WO2001056594A1 - Nasal calcitonin formulations - Google Patents
Nasal calcitonin formulations Download PDFInfo
- Publication number
- WO2001056594A1 WO2001056594A1 PCT/US2001/003212 US0103212W WO0156594A1 WO 2001056594 A1 WO2001056594 A1 WO 2001056594A1 US 0103212 W US0103212 W US 0103212W WO 0156594 A1 WO0156594 A1 WO 0156594A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- calcitonin
- pharmaceutical composition
- liquid pharmaceutical
- salt
- composition
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU36604/01A AU783952B2 (en) | 2000-02-04 | 2001-01-31 | Nasal calcitonin formulations |
CA2399505A CA2399505C (en) | 2000-02-04 | 2001-01-31 | Nasal calcitonin formulations |
EP01908769A EP1251867A4 (en) | 2000-02-04 | 2001-01-31 | Nasal calcitonin formulations |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18024100P | 2000-02-04 | 2000-02-04 | |
US60/180,241 | 2000-02-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2001056594A1 true WO2001056594A1 (en) | 2001-08-09 |
Family
ID=22659737
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/003212 WO2001056594A1 (en) | 2000-02-04 | 2001-01-31 | Nasal calcitonin formulations |
Country Status (6)
Country | Link |
---|---|
US (3) | US6440392B1 (en) |
EP (1) | EP1251867A4 (en) |
CN (1) | CN1183965C (en) |
AU (1) | AU783952B2 (en) |
CA (1) | CA2399505C (en) |
WO (1) | WO2001056594A1 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9399017B2 (en) | 2007-05-29 | 2016-07-26 | Enteris Biopharma, Inc. | Peptide pharmaceutical for oral delivery |
US9457086B2 (en) | 2013-03-05 | 2016-10-04 | Enteris Biopharma, Inc. | Pharmaceuticals for oral delivery |
US9833411B2 (en) | 2015-01-12 | 2017-12-05 | Enteris Biopharma, Inc. | Solid oral dosage forms |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1251867A4 (en) | 2000-02-04 | 2004-12-08 | Unigene Lab Inc | Nasal calcitonin formulations |
US20090035260A1 (en) * | 2002-07-29 | 2009-02-05 | Therapicon Srl | Enhanced nasal composition of active peptide |
US8008255B2 (en) | 2003-05-30 | 2011-08-30 | Amylin Pharmaceuticals, Inc. | Methods and compositions for enhanced transmucosal delivery of peptides and proteins |
CN1546169A (en) * | 2003-12-16 | 2004-11-17 | 上海医药工业研究院 | Transnasal inhalant dry powder of calcitonin and its preparation |
ITMI20040235A1 (en) * | 2004-02-13 | 2004-05-13 | Therapicon Srl | PHARMACEUTICAL PREPARATION FOR THE ORAL CABLE |
US20090069226A1 (en) * | 2004-05-28 | 2009-03-12 | Amylin Pharmaceuticals, Inc. | Transmucosal delivery of peptides and proteins |
CN101549149B (en) * | 2008-09-17 | 2011-12-28 | 北京双鹭药业股份有限公司 | New nasal spray formulation of calcitonin aqueous solution |
US20100256060A1 (en) * | 2009-04-02 | 2010-10-07 | Unigene Laboratories Inc. | Peptide pharmaceuticals for nasal delivery |
CN108969754B (en) * | 2018-09-04 | 2019-06-21 | 深圳大佛药业股份有限公司 | A kind of Salmon Calcitonin Nasal Spray and preparation method thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5059587A (en) * | 1987-08-03 | 1991-10-22 | Toyo Jozo Company, Ltd. | Physiologically active peptide composition for nasal administration |
US6087338A (en) * | 1995-02-08 | 2000-07-11 | Therapicon S.R.L. | Pharmaceutical non inorganic saline solutions for endonasal administration of a calcitonin |
Family Cites Families (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4151276A (en) | 1975-05-12 | 1979-04-24 | Armour Pharmaceutical Company | Method of suppressing gastric acid secretion by the oral administration of calcitonin |
US4900730A (en) | 1981-01-14 | 1990-02-13 | Toyo Jozo Co., Ltd. | Preparation which promotes the absorption of peptides |
JPS5885813A (en) | 1981-11-17 | 1983-05-23 | Toyo Jozo Co Ltd | Drug preparation having high absorbability |
GB2092002B (en) * | 1981-01-14 | 1985-09-11 | Toyo Jozo Kk | Suppositories injectable solutions |
US5169849A (en) | 1982-02-01 | 1992-12-08 | Sandoz Ltd. | Nasal pharmaceutical compositions |
