WO2001022868A1 - An optical device for non-invasive measurement of blood-related signals utilizing a finger holder - Google Patents

An optical device for non-invasive measurement of blood-related signals utilizing a finger holder Download PDF

Info

Publication number
WO2001022868A1
WO2001022868A1 PCT/IL2000/000603 IL0000603W WO0122868A1 WO 2001022868 A1 WO2001022868 A1 WO 2001022868A1 IL 0000603 W IL0000603 W IL 0000603W WO 0122868 A1 WO0122868 A1 WO 0122868A1
Authority
WO
WIPO (PCT)
Prior art keywords
finger
location
measurements
patient
holder according
Prior art date
Application number
PCT/IL2000/000603
Other languages
French (fr)
Inventor
Alexander Finarov
Yossie Kleinman
Ilya Fine
Original Assignee
Orsense Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orsense Ltd. filed Critical Orsense Ltd.
Priority to AT00964598T priority Critical patent/ATE243467T1/en
Priority to JP2001526088A priority patent/JP2003510120A/en
Priority to DE60003572T priority patent/DE60003572T2/en
Priority to EP00964598A priority patent/EP1217941B1/en
Priority to AU75520/00A priority patent/AU7552000A/en
Publication of WO2001022868A1 publication Critical patent/WO2001022868A1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813Specially adapted to be attached to a specific body part
    • A61B5/6825Hand
    • A61B5/6826Finger
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021Measuring pressure in heart or blood vessels
    • A61B5/022Measuring pressure in heart or blood vessels by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
    • A61B5/02233Occluders specially adapted therefor
    • A61B5/02241Occluders specially adapted therefor of small dimensions, e.g. adapted to fingers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14552Details of sensors specially adapted therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/683Means for maintaining contact with the body
    • A61B5/6838Clamps or clips

