WO2000006159A1 - Heterocyclic sulphonamide derivatives - Google Patents
Heterocyclic sulphonamide derivatives Download PDFInfo
- Publication number
- WO2000006159A1 WO2000006159A1 PCT/US1999/017143 US9917143W WO0006159A1 WO 2000006159 A1 WO2000006159 A1 WO 2000006159A1 US 9917143 W US9917143 W US 9917143W WO 0006159 A1 WO0006159 A1 WO 0006159A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- alkyl
- compound
- group
- optionally substituted
- substituted aryl
- Prior art date
Links
- -1 Heterocyclic sulphonamide derivatives Chemical class 0.000 title claims abstract description 53
- 102000018899 Glutamate Receptors Human genes 0.000 claims abstract description 16
- 108010027915 Glutamate Receptors Proteins 0.000 claims abstract description 16
- 238000000034 method Methods 0.000 claims abstract description 10
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 5
- 150000001875 compounds Chemical class 0.000 claims description 73
- 125000000217 alkyl group Chemical group 0.000 claims description 45
- 229910052739 hydrogen Inorganic materials 0.000 claims description 25
- 150000003839 salts Chemical class 0.000 claims description 25
- 239000001257 hydrogen Substances 0.000 claims description 23
- 125000003107 substituted aryl group Chemical group 0.000 claims description 19
- 229910052799 carbon Inorganic materials 0.000 claims description 13
- 125000004432 carbon atom Chemical group C* 0.000 claims description 13
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 12
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 12
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 12
- 230000003389 potentiating effect Effects 0.000 claims description 11
- 125000003342 alkenyl group Chemical group 0.000 claims description 10
- 125000003118 aryl group Chemical group 0.000 claims description 10
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 9
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 8
- 125000000623 heterocyclic group Chemical group 0.000 claims description 6
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 6
- 241000124008 Mammalia Species 0.000 claims description 5
- 125000003545 alkoxy group Chemical group 0.000 claims description 5
- 125000002837 carbocyclic group Chemical group 0.000 claims description 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 5
- 229910052736 halogen Inorganic materials 0.000 claims description 5
- 125000005843 halogen group Chemical group 0.000 claims description 5
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 5
- 229910052757 nitrogen Inorganic materials 0.000 claims description 5
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims description 4
- 239000003085 diluting agent Substances 0.000 claims description 4
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims description 4
- 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 claims description 3
- 125000002393 azetidinyl group Chemical group 0.000 claims description 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 3
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 3
- 125000004965 chloroalkyl group Chemical group 0.000 claims description 3
- 125000004218 chloromethyl group Chemical group [H]C([H])(Cl)* 0.000 claims description 3
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 3
- 125000003709 fluoroalkyl group Chemical group 0.000 claims description 3
- 125000004634 hexahydroazepinyl group Chemical group N1(CCCCCC1)* 0.000 claims description 3
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims description 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 3
- 125000003386 piperidinyl group Chemical group 0.000 claims description 3
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims description 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 3
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 3
- 125000004215 2,4-difluorophenyl group Chemical group [H]C1=C([H])C(*)=C(F)C([H])=C1F 0.000 claims description 2
- 125000006276 2-bromophenyl group Chemical group [H]C1=C([H])C(Br)=C(*)C([H])=C1[H] 0.000 claims description 2
- 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 claims description 2
- 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 claims description 2
- 125000004204 2-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C(OC([H])([H])[H])C([H])=C1[H] 0.000 claims description 2
- 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 claims description 2
- 125000006275 3-bromophenyl group Chemical group [H]C1=C([H])C(Br)=C([H])C(*)=C1[H] 0.000 claims description 2
- 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims description 2
- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims description 2
- 125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 claims description 2
- 125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 claims description 2
- 125000004801 4-cyanophenyl group Chemical group [H]C1=C([H])C(C#N)=C([H])C([H])=C1* 0.000 claims description 2
- 125000004860 4-ethylphenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims description 2
- 125000004199 4-trifluoromethylphenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C(F)(F)F 0.000 claims description 2
- 125000005842 heteroatom Chemical group 0.000 claims description 2
- 125000003261 o-tolyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])C([H])([H])[H] 0.000 claims description 2
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims description 2
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 abstract description 13
- 230000008569 process Effects 0.000 abstract description 3
- 239000000243 solution Substances 0.000 description 36
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 30
- 239000000203 mixture Substances 0.000 description 25
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 22
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 21
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 21
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 20
- 238000012360 testing method Methods 0.000 description 19
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 18
- 229930195712 glutamate Natural products 0.000 description 17
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 14
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 12
