WO2001050829A3 - Alzheimer's disease secretase, app substrates therefor, and uses therefor - Google Patents
Alzheimer's disease secretase, app substrates therefor, and uses therefor Download PDFInfo
- Publication number
- WO2001050829A3 WO2001050829A3 PCT/IB2001/000799 IB0100799W WO0150829A3 WO 2001050829 A3 WO2001050829 A3 WO 2001050829A3 IB 0100799 W IB0100799 W IB 0100799W WO 0150829 A3 WO0150829 A3 WO 0150829A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- therefor
- alzheimer
- disease
- app substrates
- assays
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6478—Aspartic endopeptidases (3.4.23)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96472—Aspartic endopeptidases (3.4.23)
Abstract
The present invention provides the enzyme and enzymatic procedures for cleaving the β secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/477,076 US20050080232A1 (en) | 1998-09-24 | 2001-05-09 | Alzheimer's disease secretase, app substrates therefor, and uses therefor |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/416,901 US6699671B1 (en) | 1998-09-24 | 1999-10-13 | Alzheimer's disease secretase, APP substrates therefor, and uses therefor |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2001050829A2 WO2001050829A2 (en) | 2001-07-19 |
WO2001050829A3 true WO2001050829A3 (en) | 2003-12-04 |
Family
ID=23651777
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2001/000797 WO2001049097A2 (en) | 1998-09-24 | 2001-05-09 | Alzheimer's disease secretase, app substrates therefor, and uses therefor |
PCT/IB2001/000798 WO2001049098A2 (en) | 1998-09-24 | 2001-05-09 | Alzheimer's disease secretase, app substrates therefor, and uses therefor |
PCT/IB2001/000799 WO2001050829A2 (en) | 1998-09-24 | 2001-05-09 | Alzheimer's disease secretase, app substrates therefor, and uses therefor |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2001/000797 WO2001049097A2 (en) | 1998-09-24 | 2001-05-09 | Alzheimer's disease secretase, app substrates therefor, and uses therefor |
PCT/IB2001/000798 WO2001049098A2 (en) | 1998-09-24 | 2001-05-09 | Alzheimer's disease secretase, app substrates therefor, and uses therefor |
Country Status (4)
Country | Link |
---|---|
US (22) | US6699671B1 (en) |
EP (1) | EP1249498A3 (en) |
GB (1) | GB2367060B (en) |
WO (3) | WO2001049097A2 (en) |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9701684D0 (en) * | 1997-01-28 | 1997-03-19 | Smithkline Beecham Plc | Novel compounds |
US20040234976A1 (en) * | 1998-09-24 | 2004-11-25 | Gurney Mark E. | Alzheimer's disease secretase, app substrates therefor, and uses therefor |
US6699671B1 (en) * | 1998-09-24 | 2004-03-02 | Pharmacia & Upjohn Company | Alzheimer's disease secretase, APP substrates therefor, and uses therefor |
SG113454A1 (en) | 1998-09-24 | 2005-08-29 | Upjohn Co | Alzheimer's disease secretase |
US7115410B1 (en) * | 1999-02-10 | 2006-10-03 | Elan Pharmaceuticals, Inc. | β-secretase enzyme compositions and methods |
US7456007B1 (en) | 1998-12-31 | 2008-11-25 | Elan Pharmaceuticals, Inc. | β-secretase enzyme compositions and methods |
CA2359785A1 (en) | 1999-02-10 | 2000-08-17 | John P. Anderson | .beta.-secretase enzyme compositions and methods |
AU3770800A (en) | 1999-03-26 | 2000-10-16 | Amgen, Inc. | Beta secretase genes and polypeptides |
WO2001000665A2 (en) * | 1999-06-28 | 2001-01-04 | Oklahoma Medical Research Foundation | Inhibitors of memapsin 2 and use thereof |
GB9924957D0 (en) * | 1999-10-21 | 1999-12-22 | Smithkline Beecham Plc | Novel treatment |
GB9925136D0 (en) * | 1999-10-22 | 1999-12-22 | Smithkline Beecham Plc | Novel treatment |
US7514408B1 (en) | 1999-12-02 | 2009-04-07 | Elan Pharmaceuticals, Inc. | β-secretase enzyme compositions and methods |
US6713276B2 (en) * | 2000-06-28 | 2004-03-30 | Scios, Inc. | Modulation of Aβ levels by β-secretase BACE2 |
WO2002055717A2 (en) * | 2000-10-10 | 2002-07-18 | Genencor Int | Enhanced secretion of a polypeptide by a microorganism |
US7601528B1 (en) | 2000-12-23 | 2009-10-13 | Elan Pharmaceuticals, Inc. | Crystallization and structure determination of glycosylated human beta secretase, an enzyme implicated in alzheimer's disease |
US7217556B1 (en) | 2000-12-23 | 2007-05-15 | Pfizer Inc | Crystallization and structure determination of glycosylated human beta secretase, an enzyme implicated in Alzheimer's disease |
US7806980B2 (en) | 2000-12-23 | 2010-10-05 | Elan Pharmaceuticals, Inc. | Method for crystallizing human beta secretase in complex with an inhibitor |
US20040121947A1 (en) * | 2000-12-28 | 2004-06-24 | Oklahoma Medical Research Foundation | Compounds which inhibit beta-secretase activity and methods of use thereof |
US7384773B1 (en) * | 2001-05-10 | 2008-06-10 | Pfizer Inc | Crystal of HIV protease-cleaved human beta secretase and method for crystallization thereof |
US7524668B1 (en) | 2001-05-10 | 2009-04-28 | Elan Pharmaceuticals, Inc. | Crystal of human beta secretase having monoclinic space group symmetry C2 and methods for crystallization thereof |
ATE376768T1 (en) * | 2001-08-21 | 2007-11-15 | Smithkline Beecham Plc | TRANSGENIC ANIMAL MODEL FOR ALZHEIMER'S DISEASE |
US20060234944A1 (en) * | 2001-10-23 | 2006-10-19 | Oklahoma Medical Reseach Foundation | Beta-secretase inhibitors and methods of use |
CA2464736A1 (en) * | 2001-10-23 | 2003-05-15 | Oklahoma Medical Research Foundation | Beta-secretase inhibitors and methods of use |
US7910586B2 (en) | 2002-01-04 | 2011-03-22 | The Rockefeller University | Compositions and methods for prevention and treatment of amyloid-β peptide-related disorders |
WO2003072733A2 (en) | 2002-02-21 | 2003-09-04 | Pharmacia & Upjohn Company | Modified bace |
US20030224512A1 (en) * | 2002-05-31 | 2003-12-04 | Isis Pharmaceuticals Inc. | Antisense modulation of beta-site APP-cleaving enzyme expression |
US7442537B1 (en) | 2002-05-10 | 2008-10-28 | Elan Pharmaceuticals, Inc. | Crystals of unliganded beta secretase and/or beta secretase-like proteins and the use thereof |
US7166454B1 (en) * | 2002-05-24 | 2007-01-23 | Schering Corporation | Codon-optimized β-secretase and methods of refolding and processing |
AU2003285892A1 (en) * | 2002-10-15 | 2004-05-04 | Bristol-Myers Squibb Company | Bace binding peptides and uses thereof |
AU2003285151A1 (en) * | 2002-11-04 | 2004-06-07 | Bioarctic Neuroscience Ab | Methods for the identification of agents that modulate the structure and processing of beta-amyloid precursor protein |
JP2006505271A (en) * | 2002-11-04 | 2006-02-16 | アイコジェネックス コーポレイション | Methods for the identification of substances that modulate the structure and processing of membrane-bound precursor proteins |
US20050074456A1 (en) * | 2002-12-04 | 2005-04-07 | Marcus Ballinger | Constructs for homogenously processed preparations of beta site APP-cleaving enzyme |
AU2003302738A1 (en) * | 2002-12-04 | 2004-07-14 | Sunesis Pharmaceuticals, Inc. | Constructs homogenously processed preparations of beta site app-cleaving enzyme |
