WO2000009096B1 - Injectable formulations of nanoparticulate naproxen - Google Patents

Injectable formulations of nanoparticulate naproxen

Info

Publication number
WO2000009096B1
WO2000009096B1 PCT/US1999/018270 US9918270W WO0009096B1 WO 2000009096 B1 WO2000009096 B1 WO 2000009096B1 US 9918270 W US9918270 W US 9918270W WO 0009096 B1 WO0009096 B1 WO 0009096B1
Authority
WO
WIPO (PCT)
Prior art keywords
less
particle size
naproxen
average particle
effective average
Prior art date
Application number
PCT/US1999/018270
Other languages
French (fr)
Other versions
WO2000009096A1 (en
Inventor
Robert Lee
Castro Lan De
Original Assignee
Nanosystems
Robert Lee
Castro Lan De
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanosystems, Robert Lee, Castro Lan De filed Critical Nanosystems
Priority to JP2000564599A priority Critical patent/JP2002522474A/en
Priority to EP99941065A priority patent/EP1105109B1/en
Priority to DE69907213T priority patent/DE69907213T2/en
Priority to AU54789/99A priority patent/AU5478999A/en
Priority to CA002340221A priority patent/CA2340221C/en
Priority to AT99941065T priority patent/ATE238042T1/en
Publication of WO2000009096A1 publication Critical patent/WO2000009096A1/en
Publication of WO2000009096B1 publication Critical patent/WO2000009096B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/778—Nanostructure within specified host or matrix material, e.g. nanocomposite films
    • Y10S977/779—Possessing nanosized particles, powders, flakes, or clusters other than simple atomic impurity doping
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/908—Mechanical repair performed/surgical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer

Abstract

Described are an injectable formulation of nanoparticulate naproxen that produces minimal or no pain or burning sensation upon administration, and methods of making and using such a formulation. The injectable formulation comprises nanoparticulate naproxen having a povidone polymer adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than about 600 nm.

