WO2001001143A3 - Attachment of biomolecule to a polymeric solid support by cycloaddition of a linker - Google Patents
Attachment of biomolecule to a polymeric solid support by cycloaddition of a linker Download PDFInfo
- Publication number
- WO2001001143A3 WO2001001143A3 PCT/US2000/017422 US0017422W WO0101143A3 WO 2001001143 A3 WO2001001143 A3 WO 2001001143A3 US 0017422 W US0017422 W US 0017422W WO 0101143 A3 WO0101143 A3 WO 0101143A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- attachment
- biomolecules
- reactive sites
- solid supports
- solid support
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
Abstract
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00941693A EP1190254B1 (en) | 1999-06-25 | 2000-06-23 | Attachment of biomolecule to a polymeric solid support by cycloaddition of a linker |
JP2001507097A JP2003524150A (en) | 1999-06-25 | 2000-06-23 | Methods and compositions for binding biomolecules to solid supports, hydrogels, and hydrogel arrays |
DE60013826T DE60013826D1 (en) | 1999-06-25 | 2000-06-23 | FASTENING A BIOMOLECULE TO A POLYMERIC SOLID PHASE BY CYCLOADDITION REACTIONS FROM A SPACER |
AT00941693T ATE276516T1 (en) | 1999-06-25 | 2000-06-23 | ATTACHMENT OF A BIOMOLECULE TO A POLYMERIC SOLID PHASE THROUGH CYCLOADDITION REACTIONS OF A SPACER |
CA002378072A CA2378072A1 (en) | 1999-06-25 | 2000-06-23 | Methods and compositions for attachment of biomolecules to solid supports, hydrogels, and hydrogel arrays |
AU56362/00A AU768326B2 (en) | 1999-06-25 | 2000-06-23 | Methods and compositions for attachment of biomolecules to solid supports, hydrogels, and hydrogel arrays |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/344,620 | 1999-06-25 | ||
US09/344,620 US6372813B1 (en) | 1999-06-25 | 1999-06-25 | Methods and compositions for attachment of biomolecules to solid supports, hydrogels, and hydrogel arrays |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2001001143A2 WO2001001143A2 (en) | 2001-01-04 |
WO2001001143A3 true WO2001001143A3 (en) | 2001-03-08 |
Family
ID=23351266
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/017422 WO2001001143A2 (en) | 1999-06-25 | 2000-06-23 | Attachment of biomolecule to a polymeric solid support by cycloaddition of a linker |
Country Status (8)
Country | Link |
---|---|
US (2) | US6372813B1 (en) |
EP (1) | EP1190254B1 (en) |
JP (1) | JP2003524150A (en) |
AT (1) | ATE276516T1 (en) |
AU (1) | AU768326B2 (en) |
CA (1) | CA2378072A1 (en) |
DE (1) | DE60013826D1 (en) |
WO (1) | WO2001001143A2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100876256B1 (en) * | 2001-03-30 | 2008-12-26 | 유씨비 소시에떼아노님 | Substrate, its manufacturing method and uses |
Families Citing this family (236)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5846717A (en) | 1996-01-24 | 1998-12-08 | Third Wave Technologies, Inc. | Detection of nucleic acid sequences by invader-directed cleavage |
US7527928B2 (en) * | 1996-11-29 | 2009-05-05 | Third Wave Technologies, Inc. | Reactions on a solid surface |
US7432048B2 (en) * | 1996-11-29 | 2008-10-07 | Third Wave Technologies, Inc. | Reactions on a solid surface |
US20060275782A1 (en) * | 1999-04-20 | 2006-12-07 | Illumina, Inc. | Detection of nucleic acid reactions on bead arrays |
US20030207295A1 (en) * | 1999-04-20 | 2003-11-06 | Kevin Gunderson | Detection of nucleic acid reactions on bead arrays |
US7638464B2 (en) | 1999-04-26 | 2009-12-29 | Biocept, Inc. | Three dimensional format biochips |
US6921638B2 (en) | 1999-06-25 | 2005-07-26 | Amersham Biosciences Ab | Hydrogel-based microarray signal amplification methods and devices therefor |
US6372813B1 (en) * | 1999-06-25 | 2002-04-16 | Motorola | Methods and compositions for attachment of biomolecules to solid supports, hydrogels, and hydrogel arrays |
US6664061B2 (en) * | 1999-06-25 | 2003-12-16 | Amersham Biosciences Ab | Use and evaluation of a [2+2] photoaddition in immobilization of oligonucleotides on a three-dimensional hydrogel matrix |
US6589778B1 (en) * | 1999-12-15 | 2003-07-08 | Amersham Biosciences Ab | Method and apparatus for performing biological reactions on a substrate surface |
US7955794B2 (en) * | 2000-09-21 | 2011-06-07 | Illumina, Inc. | Multiplex nucleic acid reactions |
US8076063B2 (en) * | 2000-02-07 | 2011-12-13 | Illumina, Inc. | Multiplexed methylation detection methods |
US7611869B2 (en) * | 2000-02-07 | 2009-11-03 | Illumina, Inc. | Multiplexed methylation detection methods |
US7582420B2 (en) * | 2001-07-12 | 2009-09-01 | Illumina, Inc. | Multiplex nucleic acid reactions |
CA2399733C (en) * | 2000-02-07 | 2011-09-20 | Illumina, Inc. | Nucleic acid detection methods using universal priming |
US6693033B2 (en) | 2000-02-10 | 2004-02-17 | Motorola, Inc. | Method of removing an amorphous oxide from a monocrystalline surface |
DE10006590B4 (en) * | 2000-02-11 | 2007-10-18 | Qiagen North American Holdings, Inc. | Use of functionalized membranes or matrices for the purification of nucleic acids and corresponding methods |