Definitions

  • This invention is generally in the field of non-invasive optical measurement techniques for measuring blood parameters and relates to an optical device for measuring blood-related parameters utilizing a finger holder.
  • Non-invasive techniques for measurement of various blood parameters have become very popular, since they advantageously do not require the withdrawal of a blood sample from a patient's body.
  • Optical monitoring techniques of the kind specified typically utilize the detection of light transmitted or reflected from the location on the patient's body under measurement.
  • Most of the known techniques utilize a measurement optical device or probe, designed in a manner to be attached to the patient's finger, which includes an optical assembly for irradiating the finger with light and detecting its light response.
  • US Patent No. 5,810,723 discloses an apparatus for the non-invasive monitoring of a patient's carboxyhemoglobin level. The patient breathes oxygen to saturate his blood hemoglobin prior to detection.
  • the apparatus utilizes a clamp with arms which hold the patient's finger: one arm supports a light emitting source and the other supports a detector. A microprocessor controls the measurements and processes the detected signals.
  • US Patent 5,638,816 and its continuation, US Patent 5,860,919 disclose an apparatus for the non-invasive monitoring of blood parameters by applying pressure to the patient's finger, thus inducing an active pulse therein. The induced change of blood volume enables a better signal-to-noise ratio to be obtained.
  • US 5,782,757 discloses a measuring devices in the form of disposable, folded adhesive sensors with optics embedded therein. The probe is designed so as to fit comfortably onto a patient's fingertip.
  • All the conventional devices of the kind specified are aimed at measuring enhanced optical pulsatile signals caused by the changes in the volume of the blood containing medium (finger). It is known that a regular optical pulsatile signal is typically 2-3% of the total transmission. The above devices are capable of obtaining the enhanced pulsatile signal that reach 8-10% of the total light transmission intensity. This enhancement of the natural pulsatile signal is a boundary of all conventional techniques of the kind specified.
  • the present invention utilizes a non-invasive measurement technique disclosed in co-pending application PCT/IL 99/00331, assigned to the assignee of the present application, where the measured signals are not pulsatile.
  • This is an occlusion based technique, according to which a state of blood flow cessation is created at a measurement location in a blood-perfused fleshy medium, and measurements are taken during this state. Measurements taken during the state of blood flow cessation allow for a significant increase of the blood-related signals, as compared to those taken during the state of normal blood flow.
  • over-systolic pressure is applied to the organ at a location upstream of the measurement location with respect to the direction of normal blood flow.
  • the fmger holder comprises a first member constructed for securing a fingertip and for supporting a measuring unit so as to apply measurements to a first location of the fmger, and a second member associated with a pressurizing assembly for applying pressure to a second location of the fmger spaced-apart from the first location.
  • the first and second members are coupled to each other through a substantially rigid connector engaging the finger along its middle phalanx and proximal intephalangeal joint.
  • the provision of the rigid connector is associated with the following.
  • the occlusion-based measurements are non- volumetric, the changes in volume of blood in the fmger portion under measurements being undesirable for such measurements. However, it is a natural tendency of the finger under pressure to fold at the proximal intephalangeal joint, thereby causing undesirable changes in blood volume.
  • the measuring unit and the pressurizing assembly are connectable to a control unit, which operates them and analyzes data generated by the measuring unit indicative of a light response of the medium at the measurement location.
  • the measurement device may be associated with any other suitable patient's organ, such as his hand or wrist. If the patient's hand is considered, the rigid connector engages the patient's arm to prevent its folding at the elbow joint. It is more practical, however, to apply the device to the patient's fmger.
  • the first member is designed as a clip that secures the fingertip between its legs (either one pair or two pairs of legs).
  • the provision of two pairs of legs advantageously enables to provide four-sided support for the finger, thereby preventing its folding at the distal phalanx.
  • the pressurizing assembly preferably comprises an air cushion cuff presenting the second member of the finger holder, and a pneumatic drive coupled to the cuff for operating inflation/deflation thereof.
  • a first member for securing a fingertip and supporting an optical measuring unit mounted so as to apply measurements to a first location of the patient's finger; - a second member associated with a pressurizing assembly mounted so as to apply desired over-systolic pressure to a second location of the finger located upstream of said first location with respect to a normal blood flow direction; and
  • a device for non- invasive measurements of patient's blood parameters comprising an optical measuring unit, a pressurizing assembly, and a control unit, wherein the finger holder comprises:
  • a first member for securing a fingertip and supporting said optical measuring unit mounted so as to apply measurements to a first location of the patient's finger; - a second member associated with said pressurizing assembly so as to apply desired over-systolic pressure to a second location of the fmger located upstream of said first location with respect to a normal blood flow direction; and
  • FIG. 1 is a schematic illustration of a device for non-invasive measurement of patient's blood parameters utilizing a fmger holder constructed according to one embodiment of the invention; and Fig. 2 illustrates another embodiment of the fmger.
  • a measurement device for the non- invasive measurement of patient's blood parameters, such as oxygen saturation, blood pressure, or the concentration of various substances, such as hemoglobin, glucose, cholesterol and other analyte concentrations.
  • the device 10 includes a fmger holder 12 to be mounted on a patient's finger F, and a control unit 14 coupled to the fmger holder either through wires or wireless.
  • the finger holder 12 includes a clip member 16 (constituting a first member) with a measuring unit 18 installed therein for applying measurements to a measurement location (constituting a first location), a second member in the form of an air cushion cuff 26 of a pressurizing assembly 20 for applying pressure to a second location upstream of the measurement location (with respect to the direction of normal blood flow), and a substantially rigid connector 22.
  • the clip member 16 is a two-legged member for securing the patient's finger F between its legs 16A and 16B that engage the finger F at both its top and bottom, respectively.
  • the pad 24 is coupled to a power source (not shown) which is operated by the control unit 14 for applying appropriate, substantially low voltages, for example in the range 1V-24V to the pad 24, enabling heating of the finger portion located between the clip legs 16A and 16B (i.e., the location under measurements) up to 37-38°.
  • the heating ability of the device increases the accuracy of the non-invasively derived blood-related parameters.
  • the substantially low voltage supply is, on the one hand, acceptable for medical devices, and, on the other hand, requires low power supply (e.g., 6-9V) that allows for using batteries, thereby rendering the entire device conveniently portable.
  • the measuring unit 18 which is partly shown in the figure, does not form part of the present invention, and therefore need not be specifically illustrated and described, except to note the following.
  • the measuring unit 18 comprises both an illumination and detection means that could be accommodated either at one side of the fmger when operating in a reflection mode, or at opposite sides of the finger when operating in a transmission mode. These reflected or transmitted signals present light response of the fmger to incident radiation.
  • the measuring unit 18 provides illumination of the finger F with at least two different wavelengths, and detects light transmitted therethrough.
  • Data indicative of the detected light is transmitted to the control unit 14 (typically through analog-to-digital converter and data processing unit) that includes a processor operated by a suitable software model for determining and analyzing the time dependency of the detected light for each incident wavelength to determine a relation between the time variations corresponding to different wavelengths, and to calculate the desired parameter of blood based on this relation.
  • the control unit 14 typically through analog-to-digital converter and data processing unit
  • a processor operated by a suitable software model for determining and analyzing the time dependency of the detected light for each incident wavelength to determine a relation between the time variations corresponding to different wavelengths, and to calculate the desired parameter of blood based on this relation.
  • the present invention utilizes the measurement of blood-related signals at a state of blood flow cessation at the measurement location.
  • the pressurizing assembly 20 is capable of applying over-systolic pressure, e.g., 270-300mmHg (generally, adjustable for each specific patient) at the second location upstream of the measuring unit 18 with respect to the direction of normal blood flow.
  • the pressurizing assembly 20 includes the air cushion cuff 26 in the form of a ring wrapping the respective location on the patient's fmger F, and a pneumatic drive 28 coupled to the cuff 26 and to the control unit 14.
  • the drive 28 whilst being actuated by the control unit 14, operates to apply over-systolic pressure to the finger portion (second location on the finger) underneath the cuff-ring 26.
  • the application of pressure is maintained for a period of time so as not to cause irreversible changes in the finger, e.g., 4 seconds (generally, lasting from one second to one minute and more).
  • the control unit operates the drive 28 to release the pressure.
  • the effective measurements i.e., the results which have to be analyzed, are those taken at the state of blood flow cessation, as will be described more specifically further below.
  • the connector 22 is shaped like a plate, and is formed with an elongated slot 22A.
  • the cuff-ring 26 is formed with a projection 26A installed in the slot 22 A for reciprocating sliding movement along its axis. This enables to adjust the length of the finger holder 12 to that of the fmger of a specific patient.
  • the rigid plate-like connector 22 engages the finger along its middle phalanx, preventing its folding at the proximal intephalangeal joint, thereby avoiding undesirable changes in blood volume.
  • the operational mode of the device 10 may be such that the control unit 14 actuates the measuring unit 18 for performing continuous measurements starting prior to the application of over-systolic pressure. In this case, only those signals which are associated with the state of blood flow cessation are taken into consideration. Measurements taken during the time period prior to the establishment of this state should be disregarded, due to the unavoidable influence of motional and/or other artifacts causing non-monotonic fluctuations of the light transmission. According to an alternative operational mode of the device 10, the control unit 14 actuates the measuring unit 18 approximately 0.5 sec after the application of the over-systolic pressure.
  • the squeezing action of the cuff 26 is ceased, and after a short delay of about 0.5 sec, the blood flow gradually increases during approximately 5 sec. Then, the control unit 14 actuates the second measurement session at a state of the transitional blood flow.
  • the illumination unit continues to illuminate the fmger, but squeezing is halted.
  • the detection unit being synchronized by the control unit 14, detects the light response of the finger.
  • control unit 14 selectively operates the measuring unit 18 and the pressurizing assembly 20, and analyzes data coming from the measuring unit.
  • the construction and operation of the control unit do not form part of the present invention, and may be of any known kind capable of running an appropriate software model.
  • Fig. 2 illustrating a fmger holder 112 having somewhat different construction of its clip member 116, as compared to that of the finger holder 12.
  • the clip member 116 is a four-leg member, wherein two opposite legs 116A and 116B engage the fmger at its top and bottom thereof, and the other opposite legs 116C and 116D engage the opposite sides of the fmger, respectively.
  • Such four-sided support of the fingertip prevents its folding at the distal phalanx, thereby avoiding undesirable blood volume changes.
  • the connector 22 may be located at either side of the patient's fmger. Alternatively, a pair of such connectors can be used located at opposite sides of the fmger.
  • the processor may be accommodated within the cuff, and the wires, if any, connecting the processor to the output circuit of the measuring unit, may pass through the rigid connector.
  • the cuff 26 may be a band formed with Velcro-like fasteners, so as to form a ring wrapping the patient's finger when in the operational position of the device.
  • a band composed of a set of various air cushions pressuring on the fmger In this case, the pressurizing assembly fits itself to each fmger size without any additional adjusting means.

Abstract

A finger holder (12) for attaching to the patient's finger (F) and an optical measurement (18) device utilizing the finger holder (12) for performing non-invasive measurements of patient's blood parameters are presented. The finger holder (12) comprises first member (16) and second member (26) spaced-apart from each other. The first member (16) is designed to secure a fingertip and to support a measuring unit (18) mounted so as to apply optical measurements to a first location of the finger (F). The second member is associated with a pressurizing assembly (26) mounted to apply desired over-systolic pressure to a second location on the patient's finger upstream of the first location with respect to a normal blood flow direction. A substantially rigid connector (22) connects the first (16) and second (26) members to each other, and is designed to engage the finger (F) along its middle phalanx and proximal interphalangeal joint, thereby preventing it from folding during the measurements, when the over-systolic pressure is applied to the finger.

