WO2000023472A3 - Interferon-beta fusion proteins and uses - Google Patents

Interferon-beta fusion proteins and uses Download PDF

Info

Publication number
WO2000023472A3
WO2000023472A3 PCT/US1999/024200 US9924200W WO0023472A3 WO 2000023472 A3 WO2000023472 A3 WO 2000023472A3 US 9924200 W US9924200 W US 9924200W WO 0023472 A3 WO0023472 A3 WO 0023472A3
Authority
WO
WIPO (PCT)
Prior art keywords
interferon
beta
fusion proteins
beta fusion
polypeptide
Prior art date
Application number
PCT/US1999/024200
Other languages
French (fr)
Other versions
WO2000023472A2 (en
Inventor
Adrian Whitty
Laura Runkel
Margot Brickelmaier
Paula Hochman
Original Assignee
Biogen Inc
Adrian Whitty
Laura Runkel
Margot Brickelmaier
Paula Hochman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA002343094A priority Critical patent/CA2343094A1/en
Priority to EEP200100223A priority patent/EE05111B1/en
Priority to AU13158/00A priority patent/AU766190B2/en
Priority to JP2000577197A priority patent/JP4761621B2/en
Priority to EA200100447A priority patent/EA005005B1/en
Priority to NZ510559A priority patent/NZ510559A/en
Priority to SI9930919T priority patent/SI1121382T1/en
Priority to DE69931507T priority patent/DE69931507T2/en
Priority to MXPA01003790A priority patent/MXPA01003790A/en
Priority to BR9915548-6A priority patent/BR9915548A/en
Priority to IL14235099A priority patent/IL142350A0/en
Priority to EP99956574A priority patent/EP1121382B9/en
Application filed by Biogen Inc, Adrian Whitty, Laura Runkel, Margot Brickelmaier, Paula Hochman filed Critical Biogen Inc
Priority to SK510-2001A priority patent/SK287491B6/en
Publication of WO2000023472A2 publication Critical patent/WO2000023472A2/en
Publication of WO2000023472A3 publication Critical patent/WO2000023472A3/en
Priority to IS5887A priority patent/IS5887A/en
Priority to IL142350A priority patent/IL142350A/en
Priority to US09/832,659 priority patent/US6800735B2/en
Priority to NO20011861A priority patent/NO20011861L/en
Priority to HK02103895.8A priority patent/HK1042098B/en
Priority to US10/868,673 priority patent/US7527946B2/en
Priority to CY20061101194T priority patent/CY1105173T1/en
Priority to US12/406,387 priority patent/US20090286958A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Abstract

A fusion polypeptide is described having the amino acid sequence X-Y-Z, or portion thereof, comprising the amino acid sequence of a glycosylated interferon-beta (X); Y is an optional linker moiety; and Z is a polypeptide comprising at least a portion of a polypeptide other than glycosylated interferon-beta. It is preferred that X is human interferon-beta-1a. Mutants of interferon-beta-1a are also described.
PCT/US1999/024200 1998-10-16 1999-10-15 Interferon-beta fusion proteins and uses WO2000023472A2 (en)

Priority Applications (21)

Application Number Priority Date Filing Date Title
IL14235099A IL142350A0 (en) 1998-10-16 1999-10-15 Interferon-beta fusion proteins and pharmaceutical compositions containing the same
AU13158/00A AU766190B2 (en) 1998-10-16 1999-10-15 Interferon-beta fusion proteins and uses
JP2000577197A JP4761621B2 (en) 1998-10-16 1999-10-15 Interferon-beta fusion proteins and uses
EA200100447A EA005005B1 (en) 1998-10-16 1999-10-15 HUMAN INTERFERON beta-1alpha HYBRID POLYPEPTIDE, MUTANTS THEREOF AND DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THEREOF
NZ510559A NZ510559A (en) 1998-10-16 1999-10-15 Glycosylated interferon-beta fusion proteins that are as active as forms that are not fusion proteins
SI9930919T SI1121382T1 (en) 1998-10-16 1999-10-15 Interferon-beta fusion proteins and uses
DE69931507T DE69931507T2 (en) 1998-10-16 1999-10-15 INTERFERON-BETA FUSION PROTEINS AND ITS USES
MXPA01003790A MXPA01003790A (en) 1998-10-16 1999-10-15 Interferon-beta fusion proteins and uses.
EEP200100223A EE05111B1 (en) 1998-10-16 1999-10-15 Interferon beta-fusion proteins and their use
EP99956574A EP1121382B9 (en) 1998-10-16 1999-10-15 Interferon-beta fusion proteins and uses
BR9915548-6A BR9915548A (en) 1998-10-16 1999-10-15 Interferon-beta fusion proteins and uses
CA002343094A CA2343094A1 (en) 1998-10-16 1999-10-15 Interferon-beta fusion proteins and uses
SK510-2001A SK287491B6 (en) 1998-10-16 1999-10-15 Interferon-beta-1 fusion proteins and their use
IS5887A IS5887A (en) 1998-10-16 2001-03-14 Interferon-beta fusion proteins and their use
IL142350A IL142350A (en) 1998-10-16 2001-04-01 Interferon-beta fusion proteins and pharmaceutical compositions containing the same
US09/832,659 US6800735B2 (en) 1998-10-16 2001-04-11 Interferon-beta fusion proteins and uses
NO20011861A NO20011861L (en) 1998-10-16 2001-04-11 Interferon <beta> fusion proteins and their use
HK02103895.8A HK1042098B (en) 1998-10-16 2002-05-24 Interferon-beta fusion proteins and uses
US10/868,673 US7527946B2 (en) 1998-10-16 2004-06-15 Interferon-beta-1a-immunoglobulin fusion proteins and uses
CY20061101194T CY1105173T1 (en) 1998-10-16 2006-08-24 INTEPHONE FUSION PROTEINS -BETA AND USES
US12/406,387 US20090286958A1 (en) 1998-10-16 2009-03-18 Interferon-beta fusion proteins and uses

