WO2001008792A3 - Charged filtration membranes and uses therefor - Google Patents

Charged filtration membranes and uses therefor Download PDF

Info

Publication number
WO2001008792A3
WO2001008792A3 PCT/US2000/019964 US0019964W WO0108792A3 WO 2001008792 A3 WO2001008792 A3 WO 2001008792A3 US 0019964 W US0019964 W US 0019964W WO 0108792 A3 WO0108792 A3 WO 0108792A3
Authority
WO
WIPO (PCT)
Prior art keywords
charge
filtration membranes
protein
uses therefor
charged filtration
Prior art date
Application number
PCT/US2000/019964
Other languages
French (fr)
Other versions
WO2001008792A2 (en
Inventor
Reis Robert D Van
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Priority to EP00947589A priority Critical patent/EP1200179B8/en
Priority to DE60028210T priority patent/DE60028210T2/en
Priority to AU61169/00A priority patent/AU778022B2/en
Priority to JP2001513512A priority patent/JP3833533B2/en
Priority to IL14786100A priority patent/IL147861A/en
Priority to CA002379413A priority patent/CA2379413A1/en
Publication of WO2001008792A2 publication Critical patent/WO2001008792A2/en
Publication of WO2001008792A3 publication Critical patent/WO2001008792A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0081—After-treatment of organic or inorganic membranes
    • B01D67/0093—Chemical modification
    • B01D67/00933—Chemical modification by addition of a layer chemically bonded to the membrane
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0081—After-treatment of organic or inorganic membranes
    • B01D67/0093—Chemical modification
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/145—Ultrafiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/02—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/08—Polysaccharides
    • B01D71/10—Cellulose; Modified cellulose
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/08—Polysaccharides
    • B01D71/12—Cellulose derivatives
    • B01D71/22—Cellulose ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis

Abstract

The invention relates to charged filtration membranes and their use for separation of a protein from solvent, low molecular weight solutes or a mixture of proteins. Modification of the membranes to generate charge includes modification of membrane pores to alter charge within a pore and alter the size of a pore. Consequently, the protein is separated from other solutes in a mixture based on size as well as net protein charge and membrane charge.
PCT/US2000/019964 1999-07-30 2000-07-21 Charged filtration membranes and uses therefor WO2001008792A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP00947589A EP1200179B8 (en) 1999-07-30 2000-07-21 Charged filtration membranes and uses therefor
DE60028210T DE60028210T2 (en) 1999-07-30 2000-07-21 LOADED FILTRATION MEMBRANES AND ITS USES
AU61169/00A AU778022B2 (en) 1999-07-30 2000-07-21 Charged filtration membranes and uses therefor
JP2001513512A JP3833533B2 (en) 1999-07-30 2000-07-21 Charge filtration membrane and its applications
IL14786100A IL147861A (en) 1999-07-30 2000-07-21 Charged filtration membranes and uses thereof
CA002379413A CA2379413A1 (en) 1999-07-30 2000-07-21 Charged filtration membranes and uses therefor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14655899P 1999-07-30 1999-07-30
US60/146,558 1999-07-30

Publications (2)

Publication Number Publication Date
WO2001008792A2 WO2001008792A2 (en) 2001-02-08
WO2001008792A3 true WO2001008792A3 (en) 2001-07-26

Family

ID=22517937

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/019964 WO2001008792A2 (en) 1999-07-30 2000-07-21 Charged filtration membranes and uses therefor

Country Status (11)

Country Link
US (2) US7001550B2 (en)
EP (1) EP1200179B8 (en)
JP (2) JP3833533B2 (en)
AT (1) ATE327033T1 (en)
AU (1) AU778022B2 (en)
CA (1) CA2379413A1 (en)
DE (1) DE60028210T2 (en)
DK (1) DK1200179T3 (en)
ES (1) ES2267552T3 (en)
IL (1) IL147861A (en)
WO (1) WO2001008792A2 (en)

