WO2000046391A3 - Genes displaying enhanced expression during cellular senescence and terminal cell differentiation and uses thereof - Google Patents

Genes displaying enhanced expression during cellular senescence and terminal cell differentiation and uses thereof Download PDF

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Publication number
WO2000046391A3
WO2000046391A3 PCT/US2000/002920 US0002920W WO0046391A3 WO 2000046391 A3 WO2000046391 A3 WO 2000046391A3 US 0002920 W US0002920 W US 0002920W WO 0046391 A3 WO0046391 A3 WO 0046391A3
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WO
WIPO (PCT)
Prior art keywords
old
protein
cell differentiation
enhanced expression
expression during
Prior art date
Application number
PCT/US2000/002920
Other languages
French (fr)
Other versions
WO2000046391A2 (en
WO2000046391A9 (en
Inventor
Paul B Fisher
Magdalena Leszczyniecka
Original Assignee
Univ Columbia
Paul B Fisher
Magdalena Leszczyniecka
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Columbia, Paul B Fisher, Magdalena Leszczyniecka filed Critical Univ Columbia
Priority to JP2000597450A priority Critical patent/JP2002535997A/en
Priority to CA002361430A priority patent/CA2361430A1/en
Priority to AU35900/00A priority patent/AU3590000A/en
Priority to EP00914520A priority patent/EP1150994A4/en
Publication of WO2000046391A2 publication Critical patent/WO2000046391A2/en
Publication of WO2000046391A3 publication Critical patent/WO2000046391A3/en
Priority to US09/907,907 priority patent/US6951923B2/en
Publication of WO2000046391A9 publication Critical patent/WO2000046391A9/en
Priority to US11/242,317 priority patent/US20060094043A1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/746—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for lactic acid bacteria (Streptococcus; Lactococcus; Lactobacillus; Pediococcus; Enterococcus; Leuconostoc; Propionibacterium; Bifidobacterium; Sporolactobacillus)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Oncology (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

This invention provides isolated nucleic acid molecules encoding an OLD-35 protein, OLD-64 protein, OLD-137 protein, OLD-139 protein, OLD-142 protein or OLD-175 protein. This invention further provides a purified OLD-35 protein, OLD-64, OLD-137, OLD-139, OLD-142 and OLD-175. Finally, this invention provides different uses of the nucleic acids and proteins.
PCT/US2000/002920 1999-02-02 2000-02-02 Genes displaying enhanced expression during cellular senescence and terminal cell differentiation and uses thereof WO2000046391A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2000597450A JP2002535997A (en) 1999-02-02 2000-02-02 Genes showing enhanced expression during cell senescence and terminal differentiation of cells, and uses thereof
CA002361430A CA2361430A1 (en) 1999-02-02 2000-02-02 Genes displaying enhanced expression during cellular senescence and terminal cell differentiation and uses thereof
AU35900/00A AU3590000A (en) 1999-02-02 2000-02-02 Genes displaying enhanced expression during cellular senescence and terminal cell differentiation and uses thereof
EP00914520A EP1150994A4 (en) 1999-02-02 2000-02-02 Genes displaying enhanced expression during cellular senescence and terminal cell differentiation and uses thereof
US09/907,907 US6951923B2 (en) 1999-02-02 2001-07-16 Genes displaying enhanced expression during cellular senescence and terminal cell differentiation and uses thereof
US11/242,317 US20060094043A1 (en) 1999-02-02 2005-10-03 Genes displaying enhanced expression during cellular senescence and terminal cell differentiation and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24327799A 1999-02-02 1999-02-02
US09/243,277 1999-02-02

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US24327799A Continuation-In-Part 1999-02-02 1999-02-02

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/907,907 Continuation US6951923B2 (en) 1999-02-02 2001-07-16 Genes displaying enhanced expression during cellular senescence and terminal cell differentiation and uses thereof

Publications (3)

Publication Number Publication Date
WO2000046391A2 WO2000046391A2 (en) 2000-08-10
WO2000046391A3 true WO2000046391A3 (en) 2000-12-07
WO2000046391A9 WO2000046391A9 (en) 2001-08-02