Claims

AMENDED CLAIMS[received by the International Bureau on 10 February 2000 (10.02.00); original claims 1-22 replaced by amended claims 1-18 (4 pages)]
1. A nanoparticulate inj ectable pharmaceutical composition comprising:
(a) naproxen particles having an effective average particle size of less than about 600 nm;
(b) a povidone polymer adsorbed on the surface of the naproxen particles, wherein the povidone polymer has a molecular weight of about 40,000 daltons or less; and
(c) a pharmaceutically acceptable carrier.
2. The composition of claim 1 , wherein the effective average particle size of the naproxen particles is less than about 450 nm.
3. The composition of claim 1, wherein the effective average particle size of the naproxen particles is selected from the group consisting of less than about 400 nm, less than about 300 nm, less than about 250 nm, and less than about 100 nm.
4. The composition of claim 1 , wherein the povidone polymer is present in an amount of about 0.1 to about 50% (w/w) based on the total weight of the naproxen and povidone polymer.
5. The composition of claim 1 , wherein the naproxen is present in an amount of about 5.0 to about 50% (w/w), by weight.
6. A method of treating a mammal comprising administering to the mammal an effective amount of a nanoparticulate injectable pharmaceutical composition comprising:
(a) naproxen particles having an effective average particle size of less than about 600 nm;
(b) a povidone polymer adsorbed on the surface of the naproxen particles, wherein the povidone polymer has a molecular weight of about 40,000 daltons or less; and (c) a pharmaceutically acceptable carrier.
7. The method of claim 6, wherein the effective average particle size of the naproxen particles is less than about 450 nm.
8. The method of claim 7, wherein the effective average particle size of the naproxen particles is selected from the group consisting of less than about 400 nm, less than about 300 nm, less than about 250 nm, and less than about 100 nm.
9. A method of preparing a nanoparticulate injectable pharmaceutical composition that produces minimal or no pain or irritation upon administration, wherein the composition comprises:
(a) naproxen particles having an effective average particle size of less than about 600 nm;
(b) a povidone polymer adsorbed on the surface of the naproxen particles, wherein the povidone polymer has a molecular weight of about 40,000 daltons or less; and
(c) a pharmaceutically acceptable carrier, wherein the method comprises: (i) dispersing the naproxen particles in a liquid dispersion medium comprising a povidone polymer; and (ii) mechanically reducing the particle size of the naproxen to an effective average particle size of less than about 600 nm.
10. The method of claim 9, wherein the effective average particle size of the naproxen particles is less than about 450 nm.
11. The method of claim 10, wherein the effective average particle size of the naproxen particles is selected from the group consisting of less than about 400 nm, less than about 300 nm, less than about 250 nm, and less than about 100 nm.
33
12. A method of preparing a nanoparticulate injectable pharmaceutical composition comprising:
(a) naproxen particles having an effective average particle size of less than about 600 nm;
(b) a povidone polymer adsorbed on the surface of the naproxen particles, wherein the povidone polymer has a molecular weight of about 40,000 daltons or less; and
(c) a pharmaceutically acceptable carrier, wherein the method comprises: (i) dispersing the naproxen particles in a liquid dispersion;
(ii) mechanically reducing the particle size of the naproxen to an effective average particle size of less than about 600 nm; and
(iii) adding a povidone polymer to the dispersion of naproxen particles.
13. The method of claim 12, wherein the effective average particle size of the naproxen particles is less than about 450 nm.
14. The method of claim 13, wherein the effective average particle size of the naproxen particles is selected from the group consisting of less than about 400 nm, less than about 300 nm, less than about 250 nm, and less than about 100 nm.
15. The composition of claim 1 , wherein the pH of the nanoparticulate composition is between about 6 to about 7.
16. The method of claim 6, wherein the pH of the nanoparticulate composition is between about 6 to about 7.
17. The method of claim 9, wherein the pH of the nanoparticulate composition is between about 6 to about 7.
34
18. The method of claim 12, wherein the pH of the nanoparticulate composition is between about 6 to about 7.
35
PCT/US1999/018270 1998-08-13 1999-08-12 Injectable formulations of nanoparticulate naproxen WO2000009096A1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2000564599A JP2002522474A (en) 1998-08-13 1999-08-12 Injectable formulation of nanoparticulate naproxen
EP99941065A EP1105109B1 (en) 1998-08-13 1999-08-12 Injectable formulations of nanoparticulate naproxen
DE69907213T DE69907213T2 (en) 1998-08-13 1999-08-12 INJECTABLE FORMULATIONS WITH NANOPARTICULAR NAPROXES
AU54789/99A AU5478999A (en) 1998-08-13 1999-08-12 Injectable formulations of nanoparticulate naproxen
CA002340221A CA2340221C (en) 1998-08-13 1999-08-12 Injectable formulations of nanoparticulate naproxen
AT99941065T ATE238042T1 (en) 1998-08-13 1999-08-12 INJECTABLE FORMULATIONS CONTAINING NANOPARTICULAR NAPROXEN

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/154,422 US6153225A (en) 1998-08-13 1998-08-13 Injectable formulations of nanoparticulate naproxen
US09/154,422 1998-08-13

Publications (2)

Publication Number Publication Date
WO2000009096A1 WO2000009096A1 (en) 2000-02-24
WO2000009096B1 true WO2000009096B1 (en) 2000-03-30

Family

ID=22551305

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/018270 WO2000009096A1 (en) 1998-08-13 1999-08-12 Injectable formulations of nanoparticulate naproxen

Country Status (8)

