WO2001028409B1 - Rapid, automatic measurement of the eye's wave aberration - Google Patents

Rapid, automatic measurement of the eye's wave aberration

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Publication number
WO2001028409B1
WO2001028409B1 PCT/US2000/029078 US0029078W WO0128409B1 WO 2001028409 B1 WO2001028409 B1 WO 2001028409B1 US 0029078 W US0029078 W US 0029078W WO 0128409 B1 WO0128409 B1 WO 0128409B1
Authority
WO
WIPO (PCT)
Prior art keywords
search
image data
eye
spots
wavefront aberration
Prior art date
Application number
PCT/US2000/029078
Other languages
French (fr)
Other versions
WO2001028409A1 (en
WO2001028409A9 (en
Inventor
David R Williams
William J Vaughn
Benjamin D Singer
Heidi Hofer
Geun Young Yoon
Pablo Artal
Juan Luis Aragon
Pedro Prieto
Original Assignee
Univ Rochester
Vargas Fernando
David R Williams
William J Vaughn
Benjamin D Singer
Heidi Hofer
Geun Young Yoon
Pablo Artal
Juan Luis Aragon
Pedro Prieto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rochester, Vargas Fernando, David R Williams, William J Vaughn, Benjamin D Singer, Heidi Hofer, Geun Young Yoon, Pablo Artal, Juan Luis Aragon, Pedro Prieto filed Critical Univ Rochester
Priority to AU13391/01A priority Critical patent/AU1339101A/en
Priority to EP00975325A priority patent/EP1221889A1/en
Priority to CA002388719A priority patent/CA2388719A1/en
Priority to BR0015231-5A priority patent/BR0015231A/en
Priority to JP2001531011A priority patent/JP4660047B2/en
Publication of WO2001028409A1 publication Critical patent/WO2001028409A1/en
Publication of WO2001028409B1 publication Critical patent/WO2001028409B1/en
Priority to US10/125,436 priority patent/US6827444B2/en
Publication of WO2001028409A9 publication Critical patent/WO2001028409A9/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/1015—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for wavefront analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J9/00—Measuring optical phase difference; Determining degree of coherence; Measuring optical wavelength

Abstract

A wavefront aberration of an eye is determined, e.g., in real time. The eye is illuminated, and the light reflected from the retina is converted into spots with a device such as a Hartmann-Shack detector. The displacement of each spot from where it would be in the absence of aberration allows calculation of the aberration. Each spot is located by an iterative technique in which a corresponding centroid is located in a box drawn on the image data, a smaller box is defined around the centroid, the centroid is located in the smaller box, and so on. The wavefront aberration is calculated from the centroid locations by using a matrix in which unusable data can be eliminated simply by eliminating rows of the matrix. Aberrations for different pupil sizes are handled in data taken for a single pupil size by renormalization.

Claims

AMENDED CLAIMS
[received by the International Bureau on 26 April 2001 (26 04 01 ), original claim 1 amended; new claims 4- 108 added, remaining claims unchanged ( 15 pages)]
1 A method of measuring a wavefront aberration of an eye, the method comprising
(a) taking image data from the eye, the image data comprising a plurality of spots having positions determined by the wavefront aberration,
(b) defining a plurality of search boxes ID the image data;
(c) determining the positions of the spots by
(i) locating a centroid in each of the search boxes, (π) replacing each of the search boxes with a search box of reduced size; (iii) locating the centroid in each of the search boxes of reduced size; and (IV) repeating steps (π) and (in) until each of the search boxes of reduced size reaches a minimum size, and
(d) calculating the wavefront aberration in accordance with the positions of the spots
2 The method of claim I , wherein step (a) is performed with a Hartmann- Shack detector havmg a plurality of lenslets; and the plurality of lenslets form a plurality of spots.
3 The method of claim 2, wherein: step (d) is performed using a matrix having rows corresponding to the lenslets, and step (d) comprises-
(l) determining which lenslets do not provide usable data; and
(n) eliminating the rows corresponding to the lenslets which do not provide usable data
4 The method of claim I, wherein the minimum size is a diffraction limited size.
5 The method of claim 1, wherein step (c)(n) comprises reducing a size of each search box to be replaced by one pixel in each direction
6 The method of claim 1, wherein steps (c)(ι) and (c)(πi) are performed only m accordance with pixels in the image data whose intensities he between a lower threshold and an upper threshold
7 The method of claim 6, further comprising prompting an operator to select the lower threshold and the upper threshold
8 The method of claim 1, wherein each of the plurality of search boxes defined in step (b) is centered on a position which one of die spots would occupy in an absence of the wavefront aberration
60
9. The method of claim 8, wherein each of the plurality of search boxes defined in stop (b) has a dimension equal to a spacing between the positions which the spots would occupy in the absence of the wavefront aberration.
