2715914C (en) 2008-03-12 2019-01-22 Otago Innovation Limited Insulin signal peptide fragment biomarkers
EP2260305A1 (en) * 2008-03-27 2010-12-15 INSERM (Institut National de la Santé et de la Recherche Medicale) Methods and kits for determining the occurrence of a liver disease in a subject
WO2009121034A2 (en) * 2008-03-28 2009-10-01 Pelican Group Holdings, Inc. Multicapillary sample preparation devices and methods for processing analytes
US8257936B2 (en) * 2008-04-09 2012-09-04 X-Body Inc. High resolution label free analysis of cellular properties
WO2009137244A1 (en) * 2008-04-15 2009-11-12 Charles River Laboratories, Inc. Cartridge and method for sample analysis
US20090263905A1 (en) * 2008-04-18 2009-10-22 Kim Scheuringer Detection test assembly for detecting the presence of a substance in a sample
SG190572A1 (en) 2008-04-29 2013-06-28 Abbott Lab Dual variable domain immunoglobulins and uses thereof
US7981664B1 (en) 2008-05-22 2011-07-19 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US8039270B2 (en) * 2008-05-22 2011-10-18 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
EP2806054A1 (en) 2008-05-28 2014-11-26 Genomedx Biosciences Inc. Systems and methods for expression-based discrimination of distinct clinical disease states in prostate cancer
US20090298082A1 (en) * 2008-05-30 2009-12-03 Klee George G Biomarker panels for predicting prostate cancer outcomes
US10407731B2 (en) 2008-05-30 2019-09-10 Mayo Foundation For Medical Education And Research Biomarker panels for predicting prostate cancer outcomes
CA2726087A1 (en) 2008-06-03 2009-12-10 Tariq Ghayur Dual variable domain immunoglobulins and uses thereof
CA2726908C (en) * 2008-06-04 2017-01-24 Talecris Biotherapeutics, Inc. Composition, method, and kit for preparing plasmin
US20100015721A1 (en) * 2008-06-04 2010-01-21 Sru Biosystems, Inc. Detection of Promiscuous Small Submicrometer Aggregates
CA2953975C (en) 2008-06-27 2019-11-26 Duke University Therapeutic agents comprising elastin-like peptides
WO2010123720A1 (en) 2009-04-23 2010-10-28 Siemens Healthcare Diagnostics Inc. Monomeric and dimeric forms of adiponectin receptor fragments and methods of use
US8021850B2 (en) * 2008-07-14 2011-09-20 Ribo Guo Universal tandem solid-phases based immunoassay
WO2010123608A2 (en) 2009-01-29 2010-10-28 The Regents Of The University Of California A spatial biomarker of disease and detection of spatial organization of cellular recptors
WO2010011860A1 (en) * 2008-07-23 2010-01-28 Diabetomics, Llc Methods for detecting pre-diabetes and diabetes
CA2738317C (en) 2008-09-24 2020-01-14 Straus Holdings Inc. Imaging analyzer for testing analytes
WO2010056337A2 (en) 2008-11-12 2010-05-20 Caris Mpi, Inc. Methods and systems of using exosomes for determining phenotypes
DK2370593T3 (en) * 2008-11-28 2016-07-04 Univ Emory A method for determining the effect of PD-1 Antagonists
JP4911639B2 (en) * 2008-12-02 2012-04-04 学校法人早稲田大学 Biosensing method and immobilization method
US8349325B2 (en) 2008-12-23 2013-01-08 Abbott Laboratories Soluble FMS-like tyrosine kinase-1 (sFLT-1) antibody and related composition, kit, methods of using, and materials and method for making
JP5684724B2 (en) 2008-12-30 2015-03-18 ヤンセン バイオテツク，インコーポレーテツド Serum markers to predict clinical response to anti-TNFα antibodies in patients with ankylosing spondylitis
US20100166739A1 (en) * 2008-12-30 2010-07-01 Lipella Paharmaceuticals Inc. Methods and Compositions for Diagnosing Urological Disorders
CA2750818A1 (en) 2009-01-27 2010-08-05 Proteogenix, Inc. Biomarkers for detection of neonatal sepsis in biological fluid
WO2010087985A2 (en) 2009-01-28 2010-08-05 Yale University Novel markers for detection of complications resulting from in utero encounters
US9958442B2 (en) 2009-02-11 2018-05-01 Duke University Sensors incorporating antibodies and methods of making and using the same
JP5789521B2 (en) 2009-03-03 2015-10-07 グリフオルス・セラピユーテイクス・インコーポレーテツドＧｒｉｆｏｌｓ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． Compositions, methods and kits for producing plasminogen; and plasmin produced therefrom
EP2810652A3 (en) 2009-03-05 2015-03-11 AbbVie Inc. IL-17 binding proteins
EP2409155A1 (en) 2009-03-15 2012-01-25 Technion Research and Development Foundation, Ltd. Soluble hla complexes for use in disease diagnosis
US20100273185A1 (en) * 2009-04-27 2010-10-28 Sru Biosystems, Inc. Detection of Biased Agonist Activation
WO2010125566A2 (en) 2009-04-27 2010-11-04 Technion Research And Development Foundation Ltd. Markers for cancer detection
US20120208291A1 (en) * 2009-05-01 2012-08-16 Univeristy Of Utah Research Foundation Methods and compositions for measuring high affinity interactions with kinetic imaging of single molecule interaction (kismi)
WO2010132890A1 (en) * 2009-05-15 2010-11-18 Sru Biosystems, Inc Detection of changes in cell populations and mixed cell populations
CN102449481B (en) * 2009-05-29 2016-05-25 德克萨斯大学系统董事会 For separating of with the class peptide part of processing autoimmune T cell
AU2010256880B2 (en) * 2009-06-02 2015-01-22 Opko Health, Inc. Identification of small molecules recognized by antibodies in subjects with neurodegenerative diseases
US20120190574A1 (en) 2009-06-19 2012-07-26 The Arizona Board of Regents, A body Corporate of the State of Arizona for and on behalf of Arizona Compound Arrays for Sample Profiling
GB0912231D0 (en) * 2009-07-14 2009-08-26 Imp Innovations Ltd Method and apparatus for determining an analyte parameter
US8685755B2 (en) * 2009-07-20 2014-04-01 The Board Of Regents Of The University Of Texas System Combinatorial multidomain mesoporous chips and a method for fractionation, stabilization, and storage of biomolecules
KR101943420B1 (en) 2009-08-14 2019-04-17 파세비오 파마수티컬스 인코포레이티드 Modified Vasoactive Intestinal Peptide
EP2504024A2 (en) 2009-09-27 2012-10-03 Ruhr-Universität Bochum Method for the therapy and diagnosis of alzheimer's disease