Family

ID=22918088

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/002920 WO2000046391A2 (en) 1999-02-02 2000-02-02 Genes displaying enhanced expression during cellular senescence and terminal cell differentiation and uses thereof

Country Status (6)

Country Link
US (2) US6951923B2 (en)
EP (1) EP1150994A4 (en)
JP (1) JP2002535997A (en)
AU (1) AU3590000A (en)
CA (1) CA2361430A1 (en)
WO (1) WO2000046391A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3590000A (en) 1999-02-02 2000-08-25 Trustees Of Columbia University In The City Of New York, The Genes displaying enhanced expression during cellular senescence and terminal cell differentiation and uses thereof
US20020137184A1 (en) * 2000-12-20 2002-09-26 Pe Corporation (Ny) Isolated human protease proteins, nucleic acid molecules encoding human protease proteins, and use thereof
AU2003245436A1 (en) * 2003-01-23 2004-08-23 The Trustees Of Columbia University In The City Of New York Old-35, a gene associated with senescence and terminal cell differentiation, and uses thereof
EP2205249B1 (en) 2007-09-28 2018-11-07 Intrexon Corporation Therapeutic gene-switch constructs and bioreactors for the expression of biotherapeutic molecules, and uses thereof
WO2014204025A1 (en) * 2013-06-18 2014-12-24 한국원자력의학원 Marker for diagnosing cellular senescence and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5710137A (en) * 1996-08-16 1998-01-20 The Trustees Of Columbia University In The City Of New York Use of a melanoma differentiation associated gene (mda 7) for reversing a cancerous phenotype

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5200313A (en) * 1983-08-05 1993-04-06 Miles Inc. Nucleic acid hybridization assay employing detectable anti-hybrid antibodies
US5194596A (en) * 1989-07-27 1993-03-16 California Biotechnology Inc. Production of vascular endothelial cell growth factor
US5350836A (en) * 1989-10-12 1994-09-27 Ohio University Growth hormone antagonists
AUPN477695A0 (en) * 1995-08-14 1995-09-07 Commonwealth Scientific And Industrial Research Organisation Gene therapy
US6025194A (en) * 1997-11-19 2000-02-15 Geron Corporation Nucleic acid sequence of senescence asssociated gene
AU3590000A (en) 1999-02-02 2000-08-25 Trustees Of Columbia University In The City Of New York, The Genes displaying enhanced expression during cellular senescence and terminal cell differentiation and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5710137A (en) * 1996-08-16 1998-01-20 The Trustees Of Columbia University In The City Of New York Use of a melanoma differentiation associated gene (mda 7) for reversing a cancerous phenotype

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
AHN ET AL.: "The structural and functional diversity of dystrophin", NATURE GENETICS,, vol. 3, 1993, pages 283 - 291, XP002930403 *
CAWTHON ET AL.: "cDNA sequence and genomic structure of EVI2B, a gene lying within an intron of the neurofibromatosis type 1 gene", GENOMICS,, vol. 9, 1991, pages 446 - 460, XP002930404 *
GURA T.: "Systems for identifying new drug are often faulty", SCIENCE,, vol. 278, 7 November 1997 (1997-11-07), pages 1041 - 1042, XP002930402 *
SORGE ET AL.: "High level transcription of the glucocerebrosidase pseudogene in normal subjects and patients with Gaucher disease", J. CLIN. INVEST.,, vol. 86, October 1990 (1990-10-01), pages 1137 - 1141, XP002930405 *
VERMA ET AL.: "Gene therapy- promises, problems and prospects", NATURE,, vol. 389, 18 September 1997 (1997-09-18), pages 239 - 242, XP002930401 *

Also Published As

Publication number Publication date
JP2002535997A (en) 2002-10-29
EP1150994A4 (en) 2003-01-29
US20060094043A1 (en) 2006-05-04
CA2361430A1 (en) 2000-08-10
EP1150994A2 (en) 2001-11-07
US6951923B2 (en) 2005-10-04
US20030099660A1 (en) 2003-05-29
WO2000046391A2 (en) 2000-08-10
WO2000046391A9 (en) 2001-08-02
AU3590000A (en) 2000-08-25

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