- 230000006870 function Effects 0.000 description 12
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 11
- 239000000872 buffer Substances 0.000 description 11
- BOCUKUHCLICSIY-QJWLJZLASA-N cyclothiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(S(N2)(=O)=O)=C1NC2C1[C@H](C=C2)C[C@H]2C1 BOCUKUHCLICSIY-QJWLJZLASA-N 0.000 description 11
- 229960003176 cyclothiazide Drugs 0.000 description 11
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 11
- 239000011734 sodium Substances 0.000 description 10
- 238000006243 chemical reaction Methods 0.000 description 9
- 239000000463 material Substances 0.000 description 9
- 102000005962 receptors Human genes 0.000 description 9
- 108020003175 receptors Proteins 0.000 description 9
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 8
- 108090000078 AMPA Receptors Proteins 0.000 description 8
- 102000003678 AMPA Receptors Human genes 0.000 description 8
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 8
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 8
- 239000002253 acid Substances 0.000 description 8
- 239000004480 active ingredient Substances 0.000 description 8
- 238000004587 chromatography analysis Methods 0.000 description 8
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 8
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 7
- 235000019439 ethyl acetate Nutrition 0.000 description 7
- 239000012047 saturated solution Substances 0.000 description 7
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 6
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 6
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
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- UUDAMDVQRQNNHZ-UHFFFAOYSA-N (S)-AMPA Chemical compound CC=1ONC(=O)C=1CC(N)C(O)=O UUDAMDVQRQNNHZ-UHFFFAOYSA-N 0.000 description 5
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 5
- 125000004429 atom Chemical group 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
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- GQHTUMJGOHRCHB-UHFFFAOYSA-N 2,3,4,6,7,8,9,10-octahydropyrimido[1,2-a]azepine Chemical compound C1CCCCN2CCCN=C21 GQHTUMJGOHRCHB-UHFFFAOYSA-N 0.000 description 4
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 description 4
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- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 4
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- 235000019359 magnesium stearate Nutrition 0.000 description 4
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- 229940049953 phenylacetate Drugs 0.000 description 1
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- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
- C07D211/28—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms to which a second hetero atom is attached
Definitions
- the present invention relates to the potentiation of glutamate receptor function using certain heterocyclic sulphonamide derivatives. It also relates to novel heterocyclic sulphonamide derivatives, to processes for their preparation and to pharmaceutical compositions containing them.
- EAA receptors excitatory amino acid receptors
- Excitatory amino acid receptors are classified into two general types. Receptors that are directly coupled to the opening of cation channels in the cell membrane of the neurons are termed "ionotropic" . This type of receptor has been subdivided into at least three subtypes, which are defined by the depolarizing actions of the selective agonists N-methyl-D-aspartate ( ⁇ MDA) , alpha-amino-3-hydroxy- 5-methylisoxazole-4-propionic acid (AMPA) , and kainic acid (KA) .
- the second general type of receptor is the G-protein or second messenger-linked "metabotropic" excitatory amino acid receptor.
- This second type is coupled to multiple second messenger systems that lead to enhanced phosphoinositide hydrolysis, activation of phospholipase D, increases or decreases in c-AMP formation, and changes in ion channel function.
- Schoepp and Conn Trends in Pharmacol . Sci . , 14, 13 (1993) . Both types of receptors appear not only to mediate normal synaptic transmission along excitatory pathways, but also participate in the modification of synaptic connections during development and throughout life.
- Schoepp, Bockaert, and Sladeczek Trends in Pharmacol . Sci . , 11, 508 (1990); McDonald and Johnson, Brain Research Reviews, 15, 41 (1990) .
- AMPA receptors are assembled from four protein sub- units known as GluRl to GluR4, while kainic acid receptors are assembled from the sub-units GluR5 to GluR7, and KA-1 and KA-2. Wong and Mayer, Mol ecular Pharmacology 44: 505- 510, 1993. It is not yet known how these sub-units are combined in the natural state. However, the structures of certain human variants of each sub-unit have been elucidated, and cell lines expressing individual sub-unit variants have been cloned and incorporated into test systems designed to identify compounds which bind to or interact with them, and hence which may modulate their function.
- European patent application, publication number EP-A2- 0574257 discloses the human sub-unit variants GluRIB, GluR2B, GluR3A and GluR3B.
- European patent application, publication number EP-A1-0583917 discloses the human sub- unit variant GluR4B.
- AMPA and kainic acid receptors are their rapid deactivation and desensitization to glutamate. Ya ada and Tang, The Journal of Neuroscience, September 1993, 13(9): 3904-3915 and Kathryn M. Partin, J. Neuroscience, November 1, 1996, 16(21): 6634-6647. The physiological implications of rapid desensitization, and deactivation if any, are unknown.
- AMPA and/or kainic acid receptors may be inhibited using certain compounds. This action of these compounds is often referred to in the alternative as "potentiation" of the receptors.
- One such compound, which selectively potentiates AMPA receptor function is cyclothiazide . Partin et al . , Neuron . Vol. 11, 1069-1082, 1993. Compounds which potentiate AMPA receptors, like cyclothiazide, are often referred to as ampakines.
- Ampakines have been shown to improve memory in a variety of animal tests. Staubli et al . , Proc . Natl . Acad. Sci . , Vol. 91, pp 777-781, 1994, Neurobi ol ogy, and Arai et al . , The Journal of Pharmacol ogy and Experimental Therapeuti cs, 278: 627-638, 1996.