WO2011047257A1 (en) * 2009-10-16 2011-04-21 The Board Of Regents Of The University Of Texas System Compositions and methods for producing cyclic peptoid libraries
KR101105328B1 (en) * 2009-11-23 2012-01-16 한국표준과학연구원 Apparatus and method for quantifying the binding and dissociation kinetics of molecular interactions
AU2010325147B2 (en) 2009-11-25 2016-06-30 Hologic, Inc. Detection of intraamniotic infection
CA2822026C (en) 2009-12-17 2018-06-12 Children's Medical Center Corporation Saposin-a derived peptides and uses thereof
US8355133B2 (en) * 2009-12-30 2013-01-15 Maven Technologies, Llc Biological testing with sawtooth-shaped prisms
US20140148348A1 (en) 2010-01-13 2014-05-29 Christine Kuslich Dectection of gastrointestinal disorders
WO2011089903A1 (en) * 2010-01-25 2011-07-28 Panasonic Corporation A method for immobilizing protein a on a self-assembled monolayer
EP2531224B1 (en) 2010-01-26 2019-06-05 Bioregency, Inc. Compositions and methods relating to argininosuccinate synthetase
JP5808349B2 (en) 2010-03-01 2015-11-10 カリス ライフ サイエンシズ スウィッツァーランド ホールディングスゲーエムベーハー Biomarkers for theranosis
JP5828195B2 (en) 2010-03-11 2015-12-02 ユニバーシティ オブ ルイスビル リサーチ ファンデーション，インコーポレイテッドＵｎｉｖｅｒｓｉｔｙ Ｏｆ Ｌｏｕｉｓｖｉｌｌｅ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ，Ｉｎｃ． Methods for predicting pregnancy loss risk and methods for reducing pregnancy loss risk
US20110229921A1 (en) 2010-03-18 2011-09-22 Abbott Laboratories METHODS OF ASSAYING URINARY NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (uNGAL) IN THE PROGNOSIS OF CADAVERIC KIDNEY TRANSPLANT FUNCTION IN A PATIENT, INCLUDING A PATIENT DIAGNOSED WITH DELAYED GRAFT FUNCTION (DGF), A METHOD OF ASSAYING uNGAL IN THE ASSESSMENT OF RISK OF DGF IN A PATIENT DIAGNOSED WITH EARLY GRAFT FUNCTION (EGF), AND RELATED KITS
EP2553151A4 (en) * 2010-03-26 2013-07-31 X Body Inc Use of induced pluripotent cells and other cells for screening compound libraries
BR112012025593A2 (en) 2010-04-06 2019-06-25 Caris Life Sciences Luxembourg Holdings circulating biomarkers for disease
EP3508854A1 (en) 2010-04-27 2019-07-10 The Regents of The University of California Cancer biomarkers and methods of use thereof
SI2571532T1 (en) 2010-05-14 2017-10-30 Abbvie Inc. Il-1 binding proteins
WO2011144743A1 (en) * 2010-05-21 2011-11-24 Eidgenössische Technische Hochschule Zürich High-density sample support plate for automated sample aliquoting
US9551714B2 (en) 2010-06-25 2017-01-24 Abbott Laboratories Materials and methods for assay of anti-hepatitis C virus (HCV) antibodies
WO2012006500A2 (en) 2010-07-08 2012-01-12 Abbott Laboratories Monoclonal antibodies against hepatitis c virus core protein
UY33492A (en) 2010-07-09 2012-01-31 Abbott Lab IMMUNOGLOBULINS WITH DUAL VARIABLE DOMAIN AND USES OF THE SAME
EP3246335A3 (en) 2010-07-19 2017-12-27 Otago Innovation Limited Signal biomarkers
KR101045209B1 (en) * 2010-07-26 2011-06-30 삼성전자주식회사 An array device comprising a photoresist film having immobilization regions and a method using the same
KR20130100118A (en) 2010-08-03 2013-09-09 아비에 인코포레이티드 Dual variable domain immunoglobulins and uses therof
CN102918064B (en) * 2010-08-30 2015-03-11 松下健康医疗控股株式会社 A method for immobilizing streptavidin on a self-assembled monolayer
WO2012037456A1 (en) 2010-09-17 2012-03-22 President And Fellows Of Harvard College Functional genomics assay for characterizing pluripotent stem cell utility and safety
JP6071886B2 (en) 2010-10-14 2017-02-01 ザ・ジョンズ・ホプキンス・ユニバーシティ Brain injury biomarkers
JP5108166B2 (en) 2010-10-19 2012-12-26 パナソニック株式会社 Method for immobilizing glucose oxidase on self-assembled membrane
US20120115244A1 (en) 2010-11-09 2012-05-10 Abbott Laboratories Materials and methods for immunoassay of pterins
CN102486474B (en) * 2010-12-06 2014-05-28 北京大学人民医院 Protein chip for chronic hepatitis C outcome prediction in chronic hepatitis C interferon treatment
KR20130133247A (en) 2010-12-21 2013-12-06 애브비 인코포레이티드 Il-1-alpha and -beta bispecific dual variable domain immunoglobulins and their use
RU2013145890A (en) 2011-03-15 2015-04-20 Юниверсити Оф Юта Рисерч Фаундейшн METHODS FOR DIAGNOSIS AND TREATMENT OF VASCULAR ASSOCIATED MACULOPATHY AND ITS SYMPTOMS
US8735175B2 (en) * 2011-03-18 2014-05-27 Chris D. Geddes Multicolor microwave-accelerated metal-enhanced fluorescence (M-MAMEF)
US9291616B2 (en) 2011-04-08 2016-03-22 The General Hospital Corporation Fungal-derived carbohydrate-conjugated scaffold
CN103562725B (en) 2011-04-15 2016-08-17 儿童医疗中心有限公司 The diagnosis marker of mucocutaneous lymphnode syndrome and therapy target
KR101158362B1 (en) * 2011-04-20 2012-06-22 한국과학기술원 Method for analyzing single protein-protein interactions in whole cell lysates
EP2707389B1 (en) 2011-05-12 2019-10-30 The Johns Hopkins University Assay reagents for a neurogranin diagnostic kit
US9561262B2 (en) 2011-06-06 2017-02-07 Phasebio Pharmaceuticals, Inc. Use of modified vasoactive intestinal peptides in the treatment of hypertension
CN103492879B (en) * 2011-06-10 2015-04-01 松下健康医疗控股株式会社 Method for affixing antibodies to self-assembled monolayer
WO2012174014A2 (en) * 2011-06-13 2012-12-20 Indevr, Inc. Low density microarrays for vaccine related protein quantification, potency determination and efficacy evaluation
CN102279261B (en) * 2011-06-20 2013-09-18 东南大学 Inkjet printing preparation method of pattern code microcarrier
JP2014527036A (en) 2011-06-27 2014-10-09 ザ ジャクソン ラボラトリー Methods and compositions for the treatment of cancer and autoimmune diseases
CN103562721B (en) * 2011-07-05 2015-04-01 松下健康医疗控股株式会社 Method for immobilizing albumin on self-assembled monolayer
CN103534592A (en) * 2011-07-08 2014-01-22 松下电器产业株式会社 Method for immobilizing protein on self-assembled film
US20140235492A1 (en) * 2011-09-20 2014-08-21 Institut National De La Sante Et De La Recherche Medicate (Inserm) Methods for preparing single domain antibody microarrays
