WO2001016166A3 - Polypeptides, comprising il-6 ligand-binding receptor domains, and related nucleic acids, antibodies, compositions, and methods of use - Google Patents

Polypeptides, comprising il-6 ligand-binding receptor domains, and related nucleic acids, antibodies, compositions, and methods of use Download PDF

Info

Publication number
WO2001016166A3
WO2001016166A3 PCT/US2000/023490 US0023490W WO0116166A3 WO 2001016166 A3 WO2001016166 A3 WO 2001016166A3 US 0023490 W US0023490 W US 0023490W WO 0116166 A3 WO0116166 A3 WO 0116166A3
Authority
WO
WIPO (PCT)
Prior art keywords
ligand
polypeptides
antibodies
compositions
methods
Prior art date
Application number
PCT/US2000/023490
Other languages
French (fr)
Other versions
WO2001016166A2 (en
Inventor
Carl Saxinger
Original Assignee
Us Health
Carl Saxinger
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Health, Carl Saxinger filed Critical Us Health
Priority to AU70782/00A priority Critical patent/AU7078200A/en
Priority to US09/721,108 priority patent/US6664374B1/en
Publication of WO2001016166A2 publication Critical patent/WO2001016166A2/en
Publication of WO2001016166A3 publication Critical patent/WO2001016166A3/en
Priority to US10/702,765 priority patent/US7144986B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

The present invention provides polypeptides, and pharmaceutically acceptable salt thereof, that inhibit the binding of IL-6 ligand with IL-6 receptor under physiological conditions, a nucleic acid that encodes such a polypeptide, an antibody that is specific to such a polypeptide, a composition comprising such a polypeptide, a method of prophylactically or therapeutically inhibiting IL-6 signaling in a mammal in need thereof, and a method of removing IL-6 ligand from a bodily fluid of an animal.
PCT/US2000/023490 1999-08-27 2000-08-25 Polypeptides, comprising il-6 ligand-binding receptor domains, and related nucleic acids, antibodies, compositions, and methods of use WO2001016166A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU70782/00A AU7078200A (en) 1999-08-27 2000-08-25 Polypeptides, comprising il-6 ligand-binding receptor domains and related nucleic acids, antibodies, compositions, and methods of use
US09/721,108 US6664374B1 (en) 1999-08-27 2000-11-22 Polypeptides comprising IL-6 ligand-binding receptor domains
US10/702,765 US7144986B2 (en) 1999-08-27 2003-11-05 Polypeptides comprising IL-6 ligand binding receptor domains

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15127799P 1999-08-27 1999-08-27
US60/151,277 1999-08-27

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/721,108 Continuation US6664374B1 (en) 1999-08-27 2000-11-22 Polypeptides comprising IL-6 ligand-binding receptor domains

Publications (2)

Publication Number Publication Date
WO2001016166A2 WO2001016166A2 (en) 2001-03-08
WO2001016166A3 true WO2001016166A3 (en) 2001-06-21

Family

ID=22538041

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/023490 WO2001016166A2 (en) 1999-08-27 2000-08-25 Polypeptides, comprising il-6 ligand-binding receptor domains, and related nucleic acids, antibodies, compositions, and methods of use

Country Status (3)

Country Link
US (2) US6664374B1 (en)
AU (1) AU7078200A (en)
WO (1) WO2001016166A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7078200A (en) * 1999-08-27 2001-03-26 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The Polypeptides, comprising il-6 ligand-binding receptor domains and related nucleic acids, antibodies, compositions, and methods of use
US7078478B2 (en) * 1999-09-02 2006-07-18 GSF-Forschungszentrum für Umwelt Gesundheit, GmbH Inhibition of the proliferation of cells of the multiple myeloma
CA2457164A1 (en) 2001-08-17 2003-02-27 Enkam Pharmaceuticals A/S Compounds capable of affecting differentiation, proliferation, regeneration, plasticity and survival of cells
ATE469921T1 (en) * 2003-08-07 2010-06-15 Enkam Pharmaceuticals As LPA-CONTAINING COMPOUNDS
CA2666599A1 (en) * 2006-08-18 2008-02-21 Ablynx N.V. Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of diseases and disorders associated with il-6-mediated signalling
EP2225272B1 (en) 2007-11-28 2015-10-21 Enkam Pharmaceuticals A/S Peptides derived from ncam (fgls)
EP2417162A2 (en) 2009-04-10 2012-02-15 Ablynx N.V. Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of il-6r related diseases and disorders
WO2010115998A2 (en) 2009-04-10 2010-10-14 Ablynx Nv Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of il-6r related diseases and disorders
WO2013041722A1 (en) 2011-09-23 2013-03-28 Ablynx Nv Prolonged inhibition of interleukin-6 mediated signaling
WO2013181016A2 (en) * 2012-05-27 2013-12-05 Felder Mitchell S Treatment for the rapid amelioration of clinical depression
CN107074954A (en) 2014-10-21 2017-08-18 埃博灵克斯股份有限公司 The treatment of IL 6R relevant diseases
JP7127272B2 (en) * 2017-01-16 2022-08-30 東ソー株式会社 Antagonists against interleukin-6 family cytokines