Description

An Optical Device for Non-Invasive Measurement of Blood-related Signals utilizing a Finger Holder
FIELD OF THE INVENTION
This invention is generally in the field of non-invasive optical measurement techniques for measuring blood parameters and relates to an optical device for measuring blood-related parameters utilizing a finger holder.
BACKGROUND OF THE INVENTION
Non-invasive techniques for measurement of various blood parameters, such as blood oxygen saturation and the concentration of substances contained in the blood, have become very popular, since they advantageously do not require the withdrawal of a blood sample from a patient's body. Optical monitoring techniques of the kind specified typically utilize the detection of light transmitted or reflected from the location on the patient's body under measurement. Most of the known techniques utilize a measurement optical device or probe, designed in a manner to be attached to the patient's finger, which includes an optical assembly for irradiating the finger with light and detecting its light response. US Patent No. 5,810,723 discloses an apparatus for the non-invasive monitoring of a patient's carboxyhemoglobin level. The patient breathes oxygen to saturate his blood hemoglobin prior to detection. The apparatus utilizes a clamp with arms which hold the patient's finger: one arm supports a light emitting source and the other supports a detector. A microprocessor controls the measurements and processes the detected signals. US Patent 5,638,816 and its continuation, US Patent 5,860,919, disclose an apparatus for the non-invasive monitoring of blood parameters by applying pressure to the patient's finger, thus inducing an active pulse therein. The induced change of blood volume enables a better signal-to-noise ratio to be obtained. US 5,782,757 discloses a measuring devices in the form of disposable, folded adhesive sensors with optics embedded therein. The probe is designed so as to fit comfortably onto a patient's fingertip.
All the conventional devices of the kind specified are aimed at measuring enhanced optical pulsatile signals caused by the changes in the volume of the blood containing medium (finger). It is known that a regular optical pulsatile signal is typically 2-3% of the total transmission. The above devices are capable of obtaining the enhanced pulsatile signal that reach 8-10% of the total light transmission intensity. This enhancement of the natural pulsatile signal is a boundary of all conventional techniques of the kind specified.
SUMMARY OF THE INVENTION
The present invention utilizes a non-invasive measurement technique disclosed in co-pending application PCT/IL 99/00331, assigned to the assignee of the present application, where the measured signals are not pulsatile. This is an occlusion based technique, according to which a state of blood flow cessation is created at a measurement location in a blood-perfused fleshy medium, and measurements are taken during this state. Measurements taken during the state of blood flow cessation allow for a significant increase of the blood-related signals, as compared to those taken during the state of normal blood flow. To create such a state of blood flow cessation at a measurement location in a patient's organ, over-systolic pressure is applied to the organ at a location upstream of the measurement location with respect to the direction of normal blood flow.
It is a major feature of the present invention to provide a finger holder for use in an optical measurement device for non-invasive measurements of patient's blood parameters capable of providing the desired substantially stationary position of the finger during measurements, when over-systolic pressure is applied to the fmger.
It is a further feature of the present invention to provide such a fmger holder whose dimensions are adjustable to the finger of a specific patient.
The fmger holder according to the invention comprises a first member constructed for securing a fingertip and for supporting a measuring unit so as to apply measurements to a first location of the fmger, and a second member associated with a pressurizing assembly for applying pressure to a second location of the fmger spaced-apart from the first location. The first and second members are coupled to each other through a substantially rigid connector engaging the finger along its middle phalanx and proximal intephalangeal joint.
The provision of the rigid connector is associated with the following. The occlusion-based measurements are non- volumetric, the changes in volume of blood in the fmger portion under measurements being undesirable for such measurements. However, it is a natural tendency of the finger under pressure to fold at the proximal intephalangeal joint, thereby causing undesirable changes in blood volume. By providing a substantially rigid support for the finger at the region of the middle phalanx during measurement, such undesirable folding can be avoided. The measuring unit and the pressurizing assembly are connectable to a control unit, which operates them and analyzes data generated by the measuring unit indicative of a light response of the medium at the measurement location.
Generally, the measurement device may be associated with any other suitable patient's organ, such as his hand or wrist. If the patient's hand is considered, the rigid connector engages the patient's arm to prevent its folding at the elbow joint. It is more practical, however, to apply the device to the patient's fmger.
Preferably, the first member is designed as a clip that secures the fingertip between its legs (either one pair or two pairs of legs). The provision of two pairs of legs advantageously enables to provide four-sided support for the finger, thereby preventing its folding at the distal phalanx. The pressurizing assembly preferably comprises an air cushion cuff presenting the second member of the finger holder, and a pneumatic drive coupled to the cuff for operating inflation/deflation thereof. There is thus provided according to one aspect of the invention, a fmger holder to be used in an optical measurement device for the non-invasive measurement of patient's blood parameters, the finger holder comprising:
- a first member for securing a fingertip and supporting an optical measuring unit mounted so as to apply measurements to a first location of the patient's finger; - a second member associated with a pressurizing assembly mounted so as to apply desired over-systolic pressure to a second location of the finger located upstream of said first location with respect to a normal blood flow direction; and
- a substantially rigid connector between the first and second member adapted to engage the fmger along its middle phalanx and proximal intephalangeal joint, thereby preventing it from folding during measurements.
According to another aspect of the present invention, there is provided a device for non- invasive measurements of patient's blood parameters, the device comprising an optical measuring unit, a pressurizing assembly, and a control unit, wherein the finger holder comprises:
- a first member for securing a fingertip and supporting said optical measuring unit mounted so as to apply measurements to a first location of the patient's finger; - a second member associated with said pressurizing assembly so as to apply desired over-systolic pressure to a second location of the fmger located upstream of said first location with respect to a normal blood flow direction; and
- a substantially rigid connector between the first and second member adapted to engage the fmger along its middle phalanx and proximal intephalangeal joint, thereby preventing it from folding during measurements.
BRIEF DESCRIPTION OF THE DRAWINGS
In order to understand the invention and to see how it may be carried out in practice, a preferred embodiment will now be described, by way of non-limiting example only, with reference to the accompanying drawings, in which:
Fig. 1 is a schematic illustration of a device for non-invasive measurement of patient's blood parameters utilizing a fmger holder constructed according to one embodiment of the invention; and Fig. 2 illustrates another embodiment of the fmger.
DETAILED DESCRIPTION OF A PREFERRED EMBODIMENT
