WO2000050049A3 - Artificial salivary gland - Google Patents

Artificial salivary gland Download PDF

Info

Publication number
WO2000050049A3
WO2000050049A3 PCT/US2000/004489 US0004489W WO0050049A3 WO 2000050049 A3 WO2000050049 A3 WO 2000050049A3 US 0004489 W US0004489 W US 0004489W WO 0050049 A3 WO0050049 A3 WO 0050049A3
Authority
WO
WIPO (PCT)
Prior art keywords
salivary gland
artificial salivary
artificial
prosthesis
novel
Prior art date
Application number
PCT/US2000/004489
Other languages
French (fr)
Other versions
WO2000050049A2 (en
Inventor
Bruce J Baum
Kenneth M Yamada
Edna Cukierman
David Mooney
Songlin Wang
Doron Aframian
Original Assignee
Us Gov Health & Human Serv
Bruce J Baum
Kenneth M Yamada
Edna Cukierman
David Mooney
Songlin Wang
Doron Aframian
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Gov Health & Human Serv, Bruce J Baum, Kenneth M Yamada, Edna Cukierman, David Mooney, Songlin Wang, Doron Aframian filed Critical Us Gov Health & Human Serv
Priority to AU38598/00A priority Critical patent/AU3859800A/en
Publication of WO2000050049A2 publication Critical patent/WO2000050049A2/en
Publication of WO2000050049A3 publication Critical patent/WO2000050049A3/en
Priority to US09/938,706 priority patent/US6743626B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/022—Artificial gland structures using bioreactors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/38—Stomach; Intestine; Goblet cells; Oral mucosa; Saliva
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/55—Glands not provided for in groups A61K35/22 - A61K35/545, e.g. thyroids, parathyroids or pineal glands
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3813—Epithelial cells, e.g. keratinocytes, urothelial cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • C12N5/0633—Cells of secretory glands, e.g. parotid gland, salivary glands, sweat glands, lacrymal glands
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

Abstract

The present invention generally relates to the field of oral prosthetics and tissue engineering. More specifically, a novel, artificial fluid secreting prosthesis for non-invasive insertion is disclosed. Further, methods of use of the foregoing are provided.
PCT/US2000/004489 1999-02-24 2000-02-23 Artificial salivary gland WO2000050049A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU38598/00A AU3859800A (en) 1999-02-24 2000-02-23 Artificial salivary gland
US09/938,706 US6743626B2 (en) 1999-02-24 2001-08-23 Artificial salivary gland

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12133599P 1999-02-24 1999-02-24
US60/121,335 1999-02-24

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/938,706 Continuation US6743626B2 (en) 1999-02-24 2001-08-23 Artificial salivary gland

Publications (2)

Publication Number Publication Date
WO2000050049A2 WO2000050049A2 (en) 2000-08-31
WO2000050049A3 true WO2000050049A3 (en) 2001-02-15

Family

ID=22396020

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/004489 WO2000050049A2 (en) 1999-02-24 2000-02-23 Artificial salivary gland

Country Status (3)

