WO2001001893A1 - Zwischenwirbelimplantat - Google Patents

Zwischenwirbelimplantat Download PDF

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Publication number
WO2001001893A1
WO2001001893A1 PCT/EP1999/004628 EP9904628W WO0101893A1 WO 2001001893 A1 WO2001001893 A1 WO 2001001893A1 EP 9904628 W EP9904628 W EP 9904628W WO 0101893 A1 WO0101893 A1 WO 0101893A1
Authority
WO
WIPO (PCT)
Prior art keywords
implant according
receptacle
joint insert
implant
intervertebral implant
Prior art date
Application number
PCT/EP1999/004628
Other languages
English (en)
French (fr)
Inventor
Thierry Marnay
Boris Beyersdorff
Original Assignee
Spine Solutions Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26062622&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2001001893(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to DE29911422U priority Critical patent/DE29911422U1/de
Priority to MXPA01013413A priority patent/MXPA01013413A/es
Priority to NZ51641099A priority patent/NZ516410A/xx
Priority to EP07004657.8A priority patent/EP1795155B1/de
Priority to AU72245/00A priority patent/AU780719B2/en
Priority to PCT/EP1999/004628 priority patent/WO2001001893A1/de
Priority to DE29924985U priority patent/DE29924985U1/de
Priority to EP99931246A priority patent/EP1194088B1/de
Priority to BR9917397-2A priority patent/BR9917397A/pt
Application filed by Spine Solutions Inc. filed Critical Spine Solutions Inc.
Priority to ES99931246T priority patent/ES2303381T3/es
Priority to KR1020027000016A priority patent/KR100665981B1/ko
Priority to JP2001507397A priority patent/JP4192262B2/ja
Priority to DE59914691T priority patent/DE59914691D1/de
Priority to CA002391330A priority patent/CA2391330C/en
Priority to AT99931246T priority patent/ATE388677T1/de
Priority to US10/018,402 priority patent/US6936071B1/en
Priority to ARP000103349A priority patent/AR024632A1/es
Publication of WO2001001893A1 publication Critical patent/WO2001001893A1/de
Priority to US10/998,951 priority patent/US8506634B2/en
Priority to AU2005200994A priority patent/AU2005200994B2/en
Priority to AU2005200997A priority patent/AU2005200997B2/en
Priority to AU2005200993A priority patent/AU2005200993B2/en
Priority to AU2005200991A priority patent/AU2005200991B2/en
Priority to US11/185,781 priority patent/US8974530B2/en
Priority to US11/766,182 priority patent/US8795371B2/en
Priority to US13/777,076 priority patent/US8882839B2/en
Priority to US14/605,055 priority patent/US9526624B2/en

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Classifications

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    • A61F2002/30878Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves with non-sharp protrusions, for instance contacting the bone for anchoring, e.g. keels, pegs, pins, posts, shanks, stems, struts
    • A61F2002/30884Fins or wings, e.g. longitudinal wings for preventing rotation within the bone cavity
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    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
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    • A61F2/30771Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
    • A61F2002/30878Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves with non-sharp protrusions, for instance contacting the bone for anchoring, e.g. keels, pegs, pins, posts, shanks, stems, struts
    • A61F2002/30891Plurality of protrusions
    • A61F2002/30892Plurality of protrusions parallel
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    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/30767Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2/30771Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
    • A61F2002/30904Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves serrated profile, i.e. saw-toothed
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    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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    • A61F2002/3093Special external or bone-contacting surface, e.g. coating for improving bone ingrowth for promoting ingrowth of bone tissue
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    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
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    • A61F2/44Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/442Intervertebral or spinal discs, e.g. resilient
    • A61F2/4425Intervertebral or spinal discs, e.g. resilient made of articulated components
    • A61F2002/443Intervertebral or spinal discs, e.g. resilient made of articulated components having two transversal endplates and at least one intermediate component
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    • A61F2220/00Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
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    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0004Rounded shapes, e.g. with rounded corners
    • A61F2230/0013Horseshoe-shaped, e.g. crescent-shaped, C-shaped, U-shaped
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    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0017Angular shapes
    • AHUMAN NECESSITIES
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    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0036Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in thickness
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005The prosthesis being constructed from a particular material
    • A61F2310/00011Metals or alloys
    • A61F2310/00023Titanium or titanium-based alloys, e.g. Ti-Ni alloys

