WO2001028589A3 - Formkörper mit amphiphilen äusseren phase und lipophilen inneren phase - Google Patents

Formkörper mit amphiphilen äusseren phase und lipophilen inneren phase Download PDF

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Publication number
WO2001028589A3
WO2001028589A3 PCT/EP2000/010113 EP0010113W WO0128589A3 WO 2001028589 A3 WO2001028589 A3 WO 2001028589A3 EP 0010113 W EP0010113 W EP 0010113W WO 0128589 A3 WO0128589 A3 WO 0128589A3
Authority
WO
WIPO (PCT)
Prior art keywords
phase
sticks
bodies
lipophilic
substances
Prior art date
Application number
PCT/EP2000/010113
Other languages
English (en)
French (fr)
Other versions
WO2001028589A2 (de
Inventor
Rainer Rogasch
Friedrich Fisseler
Marc Schmieding
Original Assignee
Rainer Rogasch
Friedrich Fisseler
Marc Schmieding
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rainer Rogasch, Friedrich Fisseler, Marc Schmieding filed Critical Rainer Rogasch
Priority to AT00974391T priority Critical patent/ATE246916T1/de
Priority to EP00974391A priority patent/EP1220656B1/de
Priority to DE50003306T priority patent/DE50003306D1/de
Priority to NZ518831A priority patent/NZ518831A/en
Priority to DK00974391T priority patent/DK1220656T3/da
Priority to JP2001531417A priority patent/JP2003512337A/ja
Priority to AU12719/01A priority patent/AU781999B2/en
Publication of WO2001028589A2 publication Critical patent/WO2001028589A2/de
Publication of WO2001028589A3 publication Critical patent/WO2001028589A3/de
Priority to US11/143,609 priority patent/US7541047B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/001—Combinations of extrusion moulding with other shaping operations
    • B29C48/0022—Combinations of extrusion moulding with other shaping operations combined with cutting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/03—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor characterised by the shape of the extruded material at extrusion
    • B29C48/05—Filamentary, e.g. strands

Abstract

Wasserdispergierbare oder wasserlösliche Polymere, insbesondere aus den Substanzklassen der Poloxamere oder der Polyester oder amphiphile Agenzien (Emulgatoren), sowie lipophile Stoffe werden durch Aufschmelzen der Komponenten bei geeigneten Temperaturen und unter Zumischung pharmazeutischer Wirkstoffe mittels mechanischer Verfahren dispergiert, d.h. eine innere lipophile Phase wird in einer äusseren hydrophilen Polymerphase stabil zerteilt. Durch gesteuerte Abkühlung, Aushärtung und Lagerung und anschliessendes Hochdruck-Pressen bei definierten Temperaturen und Arbeitsdruck lassen sich neben anderen Formkörpern disperse Polymer-Fettstifte herstellen, die sich durch besondere Bruchfestigkeit, Biegefähigkeit und eine variabel zeitbestimmte Formbeständigkeit auszeichnen.
PCT/EP2000/010113 1999-10-15 2000-10-13 Formkörper mit amphiphilen äusseren phase und lipophilen inneren phase WO2001028589A2 (de)

Priority Applications (8)

Application Number Priority Date Filing Date Title
AT00974391T ATE246916T1 (de) 1999-10-15 2000-10-13 Formkörper mit einer amphiphilen äusseren phase und einer lipophilen inneren phase
EP00974391A EP1220656B1 (de) 1999-10-15 2000-10-13 Formkörper mit einer amphiphilen äusseren phase und einer lipophilen inneren phase
DE50003306T DE50003306D1 (de) 1999-10-15 2000-10-13 Formkörper mit einer amphiphilen äusseren phase und einer lipophilen inneren phase
NZ518831A NZ518831A (en) 1999-10-15 2000-10-13 Shaped body comprising an amphiphilic outer phase and a lipophilic inner phase
DK00974391T DK1220656T3 (da) 1999-10-15 2000-10-13 Formet legeme med en amfifil ydre fase og en lipofil indre fase
JP2001531417A JP2003512337A (ja) 1999-10-15 2000-10-13 両親媒性外部相と親油性内部相とよりなる成形体
AU12719/01A AU781999B2 (en) 1999-10-15 2000-10-13 Shaped body and method for production of said body
US11/143,609 US7541047B2 (en) 1999-10-15 2005-06-03 Method for production of shaped body for treating wounds in milk producing animals