- cyclothiazide and certain heterocyclic sulphonamide derivatives potentiate agonist- induced excitability of human GluR4B receptor expressed in HEK 293 cells. Since cyclothiazide is known to potentiate glutamate receptor function in vivo, it is believed that this finding portends that the heterocyclic sulphonamide derivatives will also potentiate glutamate receptor function in vivo, and hence that the compounds will exhibit ampakine- like behavior.
- the present invention provides a compound of the formula: wherein:
- R la represents hydrogen or (1-4C) alkyl
- R lb and R lc together with the carbon atom to which they are attached form a 4 to 7 membered saturated heterocyclic ring containing as the hetero ring members a group NR a and a group X, wherein X is selected from the group consisting of -CH 2 -, -NR b -, -O- and -S-; and
- R a represents hydrogen, (1-4C) alkyl, optionally substituted aryl or optionally substituted aryl (1-4C) alkyl;
- R b represents hydrogen, (1-4C) alkyl, optionally substituted aryl or optionally substituted aryl ( 1-4C) alkyl;
- R 2 represents (1-6C) alkyl, (3-6C) cycloalkyl, (1-6C) fluoro- alkyl, ( 1-6C) chloroalkyl, (2-6C) alkenyl, ( 1-4C) alkoxy ( 1- 4C) alkyl, phenyl which is unsubstituted or substituted by halogen, (1-4C) alkyl or ( 1-4C) alkoxy, or a group of formula R 3 RN in which R 3 and R 4 each independently represents (1- 4C) alkyl or, together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl, morpholino, piperazinyl, hexahydroazepinyl or octahydroazocinyl group; and
- R ⁇ , R ⁇ , R 7 and R ⁇ represents hydrogen; (1-6C) alkyl; aryl (1-6C) alkyl; (2-6C) alkenyl; aryl (2-6C) alkenyl or aryl, or (b) two of R 5 , R 6 , R 7 and R 8 together with the carbon atom or carbon atoms to which they are attached form a (3-8C) carbocyclic ring; and the remainder of R ⁇ , R ⁇ , R7 and R 8 represent hydrogen; or a pharmaceutically acceptable salt thereof.
- the present invention provides a method of potentiating glutamate receptor function in a mammal requiring such treatment, which comprises administering an effective amount of a compound of formula I, or a pharmaceutically acceptable salt thereof as defined herein.
- the present invention provides the use of a compound of formula I, or a pharmaceutically acceptable salt thereof as defined herein for the manufacture of a medicament for potentiating glutamate receptor function.
- the present invention provides the use of a compound of formula I or a pharmaceutically acceptable salt thereof as defined herein for potentiating glutamate receptor function.
- glutamate receptor function refers to any increased responsiveness of glutamate receptors, for example AMPA receptors, to glutamate or an agonist, and includes but is not limited to inhibition of rapid desensitisation or deactivation of AMPA receptors to glutamate.
- a wide variety of conditions may be treated by the compounds of formula I and their pharmaceutically acceptable salts through their action as potentiators of glutamate receptor function.
- Such conditions include those associated with glutamate hypofunction, such as psychiatric and neurological disorders, for example cognitive disorders; neuro-degenerative disorders such as Alzheimer's disease; age-related dementias; age-induced memory impairment; movement disorders such as tardive dyskinesia, Hungtington' s chorea, myoclonus and Parkinson's disease; reversal of drug- induced states (such as cocaine, amphetamines, alcohol- induced states) ; depression; attention deficit disorder; attention deficit hyperactivity disorder; psychosis; cognitive deficits associated with psychosis; and drug- induced psychosis.
- the compounds of formula I may also be useful for improving memory (both short term and long term) and learning ability.
- the present invention provides the use of compounds of formula I for the treatment of each of these conditions.
- treating includes its generally accepted meaning which encompasses prohibiting, preventing, restraining, and slowing, stopping, or reversing progression, severity, or a resultant symptom.
- the present invention includes the pharmaceutically acceptable salts of the compounds defined by formula I.
- a compound of this invention can possess a sufficiently acidic, a sufficiently basic, or both functional groups, and accordingly react with any of a number of organic and inorganic bases, and inorganic and organic acids, to form a pharmaceutically acceptable salt.
- pharmaceutically acceptable salt refers to salts of the compounds of the above formula which are substantially non-toxic to living organisms.
- Typical pharmaceutically acceptable salts include those salts prepared by reaction of the compounds of the present invention with a pharmaceutically acceptable mineral or organic acid or an organic or inorganic base. Such salts are known as acid addition and base addition salts.
- Acids commonly employed to form acid addition salts are inorganic acids such as hydrochloric acid, hydrobromic acid, hydroiodic acid, sulfuric acid, phosphoric acid, and the like, and organic acids such as p-toluenesulfonic, methanesulfonic acid, oxalic acid, p-bromophenylsulfonic acid, carbonic acid, succinic acid, citric acid, benzoic acid, acetic acid, and the like.