Definitions

  • the invention relates to an intervertebral implant with an upper part having a support surface for a vertebral body and a lower part having a support surface for an adjacent vertebral body, on each of which access elements for a handling instrument are arranged which are accessible from one side of the intervertebral implant.
  • Such an intervertebral implant is known for example from US-A-5,314,477.
  • This intervertebral implant is used to replace an intervertebral disc removed from the intervertebral space, and accordingly the intervertebral implant must have a relatively low overall height since it must fit into the intervertebral space. This is particularly difficult when an additional joint insert is embedded between the upper part and the lower part, as is the case with the known intervertebral implant of US Pat. No. 5,314,477.
  • This object is achieved according to the invention in an intervertebral implant of the type described at the outset in that the upper part and lower part each have directed projections or recesses on the other part, which are laterally offset from one another in such a way that they engage in one another when the upper part approaches the lower part, and in that the attack elements on the upper part and on the lower part are each arranged in projections of these parts such that the attack elements of the upper part and lower part lie next to one another and at least partially overlap in the direction of the height of the intervertebral implant.
  • the engagement elements are plug-in openings for pin-shaped holding elements of a handling instrument, these plug-in openings can have a relatively large diameter due to the construction described and thus accommodate strong holding pins, and nevertheless there is a relatively low overall height of the intervertebral implant with parts placed directly on top of one another.
  • the insertion openings extend substantially parallel to the support surfaces, and this also avoids that the overall height of the intervertebral implant parts is increased.
  • the lower part has a central depression opposite the lower support surface, which is surrounded by a U-shaped edge.
  • the depression thus serves to accommodate a projection on the upper part when the lower part and upper part lie directly on top of one another.
  • the upper part has an essentially complementary central projection which fits into the recess, ie the entire volume of the recess is used for the projection.
  • the engagement elements of the lower part are arranged at the two ends of the U-shaped edge, that is to say they are on the outside.
  • attack elements of the upper part can be arranged on the central projection of the upper part, are therefore further inward compared to the attack elements of the upper part.
  • the engagement elements of the upper part can be arranged near the lateral edges of the central projection, so that the distance between the engagement elements can also be chosen to be relatively large for the upper part, as a result of which the upper part and the lower part can be reliably secured against tilting.
  • the upper part and / or the lower part are essentially plate-shaped, these parts naturally having projections and recesses which face the respective other part in accordance with the configuration according to the invention.
  • the plate-shaped design leads overall to a very low overall height of the intervertebral implant.
  • both the lower part and the upper part each have a receptacle for a joint insert.
  • This joint insert which is placed between the upper part and lower part after the insertion of the intervertebral implant, supports the upper part and lower part against each other, it takes over, for example, a resilient function and also leads to a certain pivotability of the two parts of an intervertebral implant relative to one another, so that pivoting of the adjacent vertebral bodies can also be achieved.
  • the joint insert has at least one spherical support surface which engages in the correspondingly spherically shaped receptacle.
  • the spherical receptacle is arranged in a central projection of the upper part.
  • the joint insert can be inserted from the side into the receptacle that carries the engagement elements for a handling instrument. This is the side from which the upper part and lower part are inserted into the intervertebral space, and from this side the joint insert can then also be inserted between the parts of the intervertebral implant that have already been inserted.
  • joint insert can be inserted into the receptacle along a guide.
  • the insert is also preferably essentially plate-shaped. A particularly favorable embodiment results when the insert essentially completely fills the central receptacle and projects from the receptacle with the spherical support surface.
  • FIG. 1 shows a perspective exploded view of an intervertebral implant with an upper part, a lower part and a joint insert which can be inserted between them;
  • FIG. 2 shows a perspective exploded view of the upper part and the lower part of the intervertebral implant without an inserted joint
  • FIG. 3 a view similar to FIG. 2 with the joint insert inserted into the lower part;
  • Figure 4 is a perspective view of the upper part and the lower part of the intervertebral implant in maximum mutual approximation
  • FIG. 5 a front view of the intervertebral implant of FIG. 4;
  • Figure 6 a perspective view of the intervertebral implant with inserted joint insert and
  • FIG. 7 a cross-sectional view of the intervertebral implant of FIG. 6.
  • the intervertebral implant 1 shown in the drawing comprises three parts, namely a plate-shaped upper part 2, a plate-shaped lower part 3 and a largely plate-shaped joint insert 4.
  • the upper part 2 is flat on its upper side, so that this creates a support surface 5, on which various projections 6, 7 are arranged, which serve to anchor the upper part 2 in a vertebral bone, which with its end surface facing an intervertebral space on the support surface 5 rests.
  • the upper part 2 has an essentially rectangular cross section, with a longitudinal edge 8 being bent outwards in the exemplary embodiment shown.
  • the thickness of the plate-shaped upper part 2 is smaller than in the central area, so that along the narrow sides of the upper part 2, recesses 9 pointing downward and running parallel to these edges are formed, which are open to the outside. Between the two recesses 9 there is the central region of the upper part 2, which thus has a greater thickness or height and thus has a downward-facing projection formed between the two recesses 9.
  • jump 10 trains This is delimited by an underside 11 which runs essentially parallel to the supporting surface 5 and in which there is a spherical depression 12, which forms a bearing shell for the joint insert 4.
  • the lower part 3 of the intervertebral implant 1 is also plate-shaped and has on its underside a flat support surface 13 with projections 14 and 15, which correspond to the projections 6 and 7 of the support surface 5.
  • the thickness of the lower part 3 is smaller in the central area than in an external area.
  • This outer region of greater thickness has the shape of a U with two parallel legs 16, 17, which run parallel to the narrow edges of the lower part 3, which is similar in cross section to the upper part 2, and with one connecting the two legs 16 and 17 on one side Web 18.
  • the area enclosed by the legs 16 and 17 and the web 18 forms a central recess 19, the area of which corresponds essentially to the area of the central projection 10 of the upper part 2, while the arrangement and extension of the legs 16 and 17 essentially the arrangement and extension of the recesses 9 on the upper part 2 correspond. It is thereby possible to place the upper part 2 and lower part 3 on top of one another such that the central projection 10 of the upper part 2 is immersed in the central recess 19, while the legs 16 and 17 of the lower part 3 are immersed in the recesses 9 of the upper part 2 (FIG. 4), In this position, upper part 2 and lower part 3 are maximally approximated to one another and have a minimal overall height. The dimensions are chosen so that essentially the respective recesses are completely filled by the immersed projections.
  • blind hole bores 22 and 23 are machined in the vicinity of the side edges thereof, which run parallel to the blind hole bores 20 and 21 in the lower part 3.
  • These blind holes 22 and 23 also have a relatively large diameter, which corresponds to a substantial part of the height of the projection 10 and is greater than the thickness of the upper part 2 in the region of the recesses 9.
  • the blind holes 20 and 21 of the lower part 3 and the blind holes 22 and 23 of the upper part 2 overlap at least partially in the direction of the height of the intervertebral implant 1, as can be seen from the illustration of the figures 4 and 5 becomes clear.
  • the blind holes 20, 21, 22 and 23 serve as receptacles for pin-shaped extensions of a handling instrument, not shown in the drawing and thus form attack elements for this handling instrument, which acts separately on the upper part 2 and on the lower part 3 in this way.
  • This handling instrument it is possible to insert the upper part 2 and lower part 3 of the intervertebral implant 1 into an intervertebral space, the very low overall height of the intervertebral implant 1 facilitating this insertion, which is essentially possible without a large expansion of the intervertebral space.
  • the two parts of the intervertebral implant 1 can be spread apart, i.e. their distance is increased, for example, with the aid of the handling instrument holding the upper part 2 and the lower part 3.
  • This joint insert 4 is essentially constructed in the form of a plate which has a flat underside 24 and a spherically curved top 25.
  • the outer dimensions of the plate-shaped joint insert 4 correspond to those of the central recess 19 in the lower part 3, so that the joint insert 4 can be pushed into this recess to fill it, from the side to which the blind holes 20, 21, 22, 23 open , Guide strips 26 engage on the side edges of the joint insert 4 in corresponding guide grooves 27 in the legs 16, 17, so that an insertion guide for the joint insert 4 is formed. det, which determine this after insertion in the lower part 3.
  • the inserted joint insert 4 fills in the depression 19 and protrudes with its spherically curved upper side 25 upwards over the upper side of the lower part 3, the spherical upper side 25 plunges complementarily into the spherically curved recess 12 on the underside of the projection 10 and there forms with upper part 2 a ball joint which allows the upper part 2 to be pivoted relative to the lower part 3 (FIG. 7).
  • the joint insert 4 can carry a latching projection 28 on its flat underside 24, which resiliently engages in a latching recess 29 when the joint insert 4 is inserted into the lower part 3, which recess is located at the bottom of the recess 19; as a result, the joint insert 4 is also fixed in the recess 19 in the direction of insertion.
  • Upper part 2 and lower part 3 are preferably made of body-compatible metal, for example titanium, while the joint insert 4 is preferably made of a body-compatible plastic material, for example made of polyethylene.
  • These support surfaces 5 and 13 can be made particularly bone-compatible, for example, this surface can be roughened by a coating, so that there is an optimal anchoring with the adjacent bone material.

Abstract

Um bei einem Zwischenwirbelimplantat (1) mit einem eine Stützfläche (5) für einen Wirbelkörper aufweisenden Oberteil (2) und einem eine Stützfläche (13) für einen benachbarten Wirbelkörper aufweisenden Unterteil (3), an denen jeweils von einer Seite des Zwischenwirbelimplantats her zugängliche Angriffselemente (20, 21, 22, 23) für ein Handhabungsinstrument angeordnet sind, die Bauhöhe des Zwischenwirbelimplantats (1) beim Einführen in einen Zwischenwirbelraum zu minimieren, wird vorgeschlagen, dass Oberteil (2) und Unterteil (3) jeweils zum anderen Teil gerichtete Vor- bzw. Rückspünge (9, 10, 16, 17, 19) aufweisen, die seitlich so gegeneinander versetzt sind, dass sie bei an das Unterteil (3) angenähertem Oberteil (2) ineinander eingreifen, und dass die Angriffselemente (20, 21, 22, 23) am Oberteil (2) und am Unterteil (3) jeweils in Vorsprüngen (10, 16, 17) dieser Teile derart angeordnet sind, dass die Angriffselemente (20, 21, 22, 23) von Oberteil (2) und Unterteil (3) nebeneinander liegen und sich in Richtung der Höhe des Zwischenwirbelimplantats (1) zumindest teilweise überlappen.

Description

ZWISCHENWIRBELIMPLANTAT
Die Erfindung betrifft ein Zwischenwirbelimplantat mit einem eine Stützfläche für einen Wirbelkörper aufweisenden Oberteil und einem eine Stützfläche für einen benachbarten Wirbelkörper aufweisenden Unterteil, an denen jeweils von einer Seite des Zwischenwirbelimplantats her zugängliche Angriffselemente für ein Handhabungsinstrument angeordnet sind.
Ein derartiges Zwischenwirbelimplantat ist beispielsweise aus der US-A-5,314,477 bekannt. Dieses Zwischenwirbelimplantat dient dem Ersetzen einer aus dem Zwischenwirbelraum entfernten Bandscheibe, und dementsprechend muß das Zwischenwirbelimplantat eine relativ geringe Bauhöhe aufweisen, da es in den Zwischenwirbel- spalt hineinpassen muß. Dies ist insbesondere dann schwierig, wenn zwischen dem Oberteil und dem Unterteil noch ein zusätzlicher Gelenkeinsatz eingebettet ist, wie dies bei dem bekannten Zwischenwirbelimplantat der US-A-5,314,477 der Fall ist.
Schwierigkeiten ergeben sich aber auch schon bei zweiteiligen Zwischenwirbelimplantaten insbesondere dann, wenn diese an ihren Stützflächen noch Stifte und andere Vorsprünge tragen, die der Verankerung des Zwischenwir- belimplantates im Knochen dienen sollen. Diese können dann häufig nur dadurch eingesetzt werden, daß der Zwischenwirbelraum stark aufgeweitet wird. Dies ist nicht nur sehr schwierig, sondern birgt auch die Gefahr von Verletzungen in sich. Da der Zwischenwirbelraum eine relativ geringe Höhe aufweist, ist es auch schwierig, an den beiden Teilen des Zwischenwirbelimplantates Angriffselemente zu befestigen, an denen ein Handhabungsinstrument angreifen kann. Es ist üblich, derartige Handhabungsinstrumente getrennt am Oberteil und am Unterteil angreifen zu lassen, beispielsweise durch Stifte, die in Bohrungen am Oberteil bzw. am Unterteil eingesteckt werden, so daß mit dem Handhabungsinstrument die beiden Teile des Zwischenwirbelimplantates in den Zwischenwirbelraum eingesetzt und gegebenenfalls auch in ihrem Abstand voneinander verändert werden können, so daß dadurch eine gewisse Aufspreizung des Zwischenwirbelraumes möglich ist. Hierzu wird beispielsweise verwiesen auf das zan- genförmige Handhabungsinstrument in der US-A-5,314, 477.
Aufgrund der großen Kräfte ist es notwendig, für die Angriffselemente eine gewisse Bauhöhe vorzusehen, beispielsweise müssen die Aufnahmebohrungen einen bestimmten Durchmesser aufweisen. Daraus ergibt sich eine minimale Bauhöhe für das Oberteil und für das Unterteil, und bei herkömmlichen Zwischenwirbelimplantaten addieren sich somit die Bauhöhen von Oberteil und Unterteil, so daß selbst beim unmittelbaren Aufeinanderliegen von Oberteil und Unterteil eine relativ große Bauhöhe des Zwischenwirbelimplantates unvermeidlich ist.
Es ist Aufgabe der Erfindung, ein gattungsgemäßes Zwischenwirbelimplantat so auszubilden, daß die minimale Bauhöhe herabgesetzt wird, um das Einführen des Zwischenwirbelimplantates in den Zwischenwirbelraum zu erleichtern. Diese Aufgabe wird bei einem Zwischenwirbelimplantat der eingangs beschriebenen Art erfindungsgemäß dadurch gelöst, daß Oberteil und Unterteil jeweils zum anderen Teil gerichtete Vor- bzw. Rücksprünge aufweisen, die seitlich so gegeneinander versetzt sind, daß sie bei an das Unterteil angenähertem Oberteil ineinander eingreifen, und daß die Angriffselemente am Oberteil und am Unterteil jeweils in Vorsprüngen dieser Teile derart angeordnet sind, daß die Angriffselemente von Oberteil und Unterteil nebeneinander liegen und sich in Richtung der Höhe des Zwischenwirbelimplantats zumindest teilweise überlappen.
Bei einer solchen Ausgestaltung läßt sich eine minimale Bauhöhe der beiden aufeinanderliegenden Zwischenwirbel- implantatsteile erreichen, da die Angriffselemente, die eine minimale Bauhöhe nicht unterschreiten können, jeweils in Vorsprüngen von Oberteil bzw. Unterteil angeordnet sind, also in den Teilen mit der größten Bauhöhe von Oberteil und Unterteil. Diese Bereiche großer Bauhöhe sind als Vorsprünge ausgebildet, neben denen sich jeweils Rücksprünge befinden, in die die Vorsprünge des jeweils anderen Teils eintauchen können. Daraus ergibt sich einmal, daß die Angriffselemente für die Handhabungsinstrumente nebeneinander liegen, und zum anderen, daß diese sich zumindest teilweise überlappen können, so daß die Gesamtbauhöhe der aufeinanderliegenden Teile des Zwischenwirbelimplantates gegenüber herkömmlichen Zwischenwirbelimplantaten deutlich herabgesetzt werden kann. Es ergibt sich somit eine verschachtelte Anordnung von Oberteil und Unterteil mit maximaler Ausnützung der zur Verfügung stehenden Materialhöhe. Dabei ist es günstig, wenn die Angriffselemente Einstecköffnungen für stiftförmige Halteelemente eines Handhabungsinstrumentes sind, diese Einstecköffnungen können aufgrund der beschriebenen Konstruktion einen relativ großen Durchmesser aufweisen und damit kräftige Haltestifte aufnehmen, und trotzdem ergibt sich eine relativ geringe Bauhöhe des Zwischenwirbelimplantates bei unmittelbar aufeinandergelegten Teilen.
Dabei ist es vorteilhaft, wenn sich die Einstecköffnungen im wesentlichen parallel zu den Stützflächen erstrecken, auch dadurch wird vermieden, daß die Bauhöhe der Zwischenwirbelimplantatsteile vergrößert wird.
Bei einer bevorzugten Ausführungsform ist vorgesehen, daß das Unterteil eine der unteren Stützfläche gegenüberliegende zentrale Vertiefung aufweist, die von einem U-förmigen Rand umgeben ist. Die Vertiefung dient also bei unmittelbar aufeinanderliegendem Unterteil und Oberteil der Aufnahme eines Vorsprunges am Oberteil.
Dabei ist es vorteilhaft, wenn das Oberteil einen im wesentlichen komplementär in die Vertiefung passenden zentralen Vorsprung trägt, es wird also das gesamte Volumen der Vertiefung für den Vorsprung ausgenutzt.
Es ist weiterhin vorteilhaft, wenn die Angriffselemente des Unterteils an den beiden Enden des U-förmigen Randes angeordnet sind, also außen liegen.
Die Angriffselemente des Oberteils können dagegen an dem zentralen Vorsprung des Oberteils angeordnet sein, liegen also gegenüber den Angriffselementen des Oberteils weiter innen.
Insbesondere können die Angriffselemente des Oberteils nahe der seitlichen Ränder des zentralen Vorsprungs angeordnet sein, so daß auch für das Oberteil der Abstand der Angriffselemente relativ groß gewählt werden kann, dadurch läßt sich das Oberteil ebenso wie das Unterteil gegen eine Verkippung zuverlässig sichern.
Bereits hier sei darauf hingewiesen, daß die Ausdrücke "Unterteil" und "Oberteil" nicht unbedingt etwas über die Einbaulage des Zwischenwirbelimplantates in der Wirbelsäule aussagen, das mit "Unterteil" bezeichnete Teil könnte in der Wirbelsäule tatsächlich auch oben liegen. Wesentlich ist lediglich, daß Oberteil und Unterteil das Zwischenwirbelimplantat auf einander gegenüberliegenden Seiten des Implantates begrenzen.
Besonders vorteilhaft ist es, wenn das Oberteil und/ oder das Unterteil im wesentlichen plattenförmig ausgebildet sind, wobei diese Teile natürlich entsprechend der erfindungsgemäßen Ausgestaltung Vor- und Rücksprünge aufweisen, die dem jeweils anderen Teil zugewandt sind. Die plattenförmige Ausbildung führt aber insgesamt zu einer sehr geringen Bauhöhe des Zwischenwirbelimplantates.
Bei einer bevorzugten Ausführungsform weisen sowohl das Unterteil als auch das Oberteil je eine Aufnahme für einen Gelenkeinsatz auf. Dieser Gelenkeinsatz, der nach dem Einsetzen des Zwischenwirbelimplantates zwischen Oberteil und Unterteil plaziert wird, stützt Oberteil und Unterteil gegeneinander ab, er übernimmt beispielsweise eine federnde Funktion und führt außerdem zu einer gewissen Verschwenkbarkeit der beiden Teile eines Zwischenwirbelimplantates gegeneinander, so daß damit auch eine Verschwenkbarkeit der benachbarten Wirbel- körper erreichbar ist.
Insbesondere ist es vorteilhaft, wenn der Gelenkeinsatz mindestens eine kugelige Stützfläche aufweist, die in die entsprechend kugelig geformte Aufnahme eingreift.
Günstig ist es, wenn die kugelige Aufnahme in einem zentralen Vorsprung des Oberteils angeordnet ist.
Es ist weiterhin vorteilhaft, wenn die zentrale Vertiefung des Unterteils die Aufnahme für den Gelenkeinsatz bildet.
Gemäß einer bevorzugten Ausführungsform der Erfindung ist vorgesehen, daß der Gelenkeinsatz von der Seite in die Aufnahme einschiebbar ist, die die Angriffselemente für ein Handhabungsinstrument trägt. Es handelt sich dabei um die Seite, von der Oberteil und Unterteil in den Zwischenwirbelraum eingeführt werden, und von dieser Seite her kann dann auch der Gelenkeinsatz zwischen die bereits eingesetzten Teile des Zwischenwirbelimplantats eingeschoben werden.
Dabei ist es günstig, wenn der Gelenkeinsatz längs einer Führung in die Aufnahme einschiebbar ist.
Auch der Einsatz ist vorzugsweise im wesentlichen plat- tenförmig ausgebildet. Eine besonders günstige Ausgestaltung ergibt sich, wenn der Einsatz die zentrale Aufnahme im wesentlichen vollständig ausfüllt und mit der kugeligen Stützfläche aus der Aufnahme hervorsteht.
Die nachfolgende Beschreibung bevorzugter Ausführungs- formen der Erfindung dient im Zusammenhang mit der Zeichnung der näheren Erläuterung. Es zeigen:
Figur 1: eine perspektivische Explosionsansicht eines Zwischenwirbelimplantates mit einem Oberteil, einem Unterteil und einem zwischen diese einsetzbaren Gelenkeinsatz;
Figur 2: eine perspektivische Explosionsansicht des Oberteils und des Unterteils des Zwischenwirbelimplantates ohne eingesetzten Gelenkeinsatz;
Figur 3: eine Ansicht ähnlich Figur 2 mit in das Unterteil eingeschobenem Gelenkeinsatz;
Figur 4: eine perspektivische Ansicht des Oberteils und des Unterteils des Zwischenwirbelimplantates in maximaler gegenseitiger Annäherung;
Figur 5: eine Vorderansicht des Zwischenwirbel- implantats der Figur 4; Figur 6: eine perspektivische Ansicht des Zwischenwirbelimplantates mit eingesetztem Gelenkeinsatz und
Figur 7: eine Querschnittsansicht des Zwischenwirbelimplantats der Figur 6.
Das in der Zeichnung dargestellte Zwischenwirbelimplantat 1 umfaßt drei Teile, nämlich ein plattenförmiges Oberteil 2, ein plattenförmiges Unterteil 3 und einen weitgehend plattenförmig ausgebildeten Gelenkeinsatz 4.
Das Oberteil 2 ist an seiner Oberseite eben ausgebildet, so daß dadurch eine Stützfläche 5 entsteht, auf der verschiedenartige Vorsprünge 6, 7 angeordnet sind, die der Verankerung des Oberteils 2 in einem Wirbelknochen dienen, der mit seiner einem Zwischenwirbelraum zugewandten Endfläche auf der Stützfläche 5 aufliegt.
Das Oberteil 2 hat einen im wesentlichen rechteckigen Querschnitt, wobei in dem dargestellten Ausführungsbei- spiel eine Längskante 8 nach außen gebogen ist.
An den beiden Schmalseiten dieses Rechteckes ist die Dicke des plattenförmigen Oberteiles 2 kleiner als im zentralen Bereich, so daß sich längs der schmalen Seiten des Oberteils 2 jeweils parallel zu diesen Kanten verlaufende, nach unten weisende Rücksprünge 9 ausbilden, die zur Außenseite hin offen sind. Zwischen den beiden Rücksprüngen 9 befindet sich der zentrale Bereich des Oberteils 2, der somit eine größere Dicke oder Höhe aufweist und somit einen zwischen den beiden Rücksprüngen 9 ausgebildeten, nach unten weisenden Vor- sprung 10 ausbildet. Dieser wird durch eine im wesentlichen parallel zur Stützfläche 5 verlaufende Unterseite 11 begrenzt, in der sich eine kugelige Vertiefung 12 befindet, diese bildet eine Lagerschale aus für den Gelenkeinsatz 4.
Das Unterteil 3 des Zwischenwirbelimplantates 1 ist ebenfalls plattenförmig ausgebildet und weist an seiner Unterseite eine ebene Stützfläche 13 mit VorSprüngen 14 und 15 auf, die den VorSprüngen 6 und 7 der Stützfläche 5 entsprechen. Auf der der Stützfläche 13 abgewandten Seite ist die Dicke des Unterteils 3 im zentralen Bereich geringer als in einem außenliegenden Bereich. Dieser außenliegende Bereich mit größerer Dicke hat die Form eines U mit zwei parallelen Schenkeln 16, 17, die parallel zu den Schmalkanten des im Querschnitt ähnlich wie das Oberteil 2 ausgebildeten Unterteiles 3 verlaufen, und mit einem die beiden Schenkel 16 und 17 an einer Seite verbindenden Steg 18. Der von den Schenkeln 16 und 17 und dem Steg 18 eingeschlossene Bereich bildet eine zentrale Vertiefung 19, deren Fläche im wesentlichen der Fläche des zentralen Vorsprunges 10 des Oberteils 2 entspricht, während die Anordnung und die Erstreckung der Schenkel 16 und 17 im wesentlichen der Anordnung und Erstreckung der Rücksprünge 9 am Oberteil 2 entsprechen. Es ist dadurch möglich, Oberteil 2 und Unterteil 3 so aufeinanderzulegen, daß der zentrale Vorsprung 10 des Oberteils 2 in die zentrale Vertiefung 19 eintaucht, während die Schenkel 16 und 17 des Unterteils 3 in die Rücksprünge 9 des Oberteils 2 eintauchen (Figur 4), in dieser Stellung sind Oberteil 2 und Unterteil 3 maximal einander angenähert und weisen eine minimale Bauhöhe auf. Die Abmessungen sind dabei so gewählt, daß im wesentlichen die jeweiligen Rücksprünge durch die eintauchenden Vorsprünge vollständig ausgefüllt werden.
In die beiden Schenkel 16 und 17 des Unterteils 3 sind von deren freien Enden her parallel zu diesen Schenkeln 16, 17 verlaufend Sacklochbohrungen 20 und 21 eingearbeitet, deren Durchmesser im Verhältnis zur Höhe der Schenkel 16, 17 relativ groß ist, dieser Durchmesser ist tatsächlich größer als die Dicke oder Höhe des Unterteils 3 im Bereich der zentralen Vertiefung 19.
In den zentralen Vorsprung 10 des Oberteils 2 sind in der Nähe von dessen Seitenkanten Sacklochbohrungen 22 und 23 eingearbeitet, die parallel zu den Sacklochbohrungen 20 und 21 im Unterteil 3 verlaufen. Auch diese Sacklochbohrungen 22 und 23 haben einen relativ großen Durchmesser, der einem wesentlichen Teil der Höhe des Vorsprunges 10 entspricht und größer ist als die Dicke des Oberteils 2 im Bereich der Rücksprünge 9.
Wenn Oberteil 2 und Unterteil 3 in der beschriebenen Weise dicht aneinander anliegen, überlappen sich die Sacklochbohrungen 20 und 21 des Unterteils 3 und die Sacklochbohrungen 22 und 23 des Oberteils 2 in Richtung der Höhe des Zwischenwirbelimplantates 1 zumindest teilweise, wie dies aus der Darstellung der Figuren 4 und 5 deutlich wird.
Die Sacklochbohrungen 20, 21, 22 und 23 dienen als Aufnahmen für stiftförmige Verlängerungen eines in der Zeichnung nicht dargestellten Handhabungsinstrumentes und bilden somit Angriffselemente für dieses Handhabungsinstrument, welches auf diese Weise getrennt am Oberteil 2 und am Unterteil 3 angreift. Es ist mit diesem HandhabungsInstrument möglich, Oberteil 2 und Unterteil 3 des Zwischenwirbelimplantates 1 in einen Zwischenwirbelraum einzuführen, dabei erleichtert die sehr geringe Bauhöhe des Zwischenwirbelimplantates 1 dieses Einführen, das im wesentlichen ohne große Auf- weitung des Zwischenwirbelraumes möglich ist.
Nach dem Einführen des Oberteils 2 und des Unterteils 3 in diese Weise können die beiden Teile des Zwischenwirbelimplantates 1 aufgespreizt werden, d.h. ihr Abstand wird beispielsweise mit Hilfe des das Oberteil 2 und das Unterteil 3 haltenden Handhabungsinstrumentes vergrößert.
In dieser aufgespreizten Lage von Oberteil 2 und Unterteil 3 ist es möglich, den Gelenkeinsatz 4 zwischen Oberteil 2 und Unterteil 3 einzuschieben.
Dieser Gelenkeinsatz 4 ist im wesentlichen in Form einer Platte aufgebaut, die eine ebene Unterseite 24 und eine kugelig aufgewölbte Oberseite 25 aufweist. Die Außenabmessungen des plattenförmigen Gelenkeinsatzes 4 entsprechen denen der zentralen Vertiefung 19 im Unterteil 3, so daß der Gelenkeinsatz 4 diese Vertiefung ausfüllend in diese eingeschoben werden kann, und zwar von der Seite her, auf die sich die Sacklochbohrungen 20, 21, 22, 23 öffnen. Dabei greifen Führungsleisten 26 an den Seitenkanten des Gelenkeinsatzes 4 in entsprechende Führungsnuten 27 in den Schenkeln 16, 17 ein, so daß eine Einschubführung für den Gelenkeinsatz 4 gebil- det wird, die diesen nach dem Einsetzen im Unterteil 3 festlegen. Der eingeschobene Gelenkeinsatz 4 füllt nach dem Einschieben die Vertiefung 19 aus und steht mit seiner kugelig gewölbten Oberseite 25 nach oben über die Oberseite des Unterteiles 3 hervor, die kugelige Oberseite 25 taucht dabei komplementär in die kugelig gewölbte Vertiefung 12 an der Unterseite des Vorsprunges 10 ein und bildet dort mit Oberteil 2 ein Kugelgelenk aus, welches eine gewisse Verschwenkbarkeit des Oberteils 2 gegenüber dem Unterteil 3 ermöglicht (Figur 7).
Der Gelenkeinsatz 4 kann an seiner ebenen Unterseite 24 einen Rastvorsprung 28 tragen, der beim Einschieben des Gelenkeinsatzes 4 in das Unterteil 3 elastisch in eine Rastausnehmung 29 einrastet, die sich am Boden der Vertiefung 19 befindet; dadurch wird der Gelenkeinsatz 4 auch in Einschubrichtung in der Vertiefung 19 festgelegt.
Oberteil 2 und Unterteil 3 sind vorzugsweise aus körperverträglichem Metall hergestellt, beispielsweise aus Titan, während der Gelenkeinsatz 4 vorzugsweise aus einem ebenfalls körperverträglichen Kunststoffmaterial besteht, beispielsweise aus Polyethylen. Diese Stützflächen 5 bzw. 13 können besonders knochenverträglich ausgebildet sein, beispielsweise kann diese Fläche durch eine Beschichtung aufgerauht werden, so daß sich eine optimale Verankerung mit dem benachbarten Knochenmaterial ergibt.

Claims

PATENTANSPRÜCHE
Zwischenwirbelimplantat ( 1 ) mit einem eine Stützfläche ( 5 ) für einen Wirbelkörper aufweisenden Oberteil (2) und einem eine Stützfläche (13) für einen benachbarten Wirbelkörper aufweisenden Unterteil (3), an denen jeweils von einer Seite des Zwischenwirbelimplantats her zugängliche Angriffselemente (20, 21, 22, 23) für ein Handhabungsinstrument angeordnet sind, dadurch gekennzeichnet, daß Oberteil (2) und Unterteil (3) jeweils zum anderen Teil gerichtete Vor- bzw. Rücksprünge (10, 19; 16, 17, 9) aufweisen, die seitlich so gegeneinander versetzt sind, daß sie bei an das Unterteil ( 3 ) angenähertem Oberteil ( 2 ) ineinander eingreifen, und daß die Angriffselemente (22, 23; 20, 21) am Oberteil (2) und am Unterteil (3) jeweils in Vorsprüngen (10; 16, 17) dieser Teile derart angeordnet sind, daß die Angriffselemente (22, 23; 20, 21) von Oberteil (2) und Unterteil (3) nebeneinander liegen und sich in Richtung der Höhe des Zwischenwirbelimplantats ( 1 ) zumindest teilweise überlappen.
Implantat nach Anspruch 1, dadurch gekennzeichnet, daß die Angriffselemente (20, 21, 22, 23) Ein- stecköffnungen für stiftförmige Halteelemente eines Handhabungsinstrumentes sind.
Implantat nach Anspruch 2, dadurch gekennzeichnet, daß sich die Einstecköffnungen (20, 21, 22, 23) im wesentlichen parallel zu den Stützflächen (5; 13) erstrecken.
Implantat nach einem der voranstehenden Ansprüche, dadurch gekennzeichnet, daß das Unterteil (3) eine der unteren Stützfläche ( 13 ) gegenüberliegende zentrale Vertiefung (19) aufweist, die von einem U-förmigen Rand (16, 17, 18) umgeben ist.
Implantat nach Anspruch 4, dadurch gekennzeichnet, daß das Oberteil (2) einen im wesentlichen komplementär in die Vertiefung (19) passenden zentralen Vorsprung (10) trägt.
6. Implantat nach einem der Ansprüche 4 oder 5, dadurch gekennzeichnet, daß die Angriffselemente (20, 21) des Unterteils (3) an den beiden Enden des U-förmigen Randes (16, 17, 18) angeordnet sind.
7. Implantat nach einem der Ansprüche 5 oder 6, dadurch gekennzeichnet, daß die Angriffselemente (22, 23) des Oberteils (2) an dem zentralen Vorsprung (10) des Oberteils (2) angeordnet sind.
Implantat nach Anspruch 7, dadurch gekennzeichnet, daß die Angriffselemente (22, 23) des Oberteils ( 2 ) nahe der seitlichen Ränder des zentralen Vorsprungs (10) angeordnet sind.
Implantat nach einem der voranstehenden Ansprüche, dadurch gekennzeichnet, daß das Oberteil (2) und/ oder das Unterteil (3) im wesentlichen plattenförmig ausgebildet sind.
10. Implantat nach einem der voranstehenden Ansprüche, dadurch gekennzeichnet, daß das Unterteil (3) und das Oberteil (2) je eine Aufnahme (19; 12) für einen Gelenkeinsatz (4) aufweisen.
11. Implantat nach Anspruch 10, dadurch gekennzeichnet, daß der Gelenkeinsatz (4) mindestens eine kugelige Stützfläche (25) aufweist, die in die entsprechend kugelig geformte Aufnahme ( 12 ) eingreift.
12. Implantat nach Anspruch 11, dadurch gekennzeichnet, daß die kugelige Aufnahme ( 12 ) in dem zentralen Vorsprung (10) des Oberteils (2) angeordnet ist.
13. Implantat nach einem der Ansprüche 10 bis 12, dadurch gekennzeichnet, daß die zentrale Vertiefung (19) des Unterteils (3) die Aufnahme für den Gelenkeinsatz ( 4 ) bildet.
14. Implantat nach Anspruch 13, dadurch gekennzeichnet, daß der Gelenkeinsatz (4) von der Seite in die Aufnahme (19) einschiebbar ist, die die Angriffselemente (20, 21, 22, 23) für ein HandhabungsInstrument trägt.
15. Implantat nach Anspruch 14, dadurch gekennzeichnet, daß der Gelenkeinsatz (4) längs einer Führung (26, 27) in die Aufnahme (19) einschiebbar ist.
16. Implantat nach einem der Ansprüche 10 bis 15, dadurch gekennzeichnet, daß der Gelenkeinsatz (4) im wesentlichen plattenförmig ausgebildet ist.
17. Implantat nach einem der Ansprüche 11 bis 16, dadurch gekennzeichnet, daß der Gelenkeinsatz (4) die zentrale Aufnahme (19) im wesentlichen vollständig ausfüllt und mit der kugeligen Stützfläche (25) aus der Aufnahme (19) hervorsteht.
PCT/EP1999/004628 1999-07-02 1999-07-02 Zwischenwirbelimplantat WO2001001893A1 (de)

Priority Applications (26)

Application Number Priority Date Filing Date Title
JP2001507397A JP4192262B2 (ja) 1999-07-02 1999-07-02 椎間インプラント
CA002391330A CA2391330C (en) 1999-07-02 1999-07-02 Intervertebral implant
NZ51641099A NZ516410A (en) 1999-07-02 1999-07-02 Intervertebral implant
EP07004657.8A EP1795155B1 (de) 1999-07-02 1999-07-02 Zwischenwirbelimplantat
AU72245/00A AU780719B2 (en) 1999-07-02 1999-07-02 Intervertebral implant
PCT/EP1999/004628 WO2001001893A1 (de) 1999-07-02 1999-07-02 Zwischenwirbelimplantat
DE29924985U DE29924985U1 (de) 1999-07-02 1999-07-02 Zwischenwirbelimplantat
EP99931246A EP1194088B1 (de) 1999-07-02 1999-07-02 Zwischenwirbelimplantat
BR9917397-2A BR9917397A (pt) 1999-07-02 1999-07-02 Implante intervertebral
MXPA01013413A MXPA01013413A (es) 1999-07-02 1999-07-02 Implante intervertebral.
ES99931246T ES2303381T3 (es) 1999-07-02 1999-07-02 Implante intervertebral.
KR1020027000016A KR100665981B1 (ko) 1999-07-02 1999-07-02 추간 임플란트
DE59914691T DE59914691D1 (de) 1999-07-02 1999-07-02 Zwischenwirbelimplantat
DE29911422U DE29911422U1 (de) 1999-07-02 1999-07-02 Zwischenwirbelimplantat
US10/018,402 US6936071B1 (en) 1999-07-02 1999-07-02 Intervertebral implant
AT99931246T ATE388677T1 (de) 1999-07-02 1999-07-02 Zwischenwirbelimplantat
ARP000103349A AR024632A1 (es) 1999-07-02 2000-06-30 Implante intervertebral
US10/998,951 US8506634B2 (en) 1999-07-02 2004-11-30 Intervertebral implant
AU2005200991A AU2005200991B2 (en) 1999-07-02 2005-03-04 Intervertebral implant
AU2005200994A AU2005200994B2 (en) 1999-07-02 2005-03-04 Intervertebral implant
AU2005200993A AU2005200993B2 (en) 1999-07-02 2005-03-04 Intervertebral implant
AU2005200997A AU2005200997B2 (en) 1999-07-02 2005-03-04 Intervertebral implant
US11/185,781 US8974530B2 (en) 1999-07-02 2005-07-21 Intervertebral implant
US11/766,182 US8795371B2 (en) 1999-07-02 2007-06-21 Intervertebral implant
US13/777,076 US8882839B2 (en) 1999-07-02 2013-02-26 Intervertebral implant
US14/605,055 US9526624B2 (en) 1999-07-02 2015-01-26 Intervertebral implant

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DE29911422U DE29911422U1 (de) 1999-07-02 1999-07-02 Zwischenwirbelimplantat
PCT/EP1999/004628 WO2001001893A1 (de) 1999-07-02 1999-07-02 Zwischenwirbelimplantat

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US10/018,402 A-371-Of-International US6936071B1 (en) 1999-07-02 1999-07-02 Intervertebral implant
US10018402 A-371-Of-International 1999-07-02
US10/998,951 Continuation US8506634B2 (en) 1999-07-02 2004-11-30 Intervertebral implant
US11/185,781 Continuation US8974530B2 (en) 1999-07-02 2005-07-21 Intervertebral implant

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EP (2) EP1194088B1 (de)
JP (1) JP4192262B2 (de)
AR (1) AR024632A1 (de)
AT (1) ATE388677T1 (de)
AU (5) AU780719B2 (de)
BR (1) BR9917397A (de)
CA (1) CA2391330C (de)
DE (3) DE59914691D1 (de)
ES (1) ES2303381T3 (de)
MX (1) MXPA01013413A (de)
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EP1194088A1 (de) 2002-04-10
US8882839B2 (en) 2014-11-11
BR9917397A (pt) 2002-03-05
US20050267581A1 (en) 2005-12-01
DE29924985U1 (de) 2007-09-06
US9526624B2 (en) 2016-12-27
US20050085917A1 (en) 2005-04-21
EP1194088B1 (de) 2008-03-12
EP1795155B1 (de) 2014-03-19
AU2005200994B2 (en) 2008-01-10
EP1795155A3 (de) 2007-06-27
ATE388677T1 (de) 2008-03-15
US8974530B2 (en) 2015-03-10
AU2005200991B2 (en) 2008-01-10
AU2005200994A1 (en) 2005-04-07
EP1795155A2 (de) 2007-06-13
US8795371B2 (en) 2014-08-05
DE29911422U1 (de) 1999-08-12
NZ516410A (en) 2004-12-24
AU2005200993B2 (en) 2008-01-10
CA2391330C (en) 2008-11-18
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AU7224500A (en) 2001-01-22
US8506634B2 (en) 2013-08-13
AU2005200997B2 (en) 2008-01-10
AU2005200991A1 (en) 2005-04-07
AU2005200997A1 (en) 2005-04-07
US6936071B1 (en) 2005-08-30
US20130173005A1 (en) 2013-07-04
JP2003503154A (ja) 2003-01-28
AU2005200993A1 (en) 2005-04-07
CA2391330A1 (en) 2001-01-11
DE59914691D1 (de) 2008-04-24
AU780719B2 (en) 2005-04-14
US20070265707A1 (en) 2007-11-15
JP4192262B2 (ja) 2008-12-10
AR024632A1 (es) 2002-10-16
MXPA01013413A (es) 2003-09-04
US20150142113A1 (en) 2015-05-21

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