WO2000049040A3 - Antimicrobial/endotoxin neutralizing polypeptide - Google Patents

Antimicrobial/endotoxin neutralizing polypeptide Download PDF

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Publication number
WO2000049040A3
WO2000049040A3 PCT/IB2000/000271 IB0000271W WO0049040A3 WO 2000049040 A3 WO2000049040 A3 WO 2000049040A3 IB 0000271 W IB0000271 W IB 0000271W WO 0049040 A3 WO0049040 A3 WO 0049040A3
Authority
WO
WIPO (PCT)
Prior art keywords
polypeptide
kda
present
endotoxin
patient
Prior art date
Application number
PCT/IB2000/000271
Other languages
French (fr)
Other versions
WO2000049040A2 (en
Inventor
David M Mann
Original Assignee
Endogen Res Ph Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Endogen Res Ph Ab filed Critical Endogen Res Ph Ab
Priority to CA002362153A priority Critical patent/CA2362153C/en
Priority to DK00906569T priority patent/DK1151009T3/en
Priority to EP00906569A priority patent/EP1151009B1/en
Priority to DE60036456T priority patent/DE60036456T2/en
Priority to JP2000599777A priority patent/JP2002541066A/en
Priority to MXPA01007956A priority patent/MXPA01007956A/en
Priority to AU28226/00A priority patent/AU758150B2/en
Publication of WO2000049040A2 publication Critical patent/WO2000049040A2/en
Publication of WO2000049040A3 publication Critical patent/WO2000049040A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

Disclosed is a 6 kDa host-defense polypeptide which is generated by proteolitic digestion of the lactoferrin molecule. The 6 kDa host-defense polypeptide has antimicrobial activity and also endotoxin-neutralizing activity. Also disclosed are functional variants of the 6 kDa host defense polypeptide, which include N-terminal and C-terminal truncations of the 6 kDa polypeptide, and other modifications of the polypeptide, such as amino acid substitutions which preserve or enhance activity. Another aspect of the present invention relates to a therapeutic method for treating or preventing a disease resulting from microbial bacterial or fungal infections in an individual. Another aspect of the present invention is the use of the 6 kDa LF polypeptide and functional variants thereof to potentiate the therapeutic action of an antimicrobial drug in a patient. In another aspect, the present invention relates to a method for neutralizing circulating endotoxin in a patient by administering the endotoxin-neutralizing polypeptide or functional variant thereof of the present invention to the patient. Also encompassed within the scope of the invention are methods for potentiating the endotoxin-neutralizing and antimicrobial activity of the polypeptide of the present invention. In addition, methods for increasing the in vivo production of the 6 kDa LF fragment in a patient by in vivo proteases are also disclosed.
PCT/IB2000/000271 1999-02-05 2000-01-27 Antimicrobial/endotoxin neutralizing polypeptide WO2000049040A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CA002362153A CA2362153C (en) 1999-02-05 2000-01-27 Antimicrobial/endotoxin neutralizing polypeptide
DK00906569T DK1151009T3 (en) 1999-02-05 2000-01-27 Antimicrobial / endotoxin neutralizing polypeptide
EP00906569A EP1151009B1 (en) 1999-02-05 2000-01-27 Antimicrobial/endotoxin neutralizing polypeptide
DE60036456T DE60036456T2 (en) 1999-02-05 2000-01-27 ANTIMICROBIAL EFFECTIVE OR ENDOTOXIN NEUTRALIZING POLYPEPTIDE
JP2000599777A JP2002541066A (en) 1999-02-05 2000-01-27 Antimicrobial / Endotoxin neutralizing polypeptide
MXPA01007956A MXPA01007956A (en) 1999-02-05 2000-01-27 Antimicrobial/endotoxin neutralizing polypeptide.
AU28226/00A AU758150B2 (en) 1999-02-05 2000-01-27 Antimicrobial/endotoxin neutralizing polypeptide