- inorganic acids such as hydrochloric acid, hydrobromic acid, hydroiodic acid, sulfuric acid, phosphoric acid, and the like
- organic acids such as p-toluenesulfonic, methanesulfonic acid, oxalic acid, p-bromophenylsulfonic acid, carbonic acid, succinic acid, citric acid, benzoic acid, acetic acid, and the like.
- salts examples include the sulfate, pyrosulfate, bisulfate, sulfite, bisulfite, phosphate, monohydrogenphosphate, dihydrogenphosphate, metaphosphate, pyrophosphate, chloride, bromide, iodide, acetate, propionate, decanoate, caprylate, acrylate, formate, hydrochloride, dihydrochloride, isobutyrate, caproate, heptanoate, propiolate, oxalate, malonate, succinate, suberate, sebacate, fumarate, maleate, butyne-1, 4-dioate, hexyne-1, 6-dioate, benzoate, chlorobenzoate, methylbenzoate, hydroxybenzoate, methoxybenzoate, phthalate, xylenesulfonate, phenylacetate, phenylpropionate, phenylbutyrate,
- Base addition salts include those derived from inorganic bases, such as ammonium or alkali or alkaline earth metal hydroxides, carbonates, bicarbonates, and the like.
- bases useful in preparing the salts of this invention thus include sodium hydroxide, potassium hydroxide, ammonium hydroxide, potassium carbonate, sodium carbonate, sodium bicarbonate, potassium bicarbonate, calcium hydroxide, calcium carbonate, and the like.
- the potassium and sodium salt forms are particularly preferred.
- any salt of this invention is usually not of a critical nature, so long as the salt as a whole is pharmacologically acceptable and as long as the counterion does not contribute undesired qualities to the salt as a whole. It is further understood that the above salts may form hydrates or exist in a substantially anhydrous form.
- stereoisomer refers to a compound made up of the same atoms bonded by the same bonds but having different three-dimensional structures which are not interchangeable. The three-dimensional structures are called configurations.
- enantiomer refers to two stereoisomers whose molecules are nonsuperimposable mirror images of one another.
- chiral center refers to a carbon atom to which four different groups are attached.
- diastereomers refers to stereoisomers which are not enantiomers .
- two diastereomers which have a different configuration at only one chiral center are referred to herein as “epimers”.
- racemate racemic mixture
- racemic modification refer to a mixture of equal parts of enantiomers.
- enantiomeric enrichment refers to the increase in the amount of one enantiomer as compared to the other.
- a convenient method of expressing the enantiomeric enrichment achieved is the concept of enantiomeric excess, or "ee”, which is found using the following equation:
- E 1 is the amount of the first enantiomer and E 2 is the amount of the second enantiomer.
- the initial ratio of the two enantiomers is 50:50, such as is present in a racemic mixture, and an enantiomeric enrichment sufficient to produce a final ratio of 50:30 is achieved, the ee with respect to the first enantiomer is 25%.
- the final ratio is 90:10, the ee with respect to the first enantiomer is 80%.
- An ee of greater than 90% is preferred, an ee of greater than 95% is most preferred and an ee of greater than 99% is most especially preferred.
- Enantiomeric enrichment is readily determined by one of ordinary skill in the art using standard techniques and procedures, such as gas or high performance liquid chromatography with a chiral column. Choice of the appropriate chiral column, eluent and conditions necessary to effect separation of the enantiomeric pair is well within the knowledge of one of ordinary skill in the art.
- the enantiomers of compounds of formula I can be resolved by one of ordinary skill in the art using standard techniques well known in the art, such as those described by J. Jacques, et al . , “Enantiomers, Racemates, and Resolutions", John Wiley and Sons, Inc., 1981. Examples of resolutions include recrystallization techniques or chiral chromatography.
- Some of the compounds of the present invention have one or more chiral centers and may exist in a variety of stereoisomeric configurations. As a consequence of these chiral centers, the compounds of the present invention occur as racemates, mixtures of enantiomers and as individual enantiomers, as well as diastereomers and mixtures of diastereomers. All such racemates, enantiomers, and diastereomers are within the scope of the present invention.
- R and S are used herein as commonly used in organic chemistry to denote specific configuration of a chiral center.
- the term “R” (rectus) refers to that configuration of a chiral center with a clockwise relationship of group priorities (highest to second lowest) when viewed along the bond toward the lowest priority group.
- the term “S” (sinister) refers to that configuration of a chiral center with a counterclockwise relationship of group priorities (highest to second lowest) when viewed along the bond toward the lowest priority group.
- the priority of groups is based upon their atomic number (in order of decreasing atomic number) .
- a partial list of priorities and a discussion of stereochemistry is contained in "Nomenclature of Organic Compounds: Principles and Practice", (J.H. Fletcher, et al . , eds., 1974) at pages 103- 120.
- aryl includes phenyl and a polycyclic aromatic carbocyclic ring such as naphthyl .