Country Link
US (1) US6743626B2 (en)
AU (1) AU3859800A (en)
WO (1) WO2000050049A2 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE510605T1 (en) 2003-03-14 2011-06-15 Univ Columbia SYSTEMS AND METHODS FOR BLOOD BASED THERAPY USING A MEMBRANELESS MICROFLUID EXCHANGE DEVICE
US20060076295A1 (en) 2004-03-15 2006-04-13 The Trustees Of Columbia University In The City Of New York Systems and methods of blood-based therapies having a microfluidic membraneless exchange device
US7309232B2 (en) * 2003-10-10 2007-12-18 Dentigenix Inc. Methods for treating dental conditions using tissue scaffolds
US7547447B2 (en) 2004-11-15 2009-06-16 Doheny Eye Institute Bioartificial lacrimal gland
US20060171902A1 (en) * 2005-02-01 2006-08-03 Anthony Atala Engineered oral tissue structural constructs
AU2007253702A1 (en) 2006-05-22 2007-11-29 The Trustees Of Columbia University In The City Of New York Systems and methods of microfluidic membraneless exchange using filtration of extraction fluid outlet streams
KR101308048B1 (en) * 2007-10-10 2013-09-12 삼성전자주식회사 Semiconductor memory device
US20090137925A1 (en) * 2007-11-23 2009-05-28 Divya Cantor Impedance Spectroscopy Cervix Scanning Apparatus and Method
JP2011514182A (en) 2008-02-04 2011-05-06 ザ トラスティーズ オブ コロンビア ユニバーシティ イン ザ シティ オブ ニューヨーク Fluid separation apparatus, system, and method
AU2009277252B2 (en) 2008-07-30 2014-01-16 Mesynthes Limited Tissue scaffolds derived from forestomach extracellular matrix
EP2412800A1 (en) 2010-07-29 2012-02-01 Koninklijke Nederlandse Akademie van Wetenschappen Liver organoid, uses thereof and culture method for obtaining them
PL2393917T3 (en) 2009-02-03 2016-12-30 Culture medium for epithelial stem cells and organoids comprising said stem cells.
US9752124B2 (en) * 2009-02-03 2017-09-05 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium for epithelial stem cells and organoids comprising the stem cells
US20100255059A1 (en) * 2009-04-02 2010-10-07 Ynano, Llc Artificial micro-gland
WO2011056390A2 (en) * 2009-11-03 2011-05-12 Manuel Marquez Method of making an artificial micro-gland that is anisotropic
US10597633B2 (en) 2014-05-16 2020-03-24 Koninklijke Nederlandse Akademie Van Wetenschappen Culture method for organoids
GB201421094D0 (en) 2014-11-27 2015-01-14 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium
GB201421092D0 (en) 2014-11-27 2015-01-14 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium
MX2017012286A (en) 2015-03-24 2018-02-09 Univ Connecticut Artificial salivary gland.
GB201603569D0 (en) 2016-03-01 2016-04-13 Koninklijke Nederlandse Akademie Van Wetenschappen Improved differentiation method

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997045533A1 (en) * 1996-05-28 1997-12-04 The Regents Of The University Of Michigan Engineering oral tissues
WO1999001538A1 (en) * 1997-07-03 1999-01-14 Massachusetts Institute Of Technology Tissue-engineered constructs

Family Cites Families (5)

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JPS61249998A (en) 1985-04-26 1986-11-07 Teikoku Hormone Mfg Co Ltd Peptide having tooth humor transportation promoting activity
US5082767A (en) 1989-02-27 1992-01-21 Hatfield G Wesley Codon pair utilization
US5858702A (en) 1991-12-13 1999-01-12 The Johns Hopkins University Isolation, cloning and expression of transmembrane water channel Aquaporin 5 (AQP5)
US5741671A (en) 1991-12-12 1998-04-21 The Johns Hopkins University Isolation cloning and expression of transmembrane water channel aquaporin 1(AQP1)
US5462870A (en) 1993-04-23 1995-10-31 Wayne State University Human diploid salivary gland epithelial cell lines

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997045533A1 (en) * 1996-05-28 1997-12-04 The Regents Of The University Of Michigan Engineering oral tissues
WO1999001538A1 (en) * 1997-07-03 1999-01-14 Massachusetts Institute Of Technology Tissue-engineered constructs

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BAUM BRUCE J ET AL: "Re-engineering the functions of a terminally differentiated epithelial cell in vivo.", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES., vol. 875, 18 June 1999 (1999-06-18), Conference;Banff, Alberta, Canada; July 18-22, 1998, Technology, medicine, and materials. June 18, 1999 New York Academy of Sciences 2 East 63rd Street, New York, New York 10021, USA, pages 294 - 300, XP000946428, ISBN: 1-57331-194-4 *
DELPORTE CHRISTINE ET AL: "Increased fluid secretion after adenoviral-mediated transfer of the aquaporin-1 cDNA to irradiated rat salivary glands.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 94, no. 7, 1997, 1997, pages 3268 - 3273, XP002148673, ISSN: 0027-8424 *
MASTRANGELI ANDREA ET AL: "Direct in vivo adenovirus-mediated gene transfer to salivary glands.", AMERICAN JOURNAL OF PHYSIOLOGY, vol. 266, no. 6 PART 1, 1994, pages G1146 - G1155, XP000946341, ISSN: 0002-9513 *
ROYCE L S ET AL: "DIFFERENTIATION OF A SALIVARY DUCT CELL LINE ON A RECONSTITUTED BASEMENT MEMBRANE", JOURNAL OF DENTAL RESEARCH, vol. 70, no. SPEC. ISSUE APRIL, 1991, pages 449, XP002148674, ISSN: 0022-0345 *

Also Published As

Publication number Publication date
AU3859800A (en) 2000-09-14
US6743626B2 (en) 2004-06-01
US20030031696A1 (en) 2003-02-13
WO2000050049A2 (en) 2000-08-31

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