WO2001034548A3 - 3-heteroatom substituted and two carbon homologs of 15-hete and methods of use - Google Patents

3-heteroatom substituted and two carbon homologs of 15-hete and methods of use Download PDF

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Publication number
WO2001034548A3
WO2001034548A3 PCT/US2000/029208 US0029208W WO0134548A3 WO 2001034548 A3 WO2001034548 A3 WO 2001034548A3 US 0029208 W US0029208 W US 0029208W WO 0134548 A3 WO0134548 A3 WO 0134548A3
Authority
WO
WIPO (PCT)
Prior art keywords
hete
methods
heteroatom substituted
carbon homologs
homologs
Prior art date
Application number
PCT/US2000/029208
Other languages
French (fr)
Other versions
WO2001034548A2 (en
Inventor
Peter G Klimko
Mark R Hellberg
Gustav Graff
Original Assignee
Alcon Universal Ltd
Peter G Klimko
Mark R Hellberg
Gustav Graff
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Universal Ltd, Peter G Klimko, Mark R Hellberg, Gustav Graff filed Critical Alcon Universal Ltd
Priority to DE60010503T priority Critical patent/DE60010503T2/en
Priority to DK00972335T priority patent/DK1228027T3/en
Priority to CA002386333A priority patent/CA2386333A1/en
Priority to JP2001536499A priority patent/JP2003513948A/en
Priority to AT00972335T priority patent/ATE265996T1/en
Priority to EP00972335A priority patent/EP1228027B1/en
Priority to AU11011/01A priority patent/AU776146B2/en
Publication of WO2001034548A2 publication Critical patent/WO2001034548A2/en
Publication of WO2001034548A3 publication Critical patent/WO2001034548A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/60—Unsaturated compounds containing ether groups, groups, groups, or groups the non-carboxylic part of the ether being unsaturated

Abstract

3-heteroatom substituted and two carbon homologs of 15-HETE, and their derivatives, compositions and methods of their use for treating dry eye are disclosed.
PCT/US2000/029208 1999-11-09 2000-10-23 3-heteroatom substituted and two carbon homologs of 15-hete and methods of use WO2001034548A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
DE60010503T DE60010503T2 (en) 1999-11-09 2000-10-23 TRI-HETEROATOM-SUBSTITUTED AND TWO CARBON HOMOLOGE OF 15-HETE AND METHOD FOR USE
DK00972335T DK1228027T3 (en) 1999-11-09 2000-10-23 3-heteroatom substituted and two 15-HETE carbon homologues and methods of use
CA002386333A CA2386333A1 (en) 1999-11-09 2000-10-23 3-heteroatom substituted and two carbon homologs 15-hete and methods of use
JP2001536499A JP2003513948A (en) 1999-11-09 2000-10-23 Homologs of two carbons substituted with 3-hetero atoms of 15-HETE and methods of use
AT00972335T ATE265996T1 (en) 1999-11-09 2000-10-23 TRI-HETEROATOM-SUBSTITUTED AND TWO-CARBON HOMOLOGUE OF 15-HETE AND METHOD OF USE
EP00972335A EP1228027B1 (en) 1999-11-09 2000-10-23 3-heteroatom substituted and two carbon homologs of 15-hete and methods of use
AU11011/01A AU776146B2 (en) 1999-11-09 2000-10-23 3-heteroatom substituted and two carbon homologs of 15-HETE and methods of use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16436899P 1999-11-09 1999-11-09
US60/164,368 1999-11-09

Publications (2)

Publication Number Publication Date
WO2001034548A2 WO2001034548A2 (en) 2001-05-17
WO2001034548A3 true WO2001034548A3 (en) 2001-11-01

Family

ID=22594175

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/029208 WO2001034548A2 (en) 1999-11-09 2000-10-23 3-heteroatom substituted and two carbon homologs of 15-hete and methods of use

Country Status (12)