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997013781A2 (en) * 1995-09-28 1997-04-17 Yeda Research And Development Co. Ltd. Synthetic peptides that inhibit il-6 activity
WO1997048728A1 (en) * 1996-06-20 1997-12-24 Koster, Henk, Wilhelmus Il-6 and il-6-receptor derived peptides having il-6 antagonistic or agonistic activity

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5670373A (en) 1988-01-22 1997-09-23 Kishimoto; Tadamitsu Antibody to human interleukin-6 receptor
US5171840A (en) * 1988-01-22 1992-12-15 Tadamitsu Kishimoto Receptor protein for human B cell stimulatory factor-2
GB8814085D0 (en) * 1988-06-14 1988-07-20 Marshall Cavendish Services Extruded binder spine
CA2026881A1 (en) 1989-02-08 1990-08-09 Masao Tanihara Peptide and adsorbent thereof immobilized on carrier
US5216128A (en) 1989-06-01 1993-06-01 Yeda Research And Development Co., Ltd. IFN-β2/IL-6 receptor its preparation and pharmaceutical compositions containing it
JP2898064B2 (en) 1989-08-03 1999-05-31 忠三 岸本 Human gp130 protein
US6031074A (en) 1989-08-25 2000-02-29 National Institutes Of Health Automated Peptide design and synthesis
US5171570A (en) * 1989-12-08 1992-12-15 Lotte Company Limited Substance having suppressing function for diseases relating to increase in cholesterol, and foods and drinks in which it is used
US5210075A (en) 1990-02-16 1993-05-11 Tanabe Seiyaku Co., Ltd. Interleukin 6 antagonist peptides
RU2139351C1 (en) 1991-04-25 1999-10-10 Чугаи Сейяку Кабусики Кайся H- and l-chains of monoclonal antibody pm-1 (monat) to human il-6r receptor and their v-region, modified monat, its h- and l-chains and their v-regions, cdr-sequence, dna-sequence
US5747244A (en) 1991-12-23 1998-05-05 Chiron Corporation Nucleic acid probes immobilized on polystyrene surfaces
US5869644A (en) 1992-04-15 1999-02-09 The Johns Hopkins University Synthesis of diverse and useful collections of oligonucleotidies
US5591646A (en) 1992-09-02 1997-01-07 Arris Pharmaceutical Method and apparatus for peptide synthesis and screening
US5585275A (en) 1992-09-02 1996-12-17 Arris Pharmaceutical Corporation Pilot apparatus for peptide synthesis and screening
US5702672A (en) 1992-10-08 1997-12-30 Warner-Lambert Company Apparatus and method for multiple simultaneous synthesis
US5324483B1 (en) 1992-10-08 1996-09-24 Warner Lambert Co Apparatus for multiple simultaneous synthesis
AU687763B2 (en) 1992-10-20 1998-03-05 Central Laboratory Of The Netherlands Red Cross Blood Transfusion Service Interleukin-6 receptor antagonists
IT1263022B (en) 1992-11-06 1996-07-23 Angeletti P Ist Richerche Bio INTERLEUCHINA-6 MUTANT WITH IMPROVED BIOLOGICAL ACTIVITY COMPARED TO WILD INTERLEUCHINA-6.
JP3525221B2 (en) 1993-02-17 2004-05-10 味の素株式会社 Immunosuppressants
DK72493D0 (en) 1993-06-18 1993-06-18 Risoe Forskningscenter SOLID SUPPORTS FOR USE IN PEPTIDE SYNTHESIS AND ASSAYS
US5789552A (en) 1993-06-23 1998-08-04 Istituto Di Ricerche Di Biologica Molecolare P. Angeletti S.P.A. Interleukin-6 receptor antagonists
US5470952A (en) 1993-10-20 1995-11-28 Regeneron Pharmaceuticals, Inc. CNTF and IL-6 antagonists
US5472672A (en) 1993-10-22 1995-12-05 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and method for polymer synthesis using arrays
US6015880A (en) 1994-03-16 2000-01-18 California Institute Of Technology Method and substrate for performing multiple sequential reactions on a matrix
IT1274350B (en) 1994-12-06 1997-07-17 Angeletti P Ist Richerche Bio INTERLEUCHINA-6 (IL-6) ANTAGONISTS, WHICH CONSIST OF SOLUBLE FORMS OF THE ALFA RECEPTOR OF IL-6, CHANGED IN THE INTERFACE THAT LINKS TO GP 130
IT1274782B (en) 1994-12-14 1997-07-24 Angeletti P Ist Richerche Bio METHOD FOR SELECTING SUPERAGONISTS, ANTAGONISTS AND SUPERANTAGONISTS OF HORMONES OF WHICH RECEPTOR COMPLEX IS PART OF GP 130
RU2205874C2 (en) 1995-05-11 2003-06-10 Апплайд Резеч Системз Арс Холдинг Н.В. Nucleotide sequence able to inhibit il-6 activity, plasmid vector for transfection into mammalian cells, nucleotide sequence used in therapy, pharmaceutical composition (variants)
US5869696A (en) 1996-04-22 1999-02-09 Beckman Instruments, Inc. Universal solid supports and methods for their use
US5792850A (en) 1996-05-23 1998-08-11 Zymogenetics, Inc. Hematopoietic cytokine receptor
US5874165A (en) 1996-06-03 1999-02-23 Gore Enterprise Holdings, Inc. Materials and method for the immobilization of bioactive species onto polymeric subtrates
US7968696B1 (en) 1996-07-19 2011-06-28 Behring Diagnostics Gmbh Viral interleukin-6
GB9621095D0 (en) 1996-10-09 1996-11-27 Imperial College Novel system
AU7078200A (en) * 1999-08-27 2001-03-26 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The Polypeptides, comprising il-6 ligand-binding receptor domains and related nucleic acids, antibodies, compositions, and methods of use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997013781A2 (en) * 1995-09-28 1997-04-17 Yeda Research And Development Co. Ltd. Synthetic peptides that inhibit il-6 activity
WO1997048728A1 (en) * 1996-06-20 1997-12-24 Koster, Henk, Wilhelmus Il-6 and il-6-receptor derived peptides having il-6 antagonistic or agonistic activity