CN100335500C (en) * | 2003-06-27 | 2007-09-05 | 中国科学院上海生命科学研究院 | Human amyloid precursor protein 639, coded sequence and uses thereof |
WO2005029547A2 (en) * | 2003-09-16 | 2005-03-31 | The Trustees Of Columbia University In The City Of New York | Enhancing the width of polycrystalline grains with mask |
US7790864B2 (en) * | 2003-11-06 | 2010-09-07 | Exonhit Therapeutics Sa | Antibody to BACE455, an alternative splice variant of the human beta-secretase |
US20050112696A1 (en) * | 2003-11-25 | 2005-05-26 | The University Of Texas Southwestern Medical Center | Compositions, methods and assays related to secretase cleavage specificity |
US7501397B2 (en) * | 2004-06-04 | 2009-03-10 | The Brigham And Women's Hospital, Inc. | Helical peptidomimetics with enhanced activity |
US20060019368A1 (en) * | 2004-07-20 | 2006-01-26 | Marcus Ballinger | Constructs for homogenously processed preparations of beta site APP-cleaving enzyme |
EP1801232B1 (en) * | 2004-10-01 | 2012-03-14 | Takeda Pharmaceutical Company Limited | Method of screening transmembrane enzyme inhibitory substance |
WO2006081171A1 (en) * | 2005-01-24 | 2006-08-03 | Amgen Inc. | Humanized anti-amyloid antibody |
KR100893639B1 (en) | 2005-03-04 | 2009-04-17 | 일동제약주식회사 | Inhibitory Peptidomimetics of APP metabolism Based on Human BACE1 |
CN101142194B (en) * | 2005-03-14 | 2012-10-10 | 顶点制药有限责任公司 | Benzazole derivatives, compositions, and methods of use as b-secretase inhibitors |
US20060282886A1 (en) * | 2005-06-09 | 2006-12-14 | Lockheed Martin Corporation | Service oriented security device management network |
WO2007021886A2 (en) * | 2005-08-10 | 2007-02-22 | Oklahoma Medical Research Foundation | Truncated memapsin 2 for use for treating alzheimer's disease |
US20070299011A1 (en) * | 2006-05-19 | 2007-12-27 | Yeguang Chen | Appoptosin and uses thereof for treating neurodegenerative disease and cancer |
US20070292895A1 (en) * | 2006-05-19 | 2007-12-20 | Xiao-Ping Shi | Assays and methods to detect beta-secretase and its activity in body fluids and tissue extracts |
US8524741B2 (en) * | 2006-07-10 | 2013-09-03 | Synapsin Pharmaceuticals, Inc. | Compositions and methods relating to solenopsins and their uses in treating neurological disorders and enhancing cognitive and physical performance |
US9259419B2 (en) | 2006-07-10 | 2016-02-16 | Synapsin Pharmaceuticals, Inc. | Compositions and methods relating to solenopsins and their uses in treating neurological disorders and enhancing physical performance |
US8088474B2 (en) * | 2007-03-27 | 2012-01-03 | Agfa-Gevaert N.V. | Non-transparent microvoided biaxially stretched film, its use in synthetic paper and an image recording element comprising same |
US8414893B2 (en) | 2007-12-21 | 2013-04-09 | Amgen Inc. | Anti-amyloid antibodies and uses thereof |
US20090233993A1 (en) * | 2008-03-06 | 2009-09-17 | Burnham Institute For Medical Research | Compositions and methods for inhibiting gsk3 activity and uses thereof |
CA2721156C (en) * | 2008-04-14 | 2017-09-19 | Mivac Development Aktiebolag | Stable amyloid beta monomers and oligomers |
WO2009155609A1 (en) * | 2008-06-20 | 2009-12-23 | Oklahoma Medical Research Foundation | IMMUNOGENIC MEMAPSIN 2 β-SECRETASE PEPTIDES AND METHODS OF USE |
US9023767B2 (en) * | 2009-05-07 | 2015-05-05 | Memorial Sloan-Kettering Cancer Center | γ-Secretase substrates and methods of use |
US20110177061A1 (en) | 2009-07-10 | 2011-07-21 | Martek Biosciences Corporation | Methods of treating and preventing neurological disorders using docosahexaenoic acid |
