WO2000056808A3 - Surface and its manufacture and uses - Google Patents

Surface and its manufacture and uses Download PDF

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Publication number
WO2000056808A3
WO2000056808A3 PCT/EP2000/002632 EP0002632W WO0056808A3 WO 2000056808 A3 WO2000056808 A3 WO 2000056808A3 EP 0002632 W EP0002632 W EP 0002632W WO 0056808 A3 WO0056808 A3 WO 0056808A3
Authority
WO
WIPO (PCT)
Prior art keywords
plastics
polymer material
substance
plasma
water
Prior art date
Application number
PCT/EP2000/002632
Other languages
French (fr)
Other versions
WO2000056808A2 (en
Inventor
Anders Larsson
Anette Ocklind
Helene Derand
Original Assignee
Amersham Pharm Biotech Ab
Anders Larsson
Anette Ocklind
Helene Derand
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amersham Pharm Biotech Ab, Anders Larsson, Anette Ocklind, Helene Derand filed Critical Amersham Pharm Biotech Ab
Priority to US09/937,533 priority Critical patent/US6967101B1/en
Priority to DE60003642T priority patent/DE60003642T2/en
Priority to AU41100/00A priority patent/AU4110000A/en
Priority to DK00920571T priority patent/DK1163103T3/en
Priority to JP2000606668A priority patent/JP5025043B2/en
Priority to CA002367736A priority patent/CA2367736A1/en
Priority to EP00920571A priority patent/EP1163103B1/en
Priority to AT00920571T priority patent/ATE244130T1/en
Publication of WO2000056808A2 publication Critical patent/WO2000056808A2/en
Publication of WO2000056808A3 publication Critical patent/WO2000056808A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C59/00—Surface shaping of articles, e.g. embossing; Apparatus therefor
    • B29C59/14—Surface shaping of articles, e.g. embossing; Apparatus therefor by plasma treatment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2995/00—Properties of moulding materials, reinforcements, fillers, preformed parts or moulds
    • B29K2995/0037—Other properties
    • B29K2995/0092—Other properties hydrophilic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers

Abstract

A method for rendering a surface covered by a polymer material (plastics) more hydrophilic by treatment in a gas plasma of a non-polymerizable gas. The method is characterized in that the intensity of the plasma is selected so that the surface becomes permanently more hydrophilic. A naked plasma treated surface of plastics having an immediate water-contact angle ≤ 30°, such as ≤ 20°, said water-contact angle being changed less than ± 20 % and/or less than ± 5° upon washing with ethanol/water mixture (70 % w/w). A kit comprising (a) a microfabricated device comprising a surface (i) which is manufactured from a synthetic polymer material (plastics) and (ii) on which there are at least one chamber and/or at least one channel, and (b) a fluorescent substance to be detected in the device. The kit is characterized in that the plastics has a fluorescence that is non-significant with respect to the fluorescence of the substance at the wavelength at which the substance fluoresces. A microfabricated device having a liquid transportation system which is formed in/on a polymer material (plastics) that is a polymerised aliphatic monomer containing unsaturation.
PCT/EP2000/002632 1999-03-24 2000-03-24 Surface and its manufacture and uses WO2000056808A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
US09/937,533 US6967101B1 (en) 1999-03-24 2000-03-24 Surface and its manufacture and uses
DE60003642T DE60003642T2 (en) 1999-03-24 2000-03-24 USE OF A SURFACE HYDROPHILIZED IN GASPLASMA AS A LIQUID CONTACT SURFACE AND A DEVICE PRODUCED BY A MICROPROCESS WITH A SURFACE HYDROPHILIZED IN GASPLASMA
AU41100/00A AU4110000A (en) 1999-03-24 2000-03-24 Surface and its manufacture and uses
DK00920571T DK1163103T3 (en) 1999-03-24 2000-03-24 Use of gas plasma hydrophilized surface as a liquid contact surface and microfabricated device containing a gas plasma hydrophilized surface
JP2000606668A JP5025043B2 (en) 1999-03-24 2000-03-24 Surface and its manufacture and use
CA002367736A CA2367736A1 (en) 1999-03-24 2000-03-24 Surface and its manufacture and uses
EP00920571A EP1163103B1 (en) 1999-03-24 2000-03-24 Use of gas plasma hydrophilised surface as a liquid contact surface and microfabricated device containing a gas plasma hydrophilised surface
AT00920571T ATE244130T1 (en) 1999-03-24 2000-03-24 USE OF A GAS PLASMA HYDROPHILIZED SURFACE AS A LIQUID CONTACT SURFACE AND DEVICE PRODUCED BY A MICROPROCESS HAVING A GAS PLASMA HYDROPHILIZED SURFACE

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9901100A SE9901100D0 (en) 1999-03-24 1999-03-24 Surface and tis manufacture and uses
SE9901100-9 1999-03-24

Publications (2)

Publication Number Publication Date
WO2000056808A2 WO2000056808A2 (en) 2000-09-28
WO2000056808A3 true WO2000056808A3 (en) 2001-03-22

Family

ID=20415008

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/002632 WO2000056808A2 (en) 1999-03-24 2000-03-24 Surface and its manufacture and uses

Country Status (11)

Country Link
US (1) US6967101B1 (en)
EP (2) EP1323475A3 (en)
JP (1) JP5025043B2 (en)
AT (1) ATE244130T1 (en)
AU (1) AU4110000A (en)
CA (1) CA2367736A1 (en)
DE (1) DE60003642T2 (en)
DK (1) DK1163103T3 (en)
ES (1) ES2200861T3 (en)
SE (1) SE9901100D0 (en)
WO (1) WO2000056808A2 (en)

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Also Published As

Publication number Publication date
JP2003526702A (en) 2003-09-09
DK1163103T3 (en) 2003-10-20
US6967101B1 (en) 2005-11-22
EP1163103A2 (en) 2001-12-19
WO2000056808A2 (en) 2000-09-28
JP5025043B2 (en) 2012-09-12
ES2200861T3 (en) 2004-03-16
CA2367736A1 (en) 2000-09-28
SE9901100D0 (en) 1999-03-24
ATE244130T1 (en) 2003-07-15
AU4110000A (en) 2000-10-09
EP1323475A2 (en) 2003-07-02
DE60003642T2 (en) 2004-05-13
EP1323475A3 (en) 2005-02-09
EP1163103B1 (en) 2003-07-02
DE60003642D1 (en) 2003-08-07

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