10. The method of claim 8, wherein each of the plurality of search boxes defined in step (b) has a dimension which is scaled down from a spacing between the positions which the spots would occupy in the absence of the wavefront aberration by a factor less than one,
11. The method of claim 10, wherein step (b) comprises prompting an operator for the factor.
12. The method of claim 1, wherein step (c)(iι) comprises reducing a size of each search box to be replaced by a fraction of a pixel along each side.
13. The method of claim 12, wherein the fraction of a pixel is one-half of a pixel.
14. The method of claim 12, wherein, for each search box of reduced size which includes at least one fractional pixel, step (c)(iii) comprises assigning to each of said at least one fractional pixel a contribution to the centroid which is equal to a corresponding fraction of an intensity detected in the fractional pixel centered in the fractional pixel.
15. The method of claim 1, wherein step (c) further comprises:
(v) allowing an operator to drag one of the centroids to a new location; and (vi) recalculating the centroid which has been dragged to the new location, using a light distribution around the new location.
16. The method of claim 1, wherein step (c) further comprises:
(v) allowing an operator to drag a central one of the centroids to a new location; and (vi) recalculating all of the centroids around the new location.
17. The method of claim 1, wherein step (c)(iii) is performed without reference to a location of a previously located centroid.
61
18 The method of claim 1 , wherein step (c)(uι) is performed using a location of a pr viously located centroid as a start estimate
19 The method of claim 1 , wherein step (c)(ιn) is performed using, as a start estimate, a location which a spot would occupy in an absence of the wavefront aberration.
20 The method of claim 3, wherem step (d)(ι) comprises allowing an operator to select the lenslets which do not provide usable data
21. The method of claim 3, wherein step (dχι) compπses determining automatically which lenslets do not provide usable data.
22, The method of claim 21, wherem step (d)(i) comprises determining automatically which lenslets do not provide usable data accordance with standard deviations of intensity around the corresponding centroids
23 The method of claim 21, wherein step (d)(ι) comprises determining automatically which lenslets do not provide usable data in accordance with overall intensity levels of the corresponding centroids
24 The method of claim 3, wherem the matrix has two rows corresponding to each ot the lenslets; and step (d)(u) comprises eliminating both of the rows corresponding to each of the lenslets which do not provide usable data.
25 The method of claim 24, where the two rows corresponding to each of the lenslets are a row corresponding to an * coordinate and a row corresponding to a y coordinate
26 The method of claim 1 , wherem step (d) compπses calculating a number of Zenuke modes by using a number of centroids which is at least twice the number of Zermke modes.
62
27. The method of claim 1, wherein step (d) comprises calculating the wavefront aberration for a first pupil radius R , of the eye and also for a second pupil radius Ri of the eye, wherein R, < R<*.
28. The method of claim 27, wherein the wavefront aberration is calculated for R* by renormalizing the wavefront aberration calculated for ^,
29. The method of claim 27, wherein step (d) further comprises prompting an operator for R*.
30. The method of claim 29, wherein step (d) further comprises prompting an operator for a minimum Zemike mode and a maximum Zeinike mode for use in calculating the wavefront aberration for R*.
31. The method of claim 3, wherein step (d) is performed using singular value decomposition.
32. A system for measuring a wavefront aberration of an eye, the system comprising: image data taking means for taking image data from the eye, the image data comprising a plurality of spots having positions determined by the wavefront aberration; and computation means, receiving the image data, for
(a) defining a plurality of search boxes in the image data;
(b) determining the positions of the spots by
(i) locating a centroid in each of the search boxes; (ii) replacing each of the search boxes with a search box of reduced size; (iii) locating the centroid in each of the search boxes of reduced size; and (iv) repeating steps (ii) and (iii) until each of the search boxes of reduced size reaches a minimum size; and
(c) calculating the wavefront aberration in accordance with the positions of the spots.
33. The system of claim 32, wherem:
the image data taking means comprises a Hartmann-Shack detector having a plurality of lenslets; and the plurality of lenslets form the plurality of spots.
34. The system of claim 33, wherein: the computation means performs step (c) using a matrix having rows corresponding to the lenslets; and step (c) comprises:
(i) determining which lenslets do not provide usable data; and
(ii) eliminating the rows corresponding to the lenslets which do not provide usable data.
