WO2001001966A3 - Sustained release dosage form unit having latex coating and method of making the same - Google Patents

Sustained release dosage form unit having latex coating and method of making the same Download PDF

Info

Publication number
WO2001001966A3
WO2001001966A3 PCT/US2000/017796 US0017796W WO0101966A3 WO 2001001966 A3 WO2001001966 A3 WO 2001001966A3 US 0017796 W US0017796 W US 0017796W WO 0101966 A3 WO0101966 A3 WO 0101966A3
Authority
WO
WIPO (PCT)
Prior art keywords
dosage form
form unit
latex coating
core
agent
Prior art date
Application number
PCT/US2000/017796
Other languages
French (fr)
Other versions
WO2001001966A9 (en
WO2001001966A2 (en
Inventor
Terry B Mazer
Joseph E Walton
Barbara S Arnholt
Monty L Evans
Ronita K Geckle
Daniel Hamilton
John J Kropczynski Jr
Franka A Murawski
Larry G Tucker
Sherri A Walker
Michael V Walsh
Rhonda E Walsh
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to NZ515756A priority Critical patent/NZ515756A/en
Priority to CA002375085A priority patent/CA2375085A1/en
Priority to JP2001507461A priority patent/JP4970680B2/en
Priority to AU60574/00A priority patent/AU774671B2/en
Priority to EP00946882A priority patent/EP1191925B1/en
Priority to AT00946882T priority patent/ATE303796T1/en
Application filed by Abbott Lab filed Critical Abbott Lab
Priority to DE60022507T priority patent/DE60022507T2/en
Priority to MXPA01013386A priority patent/MXPA01013386A/en
Publication of WO2001001966A2 publication Critical patent/WO2001001966A2/en
Publication of WO2001001966A3 publication Critical patent/WO2001001966A3/en
Priority to NO20016266A priority patent/NO20016266L/en
Publication of WO2001001966A9 publication Critical patent/WO2001001966A9/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer

Abstract

Dosage form unit is provided to deliver one or more beneficial agents into a fluid, such as liquid enteral nutritional product. The dosage form unit includes a core containing at least one beneficial agent, preferably a marker dye, which is dispersible in the fluid. The core also contains a compatible binding agent to bind the beneficial agent together. Additional components of the core may include a plasticizer, a standard flow agent, a lubricant, additional tableting aids and at least one hydrophilic agent. A latex coating encases the core. The latex coating includes a mixture containing a substantially hydrophobic base material, preferably formed from an emulsion of cellulose acetate microspheres, which is capable of defining a matrix-type membrane, and at least one hydrophilic component being dispersible in the fluid. A dispersible beneficial agent is preferred as one of the hydrophilic components of the latex coating to allow immediate release of the beneficial agent therefrom. A method of making the dosage form unit also is provided.
PCT/US2000/017796 1999-07-01 2000-06-28 Sustained release dosage form unit having latex coating and method of making the same WO2001001966A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
CA002375085A CA2375085A1 (en) 1999-07-01 2000-06-28 Sustained release dosage form unit having latex coating and method of making the same
JP2001507461A JP4970680B2 (en) 1999-07-01 2000-06-28 Sustained release dosage unit having latex coating and method for producing the same
AU60574/00A AU774671B2 (en) 1999-07-01 2000-06-28 Sustained release dosage form unit having latex coating and method of making the same
EP00946882A EP1191925B1 (en) 1999-07-01 2000-06-28 Sustained release dosage form unit having latex coating and method of making the same
AT00946882T ATE303796T1 (en) 1999-07-01 2000-06-28 SUSTAINED RELEASE SINGLE DOSE FORM WITH A LATEX COATING AND METHOD FOR PRODUCING THE SAME
NZ515756A NZ515756A (en) 1999-07-01 2000-06-28 Sustained release dosage form unit having latex coating and method of making the same
DE60022507T DE60022507T2 (en) 1999-07-01 2000-06-28 Single dosage form for sustained release with a latex coating and process for its preparation
MXPA01013386A MXPA01013386A (en) 1999-07-01 2000-06-28 Sustained release dosage form unit having latex coating and method of making the same.
NO20016266A NO20016266L (en) 1999-07-01 2001-12-20 Sustained release dosage form unit with latex coating and method of making same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/345,915 US6251432B1 (en) 1999-07-01 1999-07-01 Sustained release dosage form unit having latex coating and method of making the same
US09/345,915 1999-07-01

Publications (3)

Publication Number Publication Date
WO2001001966A2 WO2001001966A2 (en) 2001-01-11
WO2001001966A3 true WO2001001966A3 (en) 2001-07-26
WO2001001966A9 WO2001001966A9 (en) 2002-04-25

Family

ID=23357076

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/017796 WO2001001966A2 (en) 1999-07-01 2000-06-28 Sustained release dosage form unit having latex coating and method of making the same

Country Status (12)

Country Link
US (2) US6251432B1 (en)
EP (2) EP1191925B1 (en)
JP (2) JP4970680B2 (en)
AT (1) ATE303796T1 (en)
AU (1) AU774671B2 (en)
CA (1) CA2375085A1 (en)
DE (1) DE60022507T2 (en)
ES (1) ES2248094T3 (en)
MX (1) MXPA01013386A (en)
NO (1) NO20016266L (en)
NZ (1) NZ515756A (en)
WO (1) WO2001001966A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004530676A (en) * 2001-04-18 2004-10-07 ノストラム・ファーマスーティカルズ・インコーポレイテッド Novel coatings for sustained release pharmaceutical compositions
WO2004112756A1 (en) 2003-06-26 2004-12-29 Isa Odidi Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient
US7051606B2 (en) * 2004-01-30 2006-05-30 Andrx Labs Llc Dosage form holder device and methods for immersion testing
US8394409B2 (en) * 2004-07-01 2013-03-12 Intellipharmaceutics Corp. Controlled extended drug release technology
US10624858B2 (en) 2004-08-23 2020-04-21 Intellipharmaceutics Corp Controlled release composition using transition coating, and method of preparing same
US10064828B1 (en) 2005-12-23 2018-09-04 Intellipharmaceutics Corp. Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems
CN101453993A (en) * 2006-04-03 2009-06-10 伊萨·奥迪迪 Controlled release delivery device comprising an organosol coat
US10960077B2 (en) 2006-05-12 2021-03-30 Intellipharmaceutics Corp. Abuse and alcohol resistant drug composition
US8801688B2 (en) * 2008-10-14 2014-08-12 Mead Johnson Nutrition Company Nutritive substance delivery container
US8523837B2 (en) 2008-10-14 2013-09-03 Mead Johnson Nutrition Company Nutritive substance delivery container
TWI565418B (en) * 2012-02-22 2017-01-11 Terumo Corp Semi - solid nutrition for gastric stoma

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4983399A (en) * 1989-10-18 1991-01-08 Eastman Kodak Company Direct compression carrier composition
EP0425023A2 (en) * 1989-10-23 1991-05-02 Merck & Co. Inc. Cellulosic coating
WO1996021478A1 (en) * 1995-01-13 1996-07-18 Abbott Laboratories Method of adding marker dye to nutritional product
WO1998003161A1 (en) * 1996-07-24 1998-01-29 Dexcel Ltd. Controlled release tablets

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3993073A (en) 1969-04-01 1976-11-23 Alza Corporation Novel drug delivery device
US3854480A (en) 1969-04-01 1974-12-17 Alza Corp Drug-delivery system
US3995631A (en) 1971-01-13 1976-12-07 Alza Corporation Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient
US3760984A (en) 1971-09-29 1973-09-25 Alza Corp Osmotically powered agent dispensing device with filling means
US3948254A (en) 1971-11-08 1976-04-06 Alza Corporation Novel drug delivery device
US3921636A (en) 1973-01-15 1975-11-25 Alza Corp Novel drug delivery device
US4177256A (en) 1973-04-25 1979-12-04 Alza Corporation Osmotic bursting drug delivery device
US3993072A (en) 1974-08-28 1976-11-23 Alza Corporation Microporous drug delivery device
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
US4200098A (en) 1978-10-23 1980-04-29 Alza Corporation Osmotic system with distribution zone for dispensing beneficial agent
US4285987A (en) 1978-10-23 1981-08-25 Alza Corporation Process for manufacturing device with dispersion zone
US4968507A (en) * 1984-06-20 1990-11-06 Merck & Co., Inc. Controlled porosity osmotic pump
US4874365A (en) * 1984-10-11 1989-10-17 Baxter International Inc. Feeding tube facilitating improved placement and permitting subsequent delivery of a second prescribed product and method therefor
US4839281A (en) 1985-04-17 1989-06-13 New England Medical Center Hospitals, Inc. Lactobacillus strains and methods of selection
US4838862A (en) 1986-08-04 1989-06-13 Pharmetrix Corp. Portable controlled release osmotic infusion device
US4832690A (en) 1987-01-23 1989-05-23 Baxter International Inc. Needle-pierceable cartridge for drug delivery
US4927411A (en) 1987-05-01 1990-05-22 Abbott Laboratories Drive mechanism for disposable fluid infusion pumping cassette
IL92966A (en) * 1989-01-12 1995-07-31 Pfizer Dispensing devices powered by hydrogel
ES2064564T3 (en) * 1989-09-21 1995-02-01 American Cyanamid Co PULSE PRESSURE RELEASE SYSTEM OF DAILY UNIT DOSE OF MINOCYCLINE.
JP3078859B2 (en) * 1990-02-23 2000-08-21 武田薬品工業株式会社 Coating agent for stable controlled release formulation
US5324280A (en) 1990-04-02 1994-06-28 Alza Corporation Osmotic dosage system for delivering a formulation comprising liquid carrier and drug
US5443459A (en) 1991-01-30 1995-08-22 Alza Corporation Osmotic device for delayed delivery of agent
WO1993002558A1 (en) 1991-08-01 1993-02-18 Biogaia Biologics Ab Method and formulation for reducing microbial populations
US5200195A (en) 1991-12-06 1993-04-06 Alza Corporation Process for improving dosage form delivery kinetics
US5160742A (en) 1991-12-31 1992-11-03 Abbott Laboratories System for delivering an active substance for sustained release
US5221278A (en) 1992-03-12 1993-06-22 Alza Corporation Osmotically driven delivery device with expandable orifice for pulsatile delivery effect
US5358721A (en) 1992-12-04 1994-10-25 Alza Corporation Antiviral therapy
ATE195252T1 (en) * 1993-04-23 2000-08-15 Novartis Erfind Verwalt Gmbh DRUG DELIVERY DEVICE WITH CONTROLLED RELEASE
ES2107235T3 (en) * 1993-06-14 1997-11-16 Janssen Pharmaceutica Nv PROLONGED RELEASE TABLET, COATED WITH FILM, ASTEMIZOL AND PSEUDOEFEDRINA.
US5451409A (en) 1993-11-22 1995-09-19 Rencher; William F. Sustained release matrix system using hydroxyethyl cellulose and hydroxypropyl cellulose polymer blends
US5531682A (en) 1995-01-13 1996-07-02 Abbott Laboratories Apparatus for adding marker dye to nutritional product during enternal tube feeding
US5531734A (en) 1995-01-13 1996-07-02 Abbott Laboratories Method of altering composition of nutritional product during enteral tube feeding
US5533973A (en) 1995-01-13 1996-07-09 Abbott Laboratories Alteration of nutritional product during enteral tube feeding
US5531681A (en) 1995-01-13 1996-07-02 Abbott Laboratories Apparatus for altering composition of nutritional product during enteral tube feeding

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4983399A (en) * 1989-10-18 1991-01-08 Eastman Kodak Company Direct compression carrier composition
EP0425023A2 (en) * 1989-10-23 1991-05-02 Merck & Co. Inc. Cellulosic coating
WO1996021478A1 (en) * 1995-01-13 1996-07-18 Abbott Laboratories Method of adding marker dye to nutritional product
US5549550A (en) * 1995-01-13 1996-08-27 Abbott Laboratories Method of adding marker dye to nutritional product during enteral tube feeding
WO1998003161A1 (en) * 1996-07-24 1998-01-29 Dexcel Ltd. Controlled release tablets

Also Published As

Publication number Publication date
EP1191925A2 (en) 2002-04-03
JP2003503444A (en) 2003-01-28
JP4970680B2 (en) 2012-07-11
US6620434B2 (en) 2003-09-16
DE60022507D1 (en) 2005-10-13
EP1579853A2 (en) 2005-09-28
EP1191925B1 (en) 2005-09-07
US6251432B1 (en) 2001-06-26
ATE303796T1 (en) 2005-09-15
NO20016266L (en) 2002-02-27
NZ515756A (en) 2003-08-29
US20010024663A1 (en) 2001-09-27
MXPA01013386A (en) 2002-07-22
CA2375085A1 (en) 2001-01-11
JP2012144542A (en) 2012-08-02
DE60022507T2 (en) 2006-07-13
AU774671B2 (en) 2004-07-01
ES2248094T3 (en) 2006-03-16
AU6057400A (en) 2001-01-22
WO2001001966A2 (en) 2001-01-11
NO20016266D0 (en) 2001-12-20

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