WO2001028419B1 - Method and apparatus to measure blood flow by an introduced volume change - Google Patents

Method and apparatus to measure blood flow by an introduced volume change

Info

Publication number
WO2001028419B1
WO2001028419B1 PCT/US2000/041442 US0041442W WO0128419B1 WO 2001028419 B1 WO2001028419 B1 WO 2001028419B1 US 0041442 W US0041442 W US 0041442W WO 0128419 B1 WO0128419 B1 WO 0128419B1
Authority
WO
WIPO (PCT)
Prior art keywords
change
conduit
flow rate
resulting
sensing
Prior art date
Application number
PCT/US2000/041442
Other languages
French (fr)
Other versions
WO2001028419A2 (en
WO2001028419A3 (en
Inventor
Nikolai M Krivitski
Cornelius J Drost
Original Assignee
Transonic Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transonic Systems Inc filed Critical Transonic Systems Inc
Priority to DE60025535T priority Critical patent/DE60025535T2/en
Priority to EP00986829A priority patent/EP1223859B1/en
Publication of WO2001028419A2 publication Critical patent/WO2001028419A2/en
Publication of WO2001028419A3 publication Critical patent/WO2001028419A3/en
Publication of WO2001028419B1 publication Critical patent/WO2001028419B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/026—Measuring blood flow
    • A61B5/0265—Measuring blood flow using electromagnetic means, e.g. electromagnetic flowmeter
    • A61B5/027—Measuring blood flow using electromagnetic means, e.g. electromagnetic flowmeter using catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/024—Detecting, measuring or recording pulse rate or heart rate
    • A61B5/0255—Recording instruments specially adapted therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/026—Measuring blood flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/026—Measuring blood flow
    • A61B5/0275—Measuring blood flow using tracers, e.g. dye dilution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6852—Catheters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F1/00—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow
    • G01F1/05—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by using mechanical effects
    • G01F1/34—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by using mechanical effects by measuring pressure or differential pressure
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F1/00—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow
    • G01F1/66—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by measuring frequency, phase shift or propagation time of electromagnetic or other waves, e.g. using ultrasonic flowmeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F1/00—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow
    • G01F1/704—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow using marked regions or existing inhomogeneities within the fluid stream, e.g. statistically occurring variations in a fluid parameter
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F1/00—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow
    • G01F1/704—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow using marked regions or existing inhomogeneities within the fluid stream, e.g. statistically occurring variations in a fluid parameter
    • G01F1/708—Measuring the time taken to traverse a fixed distance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F25/00—Testing or calibration of apparatus for measuring volume, volume flow or liquid level or for metering by volume
    • G01F25/10—Testing or calibration of apparatus for measuring volume, volume flow or liquid level or for metering by volume of flowmeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A61B5/0215—Measuring pressure in heart or blood vessels by means inserted into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes

Abstract

A method and apparatus for determining an initial flow rate in a conduit is disclosed. A known change is made to the flow to be measured, resulting changes (or values corresponding to these changes), or relative changes in the flow to be measured are monitored and the initial flow in the conduit is calculated from the value of the known change and monitored changes. Devices to practice the method include catheters having one or two sensors and one or two sites for introducing the volume change.

Claims

AMENDED CLAIMS[received by the International Bureau on 6 July 2001 (06.07.01); original claims 1, 11, 20, 22 and 25 amended; remaining claims unchanged (4 pages)]
1. A method for determining an initial flow rate of a liquid in a conduit, comprising:
(a) introducing a discrete volume change to the initial flow rate;
(b) sensing a corresponding resulting change in the flow rate in the conduit; and
(c) determining the initial flow rate in response to the introduced volume change and the sensed resulting change.
2. The method of Claim 1, wherein introducing a discrete volume change includes injecting or withdrawing the discrete volume from the conduit.
3. The method of Claim 1 , further comprising employing one of a flow characteristic sensor and a liquid characteristic sensor.
4. The method of Claim 1, wherein sensing the corresponding resulting change includes sensing at an upstream location to the introduced volume change and a downstream location to the introduced volume change.
5. The method of Claim 1, wherein sensing the corresponding resulting change includes employing a sensor located ai one of in the conduit, on the conduit or spaced from an exterior of the conduit.
6. The method of Claim 1, wherein introducing the discrete volume change includes introducing the discrete volume change through a catheter in the conduit.
7. The method of Claim 1, further comprising sensing the corresponding resulting change in one of a liquid characteristic and a flow characteristic.
34
8, The method of Claim 1, wherein sensing a corresponding resulting change includes sensing a corresponding resulting change proportional to the flow in the conduit.
9. The method of Claim 1, wherein sensing a corresponding resulting change includes sensing one of a velocity, pressure and flow rate of the flow in the conduit.
10. The method of Claim 1, wherein sensing a corresponding resulting change includes sensing a dilution indicator.
11. A method for determining an initial flow rate in a conduit, comprising;
(a) locating a catheter in the conduit;
(b) introducing a known volume change to the initial flow rate through the catheter; and
(c) determining the initial flow rate in response to the introduced known volume change and a resulting flow rate change in the initial flow rate.
12. The method of Claim 11 , wherein introducing a known volume change includes introducing a discrete volume change.
13. The method of Claim 11, wherein introducing a known volume change includes injecting or withdrawing the discrete volume from the conduit.
14. The method of Claim 11, further comprising employing one of a flow characteristic sensor and a liquid characteristic sensor.
15. The method of Claim 11, wherein sensing the corresponding resulting change includes sensing at an upstream location to the introduced known volume change and a downstream location to the introduced known volume change.
16. The method of Claim 11, wherein sensing a corresponding resulting change includes sensing with a sensor located at one of in the conduit, on the conduit or spaced from an exterior of the conduit.
17. The method of Claim 11, further comprising sensing a resulting change after introducing the known volume change.
18. The method of Claim 17, wherein sensing the resulting change includes sensing a change corresponding to the introduced known volume change in one of a liquid characteristic and a flow characteristic.
19. The method of Claim 17, further comprising sensing a resulting change as proportional to the flow in the conduit.
20. A method for determining an initial flow rate in a conduit, comprising:
(a) introducing a discrete known volume change to the initial flow in the conduit to produce a resulting flow rate change in the initial flow; and
(b) determining the initial flow rate in response lo the introduced discrete known volume change and the resulting flow rate change.
36
21. The method of Claim 20, further comprising employing a sensor to sense the resulting change in the flow.
22. An apparatus for determining an initial flow rate in a conduit, comprising:
(a) means for introducing a discrete known volume change to the initial flow;
(b) a sensor for measuring a corresponding change in the flow rate in the conduit resulting from the introduced discrete known volume change; and
(c) a controller connected to the sensor, the controller configured to determine the initial flow rate in a response to the known volume change and the corresponding change in the flow rate in the conduit.
23. The apparatus of Claim 22, further comprising a catheter having an introduction port.
24. The apparatus of Claim 23, wherein the sensor is connected to the catheter.
25. An apparatus for determining an initial flow rate in a conduit, comprising:
(a) a known volume change introducer selected to effect a discrete known volume change to produce a resulting flow rate change in the initial flow in the conduit;
(b) a sensor for measuring the resulting change; and
(c) a controller connected to the sensor, the controller configured to determine the initial flow rate in a response to the known volume change and the resulting flow rate change measured by the sensor.
3 7
STATEMENT UNDER ARTICLE 19(1)
The amendments to independent Claims 1, 11, 20, 22 and 25 particularly recite the determination of an initial flow rate in a conduit from measuring a flow rate change in the conduit, wherein the flow rate change is in response to introduction of a known flow rate. In contrast to the present claims, the references of the International Search Report do not disclose or suggest (i) introducing a know flow rate in the conduit, (ii) measuring a resulting flow rate change in the conduit; and (iii) determining the initial flow rate of the conduit. That is, the present invention measures a flow rate change from the initial flow rate in the conduit, rather than measure a temperature change of the flow in the conduit, such as the cited thermal dilution reference. None of the references measure a flow rate change in the conduit, (to determine the initial flow rate), but rather measure a parameter such as temperature of the flow in the conduit. The measurements of the references are not measurements of a flow rate change.
38
PCT/US2000/041442 1999-10-19 2000-10-19 Method and apparatus to measure blood flow by an introduced volume change WO2001028419A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE60025535T DE60025535T2 (en) 1999-10-19 2000-10-19 DEVICE FOR DETERMINING THE FLOW THROUGH ADJUSTING VOLUME CHANGE
EP00986829A EP1223859B1 (en) 1999-10-19 2000-10-19 Apparatus for determining flow rate by an introduced volume change

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/419,849 1999-10-19
US09/419,849 US6868739B1 (en) 1999-10-19 1999-10-19 Method and apparatus to measure blood flow by an introduced volume change

Publications (3)

Publication Number Publication Date
WO2001028419A2 WO2001028419A2 (en) 2001-04-26
WO2001028419A3 WO2001028419A3 (en) 2001-12-27
WO2001028419B1 true WO2001028419B1 (en) 2002-01-24

Family

ID=23664020

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/041442 WO2001028419A2 (en) 1999-10-19 2000-10-19 Method and apparatus to measure blood flow by an introduced volume change

Country Status (5)

Country Link
US (4) US6868739B1 (en)
EP (2) EP1223859B1 (en)
DE (1) DE60025535T2 (en)
ES (1) ES2256080T3 (en)
WO (1) WO2001028419A2 (en)

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DE60025535D1 (en) 2006-04-06
EP1223859B1 (en) 2006-01-11
US7275447B2 (en) 2007-10-02
EP1223859A2 (en) 2002-07-24
US7121150B2 (en) 2006-10-17
US20060243061A1 (en) 2006-11-02
ES2256080T3 (en) 2006-07-16
EP1654981A3 (en) 2007-11-14
US6868739B1 (en) 2005-03-22
WO2001028419A2 (en) 2001-04-26
WO2001028419A3 (en) 2001-12-27
US7210359B2 (en) 2007-05-01
DE60025535T2 (en) 2006-11-23
US20070137296A1 (en) 2007-06-21

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