SG10201507362TA (en) | 2009-08-05 | 2015-10-29 | Intra Cellular Therapies Inc | Novel Regulatory Proteins And Inhibitors |
US9632088B2 (en) | 2010-09-07 | 2017-04-25 | Memorial Sloan-Kettering Cancer Center | Methods and compositions for gamma-secretase assay |
WO2012064836A1 (en) | 2010-11-10 | 2012-05-18 | Genentech, Inc. | Methods and compositions for neural disease immunotherapy |
US20130210638A1 (en) * | 2012-02-10 | 2013-08-15 | Jeffrey Charles Olson | Methods for sequencing nucleic acid |
KR101791296B1 (en) * | 2014-04-17 | 2017-10-27 | 제주대학교 산학협력단 | Expression cassette and vector with genes related Alzheimer's disease and transgenic cell line made from it |
US11008403B2 (en) | 2014-11-19 | 2021-05-18 | Genentech, Inc. | Anti-transferrin receptor / anti-BACE1 multispecific antibodies and methods of use |
WO2016081639A1 (en) | 2014-11-19 | 2016-05-26 | Genentech, Inc. | Antibodies against bace1 and use thereof for neural disease immunotherapy |
CN107973838B (en) * | 2017-12-06 | 2021-02-26 | 广州恒宁生物科技有限公司 | Small-molecule polypeptide for promoting skin injury repair and application thereof |
EP3759127A4 (en) | 2018-03-02 | 2022-03-30 | Ionis Pharmaceuticals, Inc. | Compounds and methods for the modulation of amyloid-beta precursor protein |
WO2021158184A1 (en) * | 2020-02-07 | 2021-08-12 | Vidyasirimedhi Institute Of Science And Technology | Method of producing modified amyloid precursor protein anchored with detectable moieties and modified amyloid peptides derived thereof |
Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996040885A2 (en) * | 1995-06-07 | 1996-12-19 | Athena Neurosciences, Inc. | β-SECRETASE, ANTIBODIES TO β-SECRETASE, AND ASSAYS FOR DETECTING β-SECRETASE INHIBITION |
WO1998021589A1 (en) * | 1996-11-15 | 1998-05-22 | The Trustees Of The University Of Pennsylvania | Screening for modulators of amyloid processing |
WO1998026059A1 (en) * | 1996-12-11 | 1998-06-18 | Athena Neurosciences, Inc. | Beta-secretase isolated from human 293 cells |
EP0855444A2 (en) * | 1997-01-28 | 1998-07-29 | Smithkline Beecham Plc | Aspartic proteinase 2 (ASP2) |
WO2000023576A2 (en) * | 1998-10-16 | 2000-04-27 | Hook Vivian Y H | Secretases related to alzheimer's dementia |
WO2000047618A2 (en) * | 1999-02-10 | 2000-08-17 | Elan Pharmaceuticals, Inc. | HUMAN β-SECRETASE ENZYME, INHIBITORS AND THEIR COMPOSITIONS AND USES |
WO2000058479A1 (en) * | 1999-03-26 | 2000-10-05 | Amgen Inc. | Beta secretase genes and polypeptides |
WO2000068266A1 (en) * | 1999-05-11 | 2000-11-16 | Eli Lilly And Company | Amyloid precursor protein protease and related nucleic acid compounds |
WO2000069262A1 (en) * | 1999-05-13 | 2000-11-23 | Scios Inc. | NOVEL β-SECRETASE AND MODULATION OF β-SECRETASE ACTIVITY |
US6211428B1 (en) * | 1994-09-01 | 2001-04-03 | Merck & Co., Inc. | Transgenic mouse expressing a familial form of human amyloid precursor protein |
WO2001029563A1 (en) * | 1999-10-21 | 2001-04-26 | Smithkline Beecham Plc | Method of screening for inhibitors of asp2 |
Family Cites Families (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US168060A (en) * | 1875-09-21 | Improvement in apparatus for condensing vapors, gases | ||
US119571A (en) * | 1871-10-03 | Improvement in stove-pipe thimbles | ||
US54334A (en) * | 1866-05-01 | Improvement in well-curbs | ||
US177836A (en) * | 1876-05-23 | Improvement in neck-yokes | ||
US139172A (en) * | 1873-05-20 | Improvement in combined heating and cooking stoves | ||
US178368A (en) * | 1876-06-06 | Improvement in coffee-pots | ||
US277229A (en) * | 1883-05-08 | William h | ||
US114408A (en) * | 1871-05-02 | Improvement in reaping-machines | ||
US471669A (en) * | 1892-03-29 | Machine for making wire fence-strands | ||
US404578A (en) * | 1889-06-04 | Alfred savill tomkins | ||
US210292A (en) * | 1878-11-26 | Improvement in loom-shuttles | ||
US501708A (en) * | 1893-07-18 | Francis ii | ||
US141363A (en) * | 1873-07-29 | Improvement in horse-powers | ||
US723722A (en) * | 1902-04-01 | 1903-03-24 | William H Parker | Punching-machine. |
US724569A (en) * | 1902-05-17 | 1903-04-07 | Elmer W Gragert | Relay-pump. |
US724571A (en) * | 1902-07-31 | 1903-04-07 | Edwin T Greenfield | Machine for making armored electric cables. |
US730329A (en) * | 1902-09-16 | 1903-06-09 | Thomas Wright | Lifting-jack. |
US724566A (en) * | 1902-10-02 | 1903-04-07 | Michael S Gooley | Variable-throw device. |
US723739A (en) * | 1902-10-31 | 1903-03-24 | Ernest G Schwarz | Station-indicator. |
US724568A (en) * | 1903-01-09 | 1903-04-07 | William N Gourley | Die for welding links. |
US5200339A (en) | 1990-08-17 | 1993-04-06 | Abraham Carmela R | Proteases causing abnormal degradation of amyloid β-protein precursor |
US5292652A (en) | 1990-10-05 | 1994-03-08 | Athena Neurosciences, Inc. | Amyloidin protease and uses thereof |
JP3510244B2 (en) | 1991-01-21 | 2004-03-22 | エラン ファーマシューティカルス,インコーポレイテッド | Tests and models for Alzheimer's disease |
IL105793A0 (en) | 1992-05-28 | 1993-09-22 | Lilly Co Eli | Protease and related dna compounds |
US5455169A (en) | 1992-06-04 | 1995-10-03 | Alzheimer's Institute Of America, Inc. | Nucleic acids for diagnosing and modeling Alzheimer's disease |
US5766846A (en) | 1992-07-10 | 1998-06-16 | Athena Neurosciences | Methods of screening for compounds which inhibit soluble β-amyloid peptide production |
US5837672A (en) | 1992-07-10 | 1998-11-17 | Athena Neurosciences, Inc. | Methods and compositions for the detection of soluble β-amyloid peptide |
DE69432629T3 (en) | 1993-01-25 | 2008-01-17 | Takeda Pharmaceutical Co. Ltd. | ANTIBODIES AGAINST BETA AMYLOID OR DERIVATIVES AND ITS USE |
CA2174429C (en) | 1993-10-27 | 2011-08-30 | Lisa C. Mcconlogue | Transgenic animals harboring app allele having swedish mutation |
WO1996031122A1 (en) | 1995-04-04 | 1996-10-10 | Eli Lilly And Company | Amyloid precursor protein protease |
US6221645B1 (en) | 1995-06-07 | 2001-04-24 | Elan Pharmaceuticals, Inc. | β-secretase antibody |
US5744346A (en) | 1995-06-07 | 1998-04-28 | Athena Neurosciences, Inc. | β-secretase |
US6329163B1 (en) | 1995-06-07 | 2001-12-11 | Elan Pharmaceuticals, Inc. | Assays for detecting β-secretase inhibition |
JPH09178743A (en) * | 1995-12-27 | 1997-07-11 | Oriental Yeast Co Ltd | Determinationof soluble app |
US5710248A (en) * | 1996-07-29 | 1998-01-20 | University Of Iowa Research Foundation | Peptide tag for immunodetection and immunopurification |
DE19641180A1 (en) | 1996-09-24 | 1998-03-26 | Schering Ag | A method of displaying APP secretase modulation and its use as an agent for the treatment of Alzheimer's disease |
GB2352496B (en) * | 1996-12-04 | 2001-04-18 | Hepworth Building Prod | Non-return device |
EP0848062A3 (en) | 1996-12-14 | 2000-07-05 | Smithkline Beecham Corporation | Aspartic protease ASP1 |
GB9626022D0 (en) | 1996-12-14 | 1997-01-29 | Smithkline Beecham Plc | Novel compounds |
GB9701939D0 (en) | 1997-01-30 | 1997-03-19 | Weatherford Lamb | Gripping arrangement for gripping casing |
GB9721094D0 (en) | 1997-10-03 | 1997-12-03 | Unilever Plc | Autophobic hairspray compositions |
JP4088359B2 (en) | 1997-10-20 | 2008-05-21 | 松下電器産業株式会社 | Collective sealed secondary battery |
CA2311572A1 (en) | 1997-12-17 | 1999-06-24 | Genset S.A. | Extended cdnas for secreted proteins |
WO1999033963A1 (en) * | 1997-12-31 | 1999-07-08 | Chiron Corporation | Metastatic cancer regulated gene |
PT1490386E (en) | 1998-03-10 | 2008-11-24 | Genentech Inc | Novel polypeptide and nucleic acids encoding the same |
AU4045599A (en) | 1998-06-05 | 1999-12-30 | Aventis Pharma S.A. | Polypeptides with beta-secretase type activity |
US6699671B1 (en) * | 1998-09-24 | 2004-03-02 | Pharmacia & Upjohn Company | Alzheimer's disease secretase, APP substrates therefor, and uses therefor |
SG113454A1 (en) * | 1998-09-24 | 2005-08-29 | Upjohn Co | Alzheimer's disease secretase |
US20040234976A1 (en) * | 1998-09-24 | 2004-11-25 | Gurney Mark E. | Alzheimer's disease secretase, app substrates therefor, and uses therefor |
US6245884B1 (en) | 1998-10-16 | 2001-06-12 | Vivian Y. H. Hook | Secretases related to alzheimer's dementia |
DE19910108C2 (en) | 1999-03-08 | 2001-02-22 | Falk Fahrenholz | Cells that co-express an amyloid precursor protein and an alpha-secretase, a test procedure for the identification of alpha-secretase-active substances and one for the identification of further secretases, a test procedure for determining the susceptibility to Alzheimer's disease and the use of nucleic acids that code for an alpha-secretase , for gene therapy |
US20020049303A1 (en) * | 1999-06-28 | 2002-04-25 | Tang Jordan J. N. | Catalytically active recombinant memapsin and methods of use thereof |
WO2001000665A2 (en) * | 1999-06-28 | 2001-01-04 | Oklahoma Medical Research Foundation | Inhibitors of memapsin 2 and use thereof |
GB9925136D0 (en) | 1999-10-22 | 1999-12-22 | Smithkline Beecham Plc | Novel treatment |
US6361975B1 (en) | 1999-11-16 | 2002-03-26 | Smithkline Beecham Corporation | Mouse aspartic secretase-2(mASP-2) |
US6291223B1 (en) | 1999-11-23 | 2001-09-18 | Smithkline Beecham Corporation | Mouse aspartic secretase-1 (mASP1) |
CN101179845B (en) | 2006-11-08 | 2011-02-02 | 华为技术有限公司 | Key management method and system between local proxy and foreign proxy |
-
1999
- 1999-10-13 US US09/416,901 patent/US6699671B1/en not_active Expired - Fee Related
-
2000
- 2000-04-12 US US09/548,370 patent/US7041473B1/en not_active Expired - Fee Related
- 2000-04-12 US US09/548,367 patent/US6440698B1/en not_active Expired - Fee Related
- 2000-04-12 US US09/548,366 patent/US6797487B2/en not_active Expired - Fee Related
- 2000-04-12 US US09/548,368 patent/US6825023B1/en not_active Expired - Fee Related
- 2000-04-12 US US09/548,372 patent/US6420534B1/en not_active Expired - Fee Related
- 2000-04-12 US US09/548,365 patent/US6867018B1/en not_active Expired - Fee Related
- 2000-04-12 US US09/548,376 patent/US6706485B1/en not_active Expired - Fee Related
- 2000-04-12 US US09/548,373 patent/US6737510B1/en not_active Expired - Fee Related
- 2000-04-18 US US09/551,853 patent/US6500667B1/en not_active Expired - Fee Related
- 2000-09-22 EP EP02015537A patent/EP1249498A3/en not_active Withdrawn
- 2000-09-22 GB GB0125934A patent/GB2367060B/en not_active Expired - Fee Related
-
2001
- 2001-02-27 US US09/794,927 patent/US6727074B2/en not_active Expired - Fee Related
- 2001-02-27 US US09/794,743 patent/US6913918B2/en not_active Expired - Fee Related
- 2001-02-27 US US09/794,925 patent/US6828117B2/en not_active Expired - Fee Related
- 2001-02-27 US US09/794,748 patent/US20020037315A1/en not_active Abandoned
