WO2001069230A3 - Methods and apparatus for the location and concentration of polar analytes using an alternating electric field - Google Patents
Methods and apparatus for the location and concentration of polar analytes using an alternating electric field Download PDFInfo
- Publication number
- WO2001069230A3 WO2001069230A3 PCT/US2001/007576 US0107576W WO0169230A3 WO 2001069230 A3 WO2001069230 A3 WO 2001069230A3 US 0107576 W US0107576 W US 0107576W WO 0169230 A3 WO0169230 A3 WO 0169230A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- electric field
- alternating electric
- concentration
- location
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/24—Extraction; Separation; Purification by electrochemical means
- C07K1/26—Electrophoresis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44756—Apparatus specially adapted therefor
- G01N27/44791—Microapparatus
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
- B01L2200/0668—Trapping microscopic beads
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
- B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
Abstract
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001568062A JP2003527601A (en) | 2000-03-10 | 2001-03-08 | Method and apparatus for locating and concentrating polar analytes using an alternating electric field |
CA002402189A CA2402189A1 (en) | 2000-03-10 | 2001-03-08 | Methods and apparatus for the location and concentration of polar analytes using an alternating electric field |
EP01918488A EP1261863B1 (en) | 2000-03-10 | 2001-03-08 | Method and apparatus for the location and concentration of polar analytes using an alternating electric field |
DE60108848T DE60108848T2 (en) | 2000-03-10 | 2001-03-08 | METHOD AND DEVICE FOR THE LOCATION AND CONCENTRATION OF POLAR ANALYTES BY MEANS OF AN ELECTRIC CHANGE AREA |
AU2001245558A AU2001245558A1 (en) | 2000-03-10 | 2001-03-08 | Methods and apparatus for the location and concentration of polar analytes usingan alternating electric field |
AT01918488T ATE289065T1 (en) | 2000-03-10 | 2001-03-08 | METHOD AND DEVICE FOR LOCATION AND CONCENTRATION OF POLAR ANALYTES USING AN ALTERNATING ELECTRICAL FIELD |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/522,638 | 2000-03-10 | ||
US09/522,638 US6537433B1 (en) | 2000-03-10 | 2000-03-10 | Methods and apparatus for the location and concentration of polar analytes using an alternating electric field |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2001069230A2 WO2001069230A2 (en) | 2001-09-20 |
WO2001069230A3 true WO2001069230A3 (en) | 2002-06-20 |
Family
ID=24081685
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/007576 WO2001069230A2 (en) | 2000-03-10 | 2001-03-08 | Methods and apparatus for the location and concentration of polar analytes using an alternating electric field |
Country Status (8)
Country | Link |
---|---|
US (4) | US6537433B1 (en) |
EP (1) | EP1261863B1 (en) |
JP (1) | JP2003527601A (en) |
AT (1) | ATE289065T1 (en) |
AU (1) | AU2001245558A1 (en) |
CA (1) | CA2402189A1 (en) |
DE (1) | DE60108848T2 (en) |
WO (1) | WO2001069230A2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9434937B2 (en) | 2011-03-07 | 2016-09-06 | Accelerate Diagnostics, Inc. | Rapid cell purification systems |
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6537433B1 (en) * | 2000-03-10 | 2003-03-25 | Applera Corporation | Methods and apparatus for the location and concentration of polar analytes using an alternating electric field |
US20050089924A1 (en) * | 2000-08-14 | 2005-04-28 | Chih-Ming Ho | Biosensors and methods for their use |