- optionally substituted as used in the term “optionally substituted aryl” or “optionally substituted aryl (1-4C) alkyl” herein signifies that the aryl group is unsubstituted or substituted by one or more (for example one or two) substituents, said substituents being selected from atoms and groups which, when present in the compound of formula I, do not prevent the compound of formula I from functioning as a potentiator of glutamate receptor function.
- substituents which may be present in an optionally substituted aryl group include halogen; nitro; cyano; (1-4C) alkyl; (1-4C) alkoxy; halo (1-4C) alkyl; and a group of formula - (L 1 ) x -X 1 - (L 2 ) y -R 9 in which each of L 1 and L 2 independently represents (1-4C) alkylene, one of x and y is 0 and the other is 0 or 1, X 1 represents a bond, 0, S, NH, CO, CONH or NHCO, and R 9 represents a phenyl group that is unsubstituted or substituted by one or two of halogen, (1- 4C) alkyl and (1-4C) haloalkyl .
- any alkyl group may be unbranched or branched.
- the term " (1-6C) alkyl” includes “ (1-4C) alkyl” .
- Examples of particular values for a (1- 6C) alkyl group include methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl and hexyl .
- (1-4C) alkylene includes (2-4C) alkylene .
- Examples of particular values are methylene and ethylene.
- the 4 to 7 membered saturated heterocyclic ring containing a group NR a and a group X, wherein X is selected from the group consisting of -CH 2 -, -NR b -, -0- and -S- may be selected, for example, from azetidinyl, pyrrolidinyl, piperidinyl, morpholinyl, thiomorpholinyl, piperazinyl, hexahydropyrimidyl, tetrahydro-1, 3-oxazinyl, tetrahydro-1, 3- thiazinyl and hexahydroazepinyl .
- Examples of 4 to 7 membered saturated heterocyclic rings are those wherein R lb and R lc together with the carbon atom to which they are attached are selected from the group consisting of:
- R a represents hydrogen, (1-4C) alkyl, optionally substituted aryl or optionally substituted aryl (1-4C) alkyl
- R b represents hydrogen, (1-4C) alkyl, optionally substituted aryl or optionally substituted aryl ( 1-4C) alkyl .
- R a and R ⁇ are methyl, ethyl, propyl, phenyl, 2-fluorophenyl, 3-fluorophenyl, 4- fluorophenyl, 2-chlorophenyl, 3-chlorophenyl, 4- chlorophenyl, 2-bromophenyl, 3-bromophenyl, 4-bromophenyl, 2, 3-difluorophenyl, 2, 4-difluorophenyl, 3, 4-dichlorophenyl, 3, 5-dichlorophenyl, 4-cyanophenyl, 3-nitrophenyl, 2- methylphenyl, 4-methylphenyl, 4-ethylphenyl, 3-propylphenyl, 4-t-butylphenyl, 2-trifluoromethylphenyl, 3- trifluoromethylphenyl, 4-trifluoromethylphenyl, 2-fluoro-4- trifluoromethylphenyl, 2-methoxyphenyl, 3-methoxyphenyl, 3-me
- a preferred value for the 4 to 7 membered saturated heterocyclic ring is a group of formula (a) above, such as N-methyl-2-pyrrolidinyl, or a group of formula (e) above, such as 1- (2-fluorophenyl) piperidin-4-yl .
- alkenyl group for example as in (2-6C) alkenyl or aryl (2-6C) alkenyl may be branched or unbranched. Examples of particular values are vinyl and prop-2-enyl.
- (3-8C) cycloalkyl includes (3-6C) cycloalkyl .
- Examples of particular values for (3-8C) cycloalkyl are cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl .
- halo ( 1-6C) alkyl includes halo (1-4C) alkyl, ( 1-6C) fluoroalkyl, such as trifluoromethyl or 2,2,2- trifluoroethyl, and (1-6C) chloroalkyl, such as chloromethyl.
- halogen includes fluorine, chlorine and bromine.
- R la is hydrogen
- R ⁇ examples of values for R ⁇ are methyl, ethyl, propyl, 2- propyl, butyl, 2-methylpropyl, cyclohexyl, trifluoromethyl, 2, 2, 2-trifluoroethyl, chloromethyl, ethenyl, prop-2-enyl, methoxyethyl, phenyl, 4-fluorophenyl, or dimethylamino .
- R2 is ethyl, 2-propyl or dimethylamino.
- R 3 and R 4 each represent methyl.
- R 7 and R 8 are methyl, ethyl and propyl.
- An example of an aryl (1-C) alkyl group is benzyl.
- An example of a (2- 6C) alkenyl group is prop-2-enyl.
- An example of a (3- 8C) carbocyclic ring is a cyclopropyl ring.
- R 6 and R 7 each represents hydrogen.
- R ⁇ and R 8 each independently represents hydrogen or (1-4C) alkyl, or together with the carbon atom to which they are attached form a (3-8C) carbocyclic ring.
- R 8 represents methyl or ethyl and R- 1 represents hydrogen or methyl, or R ⁇ and R 8 together with the carbon atom to which they are attached form a cyclopropyl ring.
