WO2001058447A1 - Controlled-release compositions containing opioid agonist and antagonist - Google Patents
Controlled-release compositions containing opioid agonist and antagonist Download PDFInfo
- Publication number
- WO2001058447A1 WO2001058447A1 PCT/US2001/004347 US0104347W WO0158447A1 WO 2001058447 A1 WO2001058447 A1 WO 2001058447A1 US 0104347 W US0104347 W US 0104347W WO 0158447 A1 WO0158447 A1 WO 0158447A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- opioid
- antagonist
- dosage form
- opioid agonist
- release
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
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- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
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- A61K9/1629—Organic macromolecular compounds
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- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
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- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
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- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
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Abstract
Description
Claims
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK01909087T DK1255547T3 (en) | 2000-02-08 | 2001-02-08 | Controlled-release compositions containing opioid agonist and antagonist |
DE60135441T DE60135441D1 (en) | 2000-02-08 | 2001-02-08 | COMPOSITIONS WITH CONTROLLED RELEASE CONTAINING AN OPIOID AGONIST AND ANTAGONIST |
KR1020027010121A KR20020071032A (en) | 2000-02-08 | 2001-02-08 | Controlled-release composition containing opioid agonist and antagonist |
BR0108379-1A BR0108379A (en) | 2000-02-08 | 2001-02-08 | Controlled release compositions containing opioid agonist and antagonist, method for preparing a controlled release opioid analgesic formulation with increased analgesic potency and delivery system through the dermis for an opioid analgesic |
AU36877/01A AU776904B2 (en) | 2000-02-08 | 2001-02-08 | Controlled-release compositions containing opioid agonist and antagonist |
HU0204163A HUP0204163A2 (en) | 2000-02-08 | 2001-02-08 | Controlled-release composition containing opioid agonist and antagonist and process for its preparation |
EP01909087A EP1255547B1 (en) | 2000-02-08 | 2001-02-08 | Controlled-release compositions containing opioid agonist and antagonist |
IL15105801A IL151058A0 (en) | 2000-02-08 | 2001-02-08 | Controlled-release compositions containing opioid agonist and antagonist |
SI200130879T SI1255547T1 (en) | 2000-02-08 | 2001-02-08 | Controlled-release compositions containing opioid agonist and antagonist |
EA200200839A EA200200839A1 (en) | 2000-02-08 | 2001-02-08 | COMPOSITIONS WITH CONTROLLED GRIPBACK, CONTAINING AN AGONIST AND ANTAGONIST OF OPIOIDS |
MXPA02007690A MXPA02007690A (en) | 2000-02-08 | 2001-02-08 | Controlled release compositions containing opioid agonist and antagonist. |
JP2001557557A JP2003522144A (en) | 2000-02-08 | 2001-02-08 | Controlled release compositions comprising opioid agonists and antagonists |
CA002400578A CA2400578C (en) | 2000-02-08 | 2001-02-08 | Controlled-release compositions containing opioid agonist and antagonist |
NO20023729A NO20023729L (en) | 2000-02-08 | 2002-08-07 | Controlled release preparations containing opioid agonist and antagonist |
HK03102267.9A HK1051487A1 (en) | 2000-02-08 | 2003-03-28 | Controlled-release compositions containing opioid agonist and antagonist |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18136900P | 2000-02-08 | 2000-02-08 | |
US60/181,369 | 2000-02-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2001058447A1 true WO2001058447A1 (en) | 2001-08-16 |
Family
ID=22663996
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/004346 WO2001058451A1 (en) | 2000-02-08 | 2001-02-08 | Tamper-resistant oral opioid agonist formulations |
PCT/US2001/004347 WO2001058447A1 (en) | 2000-02-08 | 2001-02-08 | Controlled-release compositions containing opioid agonist and antagonist |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/004346 WO2001058451A1 (en) | 2000-02-08 | 2001-02-08 | Tamper-resistant oral opioid agonist formulations |
Country Status (35)
Country | Link |
---|---|
US (15) | US6696088B2 (en) |
EP (6) | EP2283842B1 (en) |
JP (10) | JP2003522146A (en) |
KR (2) | KR20020071032A (en) |
CN (3) | CN1423559A (en) |
AP (1) | AP1665A (en) |
AT (1) | ATE431145T1 (en) |
AU (2) | AU776666B2 (en) |
BG (1) | BG65828B1 (en) |
BR (2) | BR0108379A (en) |
CA (1) | CA2400567C (en) |
CY (2) | CY1109270T1 (en) |
CZ (1) | CZ299991B6 (en) |
DE (1) | DE60138706D1 (en) |
DK (5) | DK2092936T3 (en) |
EA (1) | EA004876B1 (en) |
EE (1) | EE05171B1 (en) |
ES (5) | ES2415407T3 (en) |
GE (1) | GEP20053614B (en) |
HK (3) | HK1051487A1 (en) |
HU (2) | HUP0204163A2 (en) |
IL (5) | IL151057A0 (en) |
ME (1) | MEP48308A (en) |
MX (2) | MXPA02007690A (en) |
NO (2) | NO20023729L (en) |
NZ (1) | NZ520554A (en) |
OA (1) | OA12215A (en) |
PL (1) | PL210845B1 (en) |
PT (6) | PT1255547E (en) |
RS (1) | RS50407B (en) |
SI (5) | SI2092936T1 (en) |
SK (1) | SK287107B6 (en) |
TW (1) | TWI292317B (en) |
UA (1) | UA79069C2 (en) |
WO (2) | WO2001058451A1 (en) |
Cited By (102)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002092059A1 (en) * | 2001-05-11 | 2002-11-21 | Endo Pharmaceuticals, Inc. | Abuse-resistant opioid dosage form |
WO2002092060A1 (en) * | 2001-05-11 | 2002-11-21 | Endo Pharmaceuticals, Inc. | Abuse-resistant controlled-release opioid dosage form |
WO2003013433A2 (en) * | 2001-08-06 | 2003-02-20 | Euro-Celtique S.A. | Sequestered antagonist formulations |
WO2003070191A2 (en) * | 2002-02-19 | 2003-08-28 | Euro-Celtique, S.A. | Tamper-resistant transdermal opioid delivery devices |
WO2003080183A1 (en) * | 2002-03-19 | 2003-10-02 | Euro-Celtique S.A. | Pharmaceutical combination of the cox-2 inhibitor etodolac and opioids |
WO2004004693A1 (en) | 2002-07-05 | 2004-01-15 | Collgegium Pharmaceutical | Abuse-deterrent pharmaceutical compositions of opiods and other drugs |
WO2004006929A1 (en) * | 2002-07-11 | 2004-01-22 | Taiho Pharmaceutical Co., Ltd. | Composition for nasal absorption |
DE10237056A1 (en) * | 2002-08-09 | 2004-03-04 | Grünenthal GmbH | Transdermal therapeutic systems containing buprenorphine, useful in treating pain or urinary incontinence, also containing mu-, kappa- or delta-opioid receptor antagonist to reduce abuse potential |
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