Referring to Fig. 1, there is illustrated a measurement device, generally designated 10, for the non- invasive measurement of patient's blood parameters, such as oxygen saturation, blood pressure, or the concentration of various substances, such as hemoglobin, glucose, cholesterol and other analyte concentrations. The device 10 includes a fmger holder 12 to be mounted on a patient's finger F, and a control unit 14 coupled to the fmger holder either through wires or wireless. The finger holder 12 includes a clip member 16 (constituting a first member) with a measuring unit 18 installed therein for applying measurements to a measurement location (constituting a first location), a second member in the form of an air cushion cuff 26 of a pressurizing assembly 20 for applying pressure to a second location upstream of the measurement location (with respect to the direction of normal blood flow), and a substantially rigid connector 22.
In the present example, the clip member 16 is a two-legged member for securing the patient's finger F between its legs 16A and 16B that engage the finger F at both its top and bottom, respectively. A flexible thermoconductive pad 24, made, for example, of rubber or silicone, is provided at the inner surfaces of the legs 16 A and 16B. The pad 24 is coupled to a power source (not shown) which is operated by the control unit 14 for applying appropriate, substantially low voltages, for example in the range 1V-24V to the pad 24, enabling heating of the finger portion located between the clip legs 16A and 16B (i.e., the location under measurements) up to 37-38°. The heating ability of the device increases the accuracy of the non-invasively derived blood-related parameters. The substantially low voltage supply is, on the one hand, acceptable for medical devices, and, on the other hand, requires low power supply (e.g., 6-9V) that allows for using batteries, thereby rendering the entire device conveniently portable.
The measuring unit 18, which is partly shown in the figure, does not form part of the present invention, and therefore need not be specifically illustrated and described, except to note the following. The measuring unit 18 comprises both an illumination and detection means that could be accommodated either at one side of the fmger when operating in a reflection mode, or at opposite sides of the finger when operating in a transmission mode. These reflected or transmitted signals present light response of the fmger to incident radiation. In the present example, the measuring unit 18 provides illumination of the finger F with at least two different wavelengths, and detects light transmitted therethrough. Data indicative of the detected light (light response) is transmitted to the control unit 14 (typically through analog-to-digital converter and data processing unit) that includes a processor operated by a suitable software model for determining and analyzing the time dependency of the detected light for each incident wavelength to determine a relation between the time variations corresponding to different wavelengths, and to calculate the desired parameter of blood based on this relation.
As indicated above, the present invention utilizes the measurement of blood-related signals at a state of blood flow cessation at the measurement location. To this end, the pressurizing assembly 20 is capable of applying over-systolic pressure, e.g., 270-300mmHg (generally, adjustable for each specific patient) at the second location upstream of the measuring unit 18 with respect to the direction of normal blood flow. The pressurizing assembly 20 includes the air cushion cuff 26 in the form of a ring wrapping the respective location on the patient's fmger F, and a pneumatic drive 28 coupled to the cuff 26 and to the control unit 14.
Hence, the drive 28, whilst being actuated by the control unit 14, operates to apply over-systolic pressure to the finger portion (second location on the finger) underneath the cuff-ring 26. The application of pressure is maintained for a period of time so as not to cause irreversible changes in the finger, e.g., 4 seconds (generally, lasting from one second to one minute and more). Then, the control unit operates the drive 28 to release the pressure. The effective measurements, i.e., the results which have to be analyzed, are those taken at the state of blood flow cessation, as will be described more specifically further below.
As clearly seen in Fig. 1, the connector 22 is shaped like a plate, and is formed with an elongated slot 22A. The cuff-ring 26 is formed with a projection 26A installed in the slot 22 A for reciprocating sliding movement along its axis. This enables to adjust the length of the finger holder 12 to that of the fmger of a specific patient. The rigid plate-like connector 22 engages the finger along its middle phalanx, preventing its folding at the proximal intephalangeal joint, thereby avoiding undesirable changes in blood volume.
The operational mode of the device 10 may be such that the control unit 14 actuates the measuring unit 18 for performing continuous measurements starting prior to the application of over-systolic pressure. In this case, only those signals which are associated with the state of blood flow cessation are taken into consideration. Measurements taken during the time period prior to the establishment of this state should be disregarded, due to the unavoidable influence of motional and/or other artifacts causing non-monotonic fluctuations of the light transmission. According to an alternative operational mode of the device 10, the control unit 14 actuates the measuring unit 18 approximately 0.5 sec after the application of the over-systolic pressure. During the time period corresponding to the existence of the state of blood flow cessation, relative light transmission of blood is observed, which reaches its maximum and may last for about 2-5.5 sec (generally, from one second to one minute and more). To obtain meaningful results, either one of at least two timely separated measurement sessions should be considered, at least one of them occurring during the state of blood flow cessation, or a single long continuous measurement session is considered starting after the establishment of the state of blood flow cessation. During the first measurement session, the control unit 14 operates to maintain the cuff 26 in its squeezed position. The control unit 14 then operates the pressurizing assembly 20 to release the over-systolic pressure. The squeezing action of the cuff 26 is ceased, and after a short delay of about 0.5 sec, the blood flow gradually increases during approximately 5 sec. Then, the control unit 14 actuates the second measurement session at a state of the transitional blood flow. The illumination unit continues to illuminate the fmger, but squeezing is halted. The detection unit, being synchronized by the control unit 14, detects the light response of the finger.
In other words, the control unit 14 selectively operates the measuring unit 18 and the pressurizing assembly 20, and analyzes data coming from the measuring unit. The construction and operation of the control unit do not form part of the present invention, and may be of any known kind capable of running an appropriate software model.
Reference is made to Fig. 2 illustrating a fmger holder 112 having somewhat different construction of its clip member 116, as compared to that of the finger holder 12. The clip member 116 is a four-leg member, wherein two opposite legs 116A and 116B engage the fmger at its top and bottom thereof, and the other opposite legs 116C and 116D engage the opposite sides of the fmger, respectively. Such four-sided support of the fingertip prevents its folding at the distal phalanx, thereby avoiding undesirable blood volume changes.. It should be noted that the connector 22 may be located at either side of the patient's fmger. Alternatively, a pair of such connectors can be used located at opposite sides of the fmger. Additionally, the processor may be accommodated within the cuff, and the wires, if any, connecting the processor to the output circuit of the measuring unit, may pass through the rigid connector. Those skilled in the art will readily appreciate that various modifications and changes may be applied to the preferred embodiments of the invention as herein before exemplified without departing from its scope defined in and by the appended claims. For example, the cuff 26 may be a band formed with Velcro-like fasteners, so as to form a ring wrapping the patient's finger when in the operational position of the device. Alternatively, a band composed of a set of various air cushions pressuring on the fmger. In this case, the pressurizing assembly fits itself to each fmger size without any additional adjusting means.