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10449198P 1998-10-16 1998-10-16
US60/104,491 1998-10-16
US12023799P 1999-02-16 1999-02-16
US60/120,237 1999-02-16

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/832,659 Continuation US6800735B2 (en) 1998-10-16 2001-04-11 Interferon-beta fusion proteins and uses

Publications (2)

Publication Number Publication Date
WO2000023472A2 WO2000023472A2 (en) 2000-04-27
WO2000023472A3 true WO2000023472A3 (en) 2000-08-31

Family

ID=26801613

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/024200 WO2000023472A2 (en) 1998-10-16 1999-10-15 Interferon-beta fusion proteins and uses

Country Status (28)

Country Link
US (3) US6800735B2 (en)
EP (1) EP1121382B9 (en)
JP (2) JP4761621B2 (en)
KR (1) KR100767649B1 (en)
CN (1) CN100480266C (en)
AT (1) ATE327254T1 (en)
AU (1) AU766190B2 (en)
BR (1) BR9915548A (en)
CA (1) CA2343094A1 (en)
CY (1) CY1105173T1 (en)
CZ (1) CZ300762B6 (en)
DE (1) DE69931507T2 (en)
DK (1) DK1121382T3 (en)
EA (1) EA005005B1 (en)
EE (1) EE05111B1 (en)
ES (1) ES2265693T3 (en)
HK (1) HK1042098B (en)
HU (1) HUP0200414A2 (en)
IL (2) IL142350A0 (en)
IS (1) IS5887A (en)
MX (1) MXPA01003790A (en)
NO (1) NO20011861L (en)
NZ (1) NZ510559A (en)
PL (1) PL200586B1 (en)
PT (1) PT1121382E (en)
SK (1) SK287491B6 (en)
TR (1) TR200101087T2 (en)
WO (1) WO2000023472A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9169321B2 (en) 2007-08-22 2015-10-27 The Regents Of The University Of California Activatable binding polypeptides and methods of identification and use thereof
US9522945B2 (en) 2012-04-19 2016-12-20 Opko Biologics Ltd. Long-acting oxyntomodulin variants and methods of producing same