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ATE448866T1 (en) 2003-02-19 2009-12-15 Natrix Separations Inc SUPPORTED POROUS GELS COMPRISING COMPOSITE MATERIALS
US20040206694A1 (en) * 2003-04-16 2004-10-21 John Charkoudian Epoxide-crosslinked, charged cellulosic membrane
ES2350483T3 (en) * 2003-06-13 2011-01-24 Wadström, Torkel PRODUCT FOR ABSORPTION PURPOSES.
JP2005151977A (en) * 2003-10-31 2005-06-16 Fuji Photo Film Co Ltd Method for isolating and purifying nucleic acid
US8075780B2 (en) * 2003-11-24 2011-12-13 Millipore Corporation Purification and concentration of synthetic biological molecules
EP2821135A1 (en) 2004-02-05 2015-01-07 EMD Millipore Corporation Porous adsorptive or chromatographic media
US7425266B2 (en) * 2004-03-04 2008-09-16 Freeman Mark C Water-filtering media and filters
US20060091068A1 (en) * 2004-10-29 2006-05-04 Nieland Steven D Derivatized cellulose filtration media and method for producing same
FR2878451B1 (en) * 2004-11-29 2009-11-06 Otv Sa ELECTROKINETIC METHOD FOR DETERMINING THE STATE OF ELECTROSTATIC CHARGE OF A POROUS MEMBRANE DURING FILTRATION, AND ITS USE
US7353034B2 (en) 2005-04-04 2008-04-01 X One, Inc. Location sharing and tracking using mobile phones or other wireless devices
CN100526453C (en) * 2005-05-20 2009-08-12 麦克奥迪实业集团有限公司 Cell collection method after laser microdissection
US7510654B2 (en) 2005-12-29 2009-03-31 Spf Innovations, Llc Method and apparatus for the filtration of biological samples
KR20140071452A (en) * 2006-04-05 2014-06-11 애브비 바이오테크놀로지 리미티드 Antibody purification
US20100219115A1 (en) * 2007-06-27 2010-09-02 Ge Healthcare Biosciences Corp. System and method for assembling a large scale chromatography structure
EP2188302B1 (en) 2007-07-09 2017-11-01 Genentech, Inc. Prevention of disulfide bond reduction during recombinant production of polypeptides
WO2009017456A1 (en) * 2007-08-01 2009-02-05 Hjerten Stellan Pharmaceutical composition suitable for adsorption to the cell surface of pathogenic microbes
US9433922B2 (en) 2007-08-14 2016-09-06 Emd Millipore Corporation Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same
WO2009042641A2 (en) * 2007-09-24 2009-04-02 Parker-Hannifin Corporation Surface modified filtration media
US20090130738A1 (en) * 2007-11-19 2009-05-21 Mikhail Kozlov Media for membrane ion exchange chromatography
DE102008018732B4 (en) 2008-04-14 2022-06-09 Sartorius Stedim Biotech Gmbh Process for separating substances using a cellulose hydrate membrane in size exclusion chromatography
CA2736814C (en) 2008-09-02 2017-02-28 Natrix Separations Inc. Chromatography membranes, devices containing them, and methods of use thereof
KR20180035936A (en) 2009-08-06 2018-04-06 제넨테크, 인크. Method to improve virus removal in protein purification
US8993294B2 (en) * 2009-08-10 2015-03-31 Danisco Us Inc. Cross-flow membrane filtration-based process for protein recovery
US20120029165A1 (en) * 2010-07-16 2012-02-02 Etzel Mark R Methods and Compositions Involving Whey Protein Isolates
WO2012073566A1 (en) * 2010-12-01 2012-06-07 国立大学法人熊本大学 Pretreatment device for analysis of dissolved ion, dissolved ion analysis system, and pretreatment method for analysis of dissolved ion
WO2012149197A2 (en) 2011-04-27 2012-11-01 Abbott Laboratories Methods for controlling the galactosylation profile of recombinantly-expressed proteins
ES2686340T3 (en) 2011-05-17 2018-10-17 Natrix Separations Inc. Method of using rolled membranes for chromatography
EP2636442A1 (en) 2012-03-05 2013-09-11 Gambro Lundia AB Low cut-off ultrafiltration membranes
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
US9181572B2 (en) 2012-04-20 2015-11-10 Abbvie, Inc. Methods to modulate lysine variant distribution
US9150645B2 (en) 2012-04-20 2015-10-06 Abbvie, Inc. Cell culture methods to reduce acidic species
US9249182B2 (en) 2012-05-24 2016-02-02 Abbvie, Inc. Purification of antibodies using hydrophobic interaction chromatography
CN104507955A (en) 2012-05-31 2015-04-08 新加坡科技研究局 Chromatographic purification of immunoglobulin g preparations with particles having multimodal functionalities
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
CA2883272A1 (en) 2012-09-02 2014-03-06 Abbvie Inc. Methods to control protein heterogeneity
US20140234506A1 (en) * 2013-02-18 2014-08-21 Wisconsin Alumni Research Foundation Methods and compositions for protein concentration
SG11201507230PA (en) 2013-03-12 2015-10-29 Abbvie Inc Human antibodies that bind human tnf-alpha and methods of preparing the same
US10023608B1 (en) 2013-03-13 2018-07-17 Amgen Inc. Protein purification methods to remove impurities
US8921526B2 (en) 2013-03-14 2014-12-30 Abbvie, Inc. Mutated anti-TNFα antibodies and methods of their use
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
US9499614B2 (en) 2013-03-14 2016-11-22 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides
CN103240004B (en) * 2013-05-15 2015-04-15 北京碧水源膜科技有限公司 Charged nanofiltration membrane and preparation method thereof
CN103449572A (en) * 2013-09-18 2013-12-18 上海交通大学 Method for simultaneously recovering dye small molecules and recycling wastewater
WO2015051293A2 (en) 2013-10-04 2015-04-09 Abbvie, Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US8946395B1 (en) 2013-10-18 2015-02-03 Abbvie Inc. Purification of proteins using hydrophobic interaction chromatography
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
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WO2017086668A1 (en) * 2015-11-18 2017-05-26 Nb Postech, Inc. Receptor linked regenerated cellulose membrane and methods for producing and using the same
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US4604204A (en) * 1979-09-19 1986-08-05 Aligena Ag Porous, semipermeable membranes of chemically modified cellulose acetate