CH657779A5 (en) * | 1982-10-05 | 1986-09-30 | Sandoz Ag | GALENIC COMPOSITIONS CONTAINING CALCITONIN. |
US4476116A (en) | 1982-12-10 | 1984-10-09 | Syntex (U.S.A.) Inc. | Polypeptides/chelating agent nasal compositions having enhanced peptide absorption |
AU572815B2 (en) | 1982-12-29 | 1988-05-19 | Armour Pharmaceutical Company | Pharmaceutical calcitonin compositions for intranasal application |
CH657858A5 (en) | 1983-06-27 | 1986-09-30 | Ciba Geigy Ag | SUBSTANCE FROM THE CALCITONINE GROUP. |
JPS61267528A (en) | 1984-11-26 | 1986-11-27 | Yamanouchi Pharmaceut Co Ltd | Transnasal calcitonin agent containing absorbefacient |
US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
IT1204400B (en) | 1986-06-20 | 1989-03-01 | Sclavo Spa | PHARMACEUTICAL COMPOSITIONS CONTAINING A CALCITONIN |
US5938654A (en) | 1987-06-25 | 1999-08-17 | Alza Corporation | Osmotic device for delayed delivery of agent |
GB2212062B (en) | 1987-11-13 | 1991-07-17 | Isf Spa | Pharmaceutical compositions containing a calcitonin and a glycyrrhizinate ab- sorption enhancer |
US5026825A (en) | 1988-09-08 | 1991-06-25 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Intranasal calcitonin formulations |
US5514365A (en) | 1988-10-11 | 1996-05-07 | Schiapparelli Salute S.P.A. | Pharmaceutical compositions comprising calcitonin for intranasal administration |
US5725871A (en) | 1989-08-18 | 1998-03-10 | Danbiosyst Uk Limited | Drug delivery compositions comprising lysophosphoglycerolipid |
IT1231957B (en) * | 1989-09-15 | 1992-01-16 | Esseti Chimico Farmaco Bio | STABLE PHARMACEUTICAL COMPOSITIONS BASED ON CALCITONIN. |
ES2067624T3 (en) | 1989-11-16 | 1995-04-01 | Ph & T S R L | A PROCEDURE FOR PREPARING A LIQUID PHARMACEUTICAL COMPOSITION FOR NASAL ADMINISTRATION. |
US5733572A (en) | 1989-12-22 | 1998-03-31 | Imarx Pharmaceutical Corp. | Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles |
GB9007052D0 (en) * | 1990-03-29 | 1990-05-30 | Skua Investments Ltd | Pharmaceutical formulations |
EP0532546B1 (en) | 1990-05-10 | 1998-03-18 | Bechgaard International Research And Development A/S | A pharmaceutical preparation containing n-glycofurols and n-ethylene glycols |
US5714167A (en) | 1992-06-15 | 1998-02-03 | Emisphere Technologies, Inc. | Active agent transport systems |
JPH078806B2 (en) | 1990-08-16 | 1995-02-01 | 旭化成工業株式会社 | Nasal emulsion containing calcitonin |
IT1243390B (en) | 1990-11-22 | 1994-06-10 | Vectorpharma Int | PHARMACEUTICAL COMPOSITIONS IN THE FORM OF PARTICLES SUITABLE FOR THE CONTROLLED RELEASE OF PHARMACOLOGICALLY ACTIVE SUBSTANCES AND PROCEDURE FOR THEIR PREPARATION. |
EP0489217A1 (en) * | 1990-12-05 | 1992-06-10 | Dr. A. Tosi Farmaceutici S.R.L. | Calcitonin compositions for intranasal administration |
US5234906A (en) | 1991-01-10 | 1993-08-10 | Amylin Pharmaceuticals, Inc. | Hyperglycemic compositions |
IT1254707B (en) | 1991-02-19 | 1995-10-09 | Mediator Srl | TOPICAL USE OF CALCITONE FOR THE PREPARATION OF MEDICATIONS IN THE IDIOPATHIC SENILE CATARACT AND A PHARMACEUTICAL COMPOSITION THAT CONTAINS IT |
GB9108634D0 (en) | 1991-04-23 | 1991-06-12 | Ciba Geigy | Pharmaceutical compositions |
JP3608802B2 (en) * | 1991-09-20 | 2005-01-12 | 第一サントリーファーマ株式会社 | Stable calcitonin pharmaceutical composition and method for producing the same |
US5571788A (en) | 1991-12-09 | 1996-11-05 | Ciba-Geigy Corporation | Stable calcitonin pharmaceutical compositions |
US5534496A (en) | 1992-07-07 | 1996-07-09 | University Of Southern California | Methods and compositions to enhance epithelial drug transport |
US6509006B1 (en) | 1992-07-08 | 2003-01-21 | Inhale Therapeutic Systems, Inc. | Devices compositions and methods for the pulmonary delivery of aerosolized medicaments |
US5759566A (en) | 1992-07-28 | 1998-06-02 | Poli Industria Chimica Spa | Microemulsion pharmaceutical compositions for the delivery of pharmaceutically active agents |
US5654000A (en) | 1992-07-28 | 1997-08-05 | Poli Industria Chimica S.P.A. | Pharmaceutical compositions for transmucosal delivery of peptides |