- 2001-02-28 US US09/795,847 patent/US6753163B2/en not_active Expired - Fee Related
- 2001-04-05 US US09/681,442 patent/US20020081634A1/en not_active Abandoned
- 2001-05-09 US US09/869,414 patent/US6790610B2/en not_active Expired - Fee Related
- 2001-05-09 WO PCT/IB2001/000797 patent/WO2001049097A2/en active Application Filing
- 2001-05-09 US US10/477,076 patent/US20050080232A1/en not_active Abandoned
- 2001-05-09 WO PCT/IB2001/000798 patent/WO2001049098A2/en active Application Filing
- 2001-05-09 WO PCT/IB2001/000799 patent/WO2001050829A2/en active Application Filing
-
2003
- 2003-08-29 US US10/652,927 patent/US7368536B2/en not_active Expired - Fee Related
- 2003-08-29 US US10/652,830 patent/US7375187B2/en not_active Expired - Fee Related
- 2003-08-29 US US10/652,045 patent/US7378511B2/en not_active Expired - Fee Related
-
2007
- 2007-07-11 US US11/776,348 patent/US20080171349A1/en not_active Abandoned
Patent Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6211428B1 (en) * | 1994-09-01 | 2001-04-03 | Merck & Co., Inc. | Transgenic mouse expressing a familial form of human amyloid precursor protein |
WO1996040885A2 (en) * | 1995-06-07 | 1996-12-19 | Athena Neurosciences, Inc. | β-SECRETASE, ANTIBODIES TO β-SECRETASE, AND ASSAYS FOR DETECTING β-SECRETASE INHIBITION |
WO1998021589A1 (en) * | 1996-11-15 | 1998-05-22 | The Trustees Of The University Of Pennsylvania | Screening for modulators of amyloid processing |
WO1998026059A1 (en) * | 1996-12-11 | 1998-06-18 | Athena Neurosciences, Inc. | Beta-secretase isolated from human 293 cells |
EP0855444A2 (en) * | 1997-01-28 | 1998-07-29 | Smithkline Beecham Plc | Aspartic proteinase 2 (ASP2) |
WO2000023576A2 (en) * | 1998-10-16 | 2000-04-27 | Hook Vivian Y H | Secretases related to alzheimer's dementia |
WO2000047618A2 (en) * | 1999-02-10 | 2000-08-17 | Elan Pharmaceuticals, Inc. | HUMAN β-SECRETASE ENZYME, INHIBITORS AND THEIR COMPOSITIONS AND USES |
WO2000058479A1 (en) * | 1999-03-26 | 2000-10-05 | Amgen Inc. | Beta secretase genes and polypeptides |
WO2000068266A1 (en) * | 1999-05-11 | 2000-11-16 | Eli Lilly And Company | Amyloid precursor protein protease and related nucleic acid compounds |
WO2000069262A1 (en) * | 1999-05-13 | 2000-11-23 | Scios Inc. | NOVEL β-SECRETASE AND MODULATION OF β-SECRETASE ACTIVITY |
WO2001029563A1 (en) * | 1999-10-21 | 2001-04-26 | Smithkline Beecham Plc | Method of screening for inhibitors of asp2 |
Non-Patent Citations (5)
Title |
---|
CHYUNG et al: "Novel Beta-secretase Cleavage of Beta-amyloid Precursor Protein in the Endoplasmic Reticulum/Intermediate Compartment of NT2N Cells." J. of Cell Biol., 11 August 1997, Vol. 138, No. 3, pages 671-680 * |
HUSE et al: "Maturation and Endosomal Targeting of Beta-site Amyloid Precursor Proteincleaving Enzyme." The Alzheimer's disease Beta-secretase, J. of Biol. Chem., October 2000, Vol. 275, No. 43, pages 33729-33737 * |
HUSSAIN et al: "Identification of a Novel Aspartic Protease (Asp2) as Beta-secretase." Mol. & Cell. Neurosciences, December 1999, Vol. 14, No. 6, pages 419-427 * |
MARX et al: "Transfected Human B Cells: A New Model to Study the Functional and Immunostimulatory Consequences of APP Production." Experimental Gerontology, September 1999, Vol. 34, No. 6, pages 783-795 * |
VASSAR et al: "Beta-secretase Cleavage of alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE." Science, 22 October 1999, Vol. 286, No. 5440, pages 735-741 * |
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