Families Citing this family (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1039931T3 (en) * 1997-12-01 2005-08-08 Fang Fang Multivalent recombinant antibodies to treat HRV infections
PT1121382E (en) * 1998-10-16 2006-10-31 Biogen Idec Inc BETA INTERFERENCE FUSE PROTEINS AND THEIR RESPECTIVE USES
PT1121156E (en) * 1998-10-16 2006-05-31 Biogen Idec Inc CONJUGATES OF INTERFERRO-BETA-1A POLYMERS AND THEIR USES
US20030035798A1 (en) * 2000-08-16 2003-02-20 Fang Fang Humanized antibodies
US7144574B2 (en) 1999-08-27 2006-12-05 Maxygen Aps Interferon β variants and conjugates
US6531122B1 (en) 1999-08-27 2003-03-11 Maxygen Aps Interferon-β variants and conjugates
US7431921B2 (en) 2000-04-14 2008-10-07 Maxygen Aps Interferon beta-like molecules
US6697363B1 (en) 2000-06-28 2004-02-24 Alcatel Canada Inc. Method and apparatus for longest matching prefix determination in a communication network
AU2002212107A1 (en) * 2000-11-02 2002-05-15 Maxygen Aps New multimeric interferon beta polypeptides
AU2636602A (en) * 2000-12-06 2002-06-18 Applied Research Systems Use of sarp-1 for the treatment and/or prevention of scleroderma
CN1545553B (en) * 2001-02-01 2011-09-21 弗·哈夫曼-拉罗切有限公司 Method for producing recombinant trypsin
DE60232434D1 (en) 2001-02-27 2009-07-09 Maxygen Aps NEW INTERFERON-BETA-LIKE MOLECULES
BR0208041A (en) * 2001-03-15 2004-02-25 Merck Patent Gmbh Modified interferon beta with reduced immunogenicity
JP2005522192A (en) * 2001-07-19 2005-07-28 パーラン セラピューティクス， インコーポレイテッド Multimeric proteins and methods of making and using multimeric proteins
DK1471974T3 (en) * 2002-02-06 2007-12-03 Ares Trading Sa Tumor necrosis factor combined with interferon in demyelinating diseases
KR20050021502A (en) * 2002-07-17 2005-03-07 바이오겐 아이덱 엠에이 인코포레이티드 THERAPIES FOR RENAL FAILURE USING INTERFERON-β
WO2004020468A2 (en) * 2002-08-28 2004-03-11 Maxygen Aps Interferon beta-like molecules for treatment of cancer
ES2343518T3 (en) * 2002-09-09 2010-08-03 Hanall Biopharma Co., Ltd. ALFA INTERFERATED POLYPEPTIDES MODIFIED PROTEASAS RESISTANT.
CN102038938A (en) * 2002-09-27 2011-05-04 比奥根艾迪克Ma公司 Therapies for chronic inflammatory demyelinating polyneuropathy using interferon-beta
US20040137581A1 (en) * 2002-10-01 2004-07-15 Xencor Interferon variants with improved properties
TW200510532A (en) 2003-07-15 2005-03-16 Chugai Pharmaceutical Co Ltd IgM production by transformed cell and method of quantifying the same
JP2007503838A (en) 2003-09-05 2007-03-01 ジーティーシー バイオセラピューティクス， インコーポレイティド Method for producing fusion protein in milk of transgenic animals
US20070212346A1 (en) 2003-10-09 2007-09-13 Tomoyuki Igawa Highly Concentrated Stabilized Igm Solution
PT1682583E (en) 2003-11-13 2012-04-13 Hanmi Holdings Co Ltd Protein complex using immunoglobulin fragment and method for the preparation thereof
US8110665B2 (en) 2003-11-13 2012-02-07 Hanmi Holdings Co., Ltd. Pharmaceutical composition comprising an immunoglobulin FC region as a carrier
WO2005074524A2 (en) 2004-02-02 2005-08-18 Ambrx, Inc. Modified human interferon polypeptides and their uses
WO2005084303A2 (en) * 2004-03-01 2005-09-15 Enzon Pharmaceuticals, Inc. Interferon-beta polymer conjugates
US20050276785A1 (en) * 2004-06-09 2005-12-15 Schering Aktiengesellschaft Treatment of cardiomyopathy and of endothelial dysfunction
US7670595B2 (en) * 2004-06-28 2010-03-02 Merck Patent Gmbh Fc-interferon-beta fusion proteins
JP5192823B2 (en) 2005-01-12 2013-05-08 バイオジェン・アイデック・エムエイ・インコーポレイテッド Methods for delivering interferon-beta
BRPI0616118A2 (en) 2005-09-01 2011-06-07 Ares Trading Sa treatment of optic neuritis
US9249407B2 (en) 2006-02-03 2016-02-02 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US7553941B2 (en) * 2006-02-03 2009-06-30 Modigene Inc Long-acting polypeptides and methods of producing same
US8946155B2 (en) 2006-02-03 2015-02-03 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US9458444B2 (en) 2006-02-03 2016-10-04 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US10351615B2 (en) 2006-02-03 2019-07-16 Opko Biologics Ltd. Methods of treatment with long-acting growth hormone
US20150038413A1 (en) 2006-02-03 2015-02-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US20140113860A1 (en) 2006-02-03 2014-04-24 Prolor Biotech Ltd. Long-acting polypeptides and methods of producing and administering same
US10221228B2 (en) 2006-02-03 2019-03-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US8476234B2 (en) 2006-02-03 2013-07-02 Prolor Biotech Inc. Long-acting coagulation factors and methods of producing same
US8048849B2 (en) 2006-02-03 2011-11-01 Modigene, Inc. Long-acting polypeptides and methods of producing same
US8450269B2 (en) 2006-02-03 2013-05-28 Prolor Biotech Ltd. Long-acting growth hormone and methods of producing same
US8759292B2 (en) 2006-02-03 2014-06-24 Prolor Biotech, Llc Long-acting coagulation factors and methods of producing same
WO2007110231A2 (en) * 2006-03-28 2007-10-04 Nautilus Biotech, S.A. MODIFIED INTERFERON-β (IFN-β) POLYPEPTIDES
US9283260B2 (en) 2006-04-21 2016-03-15 Amgen Inc. Lyophilized therapeutic peptibody formulations
EA020805B1 (en) 2006-05-24 2015-01-30 Мерк Сероно С.А. Use of combination of cladribine and beta interferon for treating multiple sclerosis
US8414897B1 (en) * 2006-10-02 2013-04-09 The Uab Research Foundation Pathway for Th-17 cell development and methods utilizing same
FR2907454B1 (en) * 2006-10-18 2009-01-23 Biomethodes Sa IMPROVED VARIANTS OF INTERFERON BETA HUMAIN