35. The system of claim 32, wherein the minimum si2e is a diffraction limited size.
36. The system of claim 32, wherein step (b)(ii) comprises reducing a size of each search box to be replaced by one pixel in each direction.
37. The system of claim 32, wherein steps (b)(i) and (b)(iii) are performed only in accordance with pixels in the image data whose intensities lie between a lower threshold and an upper threshold.
38. The system of claim 37, further comprising interface means for prompting an operator to select the lower threshold and the upper threshold.
39. The system of claim 32, wherein each of the plurality of search boxes defined in step (a) is centered on a position which one of the spots would occupy in an absence of the wavefront aberration
40. The system of claim 39, wherein each of the plurality of search boxes defined in step (a) has a dimension equal to a spacing between the positions which the spots would occupy in the absence of the wavefront aberration.
64
41. The system of claim 39, wherein each of the plurality of search boxes defined in step (a) has a dimension which is scaled down from a spacing between the positions which the spots would occupy in the absence of the wavefront aberration by a factor less than one.
42. The system of claim 41, further comprising interface means for prompting an operator for the factor.
43. The system of claim 32, wherein step (bχ») comprises reducing a size of each search box to be replaced by a fraction of a pixel along each side.
44. The system of claim 43, wherein the fraction of a pixel is one-half of a pixel.
45. The system of claim 43, wherein, for each search box of reduced size which includes at least one fractional pixel, step (b)(iii) comprises assigning to each of said at least one fractional pixel a contribution to the centroid which is equal to a corresponding fraction of an intensity detected in the fractional pixel centered in the fractional pixel.
46. The system of claim 32, further comprising interface means for allowing an operator to drag one of the centroids to a new location, and wherein step (b) further comprises recalculating the centroid which has been dragged to the new location, using a light distribution around the new location.
47. The system of claim 32, further comprising interface means for allowing an operator to drag a central one of the centroids to a new location, and wherein step (b) further comprises recalculating all of the centroids around the new location.
48. The system of claim 32, wherein step (b)(ϋi) is performed without reference to a location of a previously located centroid.
49. The system of claim 32, wherein step (b)(iii) is performed using a location of a previously located centroid as a start estimate.
50. The system of claim 32, wherein step (bXiii) is performed using, as a start estimate, a location which a spot would occupy in an absence of the wavefront aberration.
51. The system of claim 34, further comprising interface means for allowing an operator to select the lenslets which do not provide usable data.
52. The system of claim 34, wherein step (c)(i) comprises determining automatically which lenslets do not provide usable data,
53. The system of claim 52, wherein step (c)(i) comprises determining automatically which lenslets do not provide usable data in accordance with standard deviations of intensity around the
65 corresponding centroids.
54. The system of claim 52, wherein step (c)(i) comprises determining automatically which lenslets do not provide usable data in accordance with overall intensity levels of the corresponding centroids.
55- The system of claim 34, wherem: the matrix has two rows corresponding to each of the lenslets; and step (c)(ii) comprises eliminating both of the rows corresponding to each of the lenslets which do not provide usable data.
56. The system of claim 55, wherein the two rows corresponding to each of the lenslets are a row corresponding to an x coordinate and a row corresponding to ay coordinate.
57. The system of claim 32, wherein step (c) comprises calculating a number of Zernike modes by using a number of centroids which is at least twice the number of Zernike modes.
58. The system of claim 32, wherein step (c) comprises calculating the wavefront aberration for a first pupil radius of the eye and also for a second pupil radius R, of the eye, wherein R* < Ro*
59. The system of claim 58, wherein the wavefront aberration is calculated for R\ by renormalizing the wavefront aberration calculated for Ro.
60. The system of claim 58. further comprising interface means for prompting an operator for
*«.
61. The system of claim 60, further comprising interface means for prompting an operator for a minimum Zernike mode and a maximum Zernike mode for use in calculating the wavefront aberration for R-.
62. The system of claim 34, wherein step (d) is performed using singular value decomposition.
63. A method of measuring a wavefront aberration of an eye, the method comprising:
(a) taking image data from the eye, the image data comprising a plurality of spots having positions determined by the wavefront aberration;
(b) defining a plurality of search boxes in the image data;
(c) determining the positions of the spots by:
(i) locating a centroid in each of the search boxes;
(ii) replacing each of the search boxes with a search box of reduced size, the search box of reduced size being clipped to fit entirely within the search box which is
66 replaced; (iii) locating the centroid in each of the search boxes of reduced size; and (iv) repeating steps (ii) and (iii) until each of the search boxes of reduced size reaches a minimum size; and (d) calculating the wavefront aberration in accordance with the positions of the spots.