- R 8 represents methyl and R ⁇ , R 6 and R 7 each represents hydrogen.
- the compounds of formula I may be prepared by reacting a compound of formula
- R 2 S02Z III in which Z represents a leaving atom or group, followed where necessary and/or desired by forming a pharmaceutically acceptable salt.
- the leaving atom or group represented by Z may be, for example, a halogen atom such as a chlorine or bromine atom.
- the reaction is conveniently performed in the presence of a base, for example an alkali metal hydroxide such as sodium hydroxide, an alkali metal carbonate such as potassium carbonate, a tertiary amine such as triethylamine or 1,8- diazabicyclo [5.4.0] undec-7-ene.
- a base for example an alkali metal hydroxide such as sodium hydroxide, an alkali metal carbonate such as potassium carbonate, a tertiary amine such as triethylamine or 1,8- diazabicyclo [5.4.0] undec-7-ene.
- Suitable solvents include halogenated hydrocarbons such as dichloromethane .
- the reaction is conveniently performed at a temperature in the range of from -20 to 100°C, preferably from -5 to 50°C.
- the compounds of formula II are known or may be prepared by reducing a corresponding nitrile or amide, for example using a borane, such as borane dimethyl sulfide, or lithium aluminium hydride.
- Convenient solvents for the reduction include ethers, such as tetrahydrofuran and diethyl ether.
- a strong base for example an alkali metal amide such as sodium or lithium bis (trimethylsilyl) amide and a compound of formula R 5 Z 1 or R 8 Z 1 in which Z 1 represents a leaving atom or group, such as an iodine atom.
- Convenient solvents include ethers, such as tetrahydrofuran. The temperature is conveniently in the range of from -78 to 25°C.
- esters are then converted to the amides by hydrolysis, for example using sodium or potassium hydroxide in an aqueous alcohol to afford an acid, and conversion of the acid to an amide, for example by reaction of the acid with thionyl chloride followed by aqueous ammonia.
- hydrolysis for example using sodium or potassium hydroxide in an aqueous alcohol to afford an acid
- conversion of the acid to an amide for example by reaction of the acid with thionyl chloride followed by aqueous ammonia.
- R VI may be reacted with toluenesulfonylmethyl isocyanide in the presence of a strong base, such as potassium t-butoxide.
- Suitable solvents include ethyleneglycol dimethyl ether
- Suitable protecting groups include acyl groups, such as acetyl or benzoyl, and acyloxy groups, such as t- butoxycarbonyl .
- a t-butoxycarbonyl may conveniently be removed using trifluoroacetic acid.
- the ability of compounds of formula I to potentiate glutamate receptor-mediated response may be determined using fluorescent calcium indicator dyes (Molecular Probes, Eugene, Oregon, Fluo-3) and by measuring glutamate-evoked efflux of calcium into GluR4 transfected HEK293 cells, as described in more detail below.
- 96 well plates containing confluent monolayers of HEK cells stably expressing human GluR4B (obtained as described in European Patent Application Publication Number EP-A1-583917 ) are prepared.
- the tissue culture medium in the wells is then discarded, and the wells are each washed once with 200 ⁇ l of buffer (glucose, lOmM, sodium chloride, 138mM, magnesium chloride, ImM, potassium chloride, 5mM, calcium chloride, 5mM, N- [2-hydroxyethyl] - piperazine-N- [2-ethanesulfonic acid], lOmM, to pH 7.1 to 7.3) .
- buffer glucose, lOmM, sodium chloride, 138mM, magnesium chloride, ImM, potassium chloride, 5mM, calcium chloride, 5mM, N- [2-hydroxyethyl] - piperazine-N- [2-ethanesulfonic acid], lOmM, to
- the plates are then incubated for 60 minutes in the dark with 20 ⁇ M Fluo3-AM dye (obtained from Molecular Probes Inc, Eugene, Oregon) in buffer in each well. After the incubation, each well is washed once with 100 ⁇ l buffer, 200 ⁇ l of buffer is added and the plates are incubated for 30 minutes .
- 20 ⁇ M Fluo3-AM dye obtained from Molecular Probes Inc, Eugene, Oregon
- Solutions for use in the test are also prepared as follows. 30 ⁇ M, 10 ⁇ M, 3 ⁇ M and 1 ⁇ M dilutions of test compound are prepared using buffer from a 10 mM solution of test compound in DMSO. 100 ⁇ M cyclothiazide solution is prepared by adding 3 ⁇ l of 100 mM cyclothiazide to 3 ml of buffer. Control buffer solution is prepared by adding 1.5 ⁇ l DMSO to 498.5 ⁇ l of buffer.
- test compounds and cyclothiazide solutions are determined by subtracting the second from the third reading (fluorescence due to addition of glutamate in the presence or absence of test compound or cyclothiazide) and are expressed relative to enhance fluorescence produced by 100 ⁇ M cyclothiazide.
- HEK293 cells stably expressing human GluR4 are used in the electro- physiological characterization of AMPA receptor potentiators .