AU2008247815B2 (en) 2007-05-02 2012-09-06 Ambrx, Inc. Modified interferon beta polypeptides and their uses
EP2200634B1 (en) 2007-09-21 2015-02-11 The Regents of The University of California Targeted interferon demonstrates potent apoptotic and anti-tumor activities
US20100203009A1 (en) * 2007-10-02 2010-08-12 The Uab Research Foundation Pathway for Th-17 Cell Development and Methods Utilizing Same
WO2009053368A1 (en) * 2007-10-22 2009-04-30 Merck Serono S.A. Single ifn-beta fused to a mutated igg fc fragment
NZ620606A (en) 2008-02-08 2015-08-28 Ambrx Inc Modified leptin polypeptides and their uses
PE20110426A1 (en) 2008-07-23 2011-07-01 Ambrx Inc MODIFIED BOVINE G-CSF POLYPEPTIDES
MY151184A (en) 2008-07-23 2014-04-30 Hanmi Science Co Ltd A polypeptide complex comprising non-peptidyl polymer having three functional ends
CN106995495A (en) 2009-01-12 2017-08-01 希托马克斯医疗有限责任公司 Modified antibodies composition and its preparation and application
RU2011138951A (en) * 2009-02-23 2013-03-27 Сайтомкс Терапьютикс, Инк. PROTEINS AND WAYS OF THEIR APPLICATION
AU2010238858A1 (en) 2009-04-22 2011-12-08 Merck Patent Gmbh Antibody fusion proteins with modified FcRn binding sites
US9663778B2 (en) 2009-07-09 2017-05-30 OPKO Biologies Ltd. Long-acting coagulation factors and methods of producing same
CA2784793A1 (en) 2009-12-21 2011-07-21 Ambrx, Inc. Modified bovine somatotropin polypeptides and their uses
CA2784800A1 (en) 2009-12-21 2011-07-21 Ambrx, Inc. Modified porcine somatotropin polypeptides and their uses
ES2555279T3 (en) * 2010-02-12 2015-12-30 Biogen Ma Inc. Neuroprotection in demyelinating diseases
WO2011106234A1 (en) 2010-02-25 2011-09-01 Provasculon, Inc. Protease-resistant mutants of stromal cell derived factor-1 in the repair of tissue damage
AR080993A1 (en) * 2010-04-02 2012-05-30 Hanmi Holdings Co Ltd FORMULATION OF PROLONGED BETA INTERFERTION ACTION WHERE AN IMMUNOGLOBULIN FRAGMENT IS USED
AR083006A1 (en) 2010-09-23 2013-01-23 Lilly Co Eli FORMULATIONS FOR THE STIMULATING FACTOR OF COLONIES OF GRANULOCITS (G-CSF) BOVINE AND VARIANTS OF THE SAME
CA2838155C (en) * 2011-06-07 2021-10-19 Provasculon, Inc. Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived factor-1
CN104080803B (en) * 2011-10-01 2020-08-04 株式会社糖锁工学研究所 Sugar chain-added polypeptide and pharmaceutical composition containing the same
CN104203982B (en) 2011-10-28 2018-08-31 特瓦制药澳大利亚私人有限公司 Polypeptide construct and application thereof
WO2014028502A1 (en) * 2012-08-13 2014-02-20 ImmunGene Inc. Engineered antibody-interferon fusion molecules for treatment of autoimmune diseases
MX363326B (en) 2012-11-20 2019-03-20 Opko Biologics Ltd Method of increasing the hydrodynamic volume of polypeptides by attaching to gonadotrophin carboxy terminal peptides.
WO2014089354A1 (en) 2012-12-07 2014-06-12 The Regents Of The University Of California Cd138-targeted interferon demonstrates potent apoptotic and anti-tumor activities
KR102073748B1 (en) 2013-01-31 2020-02-05 한미약품 주식회사 Recombinant yeast transformant and process for preparing immunoglobulin Fc fragment employing the same
MY171183A (en) 2013-03-29 2019-09-30 Glytech Inc Polypeptide glycosylated with sialylated sugar chain
US11117975B2 (en) 2013-04-29 2021-09-14 Teva Pharmaceuticals Australia Pty Ltd Anti-CD38 antibodies and fusions to attenuated interferon alpha-2B
SG11201508923VA (en) 2013-04-29 2015-11-27 Teva Pharmaceuticals Australia Pty Ltd Anti-cd38 antibodies and fusions to attenuated interferon alpha-2b
CN104151420A (en) * 2013-05-15 2014-11-19 复旦大学 Long-acting interferon, preparation method therefor and applications thereof
WO2014194100A1 (en) 2013-05-29 2014-12-04 The Regents Of The University Of California Anti-cspg4 fusions with interferon for the treatment of malignancy
AR096891A1 (en) 2013-07-12 2016-02-03 Hanmi Pharm Ind Co Ltd CONJUGATE OF BIOMOLOGICALLY ACTIVE POLYPEPTIDE MONOMER AND CONJUGATE OF FRAGMENTO FC OF IMMUNOGLOBULINA, THAT SHOWS CLEARING THROUGH REDUCED RECEPTOR, AND THE METHOD FOR PREPARING THE SAME
US20150158926A1 (en) 2013-10-21 2015-06-11 Opko Biologics, Ltd. Long-acting polypeptides and methods of producing and administering same
KR20160098277A (en) 2013-12-20 2016-08-18 에프. 호프만-라 로슈 아게 Improved recombinant polypeptide production methods
UA119352C2 (en) 2014-05-01 2019-06-10 Тева Фармасьютикалз Острейліа Пті Лтд Combination of lenalidomide or pomalidomide and cd38 antibody-attenuated interferon-alpha constructs, and the use thereof
KR102639037B1 (en) 2014-10-29 2024-02-20 테바 파마슈티컬즈 오스트레일리아 피티와이 엘티디 INTERFERON α2b VARIANTS
KR102172937B1 (en) 2015-06-19 2020-11-03 옵코 바이오로직스 리미티드 Long-acting coagulation factor and its preparation method
HRP20220304T1 (en) 2015-06-24 2022-05-13 F. Hoffmann - La Roche Ag Anti-transferrin receptor antibodies with tailored affinity
AR106189A1 (en) 2015-10-02 2017-12-20 Hoffmann La Roche BIESPECTIFIC ANTIBODIES AGAINST HUMAN A-b AND THE HUMAN TRANSFERRINE RECEIVER AND METHODS OF USE
EP3356406A1 (en) 2015-10-02 2018-08-08 H. Hoffnabb-La Roche Ag Bispecific anti-human cd20/human transferrin receptor antibodies and methods of use
US11236141B2 (en) * 2016-05-13 2022-02-01 Orionis Biosciences BV Targeted mutant interferon-beta and uses thereof
WO2021149945A1 (en) * 2020-01-23 2021-07-29 주식회사 제넥신 Fusion protein comprising pd-l1 protein and use thereof
US20230129210A1 (en) * 2020-04-03 2023-04-27 The University Of North Carolina At Chapel Hill Binding proteins useful against ace2-targeted viruses

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1983002461A1 (en) * 1982-01-19 1983-07-21 Cetus Corp Multiclass hybrid interferons
EP0225579A2 (en) * 1985-12-02 1987-06-16 G.D. Searle & Co. Covalently linked polypeptide cell modulators
WO1997024137A1 (en) * 1995-12-28 1997-07-10 Tanox Biosystems, Inc. HYBRID WITH INTERFERON-α AND AN IMMUNOGLOBULIN Fc LINKED THROUGH A NON-IMMUNOGENIC PEPTIDE
US5783181A (en) * 1994-07-29 1998-07-21 Smithkline Beecham Corporation Therapeutic uses of fusion proteins between mutant IL 4/IL13 antagonists and immunoglobulins

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3359030A (en) * 1966-12-16 1967-12-19 Newman George Bumper guard assembly
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4002531A (en) 1976-01-22 1977-01-11 Pierce Chemical Company Modifying enzymes with polyethylene glycol and product produced thereby
US4414147A (en) 1981-04-17 1983-11-08 Massachusetts Institute Of Technology Methods of decreasing the hydrophobicity of fibroblast and other interferons
US6936694B1 (en) 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
US4609546A (en) 1982-06-24 1986-09-02 Japan Chemical Research Co., Ltd. Long-acting composition
GB8334102D0 (en) 1983-12-21 1984-02-01 Searle & Co Interferons with cysteine pattern
EP0154316B1 (en) 1984-03-06 1989-09-13 Takeda Chemical Industries, Ltd. Chemically modified lymphokine and production thereof
GB8412564D0 (en) * 1984-05-17 1984-06-20 Searle & Co Structure and properties
WO1987000056A1 (en) 1985-06-26 1987-01-15 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polymer conjugation
US4917888A (en) 1985-06-26 1990-04-17 Cetus Corporation Solubilization of immunotoxins for pharmaceutical compositions using polymer conjugation
US4766106A (en) * 1985-06-26 1988-08-23 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polymer conjugation
JP2514950B2 (en) 1986-03-10 1996-07-10 エフ・ホフマン―ラ ロシユ アーゲー Chemically modified protein, its production method and intermediate
JPS63152393A (en) 1986-07-03 1988-06-24 Takeda Chem Ind Ltd Glycosyl derivative
US4868802A (en) * 1986-07-28 1989-09-19 Kabushiki Kaisha Toshiba Magnetooptic recording and erasing head which performs biasing, tracking and focusing
US4894226A (en) 1986-11-14 1990-01-16 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polyproline conjugation
US4904584A (en) 1987-12-23 1990-02-27 Genetics Institute, Inc. Site-specific homogeneous modification of polypeptides
US4847325A (en) 1988-01-20 1989-07-11 Cetus Corporation Conjugation of polymer to colony stimulating factor-1
CA1340810C (en) 1988-03-31 1999-11-02 Motoo Yamasaki Polypeptide derivatives of human granulocyte colony stimulating factor
AU4660789A (en) 1988-11-23 1990-06-12 Genentech Inc. Polypeptide derivatives
DE68925966T2 (en) 1988-12-22 1996-08-29 Kirin Amgen Inc CHEMICALLY MODIFIED GRANULOCYTE COLONY EXCITING FACTOR
US5116964A (en) * 1989-02-23 1992-05-26 Genentech, Inc. Hybrid immunoglobulins
US5286637A (en) 1989-08-07 1994-02-15 Debiopharm, S.A. Biologically active drug polymer derivatives and method for preparing same
JPH04218000A (en) 1990-02-13 1992-08-07 Kirin Amgen Inc Modified polypeptide
US5252714A (en) 1990-11-28 1993-10-12 The University Of Alabama In Huntsville Preparation and use of polyethylene glycol propionaldehyde
ES2199935T3 (en) 1991-03-15 2004-03-01 Amgen Inc. PEGILATION OF POLYPEPTIDES.
US5595732A (en) 1991-03-25 1997-01-21 Hoffmann-La Roche Inc. Polyethylene-protein conjugates
AU2147192A (en) 1991-06-28 1993-01-25 Genentech Inc. Method of stimulating immune response using growth hormone
US5281698A (en) 1991-07-23 1994-01-25 Cetus Oncology Corporation Preparation of an activated polymer ester for protein conjugation
WO1993012145A1 (en) 1991-12-19 1993-06-24 Baylor College Of Medicine Pva or peg conjugates of peptides for epitope-specific immunosuppression
