WO2001053792A2 - A system for detecting substances - Google Patents

A system for detecting substances Download PDF

Info

Publication number
WO2001053792A2
WO2001053792A2 PCT/IL2001/000053 IL0100053W WO0153792A2 WO 2001053792 A2 WO2001053792 A2 WO 2001053792A2 IL 0100053 W IL0100053 W IL 0100053W WO 0153792 A2 WO0153792 A2 WO 0153792A2
Authority
WO
WIPO (PCT)
Prior art keywords
support
reactant
body lumen
detecting unit
substance
Prior art date
Application number
PCT/IL2001/000053
Other languages
French (fr)
Other versions
WO2001053792A3 (en
Inventor
Gavriel Meron
Itamar Willner
Original Assignee
Given Imaging Ltd.
Yissum Research Development Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Given Imaging Ltd., Yissum Research Development Company filed Critical Given Imaging Ltd.
Priority to IL15081001A priority Critical patent/IL150810A0/en
Priority to AU2001227020A priority patent/AU2001227020A1/en
Priority to EP01901353A priority patent/EP1350103B1/en
Priority to AT01901353T priority patent/ATE454625T1/en
Priority to DE60141044T priority patent/DE60141044D1/en
Publication of WO2001053792A2 publication Critical patent/WO2001053792A2/en
Priority to IL150810A priority patent/IL150810A/en
Publication of WO2001053792A3 publication Critical patent/WO2001053792A3/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14546Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/07Endoradiosondes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/07Endoradiosondes
    • A61B5/073Intestinal transmitters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14539Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring pH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/041Capsule endoscopes for imaging
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/05Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances characterised by the image sensor, e.g. camera, being in the distal end portion

Abstract

The present invention relates to a method and system for the in vivo determination of the presence and/or concentration of biological and/or chemical substances in body lumens. The system of the invention comprises a solid support, the support being inserted into a body lumen and having immobilized thereon at least one reactant capable of reacting with the substance resulting in an optical change; and a detecting unit, in communication with the support, capable of detecting a reaction resulting in an optical change between the reactant and the substance.

Claims

1. A system for determining in vivo the presence and/or concentration of a biological and/or chemical substance in a body lumen comprising: a solid support, the support being inserted into a body lumen and having immobilized thereon at least one reactant capable of reacting with the substance resulting in an optical change; and a detecting unit, in communication with the support, capable of detecting a reaction resulting in an optical change between the reactant and the substance.
2. A system according to claim 1 wherein the support is attached to or is an integral part of a stent, needle or endosope.
3. A system according to claim 1 wherein the support is attached to or is an integral part of a swallowable capsule.
4. A system according to claim 1 wherein the support is a glass support.
5. A system according to claim 1 wherein the support is a plastic support.
6. A system according to claim 5 wherein the plastic is isoplast.
7. A system according to claim 1 wherein the reactant is immobilized onto the support via a bridging group.
8. A system according to claim 1 wherein the reactant is a chemical compound.
9. A system according to claim 1 wherein the reactant is a biological compound.
10. A system according to claim 1 wherein the reactant is an enzyme.
11. A system according to claim 1 wherein the reactant is an antibody.
12. A system according to claim 1 wherein the reactant is polyacrylic acid.
13. A system according to claim 1 wherein the reactant is polymethylmetacrylate having thrombin linked thereon.
14. A system according to claim 1 wherein the detecting unit is capable of imaging a reaction between the reactant and the substance.
15. A system according to claim 1 further comprising at least one illuminating
13 element for illuminating the support.
16. A system according to claim 15 wherein the support is transparent to illumination emitted from the illuminating element.
17. A system according to claim 16 wherein the reactant is transparent to the illumination emitted from the illuminating element.
18. A system according to claim 1 wherein the detecting unit detects optical density.
19. A system according to claim 1 wherein the detecting unit detects color changes.
20. A system according to claim 1 further comprising a monitoring unit in communication with the support, said monitoring unit capable of locating the support in the body lumen.
21. A system according to claim 20 further comprising a transmitting unit in communication with the support.
22. A system according to claim 21 wherein the monitoring unit comprises a reception system operable with the transmitting unit, said reception system capable of receiving transmitted output from said transmitting unit thereby locating the support along a pre prepared map of the lumen.
23. A method for determining in vivo the presence and/or concentration of a biological and/or chemical substance in a body lumen comprising the steps of: inserting into a body lumen a solid support, said support having immobilized thereon at least one reactant capable of reacting with the substance resulting in an optical change and said support being in communication with a detecting unit that is capable of detecting a reaction resulting in an optical change between the reactant and the substance; and b) receiving information from the detecting unit.
24. A method according to claim 23 wherein the support is attached to or is an
14 integral part of a stent, needle or endoscope.
25. A method according to claim 23 wherein the support is attached to or is an integral part of a swallowable capsule.
26. A method according to claim 23 wherein the support is a glass support.
27. A method according to claim 23 wherein the support is a plastic support.
28. A method according to claim 27 wherein the plastic is isoplast.
29. A method according to claim 23 wherein the reactant is immobilized onto the support via a bridging group.
30. A method according to claim 23 wherein the reactant is a chemical compound.
31. A method according to claim 23 wherein the reactant is a biological compound.
32. A method according to claim 23 wherein the reactant is an enzyme.
33. A method according to claim 23 wherein the reactant is an antibody.
34. A method according to claim 23 wherein the reactant is poly acrylic acid.
35. A method according to claim 23 wherein the reactant is polymethylmetacrylate having thrombin linked thereon.
36. A method according to claim 23 wherein the detecting unit is capable of imaging a reaction between the reactant and the substance.
37. A method according to claim 23 further comprising the step of utilizing illumination to illuminate the support.
38. A method according to claim 37 wherein the support is transparent to the illumination.
39. A method according to claim 38 wherein the reactant is transparent to the illumination.
40. A method according to claim 23 wherein the detecting unit detects optical density.
15
41. A method according to claim 23 wherein the detecting unit detects color changes.
42. A method according to claim 23 further comprising the step of locating the support in the body lumen.
43. A method according to claim 42 wherein locating the support in the body lumen is done by a monitoring unit that is in communication with the support.
44. A method according to claim 43 wherein the monitoring unit comprises a reception system operable with a transmitting unit, said transmitting unit being in communication with the support and said reception system capable of receiving transmitted output from the transmitting unit thereby locating the support along a pre prepared map of the lumen.
45. A swallowable capsule comprising the system according to claim 1.
46. A swalloable capsule comprising the system according to claim 22.
47. A method according to claim 23 for the detection of substances in the gastrointestinal tract.
48. A method according to claim 47 for the detection of blood or blood components in the gastrointestinal tract.
49. A diagnostic device for the detection of blood or blood components in a body lumen comprising a plastic support, the support being inserted into the body lumen and having immobilized thereon at least one reactant capable of reacting with the blood or blood components resulting in an optical change; and a detecting unit, in communication with the support, capable of detecting a reaction resulting in an optical change between the reactant and the blood or blood components.
16
PCT/IL2001/000053 2000-01-19 2001-01-18 A system for detecting substances WO2001053792A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
IL15081001A IL150810A0 (en) 2000-01-19 2001-01-18 A system for detecting substances
AU2001227020A AU2001227020A1 (en) 2000-01-19 2001-01-18 A system for detecting substances
EP01901353A EP1350103B1 (en) 2000-01-19 2001-01-18 A system for detecting substances
AT01901353T ATE454625T1 (en) 2000-01-19 2001-01-18 SYSTEM FOR DETECTING SUBSTANCES
DE60141044T DE60141044D1 (en) 2000-01-19 2001-01-18 SYSTEM FOR DETECTING SUBSTANCES
IL150810A IL150810A (en) 2000-01-19 2002-07-18 System for detecting substances

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48733700A 2000-01-19 2000-01-19
US09/487,337 2000-01-19

Publications (2)

Publication Number Publication Date
WO2001053792A2 true WO2001053792A2 (en) 2001-07-26
WO2001053792A3 WO2001053792A3 (en) 2003-08-07

Family

ID=23935328

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2001/000053 WO2001053792A2 (en) 2000-01-19 2001-01-18 A system for detecting substances

Country Status (7)

Country Link
US (1) US7201872B2 (en)
EP (1) EP1350103B1 (en)
AT (1) ATE454625T1 (en)
AU (1) AU2001227020A1 (en)
DE (1) DE60141044D1 (en)
IL (1) IL150810A0 (en)
WO (1) WO2001053792A2 (en)

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EP1350103A4 (en) 2005-03-23
IL150810A0 (en) 2003-02-12
DE60141044D1 (en) 2010-02-25
US7201872B2 (en) 2007-04-10
WO2001053792A3 (en) 2003-08-07
US20020146368A1 (en) 2002-10-10
AU2001227020A1 (en) 2001-07-31
EP1350103B1 (en) 2010-01-06
ATE454625T1 (en) 2010-01-15

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