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19949897A DE19949897A1 (de) 1999-10-15 1999-10-15 Formkörper und Verfahren zu dessen Herstellung
DE19949897.0 1999-10-15

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/143,609 Continuation US7541047B2 (en) 1999-10-15 2005-06-03 Method for production of shaped body for treating wounds in milk producing animals

Publications (2)

Publication Number Publication Date
WO2001028589A2 WO2001028589A2 (de) 2001-04-26
WO2001028589A3 true WO2001028589A3 (de) 2002-04-11

Family

ID=7925862

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/010113 WO2001028589A2 (de) 1999-10-15 2000-10-13 Formkörper mit amphiphilen äusseren phase und lipophilen inneren phase

Country Status (10)

Country Link
US (3) US7541047B2 (de)
EP (1) EP1220656B1 (de)
JP (1) JP2003512337A (de)
AT (1) ATE246916T1 (de)
AU (1) AU781999B2 (de)
DE (2) DE19949897A1 (de)
DK (1) DK1220656T3 (de)
ES (1) ES2204714T3 (de)
NZ (1) NZ518831A (de)
WO (1) WO2001028589A2 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9198968B2 (en) 2008-09-15 2015-12-01 The Spectranetics Corporation Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10026698A1 (de) 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
US8114429B2 (en) 2008-09-15 2012-02-14 Cv Ingenuity Corp. Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens
US8128951B2 (en) 2008-09-15 2012-03-06 Cv Ingenuity Corp. Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens
US8257722B2 (en) 2008-09-15 2012-09-04 Cv Ingenuity Corp. Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens
US8968755B2 (en) 2010-10-23 2015-03-03 Joel Schlessinger Topical base and active agent-containing compositions, and methods for improving and treating skin
US8685381B2 (en) 2010-10-23 2014-04-01 Joel Schlessinger Topical base and active agent-containing compositions, and methods for improving and treating skin
US9956385B2 (en) 2012-06-28 2018-05-01 The Spectranetics Corporation Post-processing of a medical device to control morphology and mechanical properties
JP6252202B2 (ja) * 2014-01-23 2017-12-27 ライオン株式会社 口腔内塗布用固形スティック製剤
US10525171B2 (en) 2014-01-24 2020-01-07 The Spectranetics Corporation Coatings for medical devices

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US4344968A (en) * 1978-12-09 1982-08-17 Nippon Kayaku Kabushiki Kaisha Pharmaceutical vehicle
US4347237A (en) * 1981-03-02 1982-08-31 Evenstad Kenneth L Lower fatty acid glyceride high-HLB lubricating suppository and method for making and using the same
EP0094513A2 (de) * 1982-05-14 1983-11-23 Akzo GmbH Wirkstoff enthaltender Körper für die Langzeitabgabe
EP0103995A2 (de) * 1982-08-24 1984-03-28 Cilag Ag Medizinisches Zäpfchen
US4874774A (en) * 1983-11-17 1989-10-17 Nippon Shinyaku Co., Ltd. Nifedipine compositions and the production thereof
US5393738A (en) * 1986-05-27 1995-02-28 Sandoz, Ltd. Pharmaceutical compositions containing octreotide and excipients for oral or rectal administration
EP0709085A1 (de) * 1994-09-30 1996-05-01 Takeda Chemical Industries, Ltd. Präparat mit verzögerter Wirkstoffabgabe
WO1996014059A1 (en) * 1994-11-03 1996-05-17 Euro-Celtique S.A. Pharmaceutical composition containing a fusible carrier and method for producing the same
EP0748630A1 (de) * 1994-12-29 1996-12-18 Mochida Pharmaceutical Co., Ltd. Urinastatin enthaltende zäpfchen
US5700486A (en) * 1990-11-22 1997-12-23 Vectorpharma International S.P.A. Pharmaceutical compositions in the form of particles suitable for the controlled release of pharmacologically active substances and process for preparing the same compositions
WO2000003660A1 (en) * 1998-07-17 2000-01-27 Skyepharma, Inc. Biodegradable compositions for the controlled release of encapsulated substances