US7147441B2 (en) * | 2000-12-20 | 2006-12-12 | Board Of Trustees Of The University Of Arkansas, N.A. | Microfluidics and small volume mixing based on redox magnetohydrodynamics methods |
DE60221240T2 (en) * | 2001-05-02 | 2007-10-31 | Applera Corp., Foster City | CONCENTRATION AND CLEANING OF ANALYTES WITH ELECTRIC FIELDS |
US7014744B2 (en) * | 2001-08-24 | 2006-03-21 | Applera Corporation | Method of purification and concentration using AC fields with a transfer tip |
US6814859B2 (en) * | 2002-02-13 | 2004-11-09 | Nanostream, Inc. | Frit material and bonding method for microfluidic separation devices |
GB0215779D0 (en) * | 2002-07-08 | 2002-08-14 | Deltadot Ltd | Material separation device |
JP3956389B2 (en) * | 2002-12-11 | 2007-08-08 | 横河電機株式会社 | Hybridization method and apparatus for hybridization |
JP4128084B2 (en) * | 2003-01-07 | 2008-07-30 | クラスターテクノロジー株式会社 | Sample characterization method and apparatus |
CN1761865A (en) * | 2003-03-19 | 2006-04-19 | 日本电气株式会社 | Microchip and extraction sample method, sample separation method, analytic sample method and recovery sample method |
US7147764B2 (en) * | 2003-03-28 | 2006-12-12 | Applera Corporation | Dual electrode injection of analyte into a capillary electrophoretic device |
AU2004230592B2 (en) * | 2003-04-14 | 2007-10-04 | Caliper Life Sciences, Inc. | Reduction of migration shift assay interference |
CA2532414C (en) | 2003-07-12 | 2017-03-14 | Accelr8 Technology Corporation | Sensitive and rapid biodetection |
US20120077206A1 (en) | 2003-07-12 | 2012-03-29 | Accelr8 Technology Corporation | Rapid Microbial Detection and Antimicrobial Susceptibility Testing |
JP4453334B2 (en) * | 2003-10-21 | 2010-04-21 | ソニー株式会社 | Hybridization apparatus and method |
US7384791B2 (en) * | 2004-01-21 | 2008-06-10 | Hewlett-Packard Development Company, L.P. | Method of analyzing blood |
US7390387B2 (en) * | 2004-03-25 | 2008-06-24 | Hewlett-Packard Development Company, L.P. | Method of sorting cells in series |
US7160425B2 (en) * | 2004-03-25 | 2007-01-09 | Hewlett-Packard Development Company, L.P. | Cell transporter for a biodevice |
US7390388B2 (en) * | 2004-03-25 | 2008-06-24 | Hewlett-Packard Development Company, L.P. | Method of sorting cells on a biodevice |
US8057655B1 (en) * | 2004-08-20 | 2011-11-15 | The Board Of Trustees Of The Leland Stanford Junior University | Sub-micron object control arrangement and approach therefor |
JP4619728B2 (en) * | 2004-09-02 | 2011-01-26 | 株式会社エンプラス | Sample analyzer |
WO2006066216A2 (en) * | 2004-12-16 | 2006-06-22 | Accelr8 Technology Corporation | Rapid microbial detection and antimicrobial susceptibility testing |
JP4462051B2 (en) * | 2005-01-28 | 2010-05-12 | 富士ゼロックス株式会社 | Concentration method for fine particle dispersion and concentration device for fine particle dispersion |
EP2549269A1 (en) * | 2005-10-04 | 2013-01-23 | Headway Technologies, Inc. | Microfluidic detection of analytes |
US9995668B2 (en) * | 2006-02-01 | 2018-06-12 | Ecole polytechnique fédérale de Lausanne (EPFL) | Apparatus for manipulating, modifying and characterizing particles in a micro channel |
US8029657B1 (en) * | 2006-03-14 | 2011-10-04 | University Of Tennessee Research Foundation | Parallel plate electrodes for particle concentration or removal |
US7731826B2 (en) * | 2006-08-17 | 2010-06-08 | Electronic Bio Sciences, Llc | Controlled translocation of a polymer in an electrolytic sensing system |
US8293086B2 (en) * | 2007-02-06 | 2012-10-23 | Board Of Trustees Of Michigan State University | Classification scheme for nanoobjects |
