WO2001057510A3 - Electrochemical methods and devices for use in the determination of hematocrit corrected analyte concentrations - Google Patents

Electrochemical methods and devices for use in the determination of hematocrit corrected analyte concentrations Download PDF

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Publication number
WO2001057510A3
WO2001057510A3 PCT/US2001/002465 US0102465W WO0157510A3 WO 2001057510 A3 WO2001057510 A3 WO 2001057510A3 US 0102465 W US0102465 W US 0102465W WO 0157510 A3 WO0157510 A3 WO 0157510A3
Authority
WO
WIPO (PCT)
Prior art keywords
analyte
determination
devices
time
concentration
Prior art date
Application number
PCT/US2001/002465
Other languages
French (fr)
Other versions
WO2001057510A2 (en
Inventor
Timothy J Ohara
Mahyar Z Kermani
Original Assignee
Lifescan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2001556308A priority Critical patent/JP2003521708A/en
Priority to EP01905055A priority patent/EP1252514B1/en
Priority to PL01358492A priority patent/PL358492A1/en
Priority to DE60116056T priority patent/DE60116056T2/en
Priority to AT01905055T priority patent/ATE313794T1/en
Priority to IL14966201A priority patent/IL149662A/en
Priority to MXPA02005797A priority patent/MXPA02005797A/en
Priority to KR1020027009882A priority patent/KR20020077409A/en
Application filed by Lifescan Inc filed Critical Lifescan Inc
Priority to AU32974/01A priority patent/AU783311B2/en
Priority to CA002398203A priority patent/CA2398203A1/en
Publication of WO2001057510A2 publication Critical patent/WO2001057510A2/en
Publication of WO2001057510A3 publication Critical patent/WO2001057510A3/en
Priority to HK03101950.3A priority patent/HK1049881B/en
Priority to AU2006200073A priority patent/AU2006200073A1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3274—Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Methods and devices for determining the concentration of an analyte in a physiological sample are provided. In the subject methods, the physiological sample is introduced into an electrochemical cell having a working and reference electrode. A first electric potential is applied to the cell and the resultant cell current over a period of time is measured to determine a first time-current transient. A second electric potential of opposite polarity is then applied and a second time-current transient is determined. The preliminary concentration of the analyte is then calculated from the first and/or second time-current transient. This preliminary analyte concentration less a background value is then multiplied by a hematocrit correction factor to obtain the analyte concentration in the sample, where the hematocrit correction factor is a function of the preliminary analyte concentration and the variable η of the electrochemical cell. The subject methods and devices are suited for use in the determination of a wide variety of analytes in a wide variety of samples, and are particularly suited for the determination of analytes in whole blood or derivatives thereof, where an analyte of particular interest is glucose.
PCT/US2001/002465 2000-02-02 2001-01-25 Electrochemical methods and devices for use in the determination of hematocrit corrected analyte concentrations WO2001057510A2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
MXPA02005797A MXPA02005797A (en) 2000-02-02 2001-01-25 Electrochemical methods and devices for use in the determination of hematocrit corrected analyte concentrations.
PL01358492A PL358492A1 (en) 2000-02-02 2001-01-25 Electrochemical methods and devices for use in the determination of hematocrit corrected analyte concentrations
DE60116056T DE60116056T2 (en) 2000-02-02 2001-01-25 ELECTROCHEMICAL PROCESSES AND DEVICES FOR USE IN THE MEASUREMENT OF ANALYZ CONCENTRATIONS WITH CORRECTED HAEMATOCRITING VALUE
AT01905055T ATE313794T1 (en) 2000-02-02 2001-01-25 ELECTROCHEMICAL METHODS AND DEVICES FOR USE IN MEASURING ANALYTE CONCENTRATIONS WITH CORRECTED HEMATOCRIT
IL14966201A IL149662A (en) 2000-02-02 2001-01-25 Electrochemical methods and devices for use in the determination of hematocrit corrected analyte concentrations
JP2001556308A JP2003521708A (en) 2000-02-02 2001-01-25 Electrochemical method and apparatus used for measurement of analyte concentration with corrected hematocrit value
KR1020027009882A KR20020077409A (en) 2000-02-02 2001-01-25 Electrochemical methods and devices for use in the determination of hematocrit corrected analyte concentrations
EP01905055A EP1252514B1 (en) 2000-02-02 2001-01-25 Electrochemical methods and devices for use in the determination of hematocrit corrected analyte concentrations
AU32974/01A AU783311B2 (en) 2000-02-02 2001-01-25 Electrochemical methods and devices for use in the determination of hematocrit corrected analyte concentrations
CA002398203A CA2398203A1 (en) 2000-02-02 2001-01-25 Electrochemical methods and devices for use in the determination of hematocrit corrected analyte concentrations
HK03101950.3A HK1049881B (en) 2000-02-02 2003-03-17 Electrochemical methods and devices for use in the determination of hematocrit corrected analyte concentrations
AU2006200073A AU2006200073A1 (en) 2000-02-02 2006-01-09 Electrochemical methods and devices for use in the determination of hematocrit corrected analyte concentrations

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/497,304 2000-02-02
US09/497,304 US6475372B1 (en) 2000-02-02 2000-02-02 Electrochemical methods and devices for use in the determination of hematocrit corrected analyte concentrations

Publications (2)

Publication Number Publication Date
WO2001057510A2 WO2001057510A2 (en) 2001-08-09
WO2001057510A3 true WO2001057510A3 (en) 2002-02-21

Family

ID=23976305

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/002465 WO2001057510A2 (en) 2000-02-02 2001-01-25 Electrochemical methods and devices for use in the determination of hematocrit corrected analyte concentrations

Country Status (21)

Country Link
US (3) US6475372B1 (en)
EP (2) EP1252514B1 (en)
JP (1) JP2003521708A (en)
KR (1) KR20020077409A (en)
CN (1) CN1193228C (en)
AR (1) AR027345A1 (en)
AT (1) ATE313794T1 (en)
AU (1) AU783311B2 (en)
CA (1) CA2398203A1 (en)
CZ (1) CZ20021298A3 (en)
DE (1) DE60116056T2 (en)
DK (1) DK1252514T3 (en)
ES (1) ES2254368T3 (en)
HK (1) HK1049881B (en)
IL (1) IL149662A (en)
MX (1) MXPA02005797A (en)
MY (1) MY127335A (en)
PL (1) PL358492A1 (en)
RU (2) RU2262890C2 (en)
TW (1) TW520439B (en)
WO (1) WO2001057510A2 (en)

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