WO2000045855A3 - Diagnostic imaging of lymph structures - Google Patents

Diagnostic imaging of lymph structures Download PDF

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Publication number
WO2000045855A3
WO2000045855A3 PCT/US2000/002374 US0002374W WO0045855A3 WO 2000045855 A3 WO2000045855 A3 WO 2000045855A3 US 0002374 W US0002374 W US 0002374W WO 0045855 A3 WO0045855 A3 WO 0045855A3
Authority
WO
WIPO (PCT)
Prior art keywords
lymph node
drainage
sentinel lymph
organ
tissue
Prior art date
Application number
PCT/US2000/002374
Other languages
French (fr)
Other versions
WO2000045855A2 (en
Inventor
Robert F Mattrey
Original Assignee
Univ California
Robert F Mattrey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California, Robert F Mattrey filed Critical Univ California
Priority to AU33530/00A priority Critical patent/AU3353000A/en
Publication of WO2000045855A2 publication Critical patent/WO2000045855A2/en
Publication of WO2000045855A3 publication Critical patent/WO2000045855A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/225—Microparticles, microcapsules
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/927—Diagnostic contrast agent
    • Y10S977/928—X-ray agent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/927—Diagnostic contrast agent
    • Y10S977/929—Ultrasound contrast agent

Abstract

In accordance with the present invention, there are provided methods for identifying the sentinel lymph node in a drainage field for a tissue or organ in a subject. In select embodiments, the invention allows for the identification of the first or sentinel lymph node that drains the tissue or organ, particularly those tissues associated with neoplastic or infectious diseases and disorders, and within the pertinent lymph drainage basin. Once the drainage basin from the tissue or organ, i.e., the sentinel lymph node, is identified, a pre-operative or intraoperative mapping of the affected lymphatic structure can be carried out with a contrast agent. Identification of the first or sentinel lymph node, on the most direct drainage pathway in the drainage field, can be accomplished by a variety of imaging techniques, including ultrasound, MRI, CT, nuclear and others. Moreover, once the lymphatic structure is identified as being associated with neoplastic or infectious diseases and disorders, the affected lymphatic structure can be removed surgically or by a suitable minimally invasive procedure to allow pathological analysis to be performed to determine whether certain diseases or disorders exist, without resort to more radical lymphadenectomy. Further, the agent can be made to carry diagnostic or therapeutic probes to be activated and/or delivered to the injection site or any part of the lymphatic pathway downstream from the injection site.
PCT/US2000/002374 1999-02-05 2000-01-31 Diagnostic imaging of lymph structures WO2000045855A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU33530/00A AU3353000A (en) 1999-02-05 2000-01-31 Diagnostic imaging of lymph structures

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/245,828 1999-02-05
US09/245,828 US6444192B1 (en) 1999-02-05 1999-02-05 Diagnostic imaging of lymph structures

Publications (2)

Publication Number Publication Date
WO2000045855A2 WO2000045855A2 (en) 2000-08-10
WO2000045855A3 true WO2000045855A3 (en) 2000-12-14

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/002374 WO2000045855A2 (en) 1999-02-05 2000-01-31 Diagnostic imaging of lymph structures

Country Status (3)

Country Link
US (2) US6444192B1 (en)
AU (1) AU3353000A (en)
WO (1) WO2000045855A2 (en)

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Also Published As

Publication number Publication date
US6444192B1 (en) 2002-09-03
US20020061280A1 (en) 2002-05-23
WO2000045855A2 (en) 2000-08-10
US20020197209A1 (en) 2002-12-26
AU3353000A (en) 2000-08-25

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