WO2008124706A2 (en) | 2007-04-06 | 2008-10-16 | Arizona Board Of Regents Acting For And On Behalf Of Arizona State University | Devices and methods for target molecule characterization |
EP2173467B1 (en) * | 2007-07-13 | 2016-05-04 | The Board Of Trustees Of The Leland Stanford Junior University | Method and apparatus using electric field for improved biological assays |
US20090095635A1 (en) * | 2007-07-20 | 2009-04-16 | Siemens Medical Solutions Usa, Inc. | Microfluidic radiosynthesis of a radiolabeled compound using electrochemical trapping and release |
WO2009044902A1 (en) * | 2007-10-05 | 2009-04-09 | Kyushu Institute Of Technology | Dielectrophoresis device and method |
US7655124B2 (en) * | 2007-10-05 | 2010-02-02 | Mady Attila | Apparatus to assist platelet manipulation to prevent and treat endovascular disease and its sequelae |
GB0804491D0 (en) * | 2008-03-11 | 2008-04-16 | Iti Scotland Ltd | Detecting analytes |
WO2010042514A1 (en) | 2008-10-06 | 2010-04-15 | Arizona Board Of Regents | Nanopore and carbon nanotube based dna sequencer and a serial recognition elements |
JP5047928B2 (en) * | 2008-11-11 | 2012-10-10 | シャープ株式会社 | Electrophoresis device and components thereof |
US8398839B1 (en) * | 2009-06-05 | 2013-03-19 | Sandia Corporation | System for particle concentration and detection |
WO2011028296A2 (en) * | 2009-09-07 | 2011-03-10 | Caerus Molecular Diagnostics Incorporated | Sequence determination by use of opposing forces |
US8486703B2 (en) | 2010-09-30 | 2013-07-16 | Ut-Battelle, Llc | Surface sampling concentration and reaction probe |
EP2710359B1 (en) * | 2011-02-16 | 2020-09-16 | Centrul International de Biodinamica | Systems and method for detection and quantitation of analytes using impedance analysis |
US10254204B2 (en) | 2011-03-07 | 2019-04-09 | Accelerate Diagnostics, Inc. | Membrane-assisted purification |
US11053535B2 (en) | 2011-09-12 | 2021-07-06 | The University Of North Carolina At Chapel Hill | Devices with a fluid transport nanochannel intersected by a fluid sensing nanochannel and related methods |
US8691067B2 (en) | 2011-09-16 | 2014-04-08 | International Business Machines Corporation | Charged entities as locomotive to control motion of polymers through a nanochannel |
US11198126B2 (en) * | 2011-10-31 | 2021-12-14 | Fluid-Screen, Inc. | Apparatus for pathogen detection |
US9989515B2 (en) | 2012-02-10 | 2018-06-05 | The University Of North Carolina At Chapel Hill | Devices with fluidic nanofunnels, associated methods, fabrication and analysis systems |
GB2499428B (en) * | 2012-02-16 | 2014-09-24 | Microvisk Ltd | Surface patterned micro-sensor based fluid test strip |
CN104379261A (en) * | 2012-04-16 | 2015-02-25 | 昆南诺股份有限公司 | A nanocapillary device for biomolecule detection, a fluidic network structure and a method of manufacturing thereof |
EP2682478A1 (en) * | 2012-07-02 | 2014-01-08 | Institut Curie | Methods and devices for detecting macroions in a liquid medium |
US9274430B2 (en) | 2012-10-10 | 2016-03-01 | Arizona Board Of Regents On Behalf Of Arizona State University | Systems and devices for molecule sensing and method of manufacturing thereof |
WO2014134095A1 (en) * | 2013-02-28 | 2014-09-04 | The University Of North Carolina At Chapel Hill | Nanofluidic devices with integrated components for the controlled capture, trapping, and transport of macromolecules and related methods of analysis |
EP2971180A4 (en) * | 2013-03-13 | 2016-11-23 | Univ Arizona State | Systems, devices and methods for translocation control |
