WO2001049219A1 - Implant of bone matter - Google Patents
Implant of bone matter Download PDFInfo
- Publication number
- WO2001049219A1 WO2001049219A1 PCT/EP2000/012235 EP0012235W WO0149219A1 WO 2001049219 A1 WO2001049219 A1 WO 2001049219A1 EP 0012235 W EP0012235 W EP 0012235W WO 0149219 A1 WO0149219 A1 WO 0149219A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- base body
- spinal column
- accordance
- support element
- implant
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/4455—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30721—Accessories
- A61F2/30724—Spacers for centering an implant in a bone cavity, e.g. in a cement-receiving cavity
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/442—Intervertebral or spinal discs, e.g. resilient
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- A—HUMAN NECESSITIES
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2/4603—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof
- A61F2/4611—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof of spinal prostheses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
- A61F2002/2839—Bone plugs or bone graft dowels
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30108—Shapes
- A61F2002/3011—Cross-sections or two-dimensional shapes
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
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- A61F2002/30108—Shapes
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2002/30329—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0063—Three-dimensional shapes
- A61F2230/0082—Three-dimensional shapes parallelepipedal
Definitions
- the present invention relates to an implant for the connection of bones and in particular to a spinal column implant for the fusion of vertebral bones which is introduced between two vertebral bones to be fused.
- the principle for treating these symptoms consists in the operative excavation of the vertebral disc nucleus and the laying in or insertion respectively of one — in the region of the cervical vertebral column — or of two — in the region of the lumbar vertebral column — sufficiently stable bodies in order to restore the normal height of the vertebral disc space.
- the horizontal displaceability must be prevented. This takes place either through the implant itself or through additional metal implants. These implants are subject in particular in the lumbar vertebral column to considerable forces, which can lead to the breakage of the metal implant. Therefore an attempt is made to have the intermediate vertebral insert grow together or fuse respectively as rapidly and as solidly as possible with the adjacent vertebral bodies.
- a known possibility of fusing two vertebrae consists in the insertion of a suitably shaped cylinder or dowel into a prepared cavity which reaches the two vertebrae to be fused.
- the material which is required for this is removed beforehand from the patient for example from the pelvic ridge.
- an implant is produced and then inserted into the intervertebral space of the patient between the two vertebrae to be fused (auto -grafting) .
- the object of the present invention therefore consists in creating an implant for the fusion of bones which restores the correct distance between the vertebral bodies and the stability of the spinal column, which provokes no immune reactions and which accelerates the healing process.
- a particular advantage of the spinal column implant in accordance with the invention is given through the material used, which, as a result of its biological origin does not represent a foreign body.
- the implant which is produced of bone matter, contributes in its entirety, that is, the support element of for example cortical bone marker as well as the base body of spongeous bone matter, to the fusion of the vertebral bodies in that it converts into the body's own tissue during the healing in.
- the base body has no outer shell of hard bone matter, but rather consists of spongeous bone, the spongeous bone matter of the base body comes into direct contact with the bone surfaces of the vertebral bodies in order to form a bony connection with the latter and thereby to fuse them or to connect them to one another respectively.
- the inventors have recognized that it is particularly advantageous to form the base body of spongeous, that is, relatively porous, bone matter in order to accelerate the healing in process.
- at least one load-carrying support element is embedded in the base body of spongeous bone matter which extends from one side to an oppositely lying side of the base body.
- the support element thus serves as a load-carrying part, in contrast to which the base body substantially has the function of seating the support element and enabling the growing together process with the surrounding bone matter.
- the at least one support element consists of compact or of cortical bone respectively.
- the support element can preferably be formed in the manner of a pin or a column respectively, with it also being possible for a plurality of support elements to be embedded in parallel into the base body. Depending on the stress distribution the support elements can also have different cross-sections in this situation.
- the support element is designed to be areal or wall-like, through which yet higher stresses on the implant are possible.
- a plurality of areal support elements, the planes of which intersect, are embedded in the base body.
- the support element or support elements can terminate at the outer contour of the base body or project beyond the outer contour of the base body in order to facilitate the fitting in of the implant between two vertebrae to be fused.
- the base body can contain at least one cavity which is accessible from its outer side for the reception of bone powder or bone granulate.
- the introduction of materials of this kind into a cavity of this kind improves the healing in process yet further.
- the base body can furthermore have a surface which is corrugated, toothed or provided with knobs.
- the outer shape of the base body can also vary. The latter can be formed in the shape of a block, a rectangular parallelepiped or a wedge, with it being possible for rounded off corner contours or curved base bodies to be advantageous.
- the implant is preferably matched in its size to the intervertebral space which is present between the adjacent vertebrae after the excavation of the intervertebral body.