Country Link
US (1) US6153225A (en)
EP (1) EP1105109B1 (en)
JP (1) JP2002522474A (en)
AT (1) ATE238042T1 (en)
AU (1) AU5478999A (en)
CA (1) CA2340221C (en)
DE (1) DE69907213T2 (en)
WO (1) WO2000009096A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6835396B2 (en) 2001-09-26 2004-12-28 Baxter International Inc. Preparation of submicron sized nanoparticles via dispersion lyophilization
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4990696A (en) * 1995-02-24 1996-09-11 Nanosystems L.L.C. Aerosols containing nanoparticle dispersions
US20050004049A1 (en) * 1997-03-11 2005-01-06 Elan Pharma International Limited Novel griseofulvin compositions
US8236352B2 (en) 1998-10-01 2012-08-07 Alkermes Pharma Ireland Limited Glipizide compositions
NZ511442A (en) 1998-11-02 2003-02-28 Elan Corp Plc Multiparticulate modified release composition for multiple dosing of ADD patients with methylphenidate HCl
US6969529B2 (en) 2000-09-21 2005-11-29 Elan Pharma International Ltd. Nanoparticulate compositions comprising copolymers of vinyl pyrrolidone and vinyl acetate as surface stabilizers
US7276249B2 (en) * 2002-05-24 2007-10-02 Elan Pharma International, Ltd. Nanoparticulate fibrate formulations
US7198795B2 (en) 2000-09-21 2007-04-03 Elan Pharma International Ltd. In vitro methods for evaluating the in vivo effectiveness of dosage forms of microparticulate of nanoparticulate active agent compositions
US7998507B2 (en) * 2000-09-21 2011-08-16 Elan Pharma International Ltd. Nanoparticulate compositions of mitogen-activated protein (MAP) kinase inhibitors
US20030224058A1 (en) * 2002-05-24 2003-12-04 Elan Pharma International, Ltd. Nanoparticulate fibrate formulations
US7193084B2 (en) * 2000-12-22 2007-03-20 Baxter International Inc. Polymorphic form of itraconazole
US20050048126A1 (en) 2000-12-22 2005-03-03 Barrett Rabinow Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
US6607784B2 (en) * 2000-12-22 2003-08-19 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US6976647B2 (en) * 2001-06-05 2005-12-20 Elan Pharma International, Limited System and method for milling materials
US20030087308A1 (en) * 2001-06-22 2003-05-08 Elan Pharma International Limited Method for high through put screening using a small scale mill or microfluidics
PT1429731E (en) * 2001-09-19 2007-04-30 Elan Pharma Int Ltd Nanoparticulate insulin formulations
EP1429749A2 (en) 2001-09-26 2004-06-23 Baxter International Inc. Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal
DK1443912T3 (en) * 2001-10-12 2008-01-21 Elan Pharma Int Ltd Compositions with a combination of immediate and controlled release properties
US7112340B2 (en) * 2001-10-19 2006-09-26 Baxter International Inc. Compositions of and method for preparing stable particles in a frozen aqueous matrix
EP1471887B1 (en) 2002-02-04 2010-04-21 Elan Pharma International Ltd. Nanoparticulate compositions having lysozyme as a surface stabilizer
WO2003080023A2 (en) * 2002-03-20 2003-10-02 Elan Pharma International Limited Fast dissolving dosage forms having reduced friability
CA2481390C (en) 2002-04-12 2012-11-27 Elan Pharma International Ltd. Nanoparticulate megestrol formulations
US7101576B2 (en) 2002-04-12 2006-09-05 Elan Pharma International Limited Nanoparticulate megestrol formulations
US20040105889A1 (en) * 2002-12-03 2004-06-03 Elan Pharma International Limited Low viscosity liquid dosage forms
US20100226989A1 (en) * 2002-04-12 2010-09-09 Elan Pharma International, Limited Nanoparticulate megestrol formulations
US9101540B2 (en) 2002-04-12 2015-08-11 Alkermes Pharma Ireland Limited Nanoparticulate megestrol formulations
ATE419835T1 (en) * 2002-05-06 2009-01-15 Elan Pharma Int Ltd NYSTATIN NANOPARTICLE COMPOSITIONS
JP4533134B2 (en) * 2002-06-10 2010-09-01 エラン ファーマ インターナショナル，リミティド Nanoparticulate policosanol formulations and novel policosanol combinations
JP4776229B2 (en) * 2002-07-16 2011-09-21 エラン ファーマ インターナショナル，リミティド Stable nanoparticulate active substance liquid dosage composition
ATE487470T1 (en) * 2002-09-11 2010-11-15 Elan Pharma Int Ltd GEL-STABILIZED ACTIVE COMPOSITIONS IN NANOPARTICLE SIZE
WO2004032980A1 (en) * 2002-10-04 2004-04-22 Elan Pharma International Limited Gamma irradiation of solid nanoparticulate active agents
US20040173696A1 (en) * 2002-12-17 2004-09-09 Elan Pharma International Ltd. Milling microgram quantities of nanoparticulate candidate compounds
CA2513064C (en) * 2003-01-31 2009-11-10 Elan Pharma International, Ltd. Nanoparticulate topiramate formulations
US20040208833A1 (en) * 2003-02-04 2004-10-21 Elan Pharma International Ltd. Novel fluticasone formulations
US20100297252A1 (en) 2003-03-03 2010-11-25 Elan Pharma International Ltd. Nanoparticulate meloxicam formulations
US8512727B2 (en) 2003-03-03 2013-08-20 Alkermes Pharma Ireland Limited Nanoparticulate meloxicam formulations
US7842232B2 (en) * 2003-05-22 2010-11-30 Elan Pharma International, Ltd. Sterilization of dispersions of nanoparticulate active agents with gamma radiation
DE602004018150D1 (en) * 2003-08-08 2009-01-15 Elan Pharma Int Ltd NEW METAXALON COMPOSITIONS
ATE509618T1 (en) * 2003-11-05 2011-06-15 Elan Pharma Int Ltd NANOPARTICLE-SHAPED COMPOSITIONS HAVING A PEPTIDE AS A SURFACE STABILIZER
CA2560298A1 (en) * 2004-03-24 2005-09-29 Takeda Pharmaceutical Company Limited Preparation with elevated content
AU2005307797B2 (en) * 2004-11-16 2011-06-02 Alkermes Pharma Ireland Limited Injectable nanoparticulate olanzapine formulations
UA89513C2 (en) * 2004-12-03 2010-02-10 Элан Фарма Интернешнл Лтд. Nanoparticulate raloxifene hydrochloride composition
BRPI0519088A2 (en) * 2004-12-15 2008-12-23 Elan Pharma Int Ltd nanoparticulate tacrolimus formulations
WO2006069098A1 (en) * 2004-12-22 2006-06-29 Elan Pharma International Ltd. Nanoparticulate bicalutamide formulations
KR20070118224A (en) * 2005-01-06 2007-12-14 엘란 파마 인터내셔널 리미티드 Nanoparticulate candesartan formulations
MX2007009915A (en) 2005-02-15 2007-11-06 Elan Pharma Int Ltd Aerosol and injectable formulations of nanoparticulate benzodiazepine.
EP1855659A2 (en) * 2005-02-24 2007-11-21 Elan Pharma International Limited Nanoparticulate formulations of docetaxel and analogues thereof
US20060204588A1 (en) * 2005-03-10 2006-09-14 Elan Pharma International Limited Formulations of a nanoparticulate finasteride, dutasteride or tamsulosin hydrochloride, and mixtures thereof
CN101175480A (en) * 2005-03-16 2008-05-07 伊兰制药国际有限公司 Nanoparticulate leukotriene receptor antagonist/corticosteroid formulations
KR20070121759A (en) * 2005-03-17 2007-12-27 엘란 파마 인터내셔널 리미티드 Nanoparticulate bisphosphonate compositions
WO2006102494A2 (en) * 2005-03-23 2006-09-28 Elan Pharma International Limited Nanoparticulate corticosteroid and antihistamine formulations
CN101171000A (en) 2005-04-12 2008-04-30 依兰药物国际有限公司 Nanoparticulate and controlled release compositions comprising cyclosporine
US8309133B2 (en) * 2005-04-12 2012-11-13 Alkermes Pharma Ireland Limited Nanoparticulate quinazoline derivative formulations
WO2006110809A2 (en) * 2005-04-12 2006-10-19 Elan Pharma International, Limited Nanoparticulate lipase inhibitor formulations
JP2009517485A (en) 2005-06-08 2009-04-30 エラン・ファルマ・インターナショナル・リミテッド Nanoparticulate and controlled release compositions containing cefditoren
EP1933814A2 (en) 2005-09-15 2008-06-25 Elan Pharma International Limited Nanoparticulate aripiprazole formulations
US20080227805A1 (en) * 2007-02-28 2008-09-18 Abbott Laboratories Sustained release parenteral formulations of buprenorphine
US8703204B2 (en) 2007-05-03 2014-04-22 Bend Research, Inc. Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and anon-ionizable polymer
WO2008135828A2 (en) 2007-05-03 2008-11-13 Pfizer Products Inc. Nanoparticles comprising a drug, ethylcellulose, and a bile salt
US8426467B2 (en) 2007-05-22 2013-04-23 Baxter International Inc. Colored esmolol concentrate