Claims

CLAIMS:
1. A finger holder to be used in an optical measurement device for non- invasive measurement of patient's blood parameters, the finger holder comprising: - a first member for securing a fingertip and supporting an optical measuring unit mounted so as to apply measurements to a first location of the patient's finger;
- a second member associated with a pressurizing assembly mounted so as to apply desired over-systolic pressure to a second location of the finger upstream of said first location with respect to a normal blood flow direction; and
- a substantially rigid connector between the first and second members adapted to engage the finger along its middle phalanx and proximal intephalangeal joint, thereby preventing it from folding during the measurements.
2. The finger holder according to Claim 1 , wherein said first member is a clip securing the fingertip between its legs.
3. The fmger holder according to Claim 1, wherein said second member is an air cushion cuff-ring of the pressurizing assembly wrapping said second location, the pressurizing assembly also comprising a pneumatic drive coupled to the cuff-ring so as to apply said over-systolic pressure to said second location.
4. The device according to Claim 1, wherein said connector is shaped like a plate and has an elongated slot extending the finger's axis, said second member having a projection installed in the slot for sliding movement along its axis.
5. The finger holder according to Claim 3, wherein said cuff-ring is a band having Velcro-like fasteners so as to form the ring on the patient's finger.
6. The fmger holder according to Claim 2, wherein said clip member has two clamping legs for securing the finger therebetween in a manner allowing the optical measurements.
7. The finger holder according to Claim 1, wherein said first member is provided at inner surface thereof facing the finger with a flexible member for wrapping the first location of the finger.
8. The fmger holder according to Claim 7, wherein said flexible member is made of a thermoconductive material for heating said first location under measurements up to desired temperature.
9. The finger holder according to Claim 8, wherein said desired temperature is approximately 37°-38°.
10. The finger holder according to Claim 8, wherein the flexible thermoconductive material is rubber.
11. The finger holder according to Claim 8, wherein the flexible thermoconductive material is silicone.
12. The finger holder according to Claim 1, wherein said over-systolic pressure is such as to create a state of substantial blood flow cessation at said first location.
13. The finger holder according to Claim 12, wherein said over-systolic pressure is in the range 270-300mmHg.
14. A device for non- invasive measurements of patient's blood parameters, the device comprising an optical measuring unit, a pressurizing assembly, and a control unit, wherein the finger holder comprises:
- a first member for securing a fingertip and supporting said optical measuring unit mounted so as to apply measurements to a first location of the patient's fmger;
- a second member associated with said pressurizing assembly so as to apply desired over-systolic pressure to a second location of the fmger located upstream of said first location with respect to a normal blood flow direction; and
- a substantially rigid connector between the first and second member adapted to engage the fmger along its middle phalanx and proximal intephalangeal joint, thereby preventing it from folding during measurements.
PCT/IL2000/000603 1999-09-28 2000-09-27 An optical device for non-invasive measurement of blood-related signals utilizing a finger holder WO2001022868A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AT00964598T ATE243467T1 (en) 1999-09-28 2000-09-27 OPTICAL DEVICE FOR NON-INVASIVE MEASURING BLOOD-RELATED SIGNALS USING A FINGER HOLDER
JP2001526088A JP2003510120A (en) 1999-09-28 2000-09-27 Optical device for non-invasive measurement of signals related to blood using finger holder
DE60003572T DE60003572T2 (en) 1999-09-28 2000-09-27 OPTICAL DEVICE FOR THE NON-INVASIVE MEASUREMENT OF BLOOD RELATED SIGNALS BY MEANS OF A FINGER HOLDER
EP00964598A EP1217941B1 (en) 1999-09-28 2000-09-27 An optical device for non-invasive measurement of blood-related signals utilizing a finger holder
AU75520/00A AU7552000A (en) 1999-09-28 2000-09-27 An optical device for non-invasive measurement of blood-related signals utilizing a finger holder

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/407,390 US6213952B1 (en) 1999-09-28 1999-09-28 Optical device for non-invasive measurement of blood related signals utilizing a finger holder
US09/407,390 1999-09-28

Publications (1)

Publication Number Publication Date
WO2001022868A1 true WO2001022868A1 (en) 2001-04-05

Family

ID=23611861

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2000/000603 WO2001022868A1 (en) 1999-09-28 2000-09-27 An optical device for non-invasive measurement of blood-related signals utilizing a finger holder

Country Status (7)

Country Link
US (1) US6213952B1 (en)
EP (1) EP1217941B1 (en)
JP (1) JP2003510120A (en)
AT (1) ATE243467T1 (en)
AU (1) AU7552000A (en)
DE (1) DE60003572T2 (en)
WO (1) WO2001022868A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1223851B1 (en) * 1999-10-12 2004-01-28 Orsense Ltd. An optical device for non-invasive measurement of blood-related signals and a finger holder therefor
WO2016106748A1 (en) * 2014-12-31 2016-07-07 深圳大学 Method and device for monitoring venous oxygen saturation
WO2019060212A1 (en) 2017-09-19 2019-03-28 Edwards Lifesciences Corporation Finger cuff to apply concentrated pressure to the bottom of a patient's finger