ZA933926B (en) 1992-06-17 1994-01-03 Amgen Inc Polyoxymethylene-oxyethylene copolymers in conjuction with blomolecules
US5255519A (en) 1992-08-14 1993-10-26 Millennium Technologies, Inc. Method and apparatus for increasing efficiency and productivity in a power generation cycle
US5382657A (en) 1992-08-26 1995-01-17 Hoffmann-La Roche Inc. Peg-interferon conjugates
AU5098193A (en) 1992-09-01 1994-03-29 Berlex Laboratories, Inc. Glycolation of glycosylated macromolecules
US5298410A (en) 1993-02-25 1994-03-29 Sterling Winthrop Inc. Lyophilized formulation of polyethylene oxide modified proteins with increased shelf-life
US5681811A (en) 1993-05-10 1997-10-28 Protein Delivery, Inc. Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same
US5359030A (en) 1993-05-10 1994-10-25 Protein Delivery, Inc. Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same
US5874075A (en) 1993-10-06 1999-02-23 Amgen Inc. Stable protein: phospholipid compositions and methods
US5643575A (en) 1993-10-27 1997-07-01 Enzon, Inc. Non-antigenic branched polymer conjugates
US5711944A (en) 1993-11-10 1998-01-27 Enzon, Inc. Interferon polymer conjugates
US5951974A (en) 1993-11-10 1999-09-14 Enzon, Inc. Interferon polymer conjugates
PT726778E (en) 1994-02-08 2001-12-28 Amgen Inc ORAL ADMINISTRATION SYSTEM OF CHEMICALLY MODIFIED G-CSF PROTEINS
US5545723A (en) 1994-03-15 1996-08-13 Biogen Inc. Muteins of IFN-β
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
US5738846A (en) 1994-11-10 1998-04-14 Enzon, Inc. Interferon polymer conjugates and process for preparing the same
CA2206852A1 (en) 1994-12-07 1996-06-13 Novo Nordisk A/S Polypeptide with reduced allergenicity
US5672662A (en) 1995-07-07 1997-09-30 Shearwater Polymers, Inc. Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
KR0154850B1 (en) * 1995-10-09 1998-10-15 김광호 Bicmos and its manufacturing method
US5702717A (en) 1995-10-25 1997-12-30 Macromed, Inc. Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers
US5908621A (en) 1995-11-02 1999-06-01 Schering Corporation Polyethylene glycol modified interferon therapy
US5747639A (en) 1996-03-06 1998-05-05 Amgen Boulder Inc. Use of hydrophobic interaction chromatography to purify polyethylene glycols
JP2001508783A (en) 1997-01-29 2001-07-03 ポリマスク・ファーマシューティカルズ・パブリック・リミテッド・カンパニー PEGylation method
US5990237A (en) 1997-05-21 1999-11-23 Shearwater Polymers, Inc. Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines
IL133974A0 (en) 1997-07-14 2001-04-30 Bolder Biotechnology Inc Derivatives of growth hormone and related proteins
US6180095B1 (en) 1997-12-17 2001-01-30 Enzon, Inc. Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
US5981709A (en) 1997-12-19 1999-11-09 Enzon, Inc. α-interferon-polymer-conjugates having enhanced biological activity and methods of preparing the same
US5985263A (en) 1997-12-19 1999-11-16 Enzon, Inc. Substantially pure histidine-linked protein polymer conjugates
US5965119A (en) 1997-12-30 1999-10-12 Enzon, Inc. Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents
JP4078032B2 (en) 1998-03-12 2008-04-23 ネクター セラピューティックス エイエル，コーポレイション Poly (ethylene glycol) derivatives with proximal reactive groups
DE69920002T2 (en) 1998-04-28 2005-09-22 Applied Research Systems Ars Holding N.V. CONJUGATES OF POLYOLE AND BETA-INTERFERON
US6703381B1 (en) 1998-08-14 2004-03-09 Nobex Corporation Methods for delivery therapeutic compounds across the blood-brain barrier
PT1121382E (en) * 1998-10-16 2006-10-31 Biogen Idec Inc BETA INTERFERENCE FUSE PROTEINS AND THEIR RESPECTIVE USES
PT1121156E (en) * 1998-10-16 2006-05-31 Biogen Idec Inc CONJUGATES OF INTERFERRO-BETA-1A POLYMERS AND THEIR USES
JP2003527090A (en) 1999-08-27 2003-09-16 マキシゲン・エイピーエス Novel interferon beta-like molecule
WO2001046291A1 (en) 1999-12-22 2001-06-28 Shearwater Corporation Sterically hindered derivatives of water soluble polymers
US20080033818A1 (en) 2005-03-17 2008-02-07 Inc2 Webcom Ltd. Real time interactive response system and methods