US9255288B2 (en) | 2013-03-13 | 2016-02-09 | The University Of North Carolina At Chapel Hill | Nanofluidic devices for the rapid mapping of whole genomes and related systems and methods of analysis |
US9677109B2 (en) | 2013-03-15 | 2017-06-13 | Accelerate Diagnostics, Inc. | Rapid determination of microbial growth and antimicrobial susceptibility |
EP3052237A4 (en) | 2013-10-04 | 2017-06-21 | Michigan Technological University | Methods and systems for identifying a particle using dielectrophoresis |
KR101664552B1 (en) * | 2014-08-11 | 2016-10-10 | 엘지전자 주식회사 | Apparatus for detecting particles |
US10941394B2 (en) * | 2015-01-15 | 2021-03-09 | Shimadzu Corporation | Device for manipulating magnetic particles and method for manipulating magnetic particles |
US10253355B2 (en) | 2015-03-30 | 2019-04-09 | Accelerate Diagnostics, Inc. | Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing |
WO2016161022A2 (en) | 2015-03-30 | 2016-10-06 | Accerlate Diagnostics, Inc. | Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing |
WO2017213123A1 (en) * | 2016-06-07 | 2017-12-14 | 国立大学法人東京大学 | Fluid device |
US10596567B2 (en) * | 2017-03-27 | 2020-03-24 | International Business Machines Corporation | Microfluidic ratchets for displacing particles |
DE102017121326B4 (en) | 2017-09-14 | 2021-01-14 | Leica Microsystems Cms Gmbh | Collection device and method for collecting dissected or ablated specimens and microscope with such a device |
US11686705B2 (en) * | 2020-05-08 | 2023-06-27 | Seagate Technology Llc | Gel electrophoresis for DNA purification |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5059294A (en) * | 1985-12-26 | 1991-10-22 | The University Of Puerto Rico | Method for separating nucleic acids and nucleic acid probes |
WO1993005390A1 (en) * | 1991-08-28 | 1993-03-18 | Guzman Norberto A | Automated capillary electrophoresis apparatus |
GB2266153A (en) * | 1992-04-16 | 1993-10-20 | British Tech Group | Dielectrophoretic separating of a mixture of particles |
US5344535A (en) * | 1989-11-27 | 1994-09-06 | British Technology Group Limited | Dielectrophoretic characterization of micro-organisms and other particles |
DE19500683A1 (en) * | 1994-12-10 | 1996-06-13 | Guenter Prof Dr Fuhr | Trapping or movement of micro-particles in micro-structures generating electromagnetic cage field |
WO1996042013A1 (en) * | 1995-06-08 | 1996-12-27 | Visible Genetics Inc. | Microelectrophoresis chip for moving and separating nucleic acids and other charged molecules |
WO1999063332A1 (en) * | 1998-06-05 | 1999-12-09 | Sarnoff Corporation | Apparatus for separating molecules |
US6007690A (en) * | 1996-07-30 | 1999-12-28 | Aclara Biosciences, Inc. | Integrated microfluidic devices |
Family Cites Families (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2417850A (en) | 1942-04-14 | 1947-03-25 | Willis M Winslow | Method and means for translating electrical impulses into mechanical force |
US4680201A (en) | 1985-10-30 | 1987-07-14 | Stellan Hjerten | Coating for electrophoresis tube |
US4690749A (en) | 1985-12-16 | 1987-09-01 | Universities Space Research Association | Polymer-coated surfaces to control surface zeta potential |
US4811218A (en) | 1986-06-02 | 1989-03-07 | Applied Biosystems, Inc. | Real time scanning electrophoresis apparatus for DNA sequencing |
US4874507A (en) | 1986-06-06 | 1989-10-17 | Whitlock David R | Separating constituents of a mixture of particles |
US4911806A (en) | 1987-02-27 | 1990-03-27 | Biotronics | Method and apparatus for separating particles in liquid suspension utilizing oscillating electric and magnetic fields |