Families Citing this family (116)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6517283B2 (en) * 2001-01-16 2003-02-11 Donald Edward Coffey Cascading chute drainage system
US6931268B1 (en) 1995-06-07 2005-08-16 Masimo Laboratories, Inc. Active pulse blood constituent monitoring
US6018673A (en) 1996-10-10 2000-01-25 Nellcor Puritan Bennett Incorporated Motion compatible sensor for non-invasive optical blood analysis
US6675031B1 (en) 1999-04-14 2004-01-06 Mallinckrodt Inc. Method and circuit for indicating quality and accuracy of physiological measurements
IL135077A0 (en) * 2000-03-15 2001-05-20 Orsense Ltd A probe for use in non-invasive measurements of blood related parameters
EP2684514B1 (en) 2000-04-17 2018-10-24 Covidien LP Pulse oximeter sensor with piece-wise function
US8224412B2 (en) 2000-04-17 2012-07-17 Nellcor Puritan Bennett Llc Pulse oximeter sensor with piece-wise function
DE60221841T2 (en) 2001-06-20 2008-05-15 Purdue Research Foundation, West Lafayette PRESSURE CUFF WITH BODY LIGHTING FOR USE IN THE OPTICAL NON-INVASIVE MEASUREMENT OF BLOOD PARAMETERS
US6748254B2 (en) 2001-10-12 2004-06-08 Nellcor Puritan Bennett Incorporated Stacked adhesive optical sensor
EP1332713A1 (en) * 2002-01-31 2003-08-06 Btg International Limited Venous pulse oximetry
DE60315596T2 (en) * 2002-01-31 2008-05-15 Loughborough University Enterprises Ltd., Loughborough VENOUS PULSE OXIMETRY
US7190986B1 (en) 2002-10-18 2007-03-13 Nellcor Puritan Bennett Inc. Non-adhesive oximeter sensor for sensitive skin
US20040225217A1 (en) * 2003-02-14 2004-11-11 Voegele James W. Fingertip ultrasound medical instrument
US20040199204A1 (en) * 2003-02-14 2004-10-07 Voegele James W. Multifunctional surgical instrument
US20040193211A1 (en) * 2003-02-14 2004-09-30 Voegele James W. Fingertip surgical instruments
KR100580622B1 (en) * 2003-03-19 2006-05-16 삼성전자주식회사 Method and apparatus for noninvasive blood constituent measurement
US7266400B2 (en) 2003-05-06 2007-09-04 Orsense Ltd. Glucose level control method and system
US6993372B2 (en) * 2003-06-03 2006-01-31 Orsense Ltd. Method and system for use in non-invasive optical measurements of blood parameters
EP2465420A3 (en) 2003-06-03 2012-10-24 Orsense Ltd. Method and system for use in non-invasive optical measurements of blood parameters
JP4363130B2 (en) * 2003-09-04 2009-11-11 パナソニック電工株式会社 Optical blood glucose level pickup
US7333186B2 (en) * 2004-03-17 2008-02-19 Matsushita Electric Industrial Co., Ltd. Method and device for measuring biological information
US20050228248A1 (en) * 2004-04-07 2005-10-13 Thomas Dietiker Clip-type sensor having integrated biasing and cushioning means
US7164938B2 (en) * 2004-06-21 2007-01-16 Purdue Research Foundation Optical noninvasive vital sign monitor
US7313425B2 (en) * 2004-07-08 2007-12-25 Orsense Ltd. Device and method for non-invasive optical measurements
JP4460414B2 (en) * 2004-10-06 2010-05-12 日本電信電話株式会社 Sphygmomanometer
US7590439B2 (en) 2005-08-08 2009-09-15 Nellcor Puritan Bennett Llc Bi-stable medical sensor and technique for using the same
US7657295B2 (en) * 2005-08-08 2010-02-02 Nellcor Puritan Bennett Llc Medical sensor and technique for using the same
US7657294B2 (en) 2005-08-08 2010-02-02 Nellcor Puritan Bennett Llc Compliant diaphragm medical sensor and technique for using the same
US20070060808A1 (en) 2005-09-12 2007-03-15 Carine Hoarau Medical sensor for reducing motion artifacts and technique for using the same
US7869850B2 (en) 2005-09-29 2011-01-11 Nellcor Puritan Bennett Llc Medical sensor for reducing motion artifacts and technique for using the same
US8092379B2 (en) 2005-09-29 2012-01-10 Nellcor Puritan Bennett Llc Method and system for determining when to reposition a physiological sensor
US7899510B2 (en) 2005-09-29 2011-03-01 Nellcor Puritan Bennett Llc Medical sensor and technique for using the same
US7904130B2 (en) 2005-09-29 2011-03-08 Nellcor Puritan Bennett Llc Medical sensor and technique for using the same
US8062221B2 (en) 2005-09-30 2011-11-22 Nellcor Puritan Bennett Llc Sensor for tissue gas detection and technique for using the same
US8233954B2 (en) 2005-09-30 2012-07-31 Nellcor Puritan Bennett Llc Mucosal sensor for the assessment of tissue and blood constituents and technique for using the same
US7483731B2 (en) 2005-09-30 2009-01-27 Nellcor Puritan Bennett Llc Medical sensor and technique for using the same
US7555327B2 (en) 2005-09-30 2009-06-30 Nellcor Puritan Bennett Llc Folding medical sensor and technique for using the same
US7881762B2 (en) 2005-09-30 2011-02-01 Nellcor Puritan Bennett Llc Clip-style medical sensor and technique for using the same
US7486979B2 (en) 2005-09-30 2009-02-03 Nellcor Puritan Bennett Llc Optically aligned pulse oximetry sensor and technique for using the same
US7396342B2 (en) * 2005-11-25 2008-07-08 Biotop Holding Co., Ltd. Safety syringe for taking blood
US20070123822A1 (en) * 2005-11-25 2007-05-31 Biotop Holding Co., Ltd. Safety syringe for taking blood
US8073518B2 (en) 2006-05-02 2011-12-06 Nellcor Puritan Bennett Llc Clip-style medical sensor and technique for using the same
US20080009806A1 (en) * 2006-07-10 2008-01-10 Biotop Holding Co., Ltd. Blood sampling device
US8145288B2 (en) 2006-08-22 2012-03-27 Nellcor Puritan Bennett Llc Medical sensor for reducing signal artifacts and technique for using the same
US8219170B2 (en) 2006-09-20 2012-07-10 Nellcor Puritan Bennett Llc System and method for practicing spectrophotometry using light emitting nanostructure devices
US8396527B2 (en) 2006-09-22 2013-03-12 Covidien Lp Medical sensor for reducing signal artifacts and technique for using the same
US8175671B2 (en) 2006-09-22 2012-05-08 Nellcor Puritan Bennett Llc Medical sensor for reducing signal artifacts and technique for using the same
US8190224B2 (en) 2006-09-22 2012-05-29 Nellcor Puritan Bennett Llc Medical sensor for reducing signal artifacts and technique for using the same
US7869849B2 (en) 2006-09-26 2011-01-11 Nellcor Puritan Bennett Llc Opaque, electrically nonconductive region on a medical sensor
US7574245B2 (en) 2006-09-27 2009-08-11 Nellcor Puritan Bennett Llc Flexible medical sensor enclosure
US7890153B2 (en) 2006-09-28 2011-02-15 Nellcor Puritan Bennett Llc System and method for mitigating interference in pulse oximetry
US7796403B2 (en) 2006-09-28 2010-09-14 Nellcor Puritan Bennett Llc Means for mechanical registration and mechanical-electrical coupling of a faraday shield to a photodetector and an electrical circuit
US7476131B2 (en) 2006-09-29 2009-01-13 Nellcor Puritan Bennett Llc Device for reducing crosstalk
US7684842B2 (en) 2006-09-29 2010-03-23 Nellcor Puritan Bennett Llc System and method for preventing sensor misuse
US8068891B2 (en) 2006-09-29 2011-11-29 Nellcor Puritan Bennett Llc Symmetric LED array for pulse oximetry
US8175667B2 (en) 2006-09-29 2012-05-08 Nellcor Puritan Bennett Llc Symmetric LED array for pulse oximetry
US7680522B2 (en) 2006-09-29 2010-03-16 Nellcor Puritan Bennett Llc Method and apparatus for detecting misapplied sensors