- the extracellular recording solution contains
- the intracellular recording solution contains (in mM) : 140 CsCl,
- the concentration of the test compound, both in the bathing solution and co-applied with glutamate is increased in half log units until the maximum effect was seen. Data collected in this manner are fit to the Hill equation, yielding an EC50 value, indicative of the potency of the test compound.
- Reversibility of test compound activity is determined by assessing control glutamate ImM responses. Once the control responses to the glutamate challenge are re-established, the potentiation of these responses by 100 ⁇ M cyclothiazide is determined by its inclusion in both the bathing solution and the glutamate-containing solution. In this manner, the efficacy of the test compound relative to that of cyclothiazide can be determined.
- the present invention provides a pharmaceutical composition, which comprises a compound of formula I or a pharmaceutically acceptable salt thereof as defined hereinabove and a pharmaceutically acceptable diluent or carrier.
- compositions are prepared by known procedures using well-known and readily available ingredients.
- the active ingredient will usually be mixed with a carrier, or diluted by a carrier, or enclosed within a carrier, and may be in the form of a capsule, sachet, paper, or other container.
- the carrier serves as a diluent, it may be a solid, semi-solid, or liquid material which acts as a vehicle, excipient, or medium for the active ingredient.
- compositions can be in the form of tablets, pills, powders, lozenges, sachets, cachets, elixirs, suspensions, emulsions, solutions, syrups, aerosols, ointments containing, for example, up to 10% by weight of active compound, soft and hard gelatin capsules, suppositories, sterile injectable solutions, and sterile packaged powders .
- Suitable carriers, excipients, and diluents include lactose, dextrose, sucrose, sorbitol, mannitol, starches, gum, acacia, calcium phosphate, alginates, tragcanth, gelatin, calcium silicate, micro- crystalline cellulose, polyvinylpyrrolidone, cellulose, water syrup, methyl cellulose, methyl and propyl hydroxybenzoates, talc, magnesium stearate, and mineral oil.
- the formulations can additionally include lubricating agents, wetting agents, emulsifying and suspending agents, preserving agents, sweetening agents, or flavoring agents.
- Compositions of the invention may be formulated so as to provide quick, sustained, or delayed release of the active ingredient after administration to the patient by employing procedures well known in the art.
- compositions are preferably formulated in a unit dosage form, each dosage containing from about 1 mg to about 500 mg, more preferably about 5 mg to about 300 mg (for example 25 mg) of the active ingredient.
- unit dosage form refers to a physically discrete unit suitable as unitary dosages for human subjects and other mammals, each unit containing a predetermined quantity of active material calculated to produce the desired therapeutic effect, in association with a suitable pharmaceutical carrier, diluent, or excipient.
- suitable pharmaceutical carrier diluent, or excipient.
- Hard gelatin capsules are prepared using the following ingredients :
- the above ingredients are mixed and filled into hard gelatin capsules in 460 mg quantities.
- Tablets each containing 60 mg of active ingredient are made as follows:
- the active ingredient, starch, and cellulose are passed through a No . 45 mesh U.S. sieve and mixed thoroughly.
- the solution of polyvinylpyrrolidone is mixed with the resultant powders which are then passed through a No . 14 mesh U.S. sieve.
- the granules so produced are dried at 50°C and passed through a No . 18 mesh U.S. sieve.
- the sodium carboxymethyl starch, magnesium stearate, and talc previously passed through a No . 60 mesh U.S. sieve, are then added to the granules which, after mixing, are compressed on a tablet machine to yield tablets each weighing 150 mg.
- patient refers to a mammal, such as a mouse, guinea pig, rat, dog or human. It is understood that the preferred patient is a human.
- the term "effective amount” refers to the amount or dose of the compound which provides the desired effect in the patient under diagnosis or treatment.
- the particular dose of compound administered according to this invention will of course be determined by the particular circumstances surrounding the case, including the compound administered, the route of administration, the particular condition being treated, and similar considerations.
- the compounds can be administered by a variety of routes including oral, rectal, transdermal, subcutaneous, intravenous, intramuscular, or intranasal routes. Alternatively, the compound may be administered by continuous infusion.
- a typical daily dose will contain from about 0.01 mg/kg to about 100 mg/kg of the active compound of this invention.
- daily doses will be about 0.05 mg/kg to about 50 mg/kg, more preferably from about 0.1 mg/kg to about 25 mg/kg.
- N- [2- [N-tert-butoxycarbonyl-4-piperidinyl] propyl] 2- propanesulfonamide To a ambient temperature suspension of 175 mg (4.61 mmol) of lithium aluminum hydride in 7 ml of diethyl ether was added dropwise 1.0 g (4.19 mmol) of material from step C in 7 ml of diethyl ether. The mixture was stirred for 2 h. a 2 SO «10H 2 O was added, and the mixture stirred for 30 min at ambient temperature. The solid was filtered and the organic solution was concentrated in vacuo .