64. The method of claim 63, wherein step (cXϋ) comprises forming the search box of reduced size by:
(A) reducing a size of ihe search box to be replaced by one pixel in each direction to form a pixel-reduced search box;
(B) centering the pixel-reduced search box on the centroid located in step (c)(i); and
(C) clipping the pixel-reduced search box to the boundaries of the search box to be replaced to fit entirely within the search box to be replaced.
65. The method of claim 63, wherein the minimum size in step (c)(iv) is a diffraction limited size.
66. The method of claim 63, wherein steps (c)(i) and (c)(iii) are peifoimed only in accordance with pixels in the image data whose intensities lie between a lower threshold and an upper threshold.
67. The method of claim 66, further comprising prompting an operator to select the lower threshold and the upper threshold.
68. A method of measuring a wavefront aberration of an eye, the method comprising:
(a) taking image data from the eye, the image data comprising a plurality of spots having positions determined by the wavefront aberration;
(b) defining a plurality of search boxes in the image data by: (i) defining a central search box;
(ii) defining a first set of search boxes relative to the central search box; (iii) locating centroids in the first set of search boxes; and (iv) defining successive sets of search boxes, each successive set defined in accordance with locations of centroids in a previous set;
(c) determining the positions of the spots by:
(i) locating a centroid in each of the search boxes;
67 (ii) replacing each of the search boxes with a search box of reduced size;
(iii) locating the centroid in each of the search boxes of reduced size; and (iv) repeating steps (ii) and (iii) until each of the search boxes of reduced size reaches a minimum size; and (d) calculating the wavefront aberration in accordance with the positions of the spots.
69. The method of claim 68, wherein the central search box is defined about a center point which is a position which one of the spots at a center of the image data would occupy in an absence of the wavefront aberration.
70. The method of claim 68, wherein step (a) comprises forming the spots by a plurality of lenslets having a lenslet spacing C.
71. The method of claim 70, wherein at least some of the plurality of search boxes have linear dimensions scaled from C by a factor of less than one.
72. The method of claim 71, further comprising prompting an operator for the factor.
73. The method of claim 70, wherein the central search box is defined about a center point which is a position which one of the spots at a center of the image would occupy in an absence of the wavefront aberration.
74. The method of claim 73, wherein: the first set of search boxes defined in step (b)(iϊ) have centers spaced from the center point of the central search box by C; and each successive set of search boxes defined in step (b)(iv) have centers spaced from the centroids in the previous set by C.
75. The method of claim 68, wherein, in step (c)(ii), the search box of reduced size is clipped to fit entirely within the search box which is replaced.
76. A method of measuring a wavefront aberration of an eye, the method comprising:
(a) taking image data from the eye while correcting for a spatial inhomogeneity in a retina of the eye, the image data comprising a plurality of spots having positions determined by the wavefront aberration;
(b) defining a plurality of search boxes in the image data;
(c) determining the positions of the spots by
(ϊ) locating a centroid in each of the search boxes;
68 (ii) replacing each of the search boxes with a search box of reduced size;
(iii) locating the centroid in each of the search boxes of reduced size; and (iv) repeating steps (ii) and (iii) until each of the search boxes of reduced size reaches a minimum size; and (d) calculating the wavefront aberration in accordance with the positions of the spots.
77. The method of claim 76, wherein step (a) comprises illuminating the eye with near infrared light.
78. The method of claim 76, wherein said step of correcting for the spatial inhomogeneity of the retina of the eye comprises illuminating the eye with light of a coherence length selected such that the spatial inhomogeneity does not appear in the image data.
79. The method of claim 78, wherein the coherence length is 30 microns,
80. The method of claim 78, wherein said step of correcting for the spatial inhomogeneity of the retina of the eye comprises:
(i) providing an optical scanning device;
(ii) illuminating the eye with light which has been scanned by the optical scanning device; and (iii) causing the light emerging from the eye to be scanned again by the optical scanning device and subsequently made incident on a detector such that the light is stationary as the light is made incident on the detector.
81. The method of claim 80, wherein: the detector comprises a camera having a frame lime; and the optical scanning device performs a plurality of scans within a single one of said frame time.
82. The method of claim 81, wherein the optical scanning device has a scanning frequency of 400-600 Hz.
83. The method of claim 81, wherein the optical scanning device scans with an angular extent of less than 0.5 degrees.
84. The method of claim 80, wherein the optical scanning device comprises a single scanning/de-scanning mirror which scans both the light which illuminates the eye and the light emerging from the eye.
69
85. A method of measuring a wavefront aberration of an eye, the method comprising:
(a) taking image data from a plurality of locations in the eye, the image data comprising a plurality of spots corresponding to the plurality of locations and having positions determined by the wavefront aberration, the data from the plurality of locations in the eye being taken by scanning light into the eye such that the plurality of spots are separated in time;
(b) defining a plurality of search boxes in the image data;
(c) determining the positions of the spots by
(i) locating a centroid in each of the search boxes;
(ϋ) replacing each of the search boxes with a search box of reduced size, the search box of reduced size being clipped to fit entirely within the search box which is replaced; (iii) locating the centroid in each of the search boxes of reduced size; and (i v) repeating steps (ii) and (iii) until each of the search boxes of reduced size reaches a minimum size; and
(d) calculating the wavefront aberration in accordance with the positions of the spots.
86. A device for measuring a wavefront aberration of an eye, the device comprising: image data taking means for taking image data from the eye, the image data comprising a plurality of spots having positions determined by the wavefront aberration; and data processing means, receiving the image data, for:
(a) defining a plurality of search boxes in the image data;
(b) determining the positions of the spots by:
(i) locating a centroid in each of the search boxes;
(ii) replacing each of the search boxes with a search box of reduced size, the search box of reduced size being clipped to fit entirely within the search box which is replaced; (iii) locating the centroid in each of the search boxes of reduced size: and
(iv) repeating steps (ii) and (iii) until each of the search boxes of reduced size reaches a minimum size; and
(c) calculating the wavefront aberration in accordance with the positions of the spots.
70
87. The device of claim 86, wherein the data processing means performs step (b)(ii) by forming the search box of reduced size by:
(A) reducing a size of the search box to be replaced by one pixel in each direction to form a pixel-reduced search box;
(B) centering the pixel-reduced search box on the centroid located in step (c)(i); and
(C) clipping the pixel-reduced search box to the boundaries of the search box to be replaced to fit entirely within the search box to be replaced.
88. The device of claim 86, wherein the minimum size in step (b)(iv) is a diffraction limited size.
89. The device of claim 86, wherein steps (b)(i) and (b)(iii) are performed only in accordance with pixels in the image data whose intensities lie between a lower threshold and an upper threshold.
90. The device of claim 89, wherein the data processing means comprises interface means for prompting an operator to select the lower threshold and the upper threshold.
91. A device for measuring a wavefront aberration of an eye, the device comprising: image data taking means for taking image data from the eye, the image data comprising a plurality of spots having positions determined by the wavefront aberration; and data processing means, receiving the image data, for:
(a) defining a plurality of search boxes in the image data by: (i) defining a central search box;
(ii) defining a first set of search boxes relative to the central search box; (iii) locating centroids in the first set of search boxes; and (iv) defining successive sets of search boxes, each successive set defined in accordance with locations of centroids in a previous set;
(b) determining the positions of the spots by:
(i) locating a centroid in each of the search boxes;
(ii) replacing each of the search boxes with a search box of reduced size;
(iii) locating the centroid in each of the search boxes of reduced size; and (iv) repeating steps (ii) and (iii) until each of the search boxes of reduced size reaches a minimum size; and
71 (c) calculating the wavefront aberration in accordance with the positions of the spots.
92. The device of claim 91 , wherein the central search box is defined about a center point which is a position which one of the spots at a center of the image data would occupy in an absence of the wavefront aberration.
93. The device of claim 91, wherein the image data taking means comprises a plurality of lenslets having a lenslet spacing C for forming the spots.
94. The device of claim 93, wherein at least some of the plurality of search boxes have linear dimensions scaled from C by a factor of less than one.
95. The device of claim 94, wherein the data processing means comprises interface means for prompting an operator for the factor.
96. The device of claim 93, wherein the central search box is defined about a center point which is a position which one of the spots at a center of the image would occupy in an absence of the wavefront aberration.
97. The device of claim 96, wherein: the first set of search boxes defined in step (a)(ii) have centers spaced from the center point of the central search box by C; and each successive set of search boxes defined in step (b)(iv) have centers spaced from the centroids in the previous set by C.
98. The device of claim 91, wherein, in step (b)(ii), the search box of reduced size is clipped to fit entirely within the search box which is replaced.