US7435889B1 (en) * 2006-12-20 2008-10-14 Erik Heidt Rotatable drumstick tether
US7894869B2 (en) 2007-03-09 2011-02-22 Nellcor Puritan Bennett Llc Multiple configuration medical sensor and technique for using the same
US8265724B2 (en) 2007-03-09 2012-09-11 Nellcor Puritan Bennett Llc Cancellation of light shunting
US8280469B2 (en) 2007-03-09 2012-10-02 Nellcor Puritan Bennett Llc Method for detection of aberrant tissue spectra
JP5568461B2 (en) 2007-03-27 2014-08-06 ネイボン,アリエル Apparatus and method for monitoring blood parameters
US20080243178A1 (en) * 2007-03-30 2008-10-02 T.A.G. Medical Products A Limited Partnership Surgical instrument particularly useful as tweezers for grasping and holding objects of different thicknesses
US20080243177A1 (en) * 2007-03-30 2008-10-02 T.A.G. Medical Products, A Limited Partnership Surgical instrument usable as a grasper and/or probe
US20080243174A1 (en) * 2007-03-30 2008-10-02 T.A.G. Medical Products A Limited Partnership Finger mounting for surgical instruments particularly useful in open and endoscopic surgery
US20080249393A1 (en) * 2007-04-04 2008-10-09 Alexander Finarov Method and apparatus for enhancement and quality improvement of analyte measurement signals
US8986342B2 (en) * 2007-11-25 2015-03-24 Ic Therapeutics Methods and apparatus for repeated ischemic conditioning treatment of hypertension and other medical conditions
US8352004B2 (en) 2007-12-21 2013-01-08 Covidien Lp Medical sensor and technique for using the same
US8346328B2 (en) 2007-12-21 2013-01-01 Covidien Lp Medical sensor and technique for using the same
US8366613B2 (en) 2007-12-26 2013-02-05 Covidien Lp LED drive circuit for pulse oximetry and method for using same
US8577434B2 (en) 2007-12-27 2013-11-05 Covidien Lp Coaxial LED light sources
US8452364B2 (en) 2007-12-28 2013-05-28 Covidien LLP System and method for attaching a sensor to a patient's skin
US8442608B2 (en) 2007-12-28 2013-05-14 Covidien Lp System and method for estimating physiological parameters by deconvolving artifacts
US8897850B2 (en) 2007-12-31 2014-11-25 Covidien Lp Sensor with integrated living hinge and spring
US8092993B2 (en) 2007-12-31 2012-01-10 Nellcor Puritan Bennett Llc Hydrogel thin film for use as a biosensor
US8070508B2 (en) 2007-12-31 2011-12-06 Nellcor Puritan Bennett Llc Method and apparatus for aligning and securing a cable strain relief
US8199007B2 (en) * 2007-12-31 2012-06-12 Nellcor Puritan Bennett Llc Flex circuit snap track for a biometric sensor
US8437822B2 (en) 2008-03-28 2013-05-07 Covidien Lp System and method for estimating blood analyte concentration
US8112375B2 (en) 2008-03-31 2012-02-07 Nellcor Puritan Bennett Llc Wavelength selection and outlier detection in reduced rank linear models
US7880884B2 (en) 2008-06-30 2011-02-01 Nellcor Puritan Bennett Llc System and method for coating and shielding electronic sensor components
US8071935B2 (en) 2008-06-30 2011-12-06 Nellcor Puritan Bennett Llc Optical detector with an overmolded faraday shield
US7887345B2 (en) 2008-06-30 2011-02-15 Nellcor Puritan Bennett Llc Single use connector for pulse oximetry sensors
US8364220B2 (en) 2008-09-25 2013-01-29 Covidien Lp Medical sensor and technique for using the same
US8423112B2 (en) 2008-09-30 2013-04-16 Covidien Lp Medical sensor and technique for using the same
US8914088B2 (en) 2008-09-30 2014-12-16 Covidien Lp Medical sensor and technique for using the same
US8417309B2 (en) 2008-09-30 2013-04-09 Covidien Lp Medical sensor
FR2939302B1 (en) 2008-12-05 2011-02-11 Atys Sarl METHOD FOR MEASURING SYSTEMIC PRESSURE AND DEVICE USING THE SAME
US8452366B2 (en) 2009-03-16 2013-05-28 Covidien Lp Medical monitoring device with flexible circuitry
US8221319B2 (en) 2009-03-25 2012-07-17 Nellcor Puritan Bennett Llc Medical device for assessing intravascular blood volume and technique for using the same
US8781548B2 (en) 2009-03-31 2014-07-15 Covidien Lp Medical sensor with flexible components and technique for using the same
US8509869B2 (en) 2009-05-15 2013-08-13 Covidien Lp Method and apparatus for detecting and analyzing variations in a physiologic parameter
US8634891B2 (en) 2009-05-20 2014-01-21 Covidien Lp Method and system for self regulation of sensor component contact pressure
US8311601B2 (en) 2009-06-30 2012-11-13 Nellcor Puritan Bennett Llc Reflectance and/or transmissive pulse oximeter
US9010634B2 (en) 2009-06-30 2015-04-21 Covidien Lp System and method for linking patient data to a patient and providing sensor quality assurance
US8505821B2 (en) 2009-06-30 2013-08-13 Covidien Lp System and method for providing sensor quality assurance
US8391941B2 (en) 2009-07-17 2013-03-05 Covidien Lp System and method for memory switching for multiple configuration medical sensor
US8417310B2 (en) 2009-08-10 2013-04-09 Covidien Lp Digital switching in multi-site sensor
US8428675B2 (en) 2009-08-19 2013-04-23 Covidien Lp Nanofiber adhesives used in medical devices
US8649838B2 (en) 2010-09-22 2014-02-11 Covidien Lp Wavelength switching for pulse oximetry
JP6055688B2 (en) 2013-01-31 2016-12-27 日本光電工業株式会社 Biosignal measurement system, biosignal measurement device, and control program for biosignal measurement device
US20170086722A1 (en) * 2014-03-19 2017-03-30 Konica Minolta, Inc. Biological information measurement device and pulse oximeter
JP6424014B2 (en) * 2014-05-27 2018-11-14 株式会社テクノメデイカ Fingertip blood former
CN105997267A (en) * 2016-07-29 2016-10-12 万象设计江苏有限责任公司 Fingerstall for detection
US20180235478A1 (en) * 2017-02-18 2018-08-23 VVV IP Holdings Limited Multi-Vital Sign Detector in an Electronic Medical Records System
US10492684B2 (en) 2017-02-21 2019-12-03 Arc Devices Limited Multi-vital-sign smartphone system in an electronic medical records system
US10602987B2 (en) * 2017-08-10 2020-03-31 Arc Devices Limited Multi-vital-sign smartphone system in an electronic medical records system
EP3697294B1 (en) 2017-10-16 2023-12-06 Massachusetts Institute Of Technology System and method for non-invasive hematological measurements
CN108742622A (en) * 2018-06-28 2018-11-06 北京中瑞博康医疗器械有限公司 A kind of full-automatic palm channels and collaterals detector
CN109171765B (en) * 2018-10-31 2021-04-16 上海嘉孚信息科技有限公司 Portable noninvasive blood glucose detection instrument
JP7265741B2 (en) * 2019-06-03 2023-04-27 ベルン・テクノロジー(アイピー)カンパニー・リミテッド wearable device
US11160492B2 (en) 2019-07-24 2021-11-02 Massachusetts Institute Of Technology Finger inserts for a nailfold imaging device
EP4051101A1 (en) * 2019-10-28 2022-09-07 Edwards Lifesciences Corporation Finger cuff with de-coupled sensor and bladder and associated method
JP2023528806A (en) 2020-05-28 2023-07-06 レウコ・ラボズ・インコーポレイテッド Methods for detecting leukocytes and/or leukocyte subtypes from non-invasive capillary video
CN112450922B (en) * 2021-01-02 2021-08-13 湖州威鼎科技有限公司 Pulse oximeter and use method thereof
CN113679382B (en) * 2021-09-23 2024-02-02 江西凯曼医疗技术有限公司 Finger-clamping type blood oxygen probe
WO2023235546A1 (en) * 2022-06-03 2023-12-07 Arc Devices Limited Apparatus and methods for measuring blood pressure and other vital signs via a finger