US4908112A (en) | 1988-06-16 | 1990-03-13 | E. I. Du Pont De Nemours & Co. | Silicon semiconductor wafer for analyzing micronic biological samples |
US5132012A (en) | 1988-06-24 | 1992-07-21 | Hitachi, Ltd. | Liquid chromatograph |
US4956065A (en) | 1988-11-03 | 1990-09-11 | Kaler Karen V I S | Method and apparatus for three dimensional dynamic dielectric levitation |
DD279984A1 (en) | 1989-02-02 | 1990-06-20 | Univ Berlin Humboldt | DIELECTRIC MICROMECHANICAL ELEMENT |
US5110514A (en) | 1989-05-01 | 1992-05-05 | Soane Technologies, Inc. | Controlled casting of a shrinkable material |
US5126022A (en) | 1990-02-28 | 1992-06-30 | Soane Tecnologies, Inc. | Method and device for moving molecules by the application of a plurality of electrical fields |
US5750015A (en) | 1990-02-28 | 1998-05-12 | Soane Biosciences | Method and device for moving molecules by the application of a plurality of electrical fields |
US5275710A (en) * | 1990-05-14 | 1994-01-04 | Labintelligence, Inc. | Gel electrophoresis system including optical stage, sample applicator and sample retriever |
US5569591A (en) | 1990-08-03 | 1996-10-29 | University College Of Wales Aberystwyth | Analytical or monitoring apparatus and method |
US6149789A (en) | 1990-10-31 | 2000-11-21 | Fraunhofer Gesellschaft Zur Forderung Der Angewandten Forschung E.V. | Process for manipulating microscopic, dielectric particles and a device therefor |
DE59108006D1 (en) | 1991-01-28 | 1996-08-22 | Ciba Geigy Ag | Device for the preparation of samples, in particular for analysis purposes |
JP3104995B2 (en) | 1991-01-31 | 2000-10-30 | ワーナー−ランバート・コンパニー | Substituted heteroaryl analogs of 4,6-di-tert-butyl-5-hydroxy-1,3-pyrimidine useful as anti-inflammatory agents |
DE4143573C2 (en) | 1991-08-19 | 1996-07-04 | Fraunhofer Ges Forschung | Device for separating mixtures of microscopic dielectric particles suspended in a liquid or a gel |
US5632957A (en) * | 1993-11-01 | 1997-05-27 | Nanogen | Molecular biological diagnostic systems including electrodes |
US5605662A (en) | 1993-11-01 | 1997-02-25 | Nanogen, Inc. | Active programmable electronic devices for molecular biological analysis and diagnostics |
EP0544969B1 (en) | 1991-12-06 | 1997-03-05 | Ciba-Geigy Ag | Apparatus and method for electrophoretic separation |
US5489506A (en) | 1992-10-26 | 1996-02-06 | Biolife Systems, Inc. | Dielectrophoretic cell stream sorter |
WO1995016910A1 (en) | 1993-12-17 | 1995-06-22 | Perkin-Elmer Corporation | Uncharged polymers for separation of biomolecules by capillary electrophoresis |
JPH10501454A (en) | 1994-02-24 | 1998-02-10 | フラウンホーファー、ゲゼルシャフト、ツール、フェルデルング、デァ、アンゲヴァンテン、フォルシュング、エー、ファウ | Method of forming microparticles in an electric field cage and apparatus therefor |
WO1995023245A1 (en) * | 1994-02-25 | 1995-08-31 | Labintelligence, Inc. | Real time in-gel assay |
JPH07238290A (en) * | 1994-03-01 | 1995-09-12 | Nippon Oil Co Ltd | Electroviscous fluid |
US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
US6071394A (en) * | 1996-09-06 | 2000-06-06 | Nanogen, Inc. | Channel-less separation of bioparticles on a bioelectronic chip by dielectrophoresis |
US5459325A (en) | 1994-07-19 | 1995-10-17 | Molecular Dynamics, Inc. | High-speed fluorescence scanner |
US6001229A (en) * | 1994-08-01 | 1999-12-14 | Lockheed Martin Energy Systems, Inc. | Apparatus and method for performing microfluidic manipulations for chemical analysis |
US5630924A (en) * | 1995-04-20 | 1997-05-20 | Perseptive Biosystems, Inc. | Compositions, methods and apparatus for ultrafast electroseparation analysis |