WO2013055829A1 (en) * 2011-10-11 2013-04-18 Nestec S.A. Proximity-based assays for the detection of signaling protein expression and activation
MX2014004977A (en) 2011-10-24 2014-09-11 Abbvie Inc Immunobinders directed against sclerostin.
RU2014121043A (en) 2011-10-24 2015-12-10 Эббви Инк. BISPECIFIC IMMUNO-BINDING AGENTS AIMED AGAINST TNF AND IL-17
PL3327110T3 (en) 2011-11-07 2020-07-27 Rapid Micro Biosystems, Inc. Cassette for sterility testing
JP6285865B2 (en) 2011-11-14 2018-02-28 アルファシグマ ソシエタ ペル アチオニ Assays and methods for selecting treatment regimens for subjects with depression
EP2791359B1 (en) 2011-12-13 2020-01-15 Decipher Biosciences, Inc. Cancer diagnostics using non-coding transcripts
AU2012358269B2 (en) 2011-12-22 2017-11-02 Children's Medical Center Corporation Saposin-A derived peptides and uses thereof
US8993248B2 (en) 2011-12-31 2015-03-31 Abbott Laboratories Truncated human vitamin D binding protein and mutation and fusion thereof and related materials and methods of use
WO2013106886A1 (en) 2012-01-20 2013-07-25 Adelaide Research & Innovation Pty Ltd Biomarkers for gastric cancer and uses thereof
CA2864080C (en) * 2012-02-07 2023-04-25 Vibrant Holdings, Llc Substrates, peptide arrays, and methods
DK2828282T3 (en) 2012-03-20 2018-03-05 Otago Innovation Ltd Biomarkers
CN107841461A (en) 2012-04-16 2018-03-27 快速微型生物系统公司 Cell culture apparatus
WO2014001459A1 (en) 2012-06-29 2014-01-03 Danmarks Tekniske Universitet A method of charging a test carrier and a test carrier
WO2014011955A2 (en) 2012-07-12 2014-01-16 Abbvie, Inc. Il-1 binding proteins
EP3435084B1 (en) 2012-08-16 2023-02-22 Decipher Biosciences, Inc. Prostate cancer prognostics using biomarkers
US20150309036A1 (en) 2012-08-16 2015-10-29 The Trustees Of Columbia University In The City Of New York Diagnostic Markers of Indolent Prostate Cancer
US10006909B2 (en) 2012-09-28 2018-06-26 Vibrant Holdings, Llc Methods, systems, and arrays for biomolecular analysis
ES2912033T3 (en) 2012-10-23 2022-05-24 Caris Science Inc Aptamers and uses thereof
US10942184B2 (en) 2012-10-23 2021-03-09 Caris Science, Inc. Aptamers and uses thereof
EP2935628B1 (en) 2012-12-19 2018-03-21 Caris Life Sciences Switzerland Holdings GmbH Compositions and methods for aptamer screening
AU2013202668B2 (en) 2012-12-24 2014-12-18 Adelaide Research & Innovation Pty Ltd Inhibition of cancer growth and metastasis
US9086412B2 (en) 2012-12-31 2015-07-21 University Of Louisville Research Foundation, Inc. Extracellular vesicle-associated protein markers of cancer
EP2968526A4 (en) 2013-03-14 2016-11-09 Abbott Lab Hcv antigen-antibody combination assay and methods and compositions for use therein
JP6739329B2 (en) 2013-03-14 2020-08-12 アボット・ラボラトリーズＡｂｂｏｔｔ Ｌａｂｏｒａｔｏｒｉｅｓ HCV core lipid binding domain monoclonal antibody
JP2016512241A (en) 2013-03-14 2016-04-25 アボット・ラボラトリーズＡｂｂｏｔｔ Ｌａｂｏｒａｔｏｒｉｅｓ HCVNS3 recombinant antigen for improved antibody detection and mutants thereof
US9005901B2 (en) 2013-03-15 2015-04-14 Abbott Laboratories Assay with internal calibration
US9157910B2 (en) 2013-03-15 2015-10-13 Abbott Laboratories Assay with increased dynamic range
EP4286853A3 (en) 2013-05-10 2024-03-06 Johns Hopkins University Compositions for ovarian cancer assessment having improved specificity
DE102013210138A1 (en) 2013-05-30 2014-12-04 Boehringer Ingelheim Vetmedica Gmbh Method for generating a plurality of measuring ranges on a chip and chip with measuring ranges
JP2014235115A (en) * 2013-06-04 2014-12-15 ウシオ電機株式会社 Microchip and method for forming metal thin film in microchip
EP3022322A4 (en) 2013-07-17 2017-05-17 The Johns Hopkins University A multi-protein biomarker assay for brain injury detection and outcome
KR20160080815A (en) 2013-08-28 2016-07-08 카리스 라이프 사이언스 스위스 홀딩스 게엠베하 Oligonucleotide probes and uses thereof
AU2015222944A1 (en) 2014-02-27 2016-09-08 Massachusetts Institute Of Technology T cell balance gene expression, compositions of matters and methods of use thereof
WO2015187227A2 (en) 2014-03-13 2015-12-10 Duke University Electronic platform for sensing and control of electrochemical reactions
CA2947982C (en) 2014-05-08 2022-11-29 Phasebio Pharmaceuticals, Inc. Methods and compositions for treating cystic fibrosis
EP3152347A4 (en) 2014-06-04 2018-04-11 Indevr, Inc. Universal capture array for multiplexed subtype-specific quantification and stability determination of influenza proteins
MX2016017097A (en) 2014-06-19 2017-05-01 Memorial Sloan Kettering Cancer Center Biomarkers for response to ezh2 inhibitors.
US9694518B2 (en) 2014-06-20 2017-07-04 The Regents Of The University Of Michigan Breath-activated images and anti-counterfeit authentication features formed of nanopillar arrays
CN107209188A (en) 2014-06-27 2017-09-26 雅培制药有限公司 Composition and method for detecting people Pegivirus 2 (HPgV 2)
ES2825708T3 (en) 2014-07-17 2021-05-17 Univ Pennsylvania Methods for using exosomes to monitor transplanted organ status
US20160032281A1 (en) * 2014-07-31 2016-02-04 Fei Company Functionalized grids for locating and imaging biological specimens and methods of using the same
US10222386B2 (en) 2014-09-19 2019-03-05 The Johns Hopkins University Biomarkers of congnitive dysfunction
BR112017009029A2 (en) 2014-10-29 2018-02-06 Abbott Lab anti-hcv antibody detection assays of an individual using ns3 capture peptides
KR101687950B1 (en) * 2014-11-14 2016-12-21 연세대학교 산학협력단 Surface modified micropate, menufacturing method for the surface modified micropate and immunoassays using the surface modified micropate
US11168369B2 (en) 2014-11-25 2021-11-09 The Brigham And Women's Hospital, Inc. Method of identifying and treating a person having a predisposition to or afflicted with a cardiometabolic disease
EP3224380A1 (en) 2014-11-25 2017-10-04 The Broad Institute Inc. Clonal haematopoiesis
US11543411B2 (en) 2014-12-05 2023-01-03 Prelude Corporation DCIS recurrence and invasive breast cancer