- the application of the spinal column implant in accordance with the invention takes place after excavation of the vertebral disc with subsequent exposure of the vertebral bodies lying above and below it without it being necessary to damage healthy bone matter for this. This brings about the advantage that the existing intervertebral space is not enlarged and the supporting structures remain intact.
- a suitable allogenic or xenogenic bone matter is processed in such a manner that it is preserved, is capable of storage and can be used in accordance with its purpose.
- the preservation of the bone matter can for example take place by means of freeze drying.
- the spongeous bone matter is preferably produced through solvent dehydration of native bone matter by means of an organic solvent which is miscible with water, e.g. methanol, ethanol, propanol, isopropanol, acetone, methyl ethyl ketone or mixtures of these solvents.
- the preservation and sterilization of the bone matter in accordance with this method is also a subject matter of the patent DE 29 06 650, the contents of which are taken up into the disclosure of the present application through this reference.
- This method serves for the production of transplant preserves and enables a dehydration and exposure right into the fine structure of the fibrils of the bone matter, so that the processed bone matter has a morphological structure in a histological view which is very similar to that of the natural bone, and thus the desired properties of the bone matter are retained.
- This method of solvent dehydration also has the advantage that a substantially lower apparative cost and complexity is required in comparison with freeze drying.
- the spongeous bone matter can also be produced through solvent dehydration of bone matter with the subsequent terminal sterilization, in particular through irradiation with gamma rays.
- the spongeous bone matter can be produced through aseptic processing of bone matter without terminal sterilization.
- Fig. 1 a schematic perspective view of a first embodiment of a spinal column implant in accordance with the present invention
- Fig. 2 a schematic perspective view of a further embodiment of a spinal column implant in accordance with the present invention.
- Fig. 3 a schematic perspective view of a third embodiment of a spinal column implant in accordance with the present invention.
- the same reference symbols designate in each case the same components of the illustrated embodiments.
- the illustrated exemplary embodiments are suitable both for the cervical and for the lumbar fusion of vertebral bones.
- a spinal column implant in accordance with the invention which is illustrated in Fig. 1 consists of a base body 10 of spongeous bone matter, which is designed to have substantially the shape of a rectangular parallelepiped.
- a plurality of, in the illustrated exemplary embodiment five, support elements 12 which consist of cortical bone are embedded into the base body 10.
- the support elements are formed as cylindrical pins and are embedded parallel spaced to one another into the base body 10.
- the base body 10 of spongeous bone matter is provided with corresponding parallel bores into which the support elements 12 are fitted in.
- the support elements 12 are substantially as long as the base body 10 is high, so that each support element 12 extends from one side of the base body to its oppositely lying side.
- the end sides of the load-carrying support elements 12 substantially align with the outer contour of the base body 10.
- Fig. 2 shows a further embodiment of a spinal column implant which consists of a base body 20 of spongeous bone matter which is designed having the shape of a rectangular parallelepiped.
- a load-carrying support element 22 which consists of four wall sections 22a, 22b, 22c and 22d and the planes of which intersect in the middle of the support element 22 is embedded into the base body 20.
- the support element 22 is milled in a single piece out of cortical bone and forms in plan view the shape of a diagonal cross.
- the base body 20 of spongeous bone matter is provided with a milling-out corresponding to the outer contour of the support element 22 so that the support element 22 of cortical bone can be inserted into this milling-out.
- Fig. 3 shows a further embodiment of a spinal column implant which consists of a base body 30 of spongeous bone matter having the shape of a rectangular parallelepiped.
- a pin-like support element 32 which consists of cortical bone is embedded in the center of the base body 30.
- the end sides of the support element 32 are rounded off in the manner of a dome so that the support element 32 projects with its dome-shaped end side 34 beyond the outer contour of the base body 30.
- the opposite end side of the support element 32 is formed in the same way and likewise projects beyond the base body 30.
- the securing of the support elements in the base body can take place through press seating or through adhesive bonding or another suitable securing means.
- a large number of variations is possibly in the design of the support elements.
- merely a wall-like support element can be inserted. Pinlike and wall-like support elements can however also be combined with one another.
- the base body of spongeous bone matter can have various other surface designs in addition to the illustrated rectangular parallelepipedal shape.
- its surface can be provided with knobs; it can be formed to be corrugated or toothed.
- the outer shape of the base body can be wedge-like, rounded off or also curved in the manner of a banana.
- At least one cavity which is accessible from the outer side of the base body and which can be filled with bone powder or bone granulate can be provided in the base body .
- the size of the base body is matched to the predetermined location at which the implant is to be inserted.