WO2002003437A1 (en) * | 2000-06-30 | 2002-01-10 | Motorola, Inc., A Corporation Of The State Of Delaware | Hybrid semiconductor structure and device |
US6555946B1 (en) | 2000-07-24 | 2003-04-29 | Motorola, Inc. | Acoustic wave device and process for forming the same |
AU2001279244A1 (en) * | 2000-08-09 | 2002-02-18 | Motorola, Inc. | The use and evaluation of a (2+2) photocycloaddition in immobilization of oligonucleotides on a three-dimensional hydrogel matrix |
US6638838B1 (en) | 2000-10-02 | 2003-10-28 | Motorola, Inc. | Semiconductor structure including a partially annealed layer and method of forming the same |
KR20020089315A (en) * | 2000-10-26 | 2002-11-29 | 바이오셉트 인코포레이티드 | Three dimensional format biochips |
DE60033665T2 (en) * | 2000-10-31 | 2007-10-31 | Micronas Gmbh | Patterned polymer surfaces suitable for bioconjugations and methods for their preparation |
US6673646B2 (en) | 2001-02-28 | 2004-01-06 | Motorola, Inc. | Growth of compound semiconductor structures on patterned oxide films and process for fabricating same |
US20020142304A1 (en) * | 2001-03-09 | 2002-10-03 | Anderson Daniel G. | Uses and methods of making microarrays of polymeric biomaterials |
DE50113981D1 (en) * | 2001-05-09 | 2008-06-26 | Andreas Hofmann | OBJECT WITH AN UNLOCKED, FUNCTIONALIZED HYDROGEL SURFACE |
US6709989B2 (en) | 2001-06-21 | 2004-03-23 | Motorola, Inc. | Method for fabricating a semiconductor structure including a metal oxide interface with silicon |
AU2002365110A1 (en) * | 2001-07-10 | 2003-07-15 | Massachusetts Institute Of Technology | Small molecule microarrays |
US6646293B2 (en) | 2001-07-18 | 2003-11-11 | Motorola, Inc. | Structure for fabricating high electron mobility transistors utilizing the formation of complaint substrates |
US6693298B2 (en) | 2001-07-20 | 2004-02-17 | Motorola, Inc. | Structure and method for fabricating epitaxial semiconductor on insulator (SOI) structures and devices utilizing the formation of a compliant substrate for materials used to form same |
US6667196B2 (en) | 2001-07-25 | 2003-12-23 | Motorola, Inc. | Method for real-time monitoring and controlling perovskite oxide film growth and semiconductor structure formed using the method |
US6639249B2 (en) | 2001-08-06 | 2003-10-28 | Motorola, Inc. | Structure and method for fabrication for a solid-state lighting device |
US6589856B2 (en) | 2001-08-06 | 2003-07-08 | Motorola, Inc. | Method and apparatus for controlling anti-phase domains in semiconductor structures and devices |
US6656725B2 (en) * | 2001-08-15 | 2003-12-02 | The University Of Chicago | Method of fabrication of microarray of gel-immobilized compounds on a chip by copolymerization |
US6673667B2 (en) | 2001-08-15 | 2004-01-06 | Motorola, Inc. | Method for manufacturing a substantially integral monolithic apparatus including a plurality of semiconductor materials |
CA2457142A1 (en) | 2001-08-17 | 2003-02-27 | University Of Pittsburgh | Administration of estradiol metabolites for the treatment or prevention of obesity, metabolic syndrome, diabetes, and vascular and renal disorders |
US6943267B1 (en) | 2001-08-24 | 2005-09-13 | Utah State University | Thiophosphonate inhibitors of phosphatase enzymes and metallophosphatases |
US20080279936A1 (en) * | 2001-10-10 | 2008-11-13 | The University Of Pittsburgh | Estradiol metabolites for reduction of endothelin production |
WO2003034026A2 (en) * | 2001-10-15 | 2003-04-24 | Biocept, Inc. | Microwell biochip |
EP2287330A1 (en) * | 2001-11-01 | 2011-02-23 | Rensselaer Polytechnic Institute | Biocatalytic Solgel Microarrays |
AU2002351164A1 (en) * | 2001-11-26 | 2003-06-10 | Molecular Reflections, Inc. | Microscale immobilization of molecules using a hydrogel and methods of use thereof |
KR100700462B1 (en) * | 2001-12-26 | 2007-03-29 | 캐논 가부시끼가이샤 | Probe Medium |
US20050239155A1 (en) * | 2002-01-04 | 2005-10-27 | Javier Alarcon | Entrapped binding protein as biosensors |
HU226993B1 (en) * | 2002-03-29 | 2010-04-28 | Mta Szegedi Biolog Koezpont | Novel active carrier and process for immobilization of combinatorial compounds and compound libraries |
US6916717B2 (en) * | 2002-05-03 | 2005-07-12 | Motorola, Inc. | Method for growing a monocrystalline oxide layer and for fabricating a semiconductor device on a monocrystalline substrate |
US7445894B2 (en) * | 2002-05-03 | 2008-11-04 | Molecular Probes, Inc. | Compositions and methods for detection and isolation of phosphorylated molecules |
JP2005539243A (en) * | 2002-05-03 | 2005-12-22 | モレキュラー プローブス, インコーポレイテッド | Compositions and methods for detection and separation of phosphorylated molecules |
US20040171034A1 (en) * | 2002-05-03 | 2004-09-02 | Brian Agnew | Compositions and methods for detection and isolation of phosphorylated molecules |
US6706408B2 (en) * | 2002-05-16 | 2004-03-16 | Surmodics, Inc. | Silane coating composition |
US8785179B2 (en) * | 2002-05-22 | 2014-07-22 | Texas Instruments Incorporated | Biosensor and method |
US20030219753A1 (en) * | 2002-05-22 | 2003-11-27 | Quinn John G. | Biosensor and method |