US5626734A (en) * | 1995-08-18 | 1997-05-06 | University Technologies International, Inc. | Filter for perfusion cultures of animal cells and the like |
DE19544127C1 (en) | 1995-11-27 | 1997-03-20 | Gimsa Jan Dr | Suspended particle micro-manipulation |
JP2000505545A (en) | 1996-01-31 | 2000-05-09 | ボード・オヴ・リージェンツ,ザ・ユニヴァーシティ・オヴ・テキサス・システム | Separation method and apparatus using dielectrophoresis and field flow fractionation |
DK0925494T3 (en) | 1996-09-04 | 2002-07-01 | Scandinavian Micro Biodevices | Microfluidic system for particle separation and analysis |
GB9619093D0 (en) | 1996-09-12 | 1996-10-23 | Scient Generics Ltd | Methods of analysis/separation |
DE19653659C1 (en) | 1996-12-20 | 1998-05-20 | Guenter Prof Dr Fuhr | Electrode arrangement for field cages |
WO1998049344A1 (en) * | 1997-04-28 | 1998-11-05 | Lockheed Martin Energy Research Corporation | Method and apparatus for analyzing nucleic acids |
US5869004A (en) * | 1997-06-09 | 1999-02-09 | Caliper Technologies Corp. | Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems |
WO1999017883A1 (en) | 1997-10-06 | 1999-04-15 | California Institute Of Technology | Electrostatic particle transportation |
DE19815882A1 (en) | 1998-04-08 | 1999-10-14 | Fuhr Guenther | Method and device for manipulating microparticles in fluid flows |
AU785167B2 (en) * | 1998-05-29 | 2006-10-12 | Industrial Research Limited | Method and apparatus for concentrating and/or positioning particles or cells |
US6093370A (en) * | 1998-06-11 | 2000-07-25 | Hitachi, Ltd. | Polynucleotide separation method and apparatus therefor |
EP1092144A1 (en) | 1998-06-29 | 2001-04-18 | Evotec BioSystems AG | Method and device for manipulating particles in microsystems |
US6132685A (en) * | 1998-08-10 | 2000-10-17 | Caliper Technologies Corporation | High throughput microfluidic systems and methods |
US6572830B1 (en) * | 1998-10-09 | 2003-06-03 | Motorola, Inc. | Integrated multilayered microfludic devices and methods for making the same |
US6203683B1 (en) * | 1998-11-09 | 2001-03-20 | Princeton University | Electrodynamically focused thermal cycling device |
DE19859461A1 (en) | 1998-12-22 | 2000-06-29 | Evotec Biosystems Ag | Method and device for the convective movement of liquids in microsystems |
US6352838B1 (en) * | 1999-04-07 | 2002-03-05 | The Regents Of The Universtiy Of California | Microfluidic DNA sample preparation method and device |
US6942776B2 (en) | 1999-05-18 | 2005-09-13 | Silicon Biosystems S.R.L. | Method and apparatus for the manipulation of particles by means of dielectrophoresis |
WO2000073780A1 (en) | 1999-05-28 | 2000-12-07 | Proteologics, Inc. | Methods and apparatus for nonlinear mobility electrophoresis separation |
US6824664B1 (en) | 1999-11-04 | 2004-11-30 | Princeton University | Electrode-less dielectrophorises for polarizable particles |
WO2001040786A1 (en) | 1999-12-01 | 2001-06-07 | The Regents Of The University Of California | Electric-field-assisted fluidic assembly of inorganic and organic materials, molecules and like small things including living cells |
US6537433B1 (en) | 2000-03-10 | 2003-03-25 | Applera Corporation | Methods and apparatus for the location and concentration of polar analytes using an alternating electric field |
CN1319761A (en) | 2000-03-15 | 2001-10-31 | 清华大学 | Apparatus and method for high-flux electric rotation detection |
CA2403278A1 (en) | 2000-03-16 | 2001-09-20 | Subramanian Venkat Shastri | Microlaboratory devices and methods |
ATE370793T1 (en) | 2000-04-13 | 2007-09-15 | Wako Pure Chem Ind Ltd | ELECTRODE CONSTRUCTION FOR DIELECTROPHORETIC ARRANGEMENT AND DIELECTROPHORETIC SEPARATION |