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1983002461A1 (en) * 1982-01-19 1983-07-21 Cetus Corp Multiclass hybrid interferons
EP0225579A2 (en) * 1985-12-02 1987-06-16 G.D. Searle & Co. Covalently linked polypeptide cell modulators
US5783181A (en) * 1994-07-29 1998-07-21 Smithkline Beecham Corporation Therapeutic uses of fusion proteins between mutant IL 4/IL13 antagonists and immunoglobulins
WO1997024137A1 (en) * 1995-12-28 1997-07-10 Tanox Biosystems, Inc. HYBRID WITH INTERFERON-α AND AN IMMUNOGLOBULIN Fc LINKED THROUGH A NON-IMMUNOGENIC PEPTIDE
US5908626A (en) * 1995-12-28 1999-06-01 Tanox, Inc. Hybrid with interferon-β and an immunoglobulin Fc joined by a peptide linker

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ARDUINI RM. ET AL.: "Characterization of a soluble ternary complex formed between human interferon-beta-1a and its receptor chains.", PROTEIN SCI 1999 SEP;8(9):1867-77, XP000886314 *
SANTILLAN G. E. ET AL.: "Conversion of Human Interferon-beta From A Secreted to a Phosphatidylinositol Anchored Protein by Fusion of a 17 Amino Acid Sequence to its Carboxyl Terminus", MOLECULAR AND CELLULAR BIOCHEMISTRY, vol. 110, 1992, pages 181 - 191, XP000886368 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9169321B2 (en) 2007-08-22 2015-10-27 The Regents Of The University Of California Activatable binding polypeptides and methods of identification and use thereof
US9522945B2 (en) 2012-04-19 2016-12-20 Opko Biologics Ltd. Long-acting oxyntomodulin variants and methods of producing same

