WO2001062334A3 - System and method for preventing sudden cardiac death by nerve sprouting from right stellate ganglion - Google Patents

System and method for preventing sudden cardiac death by nerve sprouting from right stellate ganglion Download PDF

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Publication number
WO2001062334A3
WO2001062334A3 PCT/US2001/005777 US0105777W WO0162334A3 WO 2001062334 A3 WO2001062334 A3 WO 2001062334A3 US 0105777 W US0105777 W US 0105777W WO 0162334 A3 WO0162334 A3 WO 0162334A3
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WO
WIPO (PCT)
Prior art keywords
stellate ganglion
patient
sudden cardiac
cardiac death
heart
Prior art date
Application number
PCT/US2001/005777
Other languages
French (fr)
Other versions
WO2001062334A2 (en
Inventor
Peng-Sheng Chen
Original Assignee
Cedars Sinai Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cedars Sinai Medical Center filed Critical Cedars Sinai Medical Center
Priority to AU2001239840A priority Critical patent/AU2001239840A1/en
Publication of WO2001062334A2 publication Critical patent/WO2001062334A2/en
Publication of WO2001062334A3 publication Critical patent/WO2001062334A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36114—Cardiac control, e.g. by vagal stimulation

Abstract

A system and method are described for reducing the likelihood of the occurrence of ventricular arrhythmia in the heart of a patient having a myocardial infarction and an atrioventricular block, particularly a ventricular arrhythmia of the type potentially leading to Sudden Cardiac Death. The likelihood of the occurrence of the ventricular arrhythmia is reduced by stimulating myocardial hyperinnervation in the sinus node and right ventricle of the heart of the patient. Myocardial hyperinnervation in the sinus node and right ventricle is stimulated by applying electrical stimulation to the right stellate ganglion of the patient or by applying Nerve Growth Factor or other neurotrophic substance to the right stellate ganglion. The system and method may also be advantageously exploited for use with patients having myocardial infarction but no atrioventricular block and for patients have other heart conditions such as Brugada syndrome.
PCT/US2001/005777 2000-02-24 2001-02-23 System and method for preventing sudden cardiac death by nerve sprouting from right stellate ganglion WO2001062334A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001239840A AU2001239840A1 (en) 2000-02-24 2001-02-23 System and method for preventing sudden cardiac death by nerve sprouting from right stellate ganglion

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/513,059 US6487450B1 (en) 2000-02-24 2000-02-24 System and method for preventing Sudden Cardiac Death by nerve sprouting from right stellate ganglion
US09/513,059 2000-02-24

Publications (2)

Publication Number Publication Date
WO2001062334A2 WO2001062334A2 (en) 2001-08-30
WO2001062334A3 true WO2001062334A3 (en) 2002-04-18

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/005777 WO2001062334A2 (en) 2000-02-24 2001-02-23 System and method for preventing sudden cardiac death by nerve sprouting from right stellate ganglion

Country Status (3)

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US (2) US6487450B1 (en)
AU (1) AU2001239840A1 (en)
WO (1) WO2001062334A2 (en)

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Also Published As

Publication number Publication date
WO2001062334A2 (en) 2001-08-30
US20030078629A1 (en) 2003-04-24
US6487450B1 (en) 2002-11-26
US6824538B2 (en) 2004-11-30
AU2001239840A1 (en) 2001-09-03

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