WO2001027135A3 - Regulators of the hedgehog pathway, compositions and uses related thereto - Google Patents

Regulators of the hedgehog pathway, compositions and uses related thereto Download PDF

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Publication number
WO2001027135A3
WO2001027135A3 PCT/US2000/028479 US0028479W WO0127135A3 WO 2001027135 A3 WO2001027135 A3 WO 2001027135A3 US 0028479 W US0028479 W US 0028479W WO 0127135 A3 WO0127135 A3 WO 0127135A3
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WIPO (PCT)
Prior art keywords
regulators
compositions
function
hedgehog pathway
uses related
Prior art date
Application number
PCT/US2000/028479
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French (fr)
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WO2001027135A2 (en
WO2001027135A9 (en
Inventor
Philip A Beachy
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Univ Johns Hopkins Med
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Priority to DE60028411T priority Critical patent/DE60028411T2/en
Priority to AU12045/01A priority patent/AU781524B2/en
Priority to IL14906900A priority patent/IL149069A0/en
Priority to CA002386190A priority patent/CA2386190C/en
Priority to EP00973544A priority patent/EP1235851B1/en
Application filed by Univ Johns Hopkins Med filed Critical Univ Johns Hopkins Med
Priority to JP2001530353A priority patent/JP5420128B2/en
Publication of WO2001027135A2 publication Critical patent/WO2001027135A2/en
Priority to IL149069A priority patent/IL149069A/en
Publication of WO2001027135A3 publication Critical patent/WO2001027135A3/en
Publication of WO2001027135A9 publication Critical patent/WO2001027135A9/en
Priority to AU2006202843A priority patent/AU2006202843B2/en
Priority to IL179814A priority patent/IL179814A/en
Priority to IL213594A priority patent/IL213594A/en

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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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    • C07J69/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by contraction of only one ring by one atom and expansion of only one ring by one atom

Abstract

The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function mutations.
PCT/US2000/028479 1999-10-13 2000-10-13 Regulators of the hedgehog pathway, compositions and uses related thereto WO2001027135A2 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
JP2001530353A JP5420128B2 (en) 1999-10-13 2000-10-13 Hedgehog pathway modulators and related compositions and methods of use
AU12045/01A AU781524B2 (en) 1999-10-13 2000-10-13 Regulators of the hedgehog pathway, compositions and uses related thereto
IL14906900A IL149069A0 (en) 1999-10-13 2000-10-13 Regulators of the hedgehog pathway, compositions and uses related thereto
CA002386190A CA2386190C (en) 1999-10-13 2000-10-13 Regulators of the hedgehog pathway, compositions and uses related thereto
EP00973544A EP1235851B1 (en) 1999-10-13 2000-10-13 Regulators of the hedgehog pathway, compositions and uses related thereto
DE60028411T DE60028411T2 (en) 1999-10-13 2000-10-13 CONNECTIONS FOR REGULATING THE HEDGEHOG SIGNAL PATH, COMPOSITIONS AND USES THEREOF
IL149069A IL149069A (en) 1999-10-13 2002-04-10 Regulators of the hedgehog pathway, compositions and uses related thereto
AU2006202843A AU2006202843B2 (en) 1999-10-13 2006-07-03 Regulators of the hedgehog pathway, compositions and uses related thereto
IL179814A IL179814A (en) 1999-10-13 2006-12-04 Compositions comprising regulators of the hedgehog pathway for use in regulating differentiation or proliferation of cells, controlling the growth or development of pancreatic tissue and treating a hyperproliferative disorder
IL213594A IL213594A (en) 1999-10-13 2011-06-16 Use of a veratrum-type alkaloid for preparing medicaments and an in-vitro method for inhibiting mitotic cell proliferation using said alkaloid

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US15921599P 1999-10-13 1999-10-13
US60/159,215 1999-10-13
US22927300P 2000-08-30 2000-08-30
US60/229,273 2000-08-30

Publications (3)

Publication Number Publication Date
WO2001027135A2 WO2001027135A2 (en) 2001-04-19
WO2001027135A3 true WO2001027135A3 (en) 2002-05-10
WO2001027135A9 WO2001027135A9 (en) 2002-08-15

Family

ID=26855755

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/028479 WO2001027135A2 (en) 1999-10-13 2000-10-13 Regulators of the hedgehog pathway, compositions and uses related thereto

Country Status (9)

Country Link
US (5) US7098196B1 (en)
EP (2) EP1728797A3 (en)
JP (2) JP5420128B2 (en)
AT (1) ATE328002T1 (en)
AU (2) AU781524B2 (en)
CA (1) CA2386190C (en)
DE (1) DE60028411T2 (en)
IL (4) IL149069A0 (en)
WO (1) WO2001027135A2 (en)

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US9238672B2 (en) 2007-12-27 2016-01-19 Infinity Pharmaceuticals, Inc. Methods for stereoselective reduction
US9376447B2 (en) 2010-09-14 2016-06-28 Infinity Pharmaceuticals, Inc. Transfer hydrogenation of cyclopamine analogs

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US7708998B2 (en) * 2000-10-13 2010-05-04 Curis, Inc. Methods of inhibiting unwanted cell proliferation using hedgehog antagonists
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AU2001272892B8 (en) * 2001-07-02 2006-05-04 Sinan Tas Use of cyclopamine in the treatment of basal cell carcinoma and other tumors
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JP6141015B2 (en) 2009-08-05 2017-06-07 インフィニティ ファーマスーティカルズ、インク． Enzymatic transamination of cyclopamine analogues.
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