FR2697022B1 (en) | 1992-10-19 | 1994-12-16 | Pasteur Institut | Plasmodium falciparum antigens capable of inducing protective antibodies with broad spectrum - Application to vaccination. |
IT1255895B (en) | 1992-10-20 | 1995-11-17 | Laura Chiodini | PHARMACEUTICAL COMPOSITIONS CONTAINING A CALCITONIN |
JP3628713B2 (en) | 1993-06-07 | 2005-03-16 | 帝國製薬株式会社 | Vaginal preparation containing physiologically active peptide |
SE9302135D0 (en) | 1993-06-18 | 1993-06-18 | Kabi Pharmacia Ab | NEW PHARMACEUTICAL COMPOSITION |
KR950007873A (en) | 1993-09-20 | 1995-04-15 | 후꾸하라 요시하루 | Biologics Sustained-Release Pharmaceutical Formulations |
US5496801A (en) | 1993-12-23 | 1996-03-05 | Allelix Biopharmaceuticals Inc. | Parathyroid hormone formulation |
WO1995033474A1 (en) | 1994-06-03 | 1995-12-14 | Tsumura & Co. | Medicinal composition |
US5670163A (en) | 1994-06-20 | 1997-09-23 | Kv Pharmaceuticals Company | Long acting GI and esophageal protectant |
US5912014A (en) | 1996-03-15 | 1999-06-15 | Unigene Laboratories, Inc. | Oral salmon calcitonin pharmaceutical products |
US5726154A (en) | 1996-06-28 | 1998-03-10 | University Of Utah Research Foundation | Stabilization and oral delivery of calcitonin |
US6440446B1 (en) | 1998-04-22 | 2002-08-27 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Agent for anti-osteoporosis |
US6153582A (en) | 1998-11-05 | 2000-11-28 | Bausch & Lomb Surgical, Inc. | Defined serumfree medical solution for ophthalmology |
US6149893A (en) * | 1999-03-01 | 2000-11-21 | Alfa Wassermann S.P.A. | Pharmaceutical compositions containing calcitonin in a spray dosing feeder for intranasal administration |
EP1251867A4 (en) | 2000-02-04 | 2004-12-08 | Unigene Lab Inc | Nasal calcitonin formulations |
US6524580B1 (en) | 2000-02-15 | 2003-02-25 | Allergan Sales, Inc. | Method for treating thyroid disorders |
-
2001
- 2001-01-31 EP EP01908769A patent/EP1251867A4/en not_active Withdrawn
- 2001-01-31 AU AU36604/01A patent/AU783952B2/en not_active Ceased
- 2001-01-31 CA CA2399505A patent/CA2399505C/en not_active Expired - Fee Related
- 2001-01-31 CN CNB01807605XA patent/CN1183965C/en not_active Expired - Fee Related
- 2001-01-31 WO PCT/US2001/003212 patent/WO2001056594A1/en active IP Right Grant
- 2001-02-02 US US09/776,537 patent/US6440392B1/en not_active Ceased
-
2004
- 2004-02-05 US US10/774,358 patent/USRE40812E1/en not_active Expired - Lifetime
-
2009
- 2009-06-29 US US12/459,385 patent/USRE43580E1/en not_active Expired - Lifetime
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5059587A (en) * | 1987-08-03 | 1991-10-22 | Toyo Jozo Company, Ltd. | Physiologically active peptide composition for nasal administration |
US6087338A (en) * | 1995-02-08 | 2000-07-11 | Therapicon S.R.L. | Pharmaceutical non inorganic saline solutions for endonasal administration of a calcitonin |
Non-Patent Citations (1)
Title |
---|
See also references of EP1251867A1 * |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9399017B2 (en) | 2007-05-29 | 2016-07-26 | Enteris Biopharma, Inc. | Peptide pharmaceutical for oral delivery |
US9457086B2 (en) | 2013-03-05 | 2016-10-04 | Enteris Biopharma, Inc. | Pharmaceuticals for oral delivery |
US9526785B2 (en) | 2013-03-05 | 2016-12-27 | Enteris Biopharma, Inc. | Pharmaceuticals for oral delivery |
US9744140B2 (en) | 2013-03-05 | 2017-08-29 | Enteris Biopharma, Inc. | Pharmaceuticals for oral delivery |
US9833411B2 (en) | 2015-01-12 | 2017-12-05 | Enteris Biopharma, Inc. | Solid oral dosage forms |
Also Published As
Publication number | Publication date |
---|---|
AU3660401A (en) | 2001-08-14 |
CN1422160A (en) | 2003-06-04 |
CN1183965C (en) | 2005-01-12 |
USRE43580E1 (en) | 2012-08-14 |
EP1251867A4 (en) | 2004-12-08 |
USRE40812E1 (en) | 2009-06-30 |
CA2399505A1 (en) | 2001-08-09 |
US6440392B1 (en) | 2002-08-27 |
AU783952B2 (en) | 2006-01-05 |
EP1251867A1 (en) | 2002-10-30 |
CA2399505C (en) | 2012-01-03 |
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