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US3756238A (en) * 1971-03-24 1973-09-04 Kimberly Clark Co Self-lubricating compound for use in hygienic and medical applications, and coated tampons and suppositories made therefrom
DE2553026A1 (de) * 1974-12-04 1976-06-10 Schlueter Edelfett Neue formulierungen
JPS6030650B2 (ja) * 1979-10-26 1985-07-17 日本油脂株式会社 座薬基剤組成物
US5248700A (en) * 1982-05-14 1993-09-28 Akzo Nv Active agent containing solid structures for prolonged release of active agents
DE3230602A1 (de) * 1982-08-18 1984-02-23 Kenneth L. 55391 Wayzata Minn. Evenstad Als gleitmittel wirkendes suppositorium, verfahren fuer dessen herstellung und anwendung desselben
US4698359A (en) * 1982-08-24 1987-10-06 Cilag, Ag Medicated suppository
US5240712A (en) * 1987-07-17 1993-08-31 The Boots Company Plc Therapeutic agents
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US5874479A (en) * 1991-03-01 1999-02-23 Warner-Lambert Company Therapeutic permeation enhanced-wound healing compositions and methods for preparing and using same
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TW359614B (en) * 1993-08-31 1999-06-01 Takeda Chemical Industries Ltd Composition containing benzimidazole compounds for rectal administration

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GB887872A (en) * 1958-06-25 1962-01-24 Upjohn Co Improvements in or relating to pharmaceutical preparations
US4344968A (en) * 1978-12-09 1982-08-17 Nippon Kayaku Kabushiki Kaisha Pharmaceutical vehicle
US4347237A (en) * 1981-03-02 1982-08-31 Evenstad Kenneth L Lower fatty acid glyceride high-HLB lubricating suppository and method for making and using the same
EP0094513A2 (de) * 1982-05-14 1983-11-23 Akzo GmbH Wirkstoff enthaltender Körper für die Langzeitabgabe
EP0103995A2 (de) * 1982-08-24 1984-03-28 Cilag Ag Medizinisches Zäpfchen
US4874774A (en) * 1983-11-17 1989-10-17 Nippon Shinyaku Co., Ltd. Nifedipine compositions and the production thereof
US5393738A (en) * 1986-05-27 1995-02-28 Sandoz, Ltd. Pharmaceutical compositions containing octreotide and excipients for oral or rectal administration
US5700486A (en) * 1990-11-22 1997-12-23 Vectorpharma International S.P.A. Pharmaceutical compositions in the form of particles suitable for the controlled release of pharmacologically active substances and process for preparing the same compositions
EP0709085A1 (de) * 1994-09-30 1996-05-01 Takeda Chemical Industries, Ltd. Präparat mit verzögerter Wirkstoffabgabe
WO1996014059A1 (en) * 1994-11-03 1996-05-17 Euro-Celtique S.A. Pharmaceutical composition containing a fusible carrier and method for producing the same
EP0748630A1 (de) * 1994-12-29 1996-12-18 Mochida Pharmaceutical Co., Ltd. Urinastatin enthaltende zäpfchen
WO2000003660A1 (en) * 1998-07-17 2000-01-27 Skyepharma, Inc. Biodegradable compositions for the controlled release of encapsulated substances

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9198968B2 (en) 2008-09-15 2015-12-01 The Spectranetics Corporation Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens

Also Published As

Publication number Publication date
EP1220656A2 (de) 2002-07-10
JP2003512337A (ja) 2003-04-02
ES2204714T3 (es) 2004-05-01
NZ518831A (en) 2003-09-26
US7541047B2 (en) 2009-06-02
WO2001028589A2 (de) 2001-04-26
AU781999B2 (en) 2005-06-23
DE19949897A1 (de) 2001-04-19
ATE246916T1 (de) 2003-08-15
DK1220656T3 (da) 2003-12-01
US20090218731A1 (en) 2009-09-03
US20050226903A1 (en) 2005-10-13
AU1271901A (en) 2001-04-30
EP1220656B1 (de) 2003-08-13
US20090074707A1 (en) 2009-03-19
DE50003306D1 (de) 2003-09-18

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