99. A device for measuring a wavefront aberration of an eye, the device comprising: image data taking means for taking image data from the eye while correcting for a spatial inhomogeneity in a retina of the eye, the image data comprising a plurality of spots having positions determined by the wavefront aberration; and data processing means, receiving the image data, for;
(a) defining a plurality of search boxes in the image data;
(b) determining the positions of the spots by
(i) locating a centroid in each of the search boxes;
(ii) replacing each of the search boxes with a search box of reduced size;
(iii) locating the centroid in each of the search boxes of reduced size; and
72 (iv) repeating steps (ii) and (iii) until each of the search boxes of reduced size reaches a minimum size; and (c) calculating the wavefront aberration in accordance with the positions of die spots.
100. The device of claim 99, wherein the image data taking means comprises means for illuminating the eye with near infrared light.
101. The device of claim 99, wherein the image data taking means comprises means for illuminating the eye with light of a coherence length selected such that the spatial inhomogeneity does not appear in the image data.
102. The device of claim 101, wherein the coherence length is 30 microns.
103. The device of claim 101, wherein the image data taking means comprises: a detector; and an optical scanning device for illuminating the eye with light which has been scanned by the optical scanning device and scanning again the light emerging from the eye, the light emerging from the eye and scanned again being subsequently made incident on the detector such that the light is stationary as the light is made incident on the detector.
104. The device of claim 103, wherein: the detector comprises a camera having a frame time; and the optical scanning device performs a plurality of scans within a single one of said frame time.
105. The device of claim 104, wherein the optical scanning device has a scanning frequency of 400-600 Hz.
106. The device of claim 104, wherein the optical scanning device scans with an angular extent of less than 0.5 degrees.
107. The device of claim 103, wherein the optical scanning device comprises a single scarming/de-scanning mirror which scans both the light which illuminates the eye and the light emerging from the eye.
108. A device for measuring a wavefront aberration of an eye, the method comprising: image data taking means for taking image data from a plurality of locations in the eye, the image data comprising a plurality of spots corresponding to the plurality of locations and having positions determined by the wavefront aberration, the image data taking means
73 comprising a scanner, the data from the plurality of locations in the eye being taken by scanning light into the eye with the scanner such that the plurality of spots are separated in time; and data processing means, receiving the image data, for:
(a) defining a plurality of search boxes in the image data;
(b) determining the positions of the spots by
(i) locating a centroid in each of the search boxes;
(ii) replacing each of the search boxes with a search box of reduced size, the search box of reduced size being clipped to fit entirely within the search box which is replaced; (iii) locating the centroid in each of the search boxes of reduced size; and (iv) repeating steps (ii) and (iii) until each of the search boxes of reduced size reaches a minimum size; and calculating the wavefront aberration in accordance with the positions of the spots.
74
PCT/US2000/029078 1999-10-21 2000-10-20 Rapid, automatic measurement of the eye's wave aberration WO2001028409A1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU13391/01A AU1339101A (en) 1999-10-21 2000-10-20 Rapid, automatic measurement of the eye's wave aberration
EP00975325A EP1221889A1 (en) 1999-10-21 2000-10-20 Rapid, automatic measurement of the eye's wave aberration
CA002388719A CA2388719A1 (en) 1999-10-21 2000-10-20 Rapid, automatic measurement of the eye's wave aberraion
BR0015231-5A BR0015231A (en) 1999-10-21 2000-10-20 Quick and automatic measurement of eye wave aberrations
JP2001531011A JP4660047B2 (en) 1999-10-21 2000-10-20 Rapid automatic measurement of eye wave aberration
US10/125,436 US6827444B2 (en) 2000-10-20 2002-04-19 Rapid, automatic measurement of the eye's wave aberration

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US09/421,892 1999-10-21
US09/421,892 US6199986B1 (en) 1999-10-21 1999-10-21 Rapid, automatic measurement of the eye's wave aberration

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WO2001028409B1 true WO2001028409B1 (en) 2001-10-18
WO2001028409A9 WO2001028409A9 (en) 2002-05-10

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CA2388719A1 (en) 2001-04-26
US6299311B1 (en) 2001-10-09
AU1339101A (en) 2001-04-30
EP1221889A1 (en) 2002-07-17
WO2001028409A1 (en) 2001-04-26
WO2001028409A9 (en) 2002-05-10
US6199986B1 (en) 2001-03-13
JP4660047B2 (en) 2011-03-30
JP2003511182A (en) 2003-03-25

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