WO2000009101A3 - Use of estrogenic compounds as anti-fungal agents - Google Patents

Use of estrogenic compounds as anti-fungal agents Download PDF

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Publication number
WO2000009101A3
WO2000009101A3 PCT/US1999/018063 US9918063W WO0009101A3 WO 2000009101 A3 WO2000009101 A3 WO 2000009101A3 US 9918063 W US9918063 W US 9918063W WO 0009101 A3 WO0009101 A3 WO 0009101A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
fungal agents
estrogenic compounds
fungi
estrogenic
Prior art date
Application number
PCT/US1999/018063
Other languages
French (fr)
Other versions
WO2000009101A2 (en
Inventor
Shawn J Green
Adonia E Papathanassiu
Original Assignee
Entremed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Entremed Inc filed Critical Entremed Inc
Priority to DK99939719T priority Critical patent/DK1124545T3/en
Priority to JP2000564604A priority patent/JP2002522477A/en
Priority to EP99939719A priority patent/EP1124545B1/en
Priority to CA002339835A priority patent/CA2339835C/en
Priority to KR1020017001747A priority patent/KR20010074814A/en
Priority to AT99939719T priority patent/ATE284682T1/en
Priority to DE69922684T priority patent/DE69922684T2/en
Priority to AU53959/99A priority patent/AU764266B2/en
Publication of WO2000009101A2 publication Critical patent/WO2000009101A2/en
Publication of WO2000009101A3 publication Critical patent/WO2000009101A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Abstract

The present invention provides compounds that are useful for inhibiting the proliferation of fungi. The compounds are estrogenic derivatives, such as 2ME2, or anti-estrogenic compounds. The compounds may be used for treating infections of fungi in humans and animals, or to prevent or inhibit the growth of fungi on any surface.
PCT/US1999/018063 1998-08-11 1999-08-10 Use of estrogenic compounds as anti-fungal agents WO2000009101A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
DK99939719T DK1124545T3 (en) 1998-08-11 1999-08-10 Use of 2-methoxyestradiol as an antifungal agent
JP2000564604A JP2002522477A (en) 1998-08-11 1999-08-10 Use of estrogen-like compounds as antifungals
EP99939719A EP1124545B1 (en) 1998-08-11 1999-08-10 Use of 2-methoxyestradiol as anti-fungal agents
CA002339835A CA2339835C (en) 1998-08-11 1999-08-10 Use of estrogenic compounds as anti-fungal agents
KR1020017001747A KR20010074814A (en) 1998-08-11 1999-08-10 Use of estrogenic compounds as anti-fungal agents
AT99939719T ATE284682T1 (en) 1998-08-11 1999-08-10 USE OF 2-METHOXYESTRADIOL AS A FUNGICIDE
DE69922684T DE69922684T2 (en) 1998-08-11 1999-08-10 USE OF 2-METHOXYESTRADIOL AS FUNGICIDES
AU53959/99A AU764266B2 (en) 1998-08-11 1999-08-10 Use of estrogenic and anti-estrogenic compounds as anti-fungal compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9614598P 1998-08-11 1998-08-11
US60/096,145 1998-08-11

Publications (2)

Publication Number Publication Date
WO2000009101A2 WO2000009101A2 (en) 2000-02-24
WO2000009101A3 true WO2000009101A3 (en) 2001-06-21

Family

ID=22255771

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/018063 WO2000009101A2 (en) 1998-08-11 1999-08-10 Use of estrogenic compounds as anti-fungal agents

Country Status (10)

Country Link
US (2) US6239123B1 (en)
EP (1) EP1124545B1 (en)
JP (1) JP2002522477A (en)
KR (1) KR20010074814A (en)
AT (1) ATE284682T1 (en)
AU (1) AU764266B2 (en)
CA (1) CA2339835C (en)
DE (1) DE69922684T2 (en)
ES (1) ES2234284T3 (en)
WO (1) WO2000009101A2 (en)

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US20040214807A1 (en) * 1993-08-06 2004-10-28 D'amato Robert J. Estrogenic compounds as anti-mitotic agents
US5504074A (en) * 1993-08-06 1996-04-02 Children's Medical Center Corporation Estrogenic compounds as anti-angiogenic agents
US6908910B2 (en) 1993-08-06 2005-06-21 The Children's Medical Center Corporation Estrogenic compounds as anti-mitotic agents
US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
US20020002294A1 (en) * 1997-09-24 2002-01-03 D' Amato Robert J. Estrogenic compounds as antiangiogenic agents
ES2234284T3 (en) 1998-08-11 2005-06-16 Entremed, Inc. USE OF ESTROGENIC COMPOUNDS AS ANTIFUNGIC AGENTS.
US7087592B1 (en) 1999-08-23 2006-08-08 Entre Med, Inc. Compositions comprising purified 2-methoxyestradiol and methods of producing same
US20050192258A1 (en) * 2000-08-18 2005-09-01 Agoston Gregory E. Antiangiogenic agents
US6995278B2 (en) 2000-08-18 2006-02-07 Entre Med, Inc. Antiangiogenic agents
US7135581B2 (en) 2000-08-18 2006-11-14 Entremed, Inc. Antiangiogenic agents
WO2003063787A2 (en) * 2002-01-30 2003-08-07 Entremed, Inc. Non-steroidal analogs of 2-methoxyestradiol
CA2527074A1 (en) * 2003-05-28 2005-04-07 Entremed, Inc. Antiangiogenic agents
US20070004689A1 (en) * 2004-03-12 2007-01-04 Agoston Gregory E Antiangiogenic agents
WO2005089256A2 (en) * 2004-03-12 2005-09-29 Entremed, Inc. Antiangiogenic agents
WO2006058298A2 (en) * 2004-11-29 2006-06-01 Entremed, Inc. A method of administering anti-angiogenic agents and a method of treating disease using same
US8168621B2 (en) 2005-09-30 2012-05-01 Endece, Llc 6-substituted estradiol derivatives and methods of use
US10174070B2 (en) 2005-09-30 2019-01-08 Endece Llc 6-substituted estradiol derivatives and methods of use
US20070185069A1 (en) * 2005-11-14 2007-08-09 Plum Stacy M Anti-angiogenic activity of 2-methoxyestradiol in combination with anti-cancer agents
US20070176403A1 (en) * 2006-02-01 2007-08-02 Dennis Calderone Air adjustable seat
AU2007227256B2 (en) * 2006-03-20 2012-10-04 Entremed, Inc. Disease modifying anti-arthritic activity of 2-methoxyestradiol
WO2008094665A1 (en) * 2007-01-31 2008-08-07 Entremed, Inc. Method of treating amyloidosis mediated diseases
CN113106027B (en) * 2021-04-25 2022-02-25 青岛农业大学 Oyster endophytic fungus and application thereof

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Also Published As

Publication number Publication date
WO2000009101A2 (en) 2000-02-24
KR20010074814A (en) 2001-08-09
US6605622B2 (en) 2003-08-12
US6239123B1 (en) 2001-05-29
JP2002522477A (en) 2002-07-23
US20010044432A1 (en) 2001-11-22
CA2339835A1 (en) 2000-02-24
EP1124545B1 (en) 2004-12-15
DE69922684D1 (en) 2005-01-20
EP1124545A2 (en) 2001-08-22
AU5395999A (en) 2000-03-06
AU764266B2 (en) 2003-08-14
ES2234284T3 (en) 2005-06-16
CA2339835C (en) 2008-12-16
DE69922684T2 (en) 2005-10-06
ATE284682T1 (en) 2005-01-15

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