US20050019747A1 (en) * | 2002-08-07 | 2005-01-27 | Anderson Daniel G. | Nanoliter-scale synthesis of arrayed biomaterials and screening thereof |
US20040028804A1 (en) * | 2002-08-07 | 2004-02-12 | Anderson Daniel G. | Production of polymeric microarrays |
EP1527202A1 (en) * | 2002-08-08 | 2005-05-04 | Siemens Aktiengesellschaft | Recognition layers made of hydrogel based on polyacrylamide for use in biosensor technology |
US7045366B2 (en) * | 2003-09-12 | 2006-05-16 | Ciphergen Biosystems, Inc. | Photocrosslinked hydrogel blend surface coatings |
US8389700B2 (en) * | 2002-09-23 | 2013-03-05 | Alcatel Lucent | Agent delivery system capable of selectively releasing an agent |
US7919600B2 (en) * | 2002-09-23 | 2011-04-05 | Alcatel-Lucent Usa Inc. | Compositions that reversibly gel and de-gel |
US20040259105A1 (en) * | 2002-10-03 | 2004-12-23 | Jian-Bing Fan | Multiplex nucleic acid analysis using archived or fixed samples |
US20040152211A1 (en) * | 2002-11-15 | 2004-08-05 | The Regents Of The University Of California | System and method for multiplexed biomolecular analysis |
JP2006507122A (en) * | 2002-11-22 | 2006-03-02 | カーネギー−メロン ユニバーシティ | Compositions and methods for reversible capture of biomolecules |
DE10259821B4 (en) * | 2002-12-19 | 2006-03-09 | Siemens Ag | Biochip |
BRPI0407667A (en) * | 2003-02-20 | 2006-03-01 | Univ Pittsburgh | estradiol metabolites for the treatment of pulmonary hypertension |
US20060194775A1 (en) * | 2003-02-20 | 2006-08-31 | University Of Pittsburgh | Estradiol metabolites for the treatment of pulmonary hypertension |
EP1615034A4 (en) * | 2003-03-31 | 2010-11-24 | Rikagaku Kenkyusho | Fixing agents, method of fixing substance with the same, and substrate having substance fixed thereto with the same |
DE10323685A1 (en) * | 2003-05-22 | 2004-12-09 | Rühe, Jürgen, Prof. Dr. | Process for the covalent immobilization of probe biomolecules on organic surfaces |
US20050136536A1 (en) * | 2003-09-15 | 2005-06-23 | Anderson Daniel G. | Embryonic epithelial cells |
CA2543091C (en) | 2003-10-24 | 2013-09-03 | John Austin | Apparatus and method for dispensing fluid, semi-solid and solid samples |
DE102004062281A1 (en) * | 2003-12-29 | 2005-07-28 | Siemens Ag | Producing a microarray of spots e.g. for use on a biochip, comprises applying a solution of a polymer and special molecules and then solidifying the polymer, especially by a non-radical method |
EP3673986A1 (en) | 2004-01-07 | 2020-07-01 | Illumina Cambridge Limited | Improvements in or relating to molecular arrays |
US7294671B2 (en) * | 2004-02-06 | 2007-11-13 | Invista North America S.A.R.L. | Reactive carriers for polymer melt injection |
DE102004010430A1 (en) * | 2004-03-01 | 2005-09-22 | Rühe, Jürgen, Prof. Dr. | Process for the covalent immobilization of biomolecules on organic surfaces |
US20090042741A1 (en) * | 2004-05-06 | 2009-02-12 | Arizona Board Of Regents, Acting For And On Behalf Of Arizona State University | Microarray of three-dimensional heteropolymer microstructures and method therefor |
US7968085B2 (en) | 2004-07-05 | 2011-06-28 | Ascendis Pharma A/S | Hydrogel formulations |
US7935479B2 (en) * | 2004-07-19 | 2011-05-03 | Cell Biosciences, Inc. | Methods and devices for analyte detection |
US7846676B2 (en) | 2004-07-19 | 2010-12-07 | Cell Biosciences, Inc. | Methods and devices for analyte detection |
US7595157B2 (en) * | 2004-08-19 | 2009-09-29 | Biocept, Inc. | Microarrays utilizing hydrogels |
KR100695134B1 (en) * | 2004-11-25 | 2007-03-14 | 삼성전자주식회사 | Microarray using laminar flow and preparation method thereof |
US20070287828A1 (en) * | 2005-02-18 | 2007-12-13 | Minden Jonathan S | Compositions and Methods for the Reversible Capture of Biomolecules |
WO2006127865A2 (en) * | 2005-05-24 | 2006-11-30 | Georgia Tech Research Corporation | Bioresponsive hydrogels |
WO2006138479A2 (en) * | 2005-06-15 | 2006-12-28 | Arizona Board Of Regents For And On Behalf Of Arizona State University | Microstructure and microdomain microarrays, methods of making and using thereof |
GB0514936D0 (en) | 2005-07-20 | 2005-08-24 | Solexa Ltd | Preparation of templates for nucleic acid sequencing |
US20070054127A1 (en) * | 2005-08-26 | 2007-03-08 | Hergenrother Robert W | Silane coating compositions, coating systems, and methods |
US20070141365A1 (en) * | 2005-08-26 | 2007-06-21 | Jelle Bruce M | Silane Coating Compositions, Coating Systems, and Methods |
CA2622955A1 (en) * | 2005-09-15 | 2007-03-29 | University Of Utah Research Foundation | Polymeric compositions and methods of making and using thereof |
WO2007035864A2 (en) * | 2005-09-20 | 2007-03-29 | Cell Biosciences, Inc. | Electrophoresis standards, methods and kits |
KR101375086B1 (en) * | 2005-11-08 | 2014-03-17 | 한국과학기술원 | Hyperbranched polymer for micro devices |
US8158832B2 (en) | 2005-11-09 | 2012-04-17 | The Trustees Of Columbia University In The City Of New York | Photochemical methods and photoactive compounds for modifying surfaces |
DE102005059535B4 (en) * | 2005-12-13 | 2010-01-14 | Siemens Ag | Device and method for carrying out a nucleic acid test, and method for producing such a device |
EP1864777B1 (en) * | 2006-06-08 | 2009-09-23 | DWI an der RWTH Aachen e.V. | Structuring hydrogels |
HUP0600668A2 (en) | 2006-08-22 | 2008-02-28 | Avicor Kft | Active carrier, process for producing thereof and the use of thereof |
US8658573B2 (en) * | 2006-09-11 | 2014-02-25 | The Trustees Of Columbia University In The City Of New York | Photo-generated carbohydrate arrays and the rapid identification of pathogen-specific antigens and antibodies |
US10107782B2 (en) | 2008-01-25 | 2018-10-23 | ProteinSimple | Method to perform limited two dimensional separation of proteins and other biologicals |
JP2011523452A (en) * | 2008-04-16 | 2011-08-11 | スマート ホログラムズ リミテッド | Photopolymerizable composition |
US8993068B2 (en) | 2008-11-04 | 2015-03-31 | The Trustees Of Columbia University In The City Of New York | Heterobifunctional polymers and methods for layer-by-layer construction of multilayer films |
EP2435461B1 (en) | 2009-05-29 | 2017-08-09 | Life Technologies Corporation | Scaffolded nucleic acid polymer particles and methods of making and using |
NZ597964A (en) | 2009-07-31 | 2014-04-30 | Sanofi Aventis Deutschland | Long acting insulin composition |
JP5738291B2 (en) | 2009-07-31 | 2015-06-24 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Prodrugs containing insulin linker conjugates |
US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
EP2438930A1 (en) | 2010-09-17 | 2012-04-11 | Sanofi-Aventis Deutschland GmbH | Prodrugs comprising an exendin linker conjugate |
AU2011312218B2 (en) | 2010-10-04 | 2015-11-05 | Sequencing Health, Inc. | Systems and methods for automated reusable parallel biological reactions |
US9006345B2 (en) | 2011-03-25 | 2015-04-14 | The Trustees Of Columbia University In The City Of New York | Heterotrifunctional molecules and methods for the synthesis of dendrimeric materials |
JP2014512826A (en) | 2011-04-25 | 2014-05-29 | バイオ−ラド ラボラトリーズ インコーポレイテッド | Methods and compositions for nucleic acid analysis |
US9926596B2 (en) | 2011-05-27 | 2018-03-27 | Genapsys, Inc. | Systems and methods for genetic and biological analysis |
EP2718465B1 (en) | 2011-06-09 | 2022-04-13 | Illumina, Inc. | Method of making an analyte array |
WO2013006824A2 (en) | 2011-07-07 | 2013-01-10 | Life Technologies Corporation | Polymer particles, nucleic acid polymer particles and methods of making and using the same |
EP2756096B1 (en) | 2011-09-12 | 2017-06-28 | Ecole Polytechnique Fédérale de Lausanne (EPFL) | Method for preparing topographically structured microarrays |
EP2771103B1 (en) | 2011-10-28 | 2017-08-16 | Illumina, Inc. | Microarray fabrication system and method |
WO2013067203A1 (en) | 2011-11-02 | 2013-05-10 | The Regents Of The University Of California | Reprogramming of cellular adhesion |
WO2013070627A2 (en) | 2011-11-07 | 2013-05-16 | Illumina, Inc. | Integrated sequencing apparatuses and methods of use |
CN106591103B (en) | 2011-12-01 | 2021-06-04 | 吉纳普赛斯股份有限公司 | System and method for efficient electronic sequencing and detection |
CA2865575C (en) | 2012-02-27 | 2024-01-16 | Cellular Research, Inc. | Compositions and kits for molecular counting |
WO2013155634A1 (en) | 2012-04-19 | 2013-10-24 | Jiaqi Wu | Dual wavelength isoelectric focusing for determining drug load in antibody drug conjugates |
US9012022B2 (en) | 2012-06-08 | 2015-04-21 | Illumina, Inc. | Polymer coatings |
US10752949B2 (en) | 2012-08-14 | 2020-08-25 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10323279B2 (en) | 2012-08-14 | 2019-06-18 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10273541B2 (en) | 2012-08-14 | 2019-04-30 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
MX364957B (en) | 2012-08-14 | 2019-05-15 | 10X Genomics Inc | Microcapsule compositions and methods. |
US11591637B2 (en) | 2012-08-14 | 2023-02-28 | 10X Genomics, Inc. | Compositions and methods for sample processing |
US9701998B2 (en) | 2012-12-14 | 2017-07-11 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10221442B2 (en) | 2012-08-14 | 2019-03-05 | 10X Genomics, Inc. | Compositions and methods for sample processing |
US10400280B2 (en) | 2012-08-14 | 2019-09-03 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US9951386B2 (en) | 2014-06-26 | 2018-04-24 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10533221B2 (en) | 2012-12-14 | 2020-01-14 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
EP3567116A1 (en) | 2012-12-14 | 2019-11-13 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
WO2014124338A1 (en) | 2013-02-08 | 2014-08-14 | 10X Technologies, Inc. | Polynucleotide barcode generation |
US9512422B2 (en) | 2013-02-26 | 2016-12-06 | Illumina, Inc. | Gel patterned surfaces |
DK2964612T3 (en) | 2013-03-08 | 2017-04-03 | Illumina Cambridge Ltd | POLYMETHIN COMPOUNDS AND USE THEREOF AS FLUORESCING LABELS |
ES2620427T3 (en) | 2013-03-08 | 2017-06-28 | Illumina Cambridge Limited | Rhodamine compounds and their use as fluorescent markers |