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/245,527 1999-02-05
US09/245,527 US6399570B1 (en) 1999-02-05 1999-02-05 Antimicrobial/endotoxin neutralizing polypeptide

Publications (2)

Publication Number Publication Date
WO2000049040A2 WO2000049040A2 (en) 2000-08-24
WO2000049040A3 true WO2000049040A3 (en) 2000-12-14

Family

ID=22927039

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2000/000271 WO2000049040A2 (en) 1999-02-05 2000-01-27 Antimicrobial/endotoxin neutralizing polypeptide

Country Status (12)

Country Link
US (2) US6399570B1 (en)
EP (1) EP1151009B1 (en)
JP (1) JP2002541066A (en)
CN (1) CN1362969A (en)
AT (1) ATE373679T1 (en)
AU (1) AU758150B2 (en)
CA (1) CA2362153C (en)
DE (1) DE60036456T2 (en)
DK (1) DK1151009T3 (en)
ES (1) ES2293892T3 (en)
MX (1) MXPA01007956A (en)
WO (1) WO2000049040A2 (en)

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US20090209486A1 (en) * 2008-02-19 2009-08-20 Roger Wayne Brown Compositions of carbohydrates as dietary supplements
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US20090209487A1 (en) * 2008-02-19 2009-08-20 Roger Wayne Brown Compositions of carbohydrates as dietary supplements
US20090209489A1 (en) * 2008-02-19 2009-08-20 Roger Wayne Brown Compositions for the treatment of diabetis, system PH disorders, high blood pressure, and a cancer marker system
CN101294188B (en) * 2008-06-20 2011-06-15 江南大学 Lactoferrin antimicrobial peptide, preparing method and uses thereof
JP5177901B2 (en) * 2009-12-02 2013-04-10 株式会社明治 Nutritional composition
CN101798337B (en) * 2010-01-29 2013-04-24 中国人民解放军第三军医大学第一附属医院 Mutant of endotoxin neutralizing peptide and application thereof
EP2481751A1 (en) 2011-01-26 2012-08-01 PharmaSurgics in Sweden AB Human lactoferrin derived peptides
JP5763024B2 (en) * 2012-09-07 2015-08-12 株式会社明治 Nutritional composition
CN105101796B (en) * 2013-02-06 2017-06-06 中央研究院 Antibacterial victory peptide derived from hepatitis B virus nucleoprotein arginine compact district
CN106794218A (en) * 2014-10-08 2017-05-31 学校法人庆应义塾 The extracellular trap baiting net of leucocyte forms inhibitor
EP3215614B1 (en) 2014-11-03 2019-05-29 Merck Patent GmbH Soluble intein fusion proteins and methods for purifying biomolecules
SG11201809928VA (en) * 2016-05-27 2018-12-28 Chiaho Shih Modified antimicrobial peptide derived from an arginine-rich domain
CN105999236A (en) * 2016-07-06 2016-10-12 方雅悯 Medicament for treating bovine mastitis and application thereof

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Also Published As

Publication number Publication date
CN1362969A (en) 2002-08-07
US20030105006A1 (en) 2003-06-05
CA2362153C (en) 2009-11-24
DK1151009T3 (en) 2008-01-28
ATE373679T1 (en) 2007-10-15
DE60036456T2 (en) 2008-06-19
AU758150B2 (en) 2003-03-13
AU2822600A (en) 2000-09-04
EP1151009A2 (en) 2001-11-07
CA2362153A1 (en) 2000-08-24
WO2000049040A2 (en) 2000-08-24
ES2293892T3 (en) 2008-04-01
US6399570B1 (en) 2002-06-04
JP2002541066A (en) 2002-12-03
MXPA01007956A (en) 2004-08-19
EP1151009B1 (en) 2007-09-19
DE60036456D1 (en) 2007-10-31
US7244706B2 (en) 2007-07-17

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