- the outer dimensions of a spinal column implant of this kind can, depending on the location of use in cervical or lumbar application, for example be as follows: length 15 to 23 mm, width 8 to 13 mm, height 5 to 13 mm.
- the edges of the base body can be rounded off in order to facilitate the introduction of the implant. Furthermore, at least one reception opening for an application tool can be provided.
- the spongeous bone matter of the base body can be of human or animal, in particular bovine, origin and preferably has osteoinductive properties in order to favor the healing in process.
- base body support element base body support element a - - 22d partial wall base body support element end side
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
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EP00983226A EP1244398B1 (en) | 2000-01-06 | 2000-12-05 | Implant of bone matter |
DE60019643T DE60019643T2 (en) | 2000-01-06 | 2000-12-05 | IMPLANT FROM BONE MATERIAL |
AT00983226T ATE293413T1 (en) | 2000-01-06 | 2000-12-05 | IMPLANT MADE OF BONE MATERIAL |
AU20052/01A AU2005201A (en) | 2000-01-06 | 2000-12-05 | Implant of bone matter |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US09/478,820 | 2000-01-06 | ||
US09/478,820 US6379385B1 (en) | 2000-01-06 | 2000-01-06 | Implant of bone matter |
Publications (1)
Publication Number | Publication Date |
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WO2001049219A1 true WO2001049219A1 (en) | 2001-07-12 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/EP2000/012235 WO2001049219A1 (en) | 2000-01-06 | 2000-12-05 | Implant of bone matter |
Country Status (6)
Country | Link |
---|---|
US (1) | US6379385B1 (en) |
EP (1) | EP1244398B1 (en) |
AT (1) | ATE293413T1 (en) |
AU (1) | AU2005201A (en) |
DE (1) | DE60019643T2 (en) |
WO (1) | WO2001049219A1 (en) |
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- 2000-01-06 US US09/478,820 patent/US6379385B1/en not_active Expired - Lifetime
- 2000-12-05 AT AT00983226T patent/ATE293413T1/en not_active IP Right Cessation
- 2000-12-05 AU AU20052/01A patent/AU2005201A/en not_active Abandoned
- 2000-12-05 DE DE60019643T patent/DE60019643T2/en not_active Expired - Lifetime
- 2000-12-05 WO PCT/EP2000/012235 patent/WO2001049219A1/en active IP Right Grant
- 2000-12-05 EP EP00983226A patent/EP1244398B1/en not_active Expired - Lifetime
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Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6635222B2 (en) | 1993-07-22 | 2003-10-21 | Clearant, Inc. | Method of sterilizing products |
US6652592B1 (en) | 1997-10-27 | 2003-11-25 | Regeneration Technologies, Inc. | Segmentally demineralized bone implant |
US7618460B2 (en) | 2000-09-19 | 2009-11-17 | Warsaw Orthopedic, Inc. | Reinforced molded implant formed of cortical bone |
WO2002024122A3 (en) * | 2000-09-19 | 2002-07-25 | Sdgi Holdings Inc | Reinforced molded implant formed of cortical bone |
US6761738B1 (en) | 2000-09-19 | 2004-07-13 | Sdgi Holdings, Inc. | Reinforced molded implant formed of cortical bone |
WO2002024122A2 (en) * | 2000-09-19 | 2002-03-28 | Sdgi Holdings, Inc. | Reinforced molded implant formed of cortical bone |
WO2002096324A3 (en) * | 2001-05-29 | 2003-11-27 | Tutogen Medical Gmbh | Bone implant |
US6696060B2 (en) | 2001-06-14 | 2004-02-24 | Clearant, Inc. | Methods for sterilizing preparations of monoclonal immunoglobulins |
US6749851B2 (en) | 2001-08-31 | 2004-06-15 | Clearant, Inc. | Methods for sterilizing preparations of digestive enzymes |
CN100428920C (en) * | 2002-03-30 | 2008-10-29 | 斯恩蒂斯有限公司 | Surgical implant |
WO2013054057A1 (en) * | 2011-10-14 | 2013-04-18 | Arthroplastie Diffusion | Intersomatic implant |
FR2981262A1 (en) * | 2011-10-14 | 2013-04-19 | Pierre Roussouly | INTERSOMATIC IMPLANT |
US9918847B2 (en) | 2011-10-14 | 2018-03-20 | Adsm | Intersomatic implant |
Also Published As
Publication number | Publication date |
---|---|
AU2005201A (en) | 2001-07-16 |
DE60019643D1 (en) | 2005-05-25 |
EP1244398B1 (en) | 2005-04-20 |
EP1244398A1 (en) | 2002-10-02 |
US6379385B1 (en) | 2002-04-30 |
DE60019643T2 (en) | 2006-03-02 |
ATE293413T1 (en) | 2005-05-15 |
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