AU2001252973A1 (en) | 2000-04-17 | 2001-10-30 | Purdue Research Foundation | Biosensor and related method |
US6780584B1 (en) | 2000-09-27 | 2004-08-24 | Nanogen, Inc. | Electronic systems and component devices for macroscopic and microscopic molecular biological reactions, analyses and diagnostics |
CN1325909C (en) | 2000-09-27 | 2007-07-11 | 清华大学 | Apparatus for particle operation and guide and use method thereof |
CN100495030C (en) | 2000-09-30 | 2009-06-03 | 清华大学 | Multi-force operator and use thereof |
US6936811B2 (en) | 2000-11-13 | 2005-08-30 | Genoptix, Inc. | Method for separating micro-particles |
US6744038B2 (en) | 2000-11-13 | 2004-06-01 | Genoptix, Inc. | Methods of separating particles using an optical gradient |
US6833542B2 (en) | 2000-11-13 | 2004-12-21 | Genoptix, Inc. | Method for sorting particles |
US20030007894A1 (en) | 2001-04-27 | 2003-01-09 | Genoptix | Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles |
US6784420B2 (en) | 2000-11-13 | 2004-08-31 | Genoptix, Inc. | Method of separating particles using an optical gradient |
US6787018B1 (en) | 2000-12-08 | 2004-09-07 | The Regents Of The University Of California | Dielectrophoretic concentration of particles under electrokinetic flow |
US6764583B2 (en) | 2000-12-13 | 2004-07-20 | The Regents Of The University Of California | Using impedance measurements for detecting pathogens trapped in an electric field |
US6685812B2 (en) | 2001-01-09 | 2004-02-03 | The Regents Of The University Of California | Movement of particles using sequentially activated dielectrophoretic particle trapping |
US6949176B2 (en) | 2001-02-28 | 2005-09-27 | Lightwave Microsystems Corporation | Microfluidic control using dielectric pumping |
US6706163B2 (en) | 2001-03-21 | 2004-03-16 | Michael Seul | On-chip analysis of particles and fractionation of particle mixtures using light-controlled electrokinetic assembly of particles near surfaces |
US6730204B2 (en) | 2001-03-27 | 2004-05-04 | The Regents Of The University Of California | Three dimensional separation trap based on dielectrophoresis and use thereof |
US6761811B2 (en) | 2001-03-27 | 2004-07-13 | The Regents Of The University Of California | Multi-stage separations based on dielectrophoresis |
US6660493B2 (en) | 2001-03-28 | 2003-12-09 | The Regents Of The University Of California | Hydrodynamic enhanced dielectrophoretic particle trapping |
ATE261114T1 (en) | 2002-02-01 | 2004-03-15 | Leister Process Tech | MICROFLUIDIC COMPONENT AND METHOD FOR SORTING PARTICLES IN A FLUID |
US6887362B2 (en) | 2002-02-06 | 2005-05-03 | Nanogen, Inc. | Dielectrophoretic separation and immunoassay methods on active electronic matrix devices |
-
2000
- 2000-03-10 US US09/522,638 patent/US6537433B1/en not_active Expired - Lifetime
-
2001
- 2001-03-08 DE DE60108848T patent/DE60108848T2/en not_active Expired - Lifetime
- 2001-03-08 AT AT01918488T patent/ATE289065T1/en not_active IP Right Cessation
- 2001-03-08 WO PCT/US2001/007576 patent/WO2001069230A2/en active IP Right Grant
- 2001-03-08 EP EP01918488A patent/EP1261863B1/en not_active Expired - Lifetime
- 2001-03-08 AU AU2001245558A patent/AU2001245558A1/en not_active Abandoned
- 2001-03-08 JP JP2001568062A patent/JP2003527601A/en not_active Withdrawn
- 2001-03-08 CA CA002402189A patent/CA2402189A1/en not_active Abandoned
-
2002
- 2002-10-27 US US10/281,770 patent/US6969454B2/en not_active Expired - Lifetime
-
2005
- 2005-11-28 US US11/288,664 patent/US7704363B2/en not_active Expired - Lifetime
-
2010
- 2010-04-26 US US12/767,644 patent/US8083917B2/en not_active Expired - Fee Related