Also Published As

Publication number Publication date
AU1315800A (en) 2000-05-08
SK5102001A3 (en) 2003-03-04
US6800735B2 (en) 2004-10-05
BR9915548A (en) 2001-08-14
SK287491B6 (en) 2010-11-08
KR100767649B1 (en) 2007-10-17
ES2265693T3 (en) 2007-02-16
EE05111B1 (en) 2008-12-15
HUP0200414A2 (en) 2002-06-29
HK1042098B (en) 2009-10-30
TR200101087T2 (en) 2001-09-21
ATE327254T1 (en) 2006-06-15
US7527946B2 (en) 2009-05-05
NZ510559A (en) 2003-12-19
CN1333785A (en) 2002-01-30
IL142350A (en) 2007-07-04
CZ20011330A3 (en) 2001-09-12
JP4761621B2 (en) 2011-08-31
PL200586B1 (en) 2009-01-30
DE69931507D1 (en) 2006-06-29
EA200100447A1 (en) 2001-10-22
CA2343094A1 (en) 2000-04-27
HK1042098A1 (en) 2002-08-02
JP2010268810A (en) 2010-12-02
JP2002527100A (en) 2002-08-27
AU766190B2 (en) 2003-10-09
US20090286958A1 (en) 2009-11-19
KR20010085932A (en) 2001-09-07
EP1121382B1 (en) 2006-05-24
CZ300762B6 (en) 2009-08-05
EA005005B1 (en) 2004-10-28
US20020155547A1 (en) 2002-10-24
EP1121382B9 (en) 2007-07-04
EE200100223A (en) 2002-06-17
CN100480266C (en) 2009-04-22
DK1121382T3 (en) 2006-11-13
NO20011861L (en) 2001-06-13
MXPA01003790A (en) 2002-09-18
WO2000023472A2 (en) 2000-04-27
US20050214253A1 (en) 2005-09-29
NO20011861D0 (en) 2001-04-11
PT1121382E (en) 2006-10-31
IS5887A (en) 2001-03-14
IL142350A0 (en) 2002-03-10
PL347932A1 (en) 2002-04-22
CY1105173T1 (en) 2010-03-03
DE69931507T2 (en) 2007-01-11
EP1121382A2 (en) 2001-08-08

Similar Documents

Publication Publication Date Title
WO2000023472A3 (en) Interferon-beta fusion proteins and uses
AU688210B2 (en) Recombinant obese (Ob) proteins
WO1999066054A3 (en) Erythropoietin analog-human serum albumin fusion protein
EP1019028A4 (en) $i(CHLAMYDIA) PROTEIN, GENE SEQUENCE AND USES THEREOF
AU7274898A (en) Recombinant antibody-enzyme fusion proteins
AU6020598A (en) Dna sequences, vectors, and fusion polypeptides for secretion of polypeptides infilamentous fungi
WO2001025438A3 (en) Ifn-alpha homologues
ZA200006309B (en) A polypeptide comprising the amino acid of an n-terminal choline binding protein a truncate, vaccine derived therefrom and uses thereof.
AU7466198A (en) Ucp3: an uncoupling protein homologue
EP1739090A3 (en) Interferon-beta fusion proteins and uses
AU2511901A (en) Basolateral sorting signal and inhibitors thereof
WO2000018909A3 (en) NUCLEIC ACIDS AND PROTEINS FROM $i(CENARCHAEUM SYMBIOSUM)
ZA963530B (en) Recombinant obese (ob) proteins
AU3479699A (en) A polypeptide comprising the amino acid of an n-terminal choline binding proteina truncate, vaccine derived therefrom and uses thereof
CA2197651A1 (en) Or-1 on orphan receptor belonging to the nuclear receptor family
AU6301698A (en) Anti-hiv peptides and proteins
AU2161699A (en) Peptides and nucleic acids derived from (eisenia foetida) and the use thereof
WO2000029564A3 (en) Human glycine transporter type 2
AU1574699A (en) Nucleic acids encoding (hev) structural proteins, (hev) structural proteins encoded thereby and uses thereof
IL135987A0 (en) Lysozyme analogous proteins and peptides, processes for the preparation thereof and compositions and methods utilizing the same
AU8299598A (en) Gmeb nucleic acids, proteins, and uses thereof
AU6981794A (en) Protein which catalyses peptide refolding and uses thereof
AU1734800A (en) (bartonella) proteins and uses thereof
AU2002301509A1 (en) Nucleic acid fragments and polypeptide fragments derived from M. tuberculosis
AU1534200A (en) Novel major facilitator superfamily polypeptide, uses thereof and nucleic acids encoding same

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 99812213.0

Country of ref document: CN

ENP Entry into the national phase

Ref document number: 2000 13158

Country of ref document: AU

Kind code of ref document: A

AK Designated states

Kind code of ref document: A2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 13158/00

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 510559

Country of ref document: NZ

ENP Entry into the national phase

Country of ref document: CA

Ref document number: 2343094

Country of ref document: CA

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 142350

Country of ref document: IL

WWE Wipo information: entry into national phase

Ref document number: 09832659

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: PV2001-1330

Country of ref document: CZ

Ref document number: 5102001

Country of ref document: SK

WWE Wipo information: entry into national phase

Ref document number: 2001/01087

Country of ref document: TR

ENP Entry into the national phase

Ref document number: 2000 577197

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: PA/a/2001/003790

Country of ref document: MX

Ref document number: 1020017004797

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 1999956574

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 200100447

Country of ref document: EA

WWP Wipo information: published in national office

Ref document number: 1999956574

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: PV2001-1330

Country of ref document: CZ

WWG Wipo information: grant in national office

Ref document number: 13158/00

Country of ref document: AU

WWG Wipo information: grant in national office

Ref document number: 1999956574

Country of ref document: EP