WO2000012497A3 - Quinazoline derivatives as medicaments - Google Patents
Quinazoline derivatives as medicaments Download PDFInfo
- Publication number
- WO2000012497A3 WO2000012497A3 PCT/US1999/019846 US9919846W WO0012497A3 WO 2000012497 A3 WO2000012497 A3 WO 2000012497A3 US 9919846 W US9919846 W US 9919846W WO 0012497 A3 WO0012497 A3 WO 0012497A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- medicaments
- positions
- ring
- quinazoline derivatives
- noninterfering
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99949568A EP1107959B1 (en) | 1998-08-28 | 1999-08-27 | Quinazoline derivatives as medicaments |
MXPA01002175A MXPA01002175A (en) | 1998-08-28 | 1999-08-27 | Quinazoline derivatives as medicaments. |
IL14172399A IL141723A0 (en) | 1998-08-28 | 1999-08-27 | Quinazoline derivatives as medicaments |
JP2000567525A JP2002523502A (en) | 1998-08-28 | 1999-08-27 | Quinazoline derivatives as pharmaceuticals |
BR9913648-1A BR9913648A (en) | 1998-08-28 | 1999-08-27 | Quinazoline derivatives as medicines |
DE69933573T DE69933573T2 (en) | 1998-08-28 | 1999-08-27 | CHINAZOLINE DERIVATIVES AS MEDICAMENTS |
KR1020017002716A KR20010083874A (en) | 1998-08-28 | 1999-08-27 | Quinazoline derivatives as medicaments |
AU62413/99A AU771947B2 (en) | 1998-08-28 | 1999-08-27 | Quinazoline derivatives as medicaments |
CA002342250A CA2342250A1 (en) | 1998-08-28 | 1999-08-27 | Quinazoline derivatives as medicaments |
HK01106212A HK1035897A1 (en) | 1998-08-28 | 2001-09-04 | Quinazoline derivatives as medicaments |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/141,916 | 1998-08-28 | ||
US09/141,916 US6184226B1 (en) | 1998-08-28 | 1998-08-28 | Quinazoline derivatives as inhibitors of P-38 α |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2000012497A2 WO2000012497A2 (en) | 2000-03-09 |
WO2000012497A3 true WO2000012497A3 (en) | 2000-06-29 |
WO2000012497B1 WO2000012497B1 (en) | 2000-09-08 |
Family
ID=22497802
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/019846 WO2000012497A2 (en) | 1998-08-28 | 1999-08-27 | Quinazoline derivatives as medicaments |
Country Status (15)
Country | Link |
---|---|
US (7) | US6184226B1 (en) |
EP (1) | EP1107959B1 (en) |
JP (1) | JP2002523502A (en) |
KR (1) | KR20010083874A (en) |
CN (1) | CN1152867C (en) |
AT (1) | ATE342256T1 (en) |
AU (1) | AU771947B2 (en) |
BR (1) | BR9913648A (en) |
CA (1) | CA2342250A1 (en) |
DE (1) | DE69933573T2 (en) |
ES (1) | ES2274642T3 (en) |
HK (1) | HK1035897A1 (en) |
IL (1) | IL141723A0 (en) |
MX (1) | MXPA01002175A (en) |
WO (1) | WO2000012497A2 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8088782B2 (en) | 2008-05-13 | 2012-01-03 | Astrazeneca Ab | Crystalline 4-(3-chloro-2-fluoroanilino)-7 methoxy-6-{[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy}quinazoline difumarate form A |
US8242117B2 (en) | 2003-06-26 | 2012-08-14 | Novartis Ag | 5-membered heterocycle-based p38 kinase inhibitors |
Families Citing this family (278)
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EP1112070B1 (en) | 1998-08-20 | 2004-05-12 | Smithkline Beecham Corporation | Novel substituted triazole compounds |
US6184226B1 (en) * | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
WO2000041698A1 (en) | 1999-01-13 | 2000-07-20 | Bayer Corporation | φ-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS |
US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
DK1154774T3 (en) | 1999-02-10 | 2005-09-26 | Astrazeneca Ab | Quinazoline derivatives as angiogenesis inhibitors |
KR20020027635A (en) | 1999-09-10 | 2002-04-13 | 폴락 돈나 엘. | Tyrosine kinase inhibitors |
US6759410B1 (en) * | 1999-11-23 | 2004-07-06 | Smithline Beecham Corporation | 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors |
US7235551B2 (en) * | 2000-03-02 | 2007-06-26 | Smithkline Beecham Corporation | 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases |
IL153947A0 (en) | 2000-08-09 | 2003-07-31 | Astrazeneca Ab | Quinoline derivatives having vegf inhibiting activity |
PE20020506A1 (en) | 2000-08-22 | 2002-07-09 | Glaxo Group Ltd | PIRAZOLE DERIVATIVES FUSED AS PROTEIN KINASE INHIBITORS |
ATE298751T1 (en) * | 2000-08-31 | 2005-07-15 | Hoffmann La Roche | 7-OXOPYRIDORYRIMIDINE |
SI1318997T1 (en) | 2000-09-15 | 2006-12-31 | Vertex Pharma | Pyrazole compounds useful as protein kinase inhibitors |
CA2422377C (en) * | 2000-09-15 | 2010-04-13 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
US7473691B2 (en) * | 2000-09-15 | 2009-01-06 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
US6660731B2 (en) | 2000-09-15 | 2003-12-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
MXPA03002411A (en) * | 2000-09-20 | 2003-06-19 | Merck Patent Gmbh | 4-amino-quinazolines. |
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US6670357B2 (en) * | 2000-11-17 | 2003-12-30 | Bristol-Myers Squibb Company | Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors |
US6867300B2 (en) | 2000-11-17 | 2005-03-15 | Bristol-Myers Squibb Company | Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors |
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CA2342250A1 (en) | 2000-03-09 |
US7345045B2 (en) | 2008-03-18 |
AU771947B2 (en) | 2004-04-08 |
US6903096B2 (en) | 2005-06-07 |
WO2000012497B1 (en) | 2000-09-08 |
JP2002523502A (en) | 2002-07-30 |
EP1107959A2 (en) | 2001-06-20 |
CN1152867C (en) | 2004-06-09 |
MXPA01002175A (en) | 2003-07-14 |
CN1333757A (en) | 2002-01-30 |
US20030069248A1 (en) | 2003-04-10 |
KR20010083874A (en) | 2001-09-03 |
ATE342256T1 (en) | 2006-11-15 |
DE69933573D1 (en) | 2006-11-23 |
US6277989B1 (en) | 2001-08-21 |
IL141723A0 (en) | 2002-03-10 |
DE69933573T2 (en) | 2007-05-03 |
US20050220784A1 (en) | 2005-10-06 |
ES2274642T3 (en) | 2007-05-16 |
HK1035897A1 (en) | 2001-12-14 |
BR9913648A (en) | 2002-01-02 |
US20050171123A1 (en) | 2005-08-04 |
AU6241399A (en) | 2000-03-21 |
EP1107959B1 (en) | 2006-10-11 |
WO2000012497A2 (en) | 2000-03-09 |
US6184226B1 (en) | 2001-02-06 |
US6476031B1 (en) | 2002-11-05 |
US20020161010A1 (en) | 2002-10-31 |
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