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5059294A (en) * | 1985-12-26 | 1991-10-22 | The University Of Puerto Rico | Method for separating nucleic acids and nucleic acid probes |
US5344535A (en) * | 1989-11-27 | 1994-09-06 | British Technology Group Limited | Dielectrophoretic characterization of micro-organisms and other particles |
WO1993005390A1 (en) * | 1991-08-28 | 1993-03-18 | Guzman Norberto A | Automated capillary electrophoresis apparatus |
GB2266153A (en) * | 1992-04-16 | 1993-10-20 | British Tech Group | Dielectrophoretic separating of a mixture of particles |
DE19500683A1 (en) * | 1994-12-10 | 1996-06-13 | Guenter Prof Dr Fuhr | Trapping or movement of micro-particles in micro-structures generating electromagnetic cage field |
WO1996042013A1 (en) * | 1995-06-08 | 1996-12-27 | Visible Genetics Inc. | Microelectrophoresis chip for moving and separating nucleic acids and other charged molecules |
US6007690A (en) * | 1996-07-30 | 1999-12-28 | Aclara Biosciences, Inc. | Integrated microfluidic devices |
WO1999063332A1 (en) * | 1998-06-05 | 1999-12-09 | Sarnoff Corporation | Apparatus for separating molecules |
Non-Patent Citations (1)
Title |
---|
FUHR G ET AL: "POSITIONING AND MANIPULATION OF CELLS AND MICROPARTICLES USING MINIATURIZED ELECTRIC FIELD TRAPS AND TRAVELLING WAVES", SENSORS AND MATERIALS, SCIENTIFIC PUBLISHING DIVISION OF MYU, TOKYO, JP, vol. 7, no. 2, 1995, pages 131 - 146, XP000617698, ISSN: 0914-4935 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9434937B2 (en) | 2011-03-07 | 2016-09-06 | Accelerate Diagnostics, Inc. | Rapid cell purification systems |
Also Published As
Publication number | Publication date |
---|---|
ATE289065T1 (en) | 2005-02-15 |
US8083917B2 (en) | 2011-12-27 |
US6969454B2 (en) | 2005-11-29 |
US20100203580A1 (en) | 2010-08-12 |
EP1261863A2 (en) | 2002-12-04 |
AU2001245558A1 (en) | 2001-09-24 |
WO2001069230A2 (en) | 2001-09-20 |
CA2402189A1 (en) | 2001-09-20 |
EP1261863B1 (en) | 2005-02-09 |
US20060081474A1 (en) | 2006-04-20 |
US6537433B1 (en) | 2003-03-25 |
DE60108848T2 (en) | 2006-02-09 |
JP2003527601A (en) | 2003-09-16 |
DE60108848D1 (en) | 2005-03-17 |
US7704363B2 (en) | 2010-04-27 |
US20030057094A1 (en) | 2003-03-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2001069230A3 (en) | Methods and apparatus for the location and concentration of polar analytes using an alternating electric field | |
AU2002346484A1 (en) | Method and apparatus for improving the accuracy of alternative site analyte concentration measurements | |
WO2003044217A3 (en) | Automated sample preparation methods and devices | |
WO2001069217A3 (en) | Faims apparatus and method with ion diverting device | |
AU2002362432A1 (en) | Phase current detection method, inverter control method, motor control method, and apparatuses used in these methods | |
AUPR899401A0 (en) | Method and apparatus for non-motion detection | |
AU2002304121A1 (en) | Biosensor apparatus and method with sample type and volume detection | |
GB0119697D0 (en) | Fundraising.Com Corporation Inc Apparatus and method for online fundraising | |
AU2002314767A1 (en) | An apparatus and method for ultrasensitive nanoelectromechanical mass detection | |
AU2002231526A1 (en) | Method and apparatus for in-process liquid analysis by laser induced plasma spectroscopy | |
AU2002213933A1 (en) | Document search and analysing method and apparatus | |
EP1432113A4 (en) | Phase current detection method, inverter control method, motor control method, and apparatuses used in these methods | |
AