WO2001004118A3 - Quinuclidine derivatives and their use as muscarinic m3 receptor ligands - Google Patents
Quinuclidine derivatives and their use as muscarinic m3 receptor ligands Download PDFInfo
- Publication number
- WO2001004118A3 WO2001004118A3 PCT/EP2000/006469 EP0006469W WO0104118A3 WO 2001004118 A3 WO2001004118 A3 WO 2001004118A3 EP 0006469 W EP0006469 W EP 0006469W WO 0104118 A3 WO0104118 A3 WO 0104118A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- muscarinic
- receptor ligands
- quinuclidine derivatives
- quinuclidine
- derivatives
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
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- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
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- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/14—Antitussive agents
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/06—Anti-spasmodics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
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-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Priority Applications (40)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE60001840.7T DE60001840T4 (en) | 1999-07-14 | 2000-07-07 | CHINUCLIDIN DERIVATIVES AND THEIR USE AS MUSCARIN M3 RECEPTOR LIGANDS |
CA2381165A CA2381165C (en) | 1999-07-14 | 2000-07-07 | Novel quinuclidine derivatives and medicinal compositions containing the same |
JP2001509727A JP4030040B2 (en) | 1999-07-14 | 2000-07-07 | Quinuclidine derivatives and their use as muscarinic M3 receptor ligands |
SK43-2002A SK287480B6 (en) | 1999-07-14 | 2000-07-07 | Quinuclidine derivatives, a method for producing them, medicinal compositions containing the same and the use of them |
EP00951361.5A EP1200431B3 (en) | 1999-07-14 | 2000-07-07 | Quinuclidine derivatives and their use as muscarinic m3 receptors ligands |
BRPI0012434A BRPI0012434B8 (en) | 1999-07-14 | 2000-07-07 | quinuclidine ester compounds useful as muscarinic m3 receptor antagonists |
AU64330/00A AU779881C (en) | 1999-07-14 | 2000-07-07 | Quinuclidine derivates and their use as muscarinic M3 receptor ligands |
HU0202100A HU228594B1 (en) | 1999-07-14 | 2000-07-07 | Novel quinuclidine derivatives, process for their preparation and medicinal compositions containing the same |
EEP200200017A EE04915B3 (en) | 1999-07-14 | 2000-07-07 | Quinuclidine derivatives, a method for preparing thereof, intermediates, a pharmaceutical composition, and use thereof |
ES951361T ES2193098T7 (en) | 1999-07-14 | 2000-07-07 | Quinuclidine derivatives and their use as ligands for M3 muscarinic receptors |
SI200030108T SI1200431T1 (en) | 1999-07-14 | 2000-07-07 | Quinuclidine derivatives and their use as muscarinic m3 receptors ligands |
UA2002010323A UA73509C2 (en) | 1999-07-14 | 2000-07-07 | Quinuclidine derivatives and use thereof as ligands of muscarinic м3-receptor |
DK00951361.5T DK1200431T6 (en) | 1999-07-14 | 2000-07-07 | Quinuclidine derivatives and their use as muscarinic M3 receptor ligands |
IL14753300A IL147533A0 (en) | 1999-07-14 | 2000-07-07 | Novel quinuclidine derivatives and medicinal compositions containing the same |
AT00951361T ATE235492T1 (en) | 1999-07-14 | 2000-07-07 | QUINUCLIDINE DERIVATIVES AND THEIR USE AS MUSCARIN M3 RECEPTOR LIGANDS |
DE60001840A DE60001840D1 (en) | 1999-07-14 | 2000-07-07 | CHINUCLIDIN DERIVATIVES AND THEIR USE AS MUSCARIN M3 RECEPTOR LIGANDS |
PL357160A PL204024B1 (en) | 1999-07-14 | 2000-07-07 | Quinuclidine derivatives and their use as muscarinic m3 receptor ligands |
US10/047,464 US6750226B2 (en) | 1999-07-14 | 2002-01-14 | Quinuclidine derivatives and their use as muscarinic M3 receptor ligands |
NO20020180A NO329484B3 (en) | 1999-07-14 | 2002-01-14 | New quinuclidine derivatives and medicinal compositions containing the same, and their use for the manufacture of medicaments |
HK02103992A HK1042487B (en) | 1999-07-14 | 2002-05-29 | Quinuclidine derivatives and their use as muscarinic m3 receptors ligands |
US10/740,264 US7109210B2 (en) | 1999-07-14 | 2003-12-17 | Quinuclidine derivatives and medicinal compositions containing the same |
US11/116,777 US7078412B2 (en) | 1999-07-14 | 2005-04-28 | Quinuclidine derivatives and medicinal compositions containing the same |
AU2005202144A AU2005202144B2 (en) | 1999-07-14 | 2005-05-18 | Quinuclidine derivatives and their use as muscarinic M3 receptor ligands |
US11/324,919 US7214687B2 (en) | 1999-07-14 | 2006-01-03 | Quinuclidine derivatives and medicinal compositions containing the same |
US11/325,059 US7196098B2 (en) | 1999-07-14 | 2006-01-03 | Quinuclidine derivatives and medicinal compositions containing the same |
US11/636,181 US7358260B2 (en) | 1999-07-14 | 2006-12-08 | Quinuclidine derivatives and medicinal compositions containing the same |
US12/074,929 US7750023B2 (en) | 1999-07-14 | 2008-03-07 | Quinuclidine derivatives and medicinal compositions containing the same |
US12/787,772 US7897617B2 (en) | 1999-07-14 | 2010-05-26 | Quinuclidine derivatives and medicinal compositions containing the same |
US13/011,131 US8129405B2 (en) | 1999-07-14 | 2011-01-21 | Quinuclidine derivatives and medicinal compositions containing the same |
US13/354,873 US8513279B2 (en) | 1999-07-14 | 2012-01-20 | Quinuclidine derivatives and medicinal compositions containing the same |
CY2013001C CY2013001I2 (en) | 1999-07-14 | 2013-01-07 | NEW QUINUCLIDINE DERIVATIVES AND MEDICINAL PREPARATION COMPRISING THEM |
FR13C0001C FR13C0001I2 (en) | 1999-07-14 | 2013-01-08 | QUINUCLIDINE DERIVATIVES AND THEIR USE AS M3 MUSCARINIC RECEPTOR LIGANDS |
NO2013002C NO2013002I2 (en) | 1999-07-14 | 2013-01-18 | Aclidinium salt with a pharmaceutically acceptable anion of a mono- or polyhydric acid, especially aclidinium bromide |
US13/939,742 US8802699B2 (en) | 1999-07-14 | 2013-07-11 | Quinuclidine derivatives and medicinal compositions containing the same |
US14/311,102 US9056100B2 (en) | 1999-07-14 | 2014-06-20 | Quinuclidine derivatives and medicinal compositions containing the same |
US14/712,866 US9333195B2 (en) | 1999-07-14 | 2015-05-14 | Quinuclidine derivatives and medicinal compositions containing the same |
US15/019,009 USRE46417E1 (en) | 1999-07-14 | 2016-02-09 | Quinuclidine derivatives and their use as muscarinic M3 receptor ligands |
US15/095,036 US9687478B2 (en) | 1999-07-14 | 2016-04-09 | Quinuclidine derivatives and medicinal compositions containing the same |
US15/599,646 US10034867B2 (en) | 1999-07-14 | 2017-05-19 | Quinuclidine derivatives and medicinal compositions containing the same |
US16/045,333 US10588895B2 (en) | 1999-07-14 | 2018-07-25 | Quinuclidine derivatives and medicinal compositions containing the same |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009901580A ES2165768B1 (en) | 1999-07-14 | 1999-07-14 | NEW DERIVATIVES OF QUINUCLIDINE AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM. |
ESP9901580 | 1999-07-14 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/047,464 Continuation US6750226B2 (en) | 1999-07-14 | 2002-01-14 | Quinuclidine derivatives and their use as muscarinic M3 receptor ligands |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2001004118A2 WO2001004118A2 (en) | 2001-01-18 |
WO2001004118A3 true WO2001004118A3 (en) | 2001-07-19 |
Family
ID=8309225
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2000/006469 WO2001004118A2 (en) | 1999-07-14 | 2000-07-07 | Quinuclidine derivatives and their use as muscarinic m3 receptor ligands |
Country Status (39)
Country | Link |
---|---|
US (16) | US6750226B2 (en) |
EP (1) | EP1200431B3 (en) |
JP (2) | JP4030040B2 (en) |
KR (3) | KR100854321B1 (en) |
CN (2) | CN1272334C (en) |
AR (1) | AR029760A1 (en) |
AT (1) | ATE235492T1 (en) |
AU (1) | AU2005202144B2 (en) |
BE (1) | BE2013C001I2 (en) |
BG (1) | BG65565B1 (en) |
BR (1) | BRPI0012434B8 (en) |
CA (1) | CA2381165C (en) |
CO (1) | CO5200759A1 (en) |
CY (1) | CY2013001I2 (en) |
CZ (1) | CZ304292B6 (en) |
DE (2) | DE60001840T4 (en) |
DK (1) | DK1200431T6 (en) |
EE (1) | EE04915B3 (en) |
EG (1) | EG24066A (en) |
ES (2) | ES2165768B1 (en) |
FR (1) | FR13C0001I2 (en) |
HK (1) | HK1042487B (en) |
HU (1) | HU228594B1 (en) |
IL (1) | IL147533A0 (en) |
LU (1) | LU92132I2 (en) |
MY (1) | MY126959A (en) |
NO (2) | NO329484B3 (en) |
PE (1) | PE20010397A1 (en) |
PL (1) | PL204024B1 (en) |
PT (1) | PT1200431E (en) |
RU (2) | RU2264401C3 (en) |
SI (1) | SI1200431T1 (en) |
SK (1) | SK287480B6 (en) |
TR (1) | TR200200768T2 (en) |
TW (1) | TWI284644B (en) |
UA (1) | UA73509C2 (en) |
UY (2) | UY26244A1 (en) |
WO (1) | WO2001004118A2 (en) |
ZA (1) | ZA200200232B (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9056100B2 (en) | 1999-07-14 | 2015-06-16 | Almirall, S.A. | Quinuclidine derivatives and medicinal compositions containing the same |
US9254262B2 (en) | 2008-03-13 | 2016-02-09 | Almirall, S.A. | Dosage and formulation |
US9463161B2 (en) | 2009-05-29 | 2016-10-11 | Pearl Therapeutics, Inc. | Compositions for pulmonary delivery of long-acting muscarinic antagonists and associated methods and systems |
Families Citing this family (216)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7214687B2 (en) | 1999-07-14 | 2007-05-08 | Almirall Ag | Quinuclidine derivatives and medicinal compositions containing the same |
AR028948A1 (en) * | 2000-06-20 | 2003-05-28 | Astrazeneca Ab | NEW COMPOUNDS |
US20040077605A1 (en) * | 2001-06-20 | 2004-04-22 | Salvati Mark E. | Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function |
US6858593B2 (en) | 2000-08-05 | 2005-02-22 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
US6787532B2 (en) | 2000-08-05 | 2004-09-07 | Smithkline Beecham Corporation | Formulation containing anti-inflammatory androstane derivatives |
US6759398B2 (en) | 2000-08-05 | 2004-07-06 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative |
US6750210B2 (en) | 2000-08-05 | 2004-06-15 | Smithkline Beecham Corporation | Formulation containing novel anti-inflammatory androstane derivative |
US6777399B2 (en) | 2000-08-05 | 2004-08-17 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
US6777400B2 (en) | 2000-08-05 | 2004-08-17 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
US6858596B2 (en) | 2000-08-05 | 2005-02-22 | Smithkline Beecham Corporation | Formulation containing anti-inflammatory androstane derivative |
GB0019172D0 (en) | 2000-08-05 | 2000-09-27 | Glaxo Group Ltd | Novel compounds |
WO2002051841A1 (en) * | 2000-12-22 | 2002-07-04 | Almirall Prodesfarma Ag | Quinuclidine carbamate derivatives and their use as m3 antagonists |
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US9056100B2 (en) | 1999-07-14 | 2015-06-16 | Almirall, S.A. | Quinuclidine derivatives and medicinal compositions containing the same |
US9333195B2 (en) | 1999-07-14 | 2016-05-10 | Almirall, S.A. | Quinuclidine derivatives and medicinal compositions containing the same |
US9254262B2 (en) | 2008-03-13 | 2016-02-09 | Almirall, S.A. | Dosage and formulation |
US9463161B2 (en) | 2009-05-29 | 2016-10-11 | Pearl Therapeutics, Inc. | Compositions for pulmonary delivery of long-acting muscarinic antagonists and associated methods and systems |
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