US10545158B2 (en) 2014-12-29 2020-01-28 North Carolina State University Multiplexed diagnostic to recognize concentrations of related proteins and peptides
AU2016219513B2 (en) 2015-02-09 2021-09-30 Immunoforge Co., Ltd. Methods and compositions for treating muscle disease and disorders
EP3259594A4 (en) 2015-02-20 2018-12-26 The Johns Hopkins University Biomarkers of myocardial injury
WO2016138488A2 (en) 2015-02-26 2016-09-01 The Broad Institute Inc. T cell balance gene expression, compositions of matters and methods of use thereof
WO2016144843A1 (en) * 2015-03-06 2016-09-15 Tymora Analyticaly Operations Llc Chemically functionalized array to analyze protein modifications
CA2979361A1 (en) 2015-03-09 2016-09-15 Caris Science, Inc. Method of preparing oligonucleotide libraries
US10294451B2 (en) 2015-04-22 2019-05-21 University Of Maryland, Baltimore County Flow and static lysing systems and methods for ultra-rapid isolation and fragmentation of biological materials by microwave irradiation
WO2017004243A1 (en) 2015-06-29 2017-01-05 Caris Science, Inc. Therapeutic oligonucleotides
AU2016291558A1 (en) 2015-07-10 2018-02-08 West Virginia University Markers of stroke and stroke severity
WO2017015531A1 (en) 2015-07-22 2017-01-26 University Of Maryland, Baltimore County Hydrophilic coatings of plasmonic metals to enable low volume metal-enhanced fluorescence
WO2017019918A1 (en) 2015-07-28 2017-02-02 Caris Science, Inc. Targeted oligonucleotides
DE102015114026A1 (en) 2015-08-24 2017-03-02 Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V. Biomarker panel for the diagnosis of recurrent prostate cancer
US10758886B2 (en) 2015-09-14 2020-09-01 Arizona Board Of Regents On Behalf Of Arizona State University Conditioned surfaces for in situ molecular array synthesis
EP3356558B1 (en) 2015-09-30 2022-03-30 Immunexpress Pty Ltd Sirs pathogen biomarkers and uses therefor
US10730071B2 (en) 2015-12-02 2020-08-04 Boehringer Ingelheim Vetmedica Gmbh Method for producing a plurality of measurement regions on a chip, and chip having a plurality of measurement regions
WO2017099829A1 (en) 2015-12-11 2017-06-15 The General Hospital Corporation Compositions and methods for treating drug-tolerant glioblastoma
WO2017106918A1 (en) 2015-12-24 2017-06-29 Immunexpress Pty Ltd Triage biomarkers and uses therefor
EP4339288A2 (en) 2016-03-18 2024-03-20 Caris Science, Inc. Oligonucleotide probes and uses thereof
AU2017271579B2 (en) 2016-05-25 2023-10-19 Caris Science, Inc. Oligonucleotide probes and uses thereof
WO2017223117A1 (en) 2016-06-20 2017-12-28 Healthtell Inc. Methods for diagnosis and treatment of autoimmune diseases
EP3472201A4 (en) 2016-06-20 2020-05-13 Healthtell Inc. Methods for differential diagnosis of autoimmune diseases
JP6420281B2 (en) * 2016-07-04 2018-11-07 花王株式会社 Solid phase carrier for protein analysis and method for producing the same
CN110506127B (en) 2016-08-24 2024-01-12 维拉科特Sd公司 Use of genomic tags to predict responsiveness of prostate cancer patients to post-operative radiation therapy
CN110168370A (en) 2016-11-11 2019-08-23 健康之语公司 Method for identifying candidate biomarker
WO2018089764A1 (en) 2016-11-11 2018-05-17 Ascendant Dx, Llc Compositions and methods for diagnosing and differentiating systemic juvenile idiopathic arthritis and kawasaki disease
AU2018210695A1 (en) 2017-01-20 2019-08-08 The University Of British Columbia Molecular subtyping, prognosis, and treatment of bladder cancer
WO2018165600A1 (en) 2017-03-09 2018-09-13 Genomedx Biosciences, Inc. Subtyping prostate cancer to predict response to hormone therapy
WO2018200489A1 (en) 2017-04-25 2018-11-01 The Brigham And Women’S Hospital, Inc. Il-8, il-6, il-1b and tet2 and dnmt3a in atherosclerosis
US11078542B2 (en) 2017-05-12 2021-08-03 Decipher Biosciences, Inc. Genetic signatures to predict prostate cancer metastasis and identify tumor aggressiveness
WO2018218250A2 (en) 2017-05-26 2018-11-29 Vibrant Holdings, Llc Photoactive compounds and methods for biomolecule detection and sequencing
AU2018318435A1 (en) 2017-08-16 2020-04-02 Medimmune, Llc Compositions and methods for treatment of atopic dermatitis and treatment selection
US11709156B2 (en) 2017-09-18 2023-07-25 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved analytical analysis
US11709155B2 (en) 2017-09-18 2023-07-25 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
US20190142722A1 (en) 2017-11-10 2019-05-16 The Trustees Of Columbia University In The City Of New York Methods and compositions for promoting or inducing hair growth
WO2019217916A1 (en) 2018-05-10 2019-11-14 The Methodist Hospital Methods for prognosis and management of disease
WO2019236632A1 (en) 2018-06-04 2019-12-12 Avon Products. Inc. Protein biomarkers for identifying and treating aging skin and skin conditions
WO2020056338A1 (en) 2018-09-14 2020-03-19 Prelude Corporation Method of selection for treatment of subjects at risk of invasive breast cancer
KR20230155589A (en) 2018-11-07 2023-11-10 시어 인코퍼레이티드 Compositions, methods and systems for protein corona analysis and uses thereof
GB201904697D0 (en) 2019-04-03 2019-05-15 Vib Vzw Means and methods for single molecule peptide sequencing
AU2020326698A1 (en) 2019-08-05 2022-02-24 Seer, Inc. Systems and methods for sample preparation, data generation, and protein corona analysis
US11918936B2 (en) 2020-01-17 2024-03-05 Waters Technologies Corporation Performance and dynamic range for oligonucleotide bioanalysis through reduction of non specific binding
EP4074820A1 (en) 2021-04-16 2022-10-19 The Trustees of The University of Pennsylvania Micro-engineered models of the human eye and methods of use
WO2023288108A1 (en) * 2021-07-16 2023-01-19 The University Of Chicago Biocompatible surface for quantum sensing and methods thereof
WO2023122723A1 (en) 2021-12-23 2023-06-29 The Broad Institute, Inc. Panels and methods for diagnosing and treating lung cancer