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Patent Citations (2)

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GB1504261A (en) * 1975-01-23 1978-03-15 Aligena Ag Porous membrane and a process for its production
US4604204A (en) * 1979-09-19 1986-08-05 Aligena Ag Porous, semipermeable membranes of chemically modified cellulose acetate

Also Published As

Publication number Publication date
DE60028210T2 (en) 2007-03-08
DE60028210D1 (en) 2006-06-29
CA2379413A1 (en) 2001-02-08
US7001550B2 (en) 2006-02-21
IL147861A (en) 2005-08-31
EP1200179A2 (en) 2002-05-02
WO2001008792A2 (en) 2001-02-08
JP2003505243A (en) 2003-02-12
US20030178368A1 (en) 2003-09-25
AU6116900A (en) 2001-02-19
EP1200179B8 (en) 2007-02-21
US7153426B2 (en) 2006-12-26
JP3833533B2 (en) 2006-10-11
EP1200179B1 (en) 2006-05-24
US20060157412A1 (en) 2006-07-20
ES2267552T3 (en) 2007-03-16
DK1200179T3 (en) 2006-09-25
ATE327033T1 (en) 2006-06-15
IL147861A0 (en) 2002-08-14
JP2006110547A (en) 2006-04-27
AU778022B2 (en) 2004-11-11

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