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2524792A1 (en) * 1982-04-13 1983-10-14 Fenestraz Louis Cardiovascular values determn. at peripheral arterial level - using photoelectric pick=up comprising two jaws to measure finger arterial section variations
US4927264A (en) * 1987-12-02 1990-05-22 Omron Tateisi Electronics Co. Non-invasive measuring method and apparatus of blood constituents
US5638816A (en) 1995-06-07 1997-06-17 Masimo Corporation Active pulse blood constituent monitoring
US5782757A (en) 1991-03-21 1998-07-21 Masimo Corporation Low-noise optical probes
US5810723A (en) 1996-12-05 1998-09-22 Essential Medical Devices Non-invasive carboxyhemoglobin analyer
US5833602A (en) * 1993-09-20 1998-11-10 Osemwota; Omoigui Process of continuous noninvasive hemometry
WO1999063884A1 (en) * 1998-06-07 1999-12-16 Itamar Medical (Cm) 1997 Ltd. Pressure applicator devices particularly useful for non-invasive detection of medical conditions
WO1999065384A1 (en) 1998-06-17 1999-12-23 Orsense Ltd. Non-invasive optical measurement of a blood constituent

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0212967A3 (en) * 1985-08-23 1987-10-14 Tripod Industries Company Limited Improvements in and relating to apparatus for measuring blood pressure
US5025793A (en) * 1986-10-07 1991-06-25 Richley Edward A Finger blood pressure measurement system
US5218966A (en) * 1987-06-12 1993-06-15 Omron Tateisi Electronics Co. Electronic blood pressure meter
US5313940A (en) * 1991-05-15 1994-05-24 Nihon Kohden Corporation Photo-electric pulse wave measuring probe
US5511546A (en) * 1993-09-20 1996-04-30 Hon; Edward H. Finger apparatus for measuring continuous cutaneous blood pressure and electrocardiogram electrode
US5924982A (en) * 1997-07-30 1999-07-20 Nellcor Puritan Bennett Incorporated Oximeter sensor with user-modifiable color surface

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2524792A1 (en) * 1982-04-13 1983-10-14 Fenestraz Louis Cardiovascular values determn. at peripheral arterial level - using photoelectric pick=up comprising two jaws to measure finger arterial section variations
US4927264A (en) * 1987-12-02 1990-05-22 Omron Tateisi Electronics Co. Non-invasive measuring method and apparatus of blood constituents
US5782757A (en) 1991-03-21 1998-07-21 Masimo Corporation Low-noise optical probes
US5833602A (en) * 1993-09-20 1998-11-10 Osemwota; Omoigui Process of continuous noninvasive hemometry
US5638816A (en) 1995-06-07 1997-06-17 Masimo Corporation Active pulse blood constituent monitoring
US5860919A (en) 1995-06-07 1999-01-19 Masimo Corporation Active pulse blood constituent monitoring method
US5810723A (en) 1996-12-05 1998-09-22 Essential Medical Devices Non-invasive carboxyhemoglobin analyer
WO1999063884A1 (en) * 1998-06-07 1999-12-16 Itamar Medical (Cm) 1997 Ltd. Pressure applicator devices particularly useful for non-invasive detection of medical conditions
WO1999065384A1 (en) 1998-06-17 1999-12-23 Orsense Ltd. Non-invasive optical measurement of a blood constituent

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1223851B1 (en) * 1999-10-12 2004-01-28 Orsense Ltd. An optical device for non-invasive measurement of blood-related signals and a finger holder therefor
WO2016106748A1 (en) * 2014-12-31 2016-07-07 深圳大学 Method and device for monitoring venous oxygen saturation
WO2019060212A1 (en) 2017-09-19 2019-03-28 Edwards Lifesciences Corporation Finger cuff to apply concentrated pressure to the bottom of a patient's finger
EP3684250A4 (en) * 2017-09-19 2020-08-26 Edwards Lifesciences Corporation Finger cuff to apply concentrated pressure to the bottom of a patient's finger

Also Published As

Publication number Publication date
EP1217941A1 (en) 2002-07-03
US6213952B1 (en) 2001-04-10
EP1217941B1 (en) 2003-06-25
DE60003572D1 (en) 2003-07-31
AU7552000A (en) 2001-04-30
JP2003510120A (en) 2003-03-18
DE60003572T2 (en) 2004-04-29
ATE243467T1 (en) 2003-07-15

Similar Documents

Publication Publication Date Title
EP1217941B1 (en) An optical device for non-invasive measurement of blood-related signals utilizing a finger holder
EP1263315B1 (en) A probe for use in non-invasive measurements of blood related parameters
JP4767464B2 (en) Optical device for non-invasive measurement of signals relating to blood and finger holder for the device
US7386336B2 (en) Method and system for use in non-invasive optical measurements of blood parameters
EP1549165B8 (en) Use of a headband to indicate tension and system comprising an oximetry sensor and a headband
US6731963B2 (en) Device for enhancement and quality improvement of blood-related signals for use in a system for non-invasive measurements of blood-related signals
US8649839B2 (en) Motion compatible sensor for non-invasive optical blood analysis
US5267563A (en) Oximeter sensor with perfusion enhancing
JPH10510180A (en) Self-luminous non-invasive infrared spectrophotometer with temperature compensation
JP5101366B2 (en) Blood component measuring device
US20070197887A1 (en) Noninvasive vital signs sensor
AU2005258095A1 (en) Optical noninvasive vital sign monitor
EP1628564B1 (en) Method and system for use in non-invasive optical measurements of blood parameters
JP5589789B2 (en) Biological component measuring apparatus and biological component measuring method
KR102320959B1 (en) a guard for searching of pulse oximeter
JP2006055528A (en) Support tool for probe for measuring in vivo component and head device for measuring in vivo component
JP2681151B2 (en) Sphygmomanometer probe and blood pressure measuring device
JPH0565177B2 (en)

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
ENP Entry into the national phase

Ref country code: JP

Ref document number: 2001 526088

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 2000964598

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2000964598

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWG Wipo information: grant in national office

Ref document number: 2000964598

Country of ref document: EP