Family Cites Families (163)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4071409A (en) 1976-05-20 1978-01-31 Corning Glass Works Immobilization of proteins on inorganic support materials
US4722896A (en) 1981-01-26 1988-02-02 The Beth Israel Hospital Association Method for affinity purification of hybridoma antibodies
US4444879A (en) * 1981-01-29 1984-04-24 Science Research Center, Inc. Immunoassay with article having support film and immunological counterpart of analyte
US4690715A (en) 1982-06-18 1987-09-01 American Telephone And Telegraph Company, At&T Bell Laboratories Modification of the properties of metals
US4514508A (en) * 1982-07-06 1985-04-30 Biond Inc. Assaying for a multiplicity of antigens or antibodies with a detection compound
US4973493A (en) 1982-09-29 1990-11-27 Bio-Metric Systems, Inc. Method of improving the biocompatibility of solid surfaces
US4994373A (en) * 1983-01-27 1991-02-19 Enzo Biochem, Inc. Method and structures employing chemically-labelled polynucleotide probes
US4591570A (en) * 1983-02-02 1986-05-27 Centocor, Inc. Matrix of antibody-coated spots for determination of antigens
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
GB8314523D0 (en) 1983-05-25 1983-06-29 Lowe C R Diagnostic device
US4608112A (en) * 1984-05-16 1986-08-26 The United States Of America As Represented By The Secretary Of The Air Force Mask aligner for solar cell fabrication
AU600885B2 (en) 1984-05-25 1990-08-30 Zymogenetics Inc. Stable DNA constructs
US5096807A (en) 1985-03-06 1992-03-17 Murex Corporation Imaging immunoassay detection system with background compensation and its use
US5523215A (en) * 1985-03-28 1996-06-04 Chiron Corporation Enhanced purification and expression of insoluble recombinant proteins
US5866363A (en) * 1985-08-28 1999-02-02 Pieczenik; George Method and means for sorting and identifying biological information
US4894146A (en) * 1986-01-27 1990-01-16 University Of Utah Thin channel split flow process and apparatus for particle fractionation
US4802951A (en) * 1986-03-07 1989-02-07 Trustees Of Boston University Method for parallel fabrication of nanometer scale multi-device structures
US5643948A (en) * 1986-06-11 1997-07-01 Procyon Pharmaceuticals, Inc. Protein kinase C modulators. K.
US5637489A (en) * 1986-08-23 1997-06-10 Hoechst Aktiengesellschaft Phosphinothricin-resistance gene, and its use
US4859538A (en) 1986-11-20 1989-08-22 Ribi Hans O Novel lipid-protein compositions and articles and methods for their preparation
US5079600A (en) 1987-03-06 1992-01-07 Schnur Joel M High resolution patterning on solid substrates
US4928112A (en) * 1987-03-23 1990-05-22 Howtek, Inc. Ink curing apparatus
US4987032A (en) 1987-06-26 1991-01-22 Fuji Photo Film Co., Ltd. Functional organic thin film and method of manufacture thereof
US5154808A (en) 1987-06-26 1992-10-13 Fuji Photo Film Co., Ltd. Functional organic thin film and process for producing the same
DE3733190A1 (en) * 1987-10-01 1989-04-13 Kugelfischer G Schaefer & Co MULTI-ROW BALL OR ROLLER BEARING OR COMBINED BALL ROLLER BEARING
US6692751B1 (en) * 1988-05-06 2004-02-17 New York Blood Center Methods and systems for producing recombinant viral antigens
US4908112A (en) 1988-06-16 1990-03-13 E. I. Du Pont De Nemours & Co. Silicon semiconductor wafer for analyzing micronic biological samples
US5281540A (en) * 1988-08-02 1994-01-25 Abbott Laboratories Test array for performing assays
US5720928A (en) * 1988-09-15 1998-02-24 New York University Image processing and analysis of individual nucleic acid molecules
SE462454B (en) 1988-11-10 1990-06-25 Pharmacia Ab METHOD FOR USE IN BIOSENSORS
JPH02272081A (en) 1989-04-14 1990-11-06 Fuji Photo Film Co Ltd Functional organic thin film
IT1229691B (en) 1989-04-21 1991-09-06 Eniricerche Spa SENSOR WITH ANTIGEN CHEMICALLY LINKED TO A SEMICONDUCTIVE DEVICE.
US5800992A (en) * 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5424186A (en) * 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US6346413B1 (en) * 1989-06-07 2002-02-12 Affymetrix, Inc. Polymer arrays
US5252743A (en) * 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
DE3939973A1 (en) 1989-12-02 1991-06-06 Basf Ag TWO-DIMENSIONAL CRYSTALLIZED MACROMOLECULAR LAYERS
US5283173A (en) * 1990-01-24 1994-02-01 The Research Foundation Of State University Of New York System to detect protein-protein interactions
US5858188A (en) 1990-02-28 1999-01-12 Aclara Biosciences, Inc. Acrylic microchannels and their use in electrophoretic applications
ATE155524T1 (en) 1990-04-12 1997-08-15 Hans Dr Sigrist METHOD FOR THE LIGHT-INDUCED IMMOBILIZATION OF BIOMOLECULES ON CHEMICALLY INERT SURFACES
US5861254A (en) * 1997-01-31 1999-01-19 Nexstar Pharmaceuticals, Inc. Flow cell SELEX
US5665582A (en) * 1990-10-29 1997-09-09 Dekalb Genetics Corp. Isolation of biological materials
WO1992008788A1 (en) * 1990-11-19 1992-05-29 The Board Of Trustees Of The University Of Illinois Mutant orientable proteins and coated substrates
US5294369A (en) 1990-12-05 1994-03-15 Akzo N.V. Ligand gold bonding
DE69132843T2 (en) * 1990-12-06 2002-09-12 Affymetrix Inc N D Ges D Staat Identification of nucleic acids in samples
US5384886A (en) * 1991-04-01 1995-01-24 Xerox Corporation Process for electronically printing envelopes
US5763170A (en) * 1991-04-16 1998-06-09 Amersham International Plc Method for forming an array of biological particles
DE69223980T2 (en) * 1991-10-15 1998-05-28 Multilyte Ltd BINDING TEST USING A MARKED REAGENT
US5605662A (en) 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US6051380A (en) * 1993-11-01 2000-04-18 Nanogen, Inc. Methods and procedures for molecular biological analysis and diagnostics
IL103674A0 (en) * 1991-11-19 1993-04-04 Houston Advanced Res Center Method and apparatus for molecule detection
US5384261A (en) 1991-11-22 1995-01-24 Affymax Technologies N.V. Very large scale immobilized polymer synthesis using mechanically directed flow paths
DE69233331T3 (en) 1991-11-22 2007-08-30 Affymetrix, Inc., Santa Clara Combinatorial Polymersynthesis Strategies
US5412087A (en) 1992-04-24 1995-05-02 Affymax Technologies N.V. Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
DK1024191T3 (en) * 1991-12-02 2008-12-08 Medical Res Council Preparation of autoantibodies displayed on phage surfaces from antibody segment libraries
DE59108591D1 (en) 1991-12-06 1997-04-10 Ciba Geigy Ag Electrophoretic separation device and electrophoretic separation process
CA2064683A1 (en) 1992-03-26 1993-09-27 Krishna Mohan Rao Kallury Formation of thermostable enzymes with extra-ordinary heat tolerance by immobilization on phospholipid matrices
US5756355A (en) 1992-04-22 1998-05-26 Ecole Polytechnique Federale De Lausanne Lipid membrane sensors
US5637469A (en) 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US5726026A (en) 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
US5304487A (en) 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
JPH0641183A (en) 1992-07-23 1994-02-15 Mitsubishi Kasei Corp Monomolecular film of oligonucleotide
DE4237113B4 (en) * 1992-11-03 2006-10-12 "Iba Gmbh" Peptides and their fusion proteins, expression vector and method of producing a fusion protein
CA2108705A1 (en) * 1992-11-06 1994-05-07 Richard Barner Biologically recognizing layers on new ti02 waveguide for biosensors
US5472881A (en) 1992-11-12 1995-12-05 University Of Utah Research Foundation Thiol labeling of DNA for attachment to gold surfaces
US5532142A (en) * 1993-02-12 1996-07-02 Board Of Regents, The University Of Texas System Method of isolation and purification of fusion polypeptides
US5677196A (en) 1993-05-18 1997-10-14 University Of Utah Research Foundation Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
US5512492A (en) 1993-05-18 1996-04-30 University Of Utah Research Foundation Waveguide immunosensor with coating chemistry providing enhanced sensitivity
NZ267842A (en) 1993-05-28 1997-09-22 Baylor College Medicine Apparatus for measuring molecular mass (by mass spectrometry) in which the sample is ionised on the sample holder and desorbed therefrom by laser pulses
US5837832A (en) 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
US5861242A (en) 1993-06-25 1999-01-19 Affymetrix, Inc. Array of nucleic acid probes on biological chips for diagnosis of HIV and methods of using the same
US5441876A (en) 1993-07-30 1995-08-15 The United States Of America As Represented By The Secretary Of The Navy Process for the preparation of headgroup-modified phospholipids using phosphatidylhydroxyalkanols as intermediates
DE69434520T3 (en) * 1993-07-30 2009-10-15 Affymax, Inc., Palo Alto BIOTINYLATION OF PROTEINS
RU2041262C1 (en) * 1993-08-11 1995-08-09 Институт молекулярной биологии им.В.А.Энгельгардта РАН Method for immobilization of water soluble bioorganic compounds on capillary-porous carrier
JPH0784372A (en) 1993-09-17 1995-03-31 Res Dev Corp Of Japan Organic silane modified oxide and modified surface light patterning oxide
DE4332003C2 (en) 1993-09-21 1996-02-22 Seeger Stefan Process for coating surfaces with biomolecules and other receptor molecules
US5512131A (en) 1993-10-04 1996-04-30 President And Fellows Of Harvard College Formation of microstamped patterns on surfaces and derivative articles
JP3488465B2 (en) * 1993-10-28 2004-01-19 ヒューストン・アドバンスド・リサーチ・センター Microfabricated flow-through porosity device for separately detecting binding reactions
US5429708A (en) 1993-12-22 1995-07-04 The Board Of Trustees Of The Leland Stanford Junior University Molecular layers covalently bonded to silicon surfaces
DE4435728A1 (en) * 1994-01-19 1995-07-20 Boehringer Mannheim Gmbh Biotin silane compounds and binding matrix containing these compounds
ES2179853T3 (en) * 1994-01-19 2003-02-01 Roche Diagnostics Gmbh BIOTIN-SILANOS COMPOUNDS AND FIXING MATRIX CONTAINING THESE COMPOUNDS.
US5623055A (en) * 1994-01-28 1997-04-22 Prolinx, Inc. Phenylboronic acid complexes derived from aminosalicylic acid for bioconjugate preparation
US5594111A (en) * 1994-01-28 1997-01-14 Prolinx, Inc. Phenylboronic acid complexes for bioconjugate preparation
AU1911795A (en) 1994-02-09 1995-08-29 Abbott Laboratories Diagnostic flow cell device
US5514501A (en) 1994-06-07 1996-05-07 The United States Of America As Represented By The Secretary Of Commerce Process for UV-photopatterning of thiolate monolayers self-assembled on gold, silver and other substrates
US6287850B1 (en) * 1995-06-07 2001-09-11 Affymetrix, Inc. Bioarray chip reaction apparatus and its manufacture
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
AU2897595A (en) 1994-07-14 1996-02-16 Technobiochip Biosensor and method and instrument for deposition of alternating monomolecular layers
US5498545A (en) * 1994-07-21 1996-03-12 Vestal; Marvin L. Mass spectrometer system and method for matrix-assisted laser desorption measurements
SE9403245D0 (en) 1994-09-26 1994-09-26 Pharmacia Biosensor Ab Improvements relating to bilayer lipid membranes
US5620850A (en) 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US5571410A (en) 1994-10-19 1996-11-05 Hewlett Packard Company Fully integrated miniaturized planar liquid sample handling and analysis device
US5585069A (en) * 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US5603351A (en) 1995-06-07 1997-02-18 David Sarnoff Research Center, Inc. Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device
US5688642A (en) 1994-12-01 1997-11-18 The United States Of America As Represented By The Secretary Of The Navy Selective attachment of nucleic acid molecules to patterned self-assembled surfaces
US5622826A (en) 1994-12-22 1997-04-22 Houston Advanced Research Center Method for immobilization of molecules on platinum solid support surfaces
US5814565A (en) 1995-02-23 1998-09-29 University Of Utah Research Foundation Integrated optic waveguide immunosensor
EP0812434B1 (en) 1995-03-01 2013-09-18 President and Fellows of Harvard College Microcontact printing on surfaces and derivative articles
US5629213A (en) 1995-03-03 1997-05-13 Kornguth; Steven E. Analytical biosensor
JPH11503005A (en) 1995-03-08 1999-03-23 アクゾ ノーベル ナムローゼ フェンノートシャップ Surface-modified affinity separation membrane
US6140045A (en) * 1995-03-10 2000-10-31 Meso Scale Technologies Multi-array, multi-specific electrochemiluminescence testing
US6066448A (en) * 1995-03-10 2000-05-23 Meso Sclae Technologies, Llc. Multi-array, multi-specific electrochemiluminescence testing
US6309820B1 (en) * 1995-04-07 2001-10-30 University Of North Carolina At Chapel Hill Polypeptides having a functional domain of interest and methods of identifying and using same
US5624711A (en) * 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
US5625184A (en) * 1995-05-19 1997-04-29 Perseptive Biosystems, Inc. Time-of-flight mass spectrometry analysis of biomolecules
US5700642A (en) 1995-05-22 1997-12-23 Sri International Oligonucleotide sizing using immobilized cleavable primers
WO1996038726A1 (en) 1995-05-30 1996-12-05 Ecole Polytechnique Federale De Lausanne (Epfl) Covalently immobilized phospholipid bilayers on solid surfaces
US5776674A (en) 1995-06-05 1998-07-07 Seq, Ltd Chemical biochemical and biological processing in thin films
US5545531A (en) * 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
WO1996039937A1 (en) 1995-06-07 1996-12-19 The Regents Of The University Of California Microfabricated devices for diagnostic applications
US6720149B1 (en) * 1995-06-07 2004-04-13 Affymetrix, Inc. Methods for concurrently processing multiple biological chip assays
US6518168B1 (en) 1995-08-18 2003-02-11 President And Fellows Of Harvard College Self-assembled monolayer directed patterning of surfaces
CA2187969C (en) * 1995-10-17 2006-05-30 Dale L. Boger A template for solution phase synthesis of combinatorial libraries
DE19543232A1 (en) 1995-11-07 1997-05-15 Knoell Hans Forschung Ev Production of matrix-bound miniaturised combinatorial polymer and oligomer library
US5763263A (en) * 1995-11-27 1998-06-09 Dehlinger; Peter J. Method and apparatus for producing position addressable combinatorial libraries
DE69632921T2 (en) 1995-12-01 2005-07-14 Innogenetics N.V. SYSTEM AND METHOD FOR DETERMINING THE IMPEDANCE AND MANUFACTURING METHOD
DE19548152A1 (en) 1995-12-22 1997-06-26 Boehringer Mannheim Gmbh Process for covering a surface with a film of an oligoethylene glycol derivative
AU723909B2 (en) 1996-03-15 2000-09-07 President And Fellows Of Harvard College Method of forming articles and patterning surfaces via capillary micromolding
JP4912517B2 (en) 1996-04-03 2012-04-11 アプライド バイオシステムズ リミテッド ライアビリティー カンパニー Devices and methods for detection of multiple analytes
US5942443A (en) 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US5925552A (en) 1996-04-25 1999-07-20 Medtronic, Inc. Method for attachment of biomolecules to medical devices surfaces
JP2000510233A (en) 1996-04-25 2000-08-08 ペンス，インコーポレイテッド Biosensor device and method
US6165335A (en) 1996-04-25 2000-12-26 Pence And Mcgill University Biosensor device and method
US5731152A (en) 1996-05-13 1998-03-24 Motorola, Inc. Methods and systems for biological reagent placement
US6075875A (en) * 1996-09-30 2000-06-13 Microsoft Corporation Segmentation of image features using hierarchical analysis of multi-valued image data and weighted averaging of segmentation results
US20030017149A1 (en) * 1996-10-10 2003-01-23 Hoeffler James P. Single chain monoclonal antibody fusion reagents that regulate transcription in vivo
AU5462498A (en) * 1996-11-29 1998-06-22 Board Of Trustees Of The Leland Stanford Junior University Arrays of independently-addressable supported fluid bilayer membranes and methods of use thereof
GB9624927D0 (en) * 1996-11-29 1997-01-15 Oxford Glycosciences Uk Ltd Gels and their use
US5905024A (en) * 1996-12-17 1999-05-18 University Of Chicago Method for performing site-specific affinity fractionation for use in DNA sequencing
US5837860A (en) 1997-03-05 1998-11-17 Molecular Tool, Inc. Covalent attachment of nucleic acid molecules onto solid-phases via disulfide bonds
US6180288B1 (en) * 1997-03-21 2001-01-30 Kimberly-Clark Worldwide, Inc. Gel sensors and method of use thereof
WO1998050773A2 (en) 1997-05-08 1998-11-12 University Of Minnesota Microcantilever biosensor
US6190619B1 (en) * 1997-06-11 2001-02-20 Argonaut Technologies, Inc. Systems and methods for parallel synthesis of compounds
NZ516848A (en) * 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
US5948621A (en) * 1997-09-30 1999-09-07 The United States Of America As Represented By The Secretary Of The Navy Direct molecular patterning using a micro-stamp gel
EP1021558A1 (en) * 1997-10-10 2000-07-26 President And Fellows Of Harvard College Surface-bound, double-stranded dna protein arrays
US6061476A (en) * 1997-11-24 2000-05-09 Cognex Corporation Method and apparatus using image subtraction and dynamic thresholding
US6232066B1 (en) * 1997-12-19 2001-05-15 Neogen, Inc. High throughput assay system
JP2002502977A (en) 1998-02-04 2002-01-29 インビトロジェン コーポレイション Microarrays and their uses
US6087103A (en) * 1998-03-04 2000-07-11 Lifespan Biosciences, Inc. Tagged ligand arrays for identifying target-ligand interactions
US6350369B1 (en) * 1998-04-14 2002-02-26 California Institute Of Technology Method and system for determining analyte activity
US6287765B1 (en) * 1998-05-20 2001-09-11 Molecular Machines, Inc. Methods for detecting and identifying single molecules
US6406921B1 (en) * 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US6682942B1 (en) * 1998-07-14 2004-01-27 Zyomyx, Inc. Microdevices for screening biomolecules
US6897073B2 (en) * 1998-07-14 2005-05-24 Zyomyx, Inc. Non-specific binding resistant protein arrays and methods for making the same
US6576478B1 (en) * 1998-07-14 2003-06-10 Zyomyx, Inc. Microdevices for high-throughput screening of biomolecules
US20020119579A1 (en) * 1998-07-14 2002-08-29 Peter Wagner Arrays devices and methods of use thereof
US6197599B1 (en) * 1998-07-30 2001-03-06 Guorong Chin Method to detect proteins
US6190908B1 (en) * 1998-08-12 2001-02-20 The Scripps Research Institute Modulation of polypeptide display on modified filamentous phage
WO2000052209A1 (en) 1999-03-02 2000-09-08 Chiron Corporation Microarrays for identifying pathway activation or induction
EP1159615A2 (en) 1999-03-10 2001-12-05 National Institutes of Health, as represented by the Secretary, Department of Health and Human Services of the Government Universal protein array system
AU3883300A (en) 1999-03-11 2000-09-28 Combimatrix Corporation Microarrays of peptide affinity probes for analyzing gene products and methods for analyzing gene products
US6899137B2 (en) * 1999-06-28 2005-05-31 California Institute Of Technology Microfabricated elastomeric valve and pump systems
KR100379411B1 (en) * 1999-06-28 2003-04-10 엘지전자 주식회사 biochip and method for patterning and measuring biomaterial of the same
US6406840B1 (en) * 1999-12-17 2002-06-18 Biomosaic Systems, Inc. Cell arrays and the uses thereof
CN1444646A (en) * 2000-02-23 2003-09-24 齐翁米克斯股份有限公司 Chips having elevated sample surfaces
US6531283B1 (en) * 2000-06-20 2003-03-11 Molecular Staging, Inc. Protein expression profiling
US7094568B2 (en) * 2000-08-17 2006-08-22 Sense Proteomic Ltd. Method for producing proteins tagged at the N- or C-terminus
US6699665B1 (en) * 2000-11-08 2004-03-02 Surface Logix, Inc. Multiple array system for integrating bioarrays
US20050095646A1 (en) * 2001-11-19 2005-05-05 Sherman Michael I. Method of using a non-antibody protein to detect and measure an analyte
US20050026215A1 (en) * 2003-07-17 2005-02-03 Predki Paul F. Method for the prediction of an epitope