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HALIMI: "Epitope peptides from interleukin-6 receptor which inhibit the growth of human myeloma cells", EUR. CYTOKINE. NETW., vol. 6, no. 3, 1995, pages 135 - 143, XP000646578 *
KALAI ET AL: "Analysis of the human interleukin-6/human interleukin-6 receptor binding interface at the amino acid level: proposed mechanism of interaction", BLOOD, vol. 89, no. 4, 15 February 1997 (1997-02-15), pages 1319 - 1333, XP002160136 *
TANNER ET AL: "The conserved Box 1 motif of cytokine receptor is required for association with JAK kinases", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 12, 1995, pages 6523 - 6530, XP002082045 *

Also Published As

Publication number Publication date
US20040092720A1 (en) 2004-05-13
AU7078200A (en) 2001-03-26
US7144986B2 (en) 2006-12-05
US6664374B1 (en) 2003-12-16
WO2001016166A2 (en) 2001-03-08

Similar Documents

Publication Publication Date Title
WO2001016166A3 (en) Polypeptides, comprising il-6 ligand-binding receptor domains, and related nucleic acids, antibodies, compositions, and methods of use
Price et al. Matrix Gla protein, a new γ-carboxyglutamic acid-containing protein which is associated with the organic matrix of bone
CA2245496C (en) Receptor protein designated 2f1
WO2002043661B1 (en) Recombinant anti-cd30 antibodies and uses thereof
JP2005503319A5 (en)
JPH06504192A (en) Polypeptides and their uses
JPH03204896A (en) Extracellular fragment of interferon receptor
WO2001058953A3 (en) Identification of a domain in the tumor necrosis factor receptor family that mediates pre-ligand receptor assembly and function
JPH0848636A (en) Antibody
JP2006512894A5 (en)
EP0911633A1 (en) A method of identifying agonists and antagonists for tumor necrosis related receptors TR1, TR3 and TR5
US20020115110A1 (en) Method of identifying agonist and antagonists for tumor necrosis related receptors TR1 and TR2
WO2002036625A3 (en) Prokineticin polypeptides, related compositions and methods
ATE542138T1 (en) HER-2 BINDING ANTAGONISTS
WO1997048804A3 (en) Tie-2 receptor ligands (tie ligand-3; tie ligand-4) and their uses
AU2002258663B2 (en) Control of growth and repair of gastro-intestinal tissues by gastrokines and inhibitors
CA2133873A1 (en) Tnf inhibitors
AU2002258663A1 (en) Control of growth and repair of gastro-intestinal tissues by gastrokines and inhibitors
ZHANG et al. Cysteinyl leukotriene receptors CysLT1 and CysLT2 are upregulated in acute neuronal injury after focal cerebral ischemia in mice 1
DE69925116D1 (en) NEW, PHYSIOLOGICAL ACTIVE PEPTIDES AND THEIR USE.
WO2001064876A3 (en) Human schizophrenia gene
Bernard et al. Immunoreactive forms of pancreatic stone protein in six mammalian species
Corti et al. Identification of two forms (31-33 and 48 kD) of the urinary soluble p55 tumor necrosis factor receptor that are differentially N-and O-glycosylated
Sundan et al. Soluble CD14 from urine copurifies with a potent inducer of cytokines
WO2001090141A3 (en) Gb1c isoform and nucleotides

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 09721108

Country of ref document: US

AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP