WO2001056468A3 - Arthroscopic impedance probe to detect cartilage degeneration - Google Patents

Arthroscopic impedance probe to detect cartilage degeneration Download PDF

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Publication number
WO2001056468A3
WO2001056468A3 PCT/US2001/003508 US0103508W WO0156468A3 WO 2001056468 A3 WO2001056468 A3 WO 2001056468A3 US 0103508 W US0103508 W US 0103508W WO 0156468 A3 WO0156468 A3 WO 0156468A3
Authority
WO
WIPO (PCT)
Prior art keywords
tissue
impedance
electrodes
probe
cartilage
Prior art date
Application number
PCT/US2001/003508
Other languages
French (fr)
Other versions
WO2001056468A2 (en
Inventor
Steven Treppo
Alan J Grodzinsky
Emerson Cheung Quan
Eliot H Frank
David Bombard
David Breslau
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Publication of WO2001056468A2 publication Critical patent/WO2001056468A2/en
Publication of WO2001056468A3 publication Critical patent/WO2001056468A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/45—For evaluating or diagnosing the musculoskeletal system or teeth
    • A61B5/4514—Cartilage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/053—Measuring electrical impedance or conductance of a portion of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0209—Special features of electrodes classified in A61B5/24, A61B5/25, A61B5/283, A61B5/291, A61B5/296, A61B5/053
    • A61B2562/0215—Silver or silver chloride containing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0261—Strain gauges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/45—For evaluating or diagnosing the musculoskeletal system or teeth
    • A61B5/4528—Joints
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device

Abstract

The change in tissue impedance due to the change in the extracellular matrix that results from the degradation of cartilage is utilized to detect degradation of articular cartilage. A probe (306) comprising electrodes (110-116) applies a current to the articular cartilage (308) which results in a current distribution and electric field within the cartilage, along with an associated voltage drop across the electrodes. The amplitude of this voltage drop is then measured and divided by the current applied to determine the tissue impedance. By measuring the impedance of patient tissue and comparing the detected patient impedance to a normal value for the tissue from clinically normal tissue, a determination of whether the patient tissue is degraded and the extent of degradation is possible. Preferably, the impedance is measured using a probe with interdigitated electrodes. By changing which electrodes are utilized, the wavelength of the current distribution changes, allowing the probe to image depth dependent focal lesions.
PCT/US2001/003508 2000-02-02 2001-02-02 Arthroscopic impedance probe to detect cartilage degeneration WO2001056468A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17982000P 2000-02-02 2000-02-02
US60/179,820 2000-02-02

Publications (2)

Publication Number Publication Date
WO2001056468A2 WO2001056468A2 (en) 2001-08-09
WO2001056468A3 true WO2001056468A3 (en) 2002-04-25

Family

ID=22658121

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/003508 WO2001056468A2 (en) 2000-02-02 2001-02-02 Arthroscopic impedance probe to detect cartilage degeneration

Country Status (2)

Country Link
US (3) US6735468B2 (en)
WO (1) WO2001056468A2 (en)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002092783A2 (en) * 2001-05-15 2002-11-21 Children's Medical Center Corporation Methods and apparatus for application of micro-mechanical forces to tissues
NO20025803D0 (en) * 2002-12-03 2002-12-03 Idex Asa Live finger
NZ547198A (en) * 2003-11-14 2008-05-30 Univ Pennsylvania Method and device for treating osteoarthritis and cartilage disease, defects, and injuries in the human hip
US7878987B2 (en) 2005-05-05 2011-02-01 The Regents Of The University Of California Methods and instruments for assessing bone fracture risk
US7205782B2 (en) * 2005-07-11 2007-04-17 Brigham Young University Scanned impedance imaging system method and apparatus
GB2461446B (en) 2007-04-19 2012-09-12 Mako Surgical Corp Implant planning using captured joint motion information
AU2008248261A1 (en) * 2007-05-01 2008-11-13 The Brigham And Women's Hospital, Inc. Wound healing device
EP2180833A4 (en) * 2007-08-20 2013-03-13 Univ California Methods and instruments for measuring tissue mechanical properties
US8222533B2 (en) * 2007-10-02 2012-07-17 Tyco Electronics Corporation Low profile photovoltaic (LPPV) box
US8915866B2 (en) * 2008-01-18 2014-12-23 Warsaw Orthopedic, Inc. Implantable sensor and associated methods
US8862222B2 (en) * 2008-02-29 2014-10-14 Polyvalor, Limited Partnership Non-invasive measuring of load-induced electric potentials in diarthroidial joints
DE102009006176A1 (en) * 2008-09-26 2010-04-08 Ketek Gmbh Measuring system, syringe assembly, measuring system arrangement and method for finding a suitable injection site of a needle in a body
US8386010B2 (en) * 2008-10-23 2013-02-26 Covidien Lp Surgical tissue monitoring system
US9364291B2 (en) 2008-12-11 2016-06-14 Mako Surgical Corp. Implant planning using areas representing cartilage
US8224481B2 (en) * 2009-01-19 2012-07-17 Access Business Group International Llc Method and apparatus for dispensing fluid compositions
US8948838B2 (en) * 2009-01-27 2015-02-03 Scibase Ab Switch probe for multiple electrode measurement of impedance
US20100191141A1 (en) * 2009-01-27 2010-07-29 Peter Aberg Method and apparatus for diagnosing a diseased condition in tissue of a subject
US8740817B2 (en) * 2009-03-31 2014-06-03 Depuy (Ireland) Device and method for determining forces of a patient's joint
US8721568B2 (en) 2009-03-31 2014-05-13 Depuy (Ireland) Method for performing an orthopaedic surgical procedure
US8551023B2 (en) 2009-03-31 2013-10-08 Depuy (Ireland) Device and method for determining force of a knee joint
US8597210B2 (en) * 2009-03-31 2013-12-03 Depuy (Ireland) System and method for displaying joint force data
US20110082389A1 (en) * 2009-10-07 2011-04-07 The Regents Of The University Of California Apparatus and method for assessing condition of articular cartilage
US20120046570A1 (en) * 2010-03-08 2012-02-23 Alpha Orthopaedics, Inc. Methods and devices for real time monitoring of collagen content and for altering collagen status
US20120061257A1 (en) * 2010-09-14 2012-03-15 University Of Southern California Concentric bipolar electrochemical impedance spectroscopy to assess vascular oxidative stress
US9364169B2 (en) * 2012-02-15 2016-06-14 Brigham Young University Apparatus method and system for measuring strain in biological tissue
US9381011B2 (en) 2012-03-29 2016-07-05 Depuy (Ireland) Orthopedic surgical instrument for knee surgery
US10206792B2 (en) 2012-03-31 2019-02-19 Depuy Ireland Unlimited Company Orthopaedic surgical system for determining joint forces of a patients knee joint
US10070973B2 (en) 2012-03-31 2018-09-11 Depuy Ireland Unlimited Company Orthopaedic sensor module and system for determining joint forces of a patient's knee joint
US9545459B2 (en) 2012-03-31 2017-01-17 Depuy Ireland Unlimited Company Container for surgical instruments and system including same
US20140031894A1 (en) * 2012-07-23 2014-01-30 Eugene G. Lipov Method and device for post-operative application of pulsed radiofrequency for prevention of pain and cartilage loss
US9238090B1 (en) 2014-12-24 2016-01-19 Fettech, Llc Tissue-based compositions
WO2016194690A1 (en) * 2015-05-29 2016-12-08 株式会社村田製作所 Piezoelectric film sensor and holding state detection device
WO2023250123A1 (en) * 2022-06-23 2023-12-28 Trustees Of Tufts College Controlled indentation instrumentation working in dynamical mechanical analysis mode

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992006634A1 (en) * 1990-10-18 1992-04-30 Centrum för Dentalteknik och Biomaterial A device for measurement of electrical impedance of organic and biological materials
WO1996008198A1 (en) * 1994-09-15 1996-03-21 Ki Chul Cha Apparatus and method for analyzing body composition based on bioelectrical impedance analysis

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4895163A (en) * 1988-05-24 1990-01-23 Bio Analogics, Inc. System for body impedance data acquisition
US4951683A (en) * 1989-01-19 1990-08-28 Davis Jeffrey P Device for detecting keratoconjunctivitis sicca
US5246013A (en) 1989-12-22 1993-09-21 Massachusetts Institute Of Technology Probe, system and method for detecting cartilage degeneration
US5766153A (en) * 1993-05-10 1998-06-16 Arthrocare Corporation Methods and apparatus for surgical cutting
JP3240401B2 (en) * 1994-12-07 2001-12-17 オムロン株式会社 Impedance measurement device and health management guideline advice device
US5779651A (en) * 1997-02-07 1998-07-14 Bio Syntech Medical apparatus for the diagnosis of cartilage degeneration via spatial mapping of compression-induced electrical potentials

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992006634A1 (en) * 1990-10-18 1992-04-30 Centrum för Dentalteknik och Biomaterial A device for measurement of electrical impedance of organic and biological materials
WO1996008198A1 (en) * 1994-09-15 1996-03-21 Ki Chul Cha Apparatus and method for analyzing body composition based on bioelectrical impedance analysis

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
SACHS JEFFREY R ET AL: "Electromechanically coupled poroelastic medium driven by an applied electric current. Surface detection of bulk material properties", PCH PHYSICOCHEM HYDRODYN;PCH, PHYSICOCHEMICAL HYDRODYNAMICS 1989, vol. 11, no. 4, 1989, pages 585 - 614, XP001004559 *
VAN DER MOLEN J N ET AL: "Current clamping amplifier", MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, MAY 1979, UK, vol. 17, no. 3, pages 407 - 409, XP002167817, ISSN: 0140-0118 *

Also Published As

Publication number Publication date
US6856834B2 (en) 2005-02-15
US20030149376A1 (en) 2003-08-07
US6882880B2 (en) 2005-04-19
US20020045838A1 (en) 2002-04-18
WO2001056468A2 (en) 2001-08-09
US6735468B2 (en) 2004-05-11
US20040087869A1 (en) 2004-05-06

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