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9290382B2 (en) 2001-09-06 2016-03-22 Rapid Micro Biosystems Rapid detection of replicating cells

Also Published As

Publication number Publication date
AU5102399A (en) 2000-02-07
US20110086779A1 (en) 2011-04-14
US6630358B1 (en) 2003-10-07
US6475809B1 (en) 2002-11-05
EP1097377B1 (en) 2008-06-04
US20050008674A1 (en) 2005-01-13
JP2002520620A (en) 2002-07-09
WO2000004389A3 (en) 2000-04-27
EP1097380A1 (en) 2001-05-09
US20050014292A1 (en) 2005-01-20
DE69938867D1 (en) 2008-07-17
CA2337654A1 (en) 2000-01-27
US6365418B1 (en) 2002-04-02
AU5102599A (en) 2000-02-07
EP1097377A2 (en) 2001-05-09
AU773068B2 (en) 2004-05-13
US6475808B1 (en) 2002-11-05
US6329209B1 (en) 2001-12-11
US20090131278A1 (en) 2009-05-21
WO2000004382A1 (en) 2000-01-27
AU765508B2 (en) 2003-09-18
US6406921B1 (en) 2002-06-18
ATE397752T1 (en) 2008-06-15
US20020106702A1 (en) 2002-08-08
US20060228701A1 (en) 2006-10-12
WO2000004389A2 (en) 2000-01-27
JP2002520618A (en) 2002-07-09
US20030003599A1 (en) 2003-01-02
CA2337075A1 (en) 2000-01-27
US20020110933A1 (en) 2002-08-15

Similar Documents

Publication Publication Date Title
WO2000004382A8 (en) Arrays of proteins and methods of use thereof
NZ501836A (en) Retentate chromatography and protein chip arrays with applications in biology and medicine
EP3021106B8 (en) Methods of using assay electrode having immobilized lipid/protein layers for luminescence test measurements
WO2000054046A3 (en) Universal protein array system
AU2003256703A1 (en) Biosensor arrays and methods
ATE435423T1 (en) COMPOSITE MATRIX
DK0749325T3 (en) Bispecific molecules with clinical application
AU4058100A (en) Generic cdna or protein array for customized assays
AU9786798A (en) Aligned multiwell multiplate stack and method for processing biological/chemicalsamples using the same
AU8760898A (en) Surfactant-lipase complex immobilized on insoluble matrix
AU6243596A (en) Anti-Fas ligand antibody and assay method using the anti-Fas ligand antibody
WO2001098458A3 (en) Methods for immobilizing polypeptides
AU7616100A (en) Addressable arrays using morphology dependent resonance for analyte detection
AU7247896A (en) Protein signature analysis
WO2003008635A8 (en) η-SECRETASE IN VITRO SCREENING ASSAY
AU5143099A (en) Protein fragment complementation assays for the detection of biological or drug interactions
WO2004017042A3 (en) Methods and reagents for surface functionalization
AU2002259316A1 (en) Protein arrays and methods and systems for producing the same
AU649961B2 (en) Method for protein binding enzyme complementation assays
AU5971598A (en) Novel antibody, renin-active substance containing the same and prorenin assay reagent using the same
AU6601096A (en) Dax-1 protein, methods for production and use thereof
AU2136601A (en) Modified leukotoxin gene and protein
AU5186396A (en) Hematophagous insect calreticulin nucleic acid molecules, proteins and uses thereof
DE3852498T2 (en) ENZYME TEST FOR BIOLOGICAL SUBSTANCES.
EP1387390A3 (en) Retentate chromatography and protein chip arrays with applications in biology and medicine

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
ENP Entry into the national phase

Ref document number: 2337654

Country of ref document: CA

Ref country code: CA

Ref document number: 2337654

Kind code of ref document: A

Format of ref document f/p: F

ENP Entry into the national phase

Ref country code: JP

Ref document number: 2000 560449

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 51025/99

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 1999935573

Country of ref document: EP

AK Designated states

Kind code of ref document: C1

Designated state(s): AE AL AM AT AT AU AZ BA BB BG BR BY CA CH CN CU CZ CZ DE DE DK DK EE EE ES FI FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SK SL TJ TM TR TT UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: C1

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

CFP Corrected version of a pamphlet front page
CR1 Correction of entry in section i

Free format text: PAT. BUL. 04/2000 UNDER (81) ADD "AT (UTILITY MODEL), CZ (UTILITY MODEL, DE (UTILITY MODEL), DK (UTILITY MODEL), EE (UTILITY MODEL), FI (UTILITY MODEL), SK (UTILITY MODEL)"

WWP Wipo information: published in national office

Ref document number: 1999935573

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWG Wipo information: grant in national office

Ref document number: 51025/99

Country of ref document: AU