CN105051214B (en) | 2013-03-15 | 2018-12-28 | 吉纳普赛斯股份有限公司 | System and method for bioanalysis |
KR102266002B1 (en) | 2013-07-01 | 2021-06-16 | 일루미나, 인코포레이티드 | Catalyst-free surface functionalization and polymer grafting |
WO2015017694A1 (en) * | 2013-07-31 | 2015-02-05 | Regents Of The University Of California | Dna double-write/double binding identity |
SG10201806890VA (en) | 2013-08-28 | 2018-09-27 | Cellular Res Inc | Massively parallel single cell analysis |
US10395758B2 (en) | 2013-08-30 | 2019-08-27 | 10X Genomics, Inc. | Sequencing methods |
CN105658817A (en) | 2013-09-13 | 2016-06-08 | 生命技术公司 | Device preparation using condensed nucleic acid particles |
US9766206B2 (en) | 2013-09-27 | 2017-09-19 | ProteinSimple | Apparatus, systems, and methods for capillary electrophoresis |
EP3080300B1 (en) | 2013-12-11 | 2020-09-02 | Genapsys Inc. | Systems and methods for biological analysis and computation |
US9824068B2 (en) | 2013-12-16 | 2017-11-21 | 10X Genomics, Inc. | Methods and apparatus for sorting data |
CN105874385B (en) | 2013-12-19 | 2021-08-20 | Illumina公司 | Substrate comprising a nanopatterned surface and method for the production thereof |
WO2015103225A1 (en) | 2013-12-31 | 2015-07-09 | Illumina, Inc. | Addressable flow cell using patterned electrodes |
EP3129143B1 (en) | 2014-04-10 | 2022-11-23 | 10X Genomics, Inc. | Method for partitioning microcapsules |
EP3556864B1 (en) | 2014-04-18 | 2020-12-09 | Genapsys, Inc. | Methods and systems for nucleic acid amplification |
GB201408077D0 (en) | 2014-05-07 | 2014-06-18 | Illumina Cambridge Ltd | Polymethine compounds and their use as fluorescent labels |
CN106795553B (en) | 2014-06-26 | 2021-06-04 | 10X基因组学有限公司 | Methods of analyzing nucleic acids from individual cells or cell populations |
CN110211637B (en) | 2014-06-26 | 2023-10-27 | 10X基因组学有限公司 | Method and system for assembling nucleic acid sequences |
EP3212807B1 (en) | 2014-10-29 | 2020-09-02 | 10X Genomics, Inc. | Methods and compositions for targeted nucleic acid sequencing |
US9975122B2 (en) | 2014-11-05 | 2018-05-22 | 10X Genomics, Inc. | Instrument systems for integrated sample processing |
US11754563B2 (en) * | 2014-11-20 | 2023-09-12 | Global Life Sciences Solutions Operations UK Ltd | Porous membranes with a polymer grafting, methods and uses thereof |
US10221436B2 (en) | 2015-01-12 | 2019-03-05 | 10X Genomics, Inc. | Processes and systems for preparation of nucleic acid sequencing libraries and libraries prepared using same |
WO2016115273A1 (en) | 2015-01-13 | 2016-07-21 | 10X Genomics, Inc. | Systems and methods for visualizing structural variation and phasing information |
AU2016218254B2 (en) | 2015-02-09 | 2019-12-19 | Slingshot Biosciences, Inc. | Hydrogel particles with tunable optical properties and methods for using the same |
US10854315B2 (en) | 2015-02-09 | 2020-12-01 | 10X Genomics, Inc. | Systems and methods for determining structural variation and phasing using variant call data |
EP3259371B1 (en) | 2015-02-19 | 2020-09-02 | Becton, Dickinson and Company | High-throughput single-cell analysis combining proteomic and genomic information |
EP3262188B1 (en) | 2015-02-24 | 2021-05-05 | 10X Genomics, Inc. | Methods for targeted nucleic acid sequence coverage |
WO2016137973A1 (en) | 2015-02-24 | 2016-09-01 | 10X Genomics Inc | Partition processing methods and systems |
EP3262192B1 (en) | 2015-02-27 | 2020-09-16 | Becton, Dickinson and Company | Spatially addressable molecular barcoding |
EP3835431B1 (en) | 2015-03-30 | 2022-11-02 | Becton, Dickinson and Company | Methods for combinatorial barcoding |
WO2016172373A1 (en) | 2015-04-23 | 2016-10-27 | Cellular Research, Inc. | Methods and compositions for whole transcriptome amplification |
GB201508858D0 (en) | 2015-05-22 | 2015-07-01 | Illumina Cambridge Ltd | Polymethine compounds with long stokes shifts and their use as fluorescent labels |
WO2016196229A1 (en) | 2015-06-01 | 2016-12-08 | Cellular Research, Inc. | Methods for rna quantification |
ES2945607T3 (en) | 2015-07-17 | 2023-07-04 | Illumina Inc | Polymer sheets for sequencing applications |
KR102395450B1 (en) | 2015-09-11 | 2022-05-09 | 셀룰러 리서치, 인크. | Methods and Compositions for Normalizing Nucleic Acid Libraries |
GB201516987D0 (en) | 2015-09-25 | 2015-11-11 | Illumina Cambridge Ltd | Polymethine compounds and their use as fluorescent labels |
US20200292944A1 (en) | 2015-11-18 | 2020-09-17 | Massachusetts Institute Of Technology | Method of making a patterned hydrogel and kit to make it |
EP3384048B1 (en) | 2015-12-04 | 2021-03-24 | 10X Genomics, Inc. | Methods and compositions for nucleic acid analysis |
US11081208B2 (en) | 2016-02-11 | 2021-08-03 | 10X Genomics, Inc. | Systems, methods, and media for de novo assembly of whole genome sequence data |
WO2017197338A1 (en) | 2016-05-13 | 2017-11-16 | 10X Genomics, Inc. | Microfluidic systems and methods of use |
EP3458913B1 (en) | 2016-05-18 | 2020-12-23 | Illumina, Inc. | Self assembled patterning using patterned hydrophobic surfaces |
US10301677B2 (en) | 2016-05-25 | 2019-05-28 | Cellular Research, Inc. | Normalization of nucleic acid libraries |
US10202641B2 (en) | 2016-05-31 | 2019-02-12 | Cellular Research, Inc. | Error correction in amplification of samples |
US10640763B2 (en) | 2016-05-31 | 2020-05-05 | Cellular Research, Inc. | Molecular indexing of internal sequences |
US10544456B2 (en) | 2016-07-20 | 2020-01-28 | Genapsys, Inc. | Systems and methods for nucleic acid sequencing |
AU2017331459B2 (en) | 2016-09-26 | 2023-04-13 | Becton, Dickinson And Company | Measurement of protein expression using reagents with barcoded oligonucleotide sequences |
US10385214B2 (en) | 2016-09-30 | 2019-08-20 | Illumina Cambridge Limited | Fluorescent dyes and their uses as biomarkers |
ES2937782T3 (en) | 2016-10-03 | 2023-03-31 | Illumina Inc | Fluorescent detection of amines and hydrazines and methods of testing the same |
MX2019006705A (en) | 2016-12-22 | 2019-11-08 | Illumina Inc | Arrays including a resin film and a patterned polymer layer. |
EP3559262A4 (en) | 2016-12-22 | 2020-07-22 | Illumina, Inc. | Arrays with quality control tracers |
WO2018118932A1 (en) | 2016-12-22 | 2018-06-28 | Illumina, Inc. | Imprinting apparatus |
US10815525B2 (en) | 2016-12-22 | 2020-10-27 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
WO2018119057A2 (en) | 2016-12-22 | 2018-06-28 | Illumina, Inc. | Array including sequencing primer and non-sequencing entity |
US10550429B2 (en) | 2016-12-22 | 2020-02-04 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10011872B1 (en) | 2016-12-22 | 2018-07-03 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
EP3559982A4 (en) | 2016-12-22 | 2020-07-01 | Illumina, Inc. | Flow cell package and method for making the same |
CN109476674B (en) | 2016-12-22 | 2021-12-10 | 伊鲁米纳剑桥有限公司 | Coumarin compound and application thereof as fluorescent marker |
KR20190104041A (en) | 2016-12-29 | 2019-09-05 | 아도르 디아그노스틱스 에스.알.엘. | Electrophoresis chip for electrophoretic applications |
EP4029939B1 (en) | 2017-01-30 | 2023-06-28 | 10X Genomics, Inc. | Methods and systems for droplet-based single cell barcoding |
US11319583B2 (en) | 2017-02-01 | 2022-05-03 | Becton, Dickinson And Company | Selective amplification using blocking oligonucleotides |
EP3625715A4 (en) | 2017-05-19 | 2021-03-17 | 10X Genomics, Inc. | Systems and methods for analyzing datasets |
US10844372B2 (en) | 2017-05-26 | 2020-11-24 | 10X Genomics, Inc. | Single cell analysis of transposase accessible chromatin |
SG11201901822QA (en) | 2017-05-26 | 2019-03-28 | 10X Genomics Inc | Single cell analysis of transposase accessible chromatin |
KR20220124280A (en) | 2017-06-05 | 2022-09-13 | 백톤 디킨슨 앤드 컴퍼니 | Sample indexing for single cells |
GB201711219D0 (en) | 2017-07-12 | 2017-08-23 | Illumina Cambridge Ltd | Short pendant arm linkers for nucleotides in sequencing applications |
SG11202002516WA (en) | 2017-09-21 | 2020-04-29 | Genapsys Inc | Systems and methods for nucleic acid sequencing |
GB201716931D0 (en) | 2017-10-16 | 2017-11-29 | Illumina Cambridge Ltd | New fluorescent compounds and their use as biomarkers |
EP3954782A1 (en) | 2017-11-15 | 2022-02-16 | 10X Genomics, Inc. | Functionalized gel beads |
US10829815B2 (en) | 2017-11-17 | 2020-11-10 | 10X Genomics, Inc. | Methods and systems for associating physical and genetic properties of biological particles |
WO2019195166A1 (en) | 2018-04-06 | 2019-10-10 | 10X Genomics, Inc. | Systems and methods for quality control in single cell processing |
US11365409B2 (en) | 2018-05-03 | 2022-06-21 | Becton, Dickinson And Company | Molecular barcoding on opposite transcript ends |
ES2945191T3 (en) | 2018-05-03 | 2023-06-29 | Becton Dickinson Co | High-throughput multi-omics sample analysis |
JP2022511398A (en) | 2018-10-01 | 2022-01-31 | ベクトン・ディキンソン・アンド・カンパニー | Determining the 5'transcription sequence |
KR102313444B1 (en) * | 2018-10-15 | 2021-10-15 | 세종대학교산학협력단 | Cellulose nanofiber comprising biocompatible inorganic material on the surface thereof and polymer composites having the same |
EP3894552A1 (en) | 2018-12-13 | 2021-10-20 | Becton, Dickinson and Company | Selective extension in single cell whole transcriptome analysis |
US11293061B2 (en) | 2018-12-26 | 2022-04-05 | Illumina Cambridge Limited | Sequencing methods using nucleotides with 3′ AOM blocking group |
WO2020150356A1 (en) | 2019-01-16 | 2020-07-23 | Becton, Dickinson And Company | Polymerase chain reaction normalization through primer titration |
EP4242322A3 (en) | 2019-01-23 | 2023-09-20 | Becton, Dickinson and Company | Oligonucleotides associated with antibodies |
WO2020178231A1 (en) | 2019-03-01 | 2020-09-10 | Illumina, Inc. | Multiplexed fluorescent detection of analytes |
KR20210134210A (en) | 2019-03-01 | 2021-11-09 | 일루미나 케임브리지 리미티드 | Tertiary amine substituted coumarin compounds and their use as fluorescent labels |
NL2023327B1 (en) | 2019-03-01 | 2020-09-17 | Illumina Inc | Multiplexed fluorescent detection of analytes |
SG11202012555UA (en) | 2019-03-01 | 2021-01-28 | Illumina Cambridge Ltd | Exocyclic amine-substituted coumarin compounds and their uses as fluorescent labels |
US11421271B2 (en) | 2019-03-28 | 2022-08-23 | Illumina Cambridge Limited | Methods and compositions for nucleic acid sequencing using photoswitchable labels |
WO2021092386A1 (en) | 2019-11-08 | 2021-05-14 | Becton Dickinson And Company | Using random priming to obtain full-length v(d)j information for immune repertoire sequencing |
KR20220107231A (en) | 2019-11-27 | 2022-08-02 | 일루미나 케임브리지 리미티드 | Dyes and compositions containing cyclooctatetraene |
US11649497B2 (en) | 2020-01-13 | 2023-05-16 | Becton, Dickinson And Company | Methods and compositions for quantitation of proteins and RNA |
AU2021209907A1 (en) | 2020-01-24 | 2022-07-07 | Slingshot Biosciences, Inc. | Compositions and methods for cell-like calibration particles |
WO2021231779A1 (en) | 2020-05-14 | 2021-11-18 | Becton, Dickinson And Company | Primers for immune repertoire profiling |
CN115867560A (en) | 2020-06-22 | 2023-03-28 | 伊鲁米纳剑桥有限公司 | Nucleosides and nucleotides having 3' acetal capping groups |
US20220033900A1 (en) | 2020-07-28 | 2022-02-03 | Illumina Cambridge Limited | Substituted coumarin dyes and uses as fluorescent labels |
WO2022096294A2 (en) | 2020-11-03 | 2022-05-12 | Droplet Genomics, Uab | Integrated platform for selective microfluidic particle processing |
US11739443B2 (en) | 2020-11-20 | 2023-08-29 | Becton, Dickinson And Company | Profiling of highly expressed and lowly expressed proteins |
US20220195516A1 (en) | 2020-12-17 | 2022-06-23 | Illumina Cambridge Limited | Methods, systems and compositions for nucleic acid sequencing |
US20220195517A1 (en) | 2020-12-17 | 2022-06-23 | Illumina Cambridge Limited | Long stokes shift chromenoquinoline dyes and uses in sequencing applications |
US20220195196A1 (en) | 2020-12-17 | 2022-06-23 | Illumina Cambridge Limited | Alkylpyridinium coumarin dyes and uses in sequencing applications |
US20220195518A1 (en) | 2020-12-22 | 2022-06-23 | Illumina Cambridge Limited | Methods and compositions for nucleic acid sequencing |
EP4334327A1 (en) | 2021-05-05 | 2024-03-13 | Illumina Cambridge Limited | Fluorescent dyes containing bis-boron fused heterocycles and uses in sequencing |
CA3216735A1 (en) | 2021-05-20 | 2022-11-24 | Patrizia IAVICOLI | Compositions and methods for sequencing by synthesis |
WO2023288225A1 (en) * | 2021-07-13 | 2023-01-19 | 10X Genomics, Inc. | Methods for preparing polymerized matrix with controllable thickness |
CA3222829A1 (en) | 2021-12-16 | 2023-06-22 | Gabriele CANZI | Methods for metal directed cleavage of surface-bound polynucleotides |
CA3223274A1 (en) | 2021-12-20 | 2023-06-29 | Illumina, Inc. | Periodate compositions and methods for chemical cleavage of surface-bound polynucleotides |
CA3222842A1 (en) | 2021-12-20 | 2023-06-29 | Oliver MILLER | Periodate compositions and methods for chemical cleavage of surface-bound polynucleotides |
WO2023186815A1 (en) | 2022-03-28 | 2023-10-05 | Illumina Cambridge Limited | Labeled avidin and methods for sequencing |
AU2023246772A1 (en) | 2022-03-29 | 2024-01-18 | Illumina Inc. | Chromenoquinoline dyes and uses in sequencing |
AU2023246691A1 (en) | 2022-03-30 | 2024-01-18 | Illumina, Inc. | Methods for chemical cleavage of surface-bound polynucleotides |
WO2023192900A1 (en) | 2022-03-31 | 2023-10-05 | Illumina Singapore Pte. Ltd. | Nucleosides and nucleotides with 3' vinyl blocking group useful in sequencing by synthesis |
WO2023186982A1 (en) | 2022-03-31 | 2023-10-05 | Illumina, Inc. | Compositions and methods for improving sequencing signals |
WO2023232829A1 (en) | 2022-05-31 | 2023-12-07 | Illumina, Inc | Compositions and methods for nucleic acid sequencing |
US20230416279A1 (en) | 2022-06-28 | 2023-12-28 | Illumina Cambridge Limited | Fluorescent dyes containing fused tetracyclic bis-boron heterocycle and uses in sequencing |
WO2024039516A1 (en) | 2022-08-19 | 2024-02-22 | Illumina, Inc. | Third dna base pair site-specific dna detection |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0386644A2 (en) * | 1989-03-10 | 1990-09-12 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Reagents for the determination of drugs |
DE3919915A1 (en) * | 1989-06-19 | 1990-12-20 | Boehringer Mannheim Gmbh | AMINOALKYLMALEIMIDES AND DERIVED HAPTEN AND ANTIGEN DERIVATIVES AND CONJUGATES WITH PEPTIDES OR PROTEINS |
US5582955A (en) * | 1994-06-23 | 1996-12-10 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon | Chemical functionalization of surfaces |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3826678A (en) * | 1972-06-06 | 1974-07-30 | Atomic Energy Commission | Method for preparation of biocompatible and biofunctional materials and product thereof |
US4315998A (en) * | 1974-06-12 | 1982-02-16 | Research Corporation | Polymer-bound photosensitizing catalysts |
GB8530715D0 (en) | 1985-12-13 | 1986-01-22 | Unilever Plc | Microchemical testing |
US5449602A (en) * | 1988-01-13 | 1995-09-12 | Amoco Corporation | Template-directed photoligation |
CA2028804C (en) * | 1989-11-21 | 2000-06-20 | Howard J. Buttery | Biomosaic polymers and method for preparing same |
US5410016A (en) * | 1990-10-15 | 1995-04-25 | Board Of Regents, The University Of Texas System | Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers |
US6051380A (en) * | 1993-11-01 | 2000-04-18 | Nanogen, Inc. | Methods and procedures for molecular biological analysis and diagnostics |
US5605662A (en) * | 1993-11-01 | 1997-02-25 | Nanogen, Inc. | Active programmable electronic devices for molecular biological analysis and diagnostics |
EP0585436B1 (en) * | 1992-02-13 | 2000-05-03 | SurModics, Inc. | Immobilization of chemical species in crosslinked matrices |
RU2041261C1 (en) | 1993-08-11 | 1995-08-09 | Институт молекулярной биологии им.В.А.Энгельгардта РАН | Method for manufacturing of matrix for detecting of mismatches |
US5736257A (en) | 1995-04-25 | 1998-04-07 | Us Navy | Photoactivatable polymers for producing patterned biomolecular assemblies |
US5990193A (en) * | 1995-12-12 | 1999-11-23 | University Of Pittsburgh | Polymers for reversible photoinduced sol gel transitions |
US5861247A (en) | 1996-01-26 | 1999-01-19 | University Of Chicago | Rapid method to detect duplex formation in sequencing by hybridization methods |
US5942555A (en) | 1996-03-21 | 1999-08-24 | Surmodics, Inc. | Photoactivatable chain transfer agents and semi-telechelic photoactivatable polymers prepared therefrom |
US5905024A (en) * | 1996-12-17 | 1999-05-18 | University Of Chicago | Method for performing site-specific affinity fractionation for use in DNA sequencing |
US5932711A (en) | 1997-03-05 | 1999-08-03 | Mosaic Technologies, Inc. | Nucleic acid-containing polymerizable complex |
US5858653A (en) | 1997-09-30 | 1999-01-12 | Surmodics, Inc. | Reagent and method for attaching target molecules to a surface |
US5962578A (en) | 1997-11-19 | 1999-10-05 | Amcol International Corporation | Poly(dialkylaminoalkyl (meth)acrylamide)-based superabsorbent gels |
US6391937B1 (en) | 1998-11-25 | 2002-05-21 | Motorola, Inc. | Polyacrylamide hydrogels and hydrogel arrays made from polyacrylamide reactive prepolymers |
US6174683B1 (en) * | 1999-04-26 | 2001-01-16 | Biocept, Inc. | Method of making biochips and the biochips resulting therefrom |
US6372813B1 (en) * | 1999-06-25 | 2002-04-16 | Motorola | Methods and compositions for attachment of biomolecules to solid supports, hydrogels, and hydrogel arrays |
US6423818B1 (en) * | 1999-07-30 | 2002-07-23 | Takehisa Matsuda | Coumarin endcapped absorbable polymers |
US20020103348A1 (en) * | 1999-12-27 | 2002-08-01 | Fuji Photo Film Co., Ltd. | DNA chip and its preparation |
-
1999
- 1999-06-25 US US09/344,620 patent/US6372813B1/en not_active Expired - Lifetime
-
2000
- 2000-06-23 AU AU56362/00A patent/AU768326B2/en not_active Ceased
- 2000-06-23 DE DE60013826T patent/DE60013826D1/en not_active Expired - Lifetime
- 2000-06-23 EP EP00941693A patent/EP1190254B1/en not_active Expired - Lifetime
- 2000-06-23 CA CA002378072A patent/CA2378072A1/en not_active Abandoned
- 2000-06-23 WO PCT/US2000/017422 patent/WO2001001143A2/en active Search and Examination
- 2000-06-23 AT AT00941693T patent/ATE276516T1/en not_active IP Right Cessation
- 2000-06-23 JP JP2001507097A patent/JP2003524150A/en active Pending
-
2001
- 2001-10-11 US US09/976,986 patent/US6686161B2/en not_active Expired - Lifetime
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0386644A2 (en) * | 1989-03-10 | 1990-09-12 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Reagents for the determination of drugs |
DE3919915A1 (en) * | 1989-06-19 | 1990-12-20 | Boehringer Mannheim Gmbh | AMINOALKYLMALEIMIDES AND DERIVED HAPTEN AND ANTIGEN DERIVATIVES AND CONJUGATES WITH PEPTIDES OR PROTEINS |
US5582955A (en) * | 1994-06-23 | 1996-12-10 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon | Chemical functionalization of surfaces |
Non-Patent Citations (2)
Title |
---|
BOOKER-MILBURN K.I., COWELL J.K., JIMÉNEZ F.D., SHARPE A., WHITE A.J.: "Stereoselective Intermolecular [2+2] Photocycloaddition Reactions of Tetrahydrophthalic Anhydride and Derivatives with Alkenols and Alkynols", TETRAHEDRON, vol. 55, 1999, pages 5875 - 5887, XP002153920 * |
WALKER M.A.: "The Mitsunobu Reaction: A novel Method for the Synthesis of Bifunctional Maleimide Linkers", TETRAHEDRON LETTERS, vol. 35, no. 5, 1994, pages 665 - 668, XP002153919 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100876256B1 (en) * | 2001-03-30 | 2008-12-26 | 유씨비 소시에떼아노님 | Substrate, its manufacturing method and uses |
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AU5636200A (en) | 2001-01-31 |
EP1190254A2 (en) | 2002-03-27 |
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JP2003524150A (en) | 2003-08-12 |
US6372813B1 (en) | 2002-04-16 |
ATE276516T1 (en) | 2004-10-15 |
US6686161B2 (en) | 2004-02-03 |
US20030078314A1 (en) | 2003-04-24 |
CA2378072A1 (en) | 2001-01-04 |
EP1190254B1 (en) | 2004-09-15 |
DE60013826D1 (en) | 2004-10-21 |
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