WO2001036604A3 - Nucleic acids encoding endotheliases, endotheliases and uses thereof - Google Patents

Nucleic acids encoding endotheliases, endotheliases and uses thereof Download PDF

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Publication number
WO2001036604A3
WO2001036604A3 PCT/US2000/031803 US0031803W WO0136604A3 WO 2001036604 A3 WO2001036604 A3 WO 2001036604A3 US 0031803 W US0031803 W US 0031803W WO 0136604 A3 WO0136604 A3 WO 0136604A3
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WO
WIPO (PCT)
Prior art keywords
endotheliases
nucleic acids
acids encoding
screening
portions
Prior art date
Application number
PCT/US2000/031803
Other languages
French (fr)
Other versions
WO2001036604A2 (en
Inventor
Edwin L Madison
Edgar O Ong
Original Assignee
Corvas Int Inc
Edwin L Madison
Edgar O Ong
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corvas Int Inc, Edwin L Madison, Edgar O Ong filed Critical Corvas Int Inc
Priority to EP00978819A priority Critical patent/EP1230349B1/en
Priority to DE60035218T priority patent/DE60035218D1/en
Priority to KR1020027006388A priority patent/KR20020056923A/en
Priority to IL14934000A priority patent/IL149340A0/en
Priority to CA2387805A priority patent/CA2387805C/en
Priority to JP2001538483A priority patent/JP2003514524A/en
Priority to AU16239/01A priority patent/AU784746B2/en
Priority to NZ518407A priority patent/NZ518407A/en
Priority to US09/717,473 priority patent/US7276364B1/en
Publication of WO2001036604A2 publication Critical patent/WO2001036604A2/en
Publication of WO2001036604A3 publication Critical patent/WO2001036604A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

Provided herein endotheliases and portions, particularly, the protease domains, and nucleic acids that encode the endotheliases. The endotheliases are transmembrane proteases expressed in endothelial cells. The nucleic acids and encoded proteins and protease domain portions thereof are used in a variety of prognostic, diagnostic, therapeutic and screening methods, including methods for screening for compounds that modulate angiogenesis.
PCT/US2000/031803 1999-11-18 2000-11-17 Nucleic acids encoding endotheliases, endotheliases and uses thereof WO2001036604A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
EP00978819A EP1230349B1 (en) 1999-11-18 2000-11-17 Nucleic acids encoding endotheliases, endotheliases and uses thereof
DE60035218T DE60035218D1 (en) 1999-11-18 2000-11-17 NUCLEIC ACIDS THAT CODE ENDOTHELIAS, ENDOTHELIASES, AND THEIR USE
KR1020027006388A KR20020056923A (en) 1999-11-18 2000-11-17 Nucleic acids encoding endotheliases, endotheliases and uses thereof
IL14934000A IL149340A0 (en) 1999-11-18 2000-11-17 Nucleic acids encoding endotheliases, endotheliases and uses thereof
CA2387805A CA2387805C (en) 1999-11-18 2000-11-17 Nucleic acids encoding endotheliases, endotheliases and uses thereof
JP2001538483A JP2003514524A (en) 1999-11-18 2000-11-17 Nucleic acid encoding an endoceliase, endotheliase and uses thereof
AU16239/01A AU784746B2 (en) 1999-11-18 2000-11-17 Nucleic acids encoding endotheliases, endotheliases and uses thereof
NZ518407A NZ518407A (en) 1999-11-18 2000-11-17 Nucleic acids encoding membrane proteases that are expressed on endothelial cells and participate in angiogenesis and their uses
US09/717,473 US7276364B1 (en) 1999-11-18 2000-11-20 Nucleic acids encoding endotheliases, endotheliases and uses thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US16639199P 1999-11-18 1999-11-18
US60/166,391 1999-11-18
US23484000P 2000-09-22 2000-09-22
US60/234,840 2000-09-22

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/717,473 Continuation US7276364B1 (en) 1999-11-18 2000-11-20 Nucleic acids encoding endotheliases, endotheliases and uses thereof

Publications (2)

Publication Number Publication Date
WO2001036604A2 WO2001036604A2 (en) 2001-05-25
WO2001036604A3 true WO2001036604A3 (en) 2001-11-01

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/031803 WO2001036604A2 (en) 1999-11-18 2000-11-17 Nucleic acids encoding endotheliases, endotheliases and uses thereof

Country Status (11)

Country Link
US (1) US7276364B1 (en)
EP (1) EP1230349B1 (en)
JP (1) JP2003514524A (en)
KR (1) KR20020056923A (en)
AT (1) ATE364689T1 (en)
AU (1) AU784746B2 (en)
CA (1) CA2387805C (en)
DE (1) DE60035218D1 (en)
IL (1) IL149340A0 (en)
RU (1) RU2002113076A (en)
WO (1) WO2001036604A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20020056923A (en) 1999-11-18 2002-07-10 코르바스 인터내셔날, 인코포레이티드 Nucleic acids encoding endotheliases, endotheliases and uses thereof
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JP2005518332A (en) * 2001-05-23 2005-06-23 デンドレオン コーポレイション Conjugates activated by cell surface proteases and their therapeutic use
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CA2535859A1 (en) * 2003-08-14 2005-03-03 Dyax Corp. Endotheliase-2 ligands
US20050054027A1 (en) * 2003-09-09 2005-03-10 Irm Llc Modulators of transmembrane protease serine 6
KR100783670B1 (en) * 2006-05-22 2007-12-07 한국표준과학연구원 Method for Screening Drug Candidates by Using Domain Protein

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