US8722736B2 (en) 2007-05-22 2014-05-13 Baxter International Inc. Multi-dose concentrate esmolol with benzyl alcohol
WO2008149192A2 (en) 2007-06-04 2008-12-11 Pfizer Products Inc. Nanoparticles comprising a non-ionizable cellulosic polymer and an amphiphilic non-ionizable block copolymer
WO2008149230A2 (en) 2007-06-04 2008-12-11 Pfizer Products Inc. Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glycol succinate
EP2240162A4 (en) 2007-12-06 2013-10-09 Bend Res Inc Nanoparticles comprising a non-ionizable polymer and an amine-functionalized methacrylate copolymer
EP2231169B1 (en) 2007-12-06 2016-05-04 Bend Research, Inc. Pharmaceutical compositions comprising nanoparticles and a resuspending material
EP2389159A1 (en) 2009-01-22 2011-11-30 Noramco, Inc. Process for preparing particles of opioids and compositions produced thereby
FR2945950A1 (en) 2009-05-27 2010-12-03 Elan Pharma Int Ltd ANTICANCER NANOPARTICLE COMPOSITIONS AND METHODS FOR PREPARING THE SAME
EP2435027B1 (en) 2009-05-27 2016-10-05 Alkermes Pharma Ireland Limited Reduction of flake-like aggregation in nanoparticulate meloxicam compositions
GB201118181D0 (en) 2011-10-21 2011-12-07 Jagotec Ag Pharmaceutical compositions
CN105007898A (en) * 2012-12-19 2015-10-28 卡希夫制药有限责任公司 Supersaturated stabilized nanoparticles for poorly soluble drugs
US10166197B2 (en) 2015-02-13 2019-01-01 St. John's University Sugar ester nanoparticle stabilizers
MX2017013956A (en) 2015-05-01 2018-09-05 Cocrystal Pharma Inc Nucleoside analogs for treatment of the flaviviridae family of viruses and cancer.
CN113730344B (en) * 2021-09-13 2023-10-20 艾迈华创(武汉)科技有限公司 Naproxen preparation for injection and application thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4009197A (en) * 1967-01-13 1977-02-22 Syntex Corporation 2-(6-Substituted-2'-naphthyl) acetic acid derivatives and the salts and esters thereof
US3904682A (en) * 1967-01-13 1975-09-09 Syntex Corp 2-(6{40 -Methoxy-2{40 -naphthyl)acetic acid
DE2914788A1 (en) * 1979-04-11 1980-10-16 Nattermann A & Cie PARENTERAL APPLICABLE, STABLE DRUG SOLUTIONS WITH ANTI-INFLAMMATORY EFFECT
IE58110B1 (en) * 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
US4780320A (en) * 1986-04-29 1988-10-25 Pharmetrix Corp. Controlled release drug delivery system for the periodontal pocket
US4919939A (en) * 1986-04-29 1990-04-24 Pharmetrix Corporation Periodontal disease treatment system
IT1200178B (en) * 1986-07-23 1989-01-05 Alfa Farmaceutici Spa GALENIC FORMULATIONS WITH SCHEDULED SALE CONTAINING DRUGS WITH ANTI-FLOGISTIC ACTIVITY
US5200193A (en) * 1987-04-22 1993-04-06 Mcneilab, Inc. Pharmaceutical sustained release matrix and process
US5580575A (en) * 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
IT1242642B (en) * 1990-04-17 1994-05-16 Alfa Wassermann Spa INJECTABLE FORMULATIONS CONTAINING NAPROXEN SODIUM SALT.
US5399363A (en) * 1991-01-25 1995-03-21 Eastman Kodak Company Surface modified anticancer nanoparticles
US5145684A (en) * 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
IT1258143B (en) * 1992-09-11 1996-02-20 Alfa Wassermann Spa PROGRAMMED SALE TABS CONTAINING NAPROXEN
US5510118A (en) * 1995-02-14 1996-04-23 Nanosystems Llc Process for preparing therapeutic compositions containing nanoparticles

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US6835396B2 (en) 2001-09-26 2004-12-28 Baxter International Inc. Preparation of submicron sized nanoparticles via dispersion lyophilization

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EP1105109B1 (en) 2003-04-23
DE69907213D1 (en) 2003-05-28
JP2002522474A (en) 2002-07-23
DE69907213T2 (en) 2004-04-15
US6153225A (en) 2000-11-28
ATE238042T1 (en) 2003-05-15
AU5478999A (en) 2000-03-06
CA2340221C (en) 2003-10-14
WO2000009096A1 (en) 2000-02-24
CA2340221A1 (en) 2000-02-24
EP1105109A1 (en) 2001-06-13

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