Country Link
US (2) US6331644B1 (en)
EP (1) EP1228027B1 (en)
JP (1) JP2003513948A (en)
AR (1) AR034398A1 (en)
AT (1) ATE265996T1 (en)
AU (1) AU776146B2 (en)
CA (1) CA2386333A1 (en)
DE (1) DE60010503T2 (en)
DK (1) DK1228027T3 (en)
ES (1) ES2215740T3 (en)
PT (1) PT1228027E (en)
WO (1) WO2001034548A2 (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE265996T1 (en) * 1999-11-09 2004-05-15 Alcon Inc TRI-HETEROATOM-SUBSTITUTED AND TWO-CARBON HOMOLOGUE OF 15-HETE AND METHOD OF USE
WO2003030894A1 (en) * 2001-10-11 2003-04-17 Alcon, Inc. Methods for treating dry eye
MXPA04003299A (en) * 2001-10-11 2004-07-23 Alcon Inc Methods for treating dry eye by a combination of an antiinflammatory steroid and a muc-1 secretagogue.
US6831186B2 (en) 2001-11-06 2004-12-14 Schering Aktiengesellschft Lipoxin A4 analogs
US20040002514A1 (en) * 2002-06-14 2004-01-01 Alcon, Inc. Topical use of hydroxyeicosatetraenoic acid compounds to treat psoriasis
EP1583527A1 (en) * 2002-06-14 2005-10-12 Alcon, Inc. Use of hydroxyeicosatetraenoic acid compounds to treat ophthalmic inflammatory disorders
KR20050057175A (en) * 2002-09-20 2005-06-16 알콘, 인코퍼레이티드 Use of cytokine synthesis inhibitors for the treatment of dry eye disorders

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US5696166A (en) * 1995-10-31 1997-12-09 Yanni; John M. Compositions containing hydroxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders

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AU546872B2 (en) 1982-06-16 1985-09-26 Unilever Plc Skin treatment compositions containing a fatty acid or ester
US4421748A (en) 1982-07-13 1983-12-20 Trager Seymour F Artificial tear aid
GB8319073D0 (en) 1983-07-14 1983-08-17 Efamol Ltd Fatty acid compositions
US4868154A (en) 1986-02-19 1989-09-19 Eye Research Institute Of Retina Foundation Stimulation of tear secretion with melanocyte stimulating hormones
US4753945A (en) 1986-02-19 1988-06-28 Eye Research Institute Of Retina Foundation Stimulation of tear secretion with phosphodiesterase inhibitors
US4883658A (en) 1986-04-28 1989-11-28 Holly Frank J Ophthalmic solution for treatment of dry-eye syndrome
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US4966773A (en) 1986-11-25 1990-10-30 Alcon Laboratories, Inc. Topical ophthalmic compositions containing microfine retinoid particles
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ZA927277B (en) 1991-10-02 1993-05-19 Boston Ocular Res Dry eye treatment process and solution.
EP0546728A3 (en) 1991-12-13 1993-09-08 Alcon Laboratories Inc Physiological tear compositions and methods for their preparation
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EP0691327A1 (en) * 1993-03-17 1996-01-10 Kao Corporation Amine derivative and dermatologic preparation containing the same
US5696166A (en) * 1995-10-31 1997-12-09 Yanni; John M. Compositions containing hydroxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders

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Also Published As

Publication number Publication date
WO2001034548A2 (en) 2001-05-17
CA2386333A1 (en) 2001-05-17
EP1228027A2 (en) 2002-08-07
DK1228027T3 (en) 2004-07-19
ATE265996T1 (en) 2004-05-15
US6331644B1 (en) 2001-12-18
DE60010503D1 (en) 2004-06-09
EP1228027B1 (en) 2004-05-06
AU776146B2 (en) 2004-08-26
US6437160B1 (en) 2002-08-20
JP2003513948A (en) 2003-04-15
ES2215740T3 (en) 2004-10-16
AR034398A1 (en) 2004-02-25
PT1228027E (en) 2004-08-31
US20020082286A1 (en) 2002-06-27
AU1101101A (en) 2001-06-06
DE60010503T2 (en) 2004-09-23

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