- N- [2- (N- (2-fluorophenyl) -4-piperidinyl) propyl] 2- propanesulfonamide A solution of the material from step C, 390 mg, (1.42 mmol) in dichloromethane (5 ml) was cooled to 0°C, triethylamine 0.45 ml (3.26 mmol) was added, followed by isopropylsulfonyl chloride (0.20 ml, 1.84 mmol). The ice- bath was removed and the solution was stirred at ambient temperature for 4 h. The organic solution was washed with 1 N hydrochloric acid, sodium bicarbonate saturated solution, brine, dried over Na S0 4 filtered and concentrated in vacuo .
Abstract
Description
Claims
Priority Applications (5)
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EP99937600A EP1100498A4 (en) | 1998-07-31 | 1999-07-28 | Heterocyclic sulphonamide derivatives |
CA002338930A CA2338930A1 (en) | 1998-07-31 | 1999-07-28 | Heterocyclic sulphonamide derivatives |
AU52400/99A AU5240099A (en) | 1998-07-31 | 1999-07-28 | Heterocyclic sulphonamide derivatives |
US09/744,457 US6355655B1 (en) | 1998-07-31 | 1999-07-28 | Heterocyclic sulphonamide derivatives |
JP2000562014A JP2002521445A (en) | 1998-07-31 | 1999-07-28 | Heterocyclic sulfonamide derivatives |
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US9477098P | 1998-07-31 | 1998-07-31 | |
US60/094,770 | 1998-07-31 |
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PCT/US1999/017143 WO2000006159A1 (en) | 1998-07-31 | 1999-07-28 | Heterocyclic sulphonamide derivatives |
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US (1) | US6355655B1 (en) |
EP (1) | EP1100498A4 (en) |
JP (1) | JP2002521445A (en) |
AU (1) | AU5240099A (en) |
CA (1) | CA2338930A1 (en) |
WO (1) | WO2000006159A1 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6303816B1 (en) | 1997-02-04 | 2001-10-16 | Eli Lilly And Company | Sulphonamide derivatives |
US6358981B1 (en) | 1998-07-31 | 2002-03-19 | Eli Lilly And Company | Sulphonamide derivatives |
US6639107B1 (en) | 1999-12-08 | 2003-10-28 | Eli Lilly And Company | Cyclopentyl sulfonamide derivatives |
US6693137B1 (en) | 1998-07-31 | 2004-02-17 | Eli Lilly And Company | Sulphonamide derivatives |
EP3311842A1 (en) | 2013-06-13 | 2018-04-25 | VeroScience LLC | Compositions and methods for treating metabolic disorders |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU5235599A (en) | 1998-07-31 | 2000-02-21 | Eli Lilly And Company | N-substituted sulfonamide derivatives |
US20070270471A1 (en) * | 2004-08-09 | 2007-11-22 | Glaxo Group Limited | Compounds Which Potentiate Glutamate Receptor and Uses Thereof in Medicine |
WO2010054336A2 (en) * | 2008-11-10 | 2010-05-14 | The Regents Of The University Of California | Therapeutic uses of ampa receptor modulators for treatment of motor dysfunction |
WO2020113094A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
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- 1999-07-28 AU AU52400/99A patent/AU5240099A/en not_active Abandoned
- 1999-07-28 WO PCT/US1999/017143 patent/WO2000006159A1/en not_active Application Discontinuation
- 1999-07-28 US US09/744,457 patent/US6355655B1/en not_active Expired - Fee Related
- 1999-07-28 EP EP99937600A patent/EP1100498A4/en not_active Withdrawn
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- 1999-07-28 CA CA002338930A patent/CA2338930A1/en not_active Abandoned
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Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
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US6303816B1 (en) | 1997-02-04 | 2001-10-16 | Eli Lilly And Company | Sulphonamide derivatives |
US6596716B2 (en) | 1997-02-04 | 2003-07-22 | Eli Lilly And Company | 2-propane-sulphonamide derivatives |
US6358981B1 (en) | 1998-07-31 | 2002-03-19 | Eli Lilly And Company | Sulphonamide derivatives |
US6515026B2 (en) | 1998-07-31 | 2003-02-04 | Eli Lilly And Company | Sulphonamide derivatives |
US6693137B1 (en) | 1998-07-31 | 2004-02-17 | Eli Lilly And Company | Sulphonamide derivatives |
US6713516B2 (en) | 1998-07-31 | 2004-03-30 | Eli Lilly And Company | Sulphonamide derivatives |
US6639107B1 (en) | 1999-12-08 | 2003-10-28 | Eli Lilly And Company | Cyclopentyl sulfonamide derivatives |
EP3311842A1 (en) | 2013-06-13 | 2018-04-25 | VeroScience LLC | Compositions and methods for treating metabolic disorders |
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AU5240099A (en) | 2000-02-21 |
JP2002521445A (en) | 2002-07-16 |
EP1100498A1 (en) | 2001-05-23 |
US6355655B1 (en) | 2002-03-12 |
EP1100498A4 (en) | 2001-10-24 |
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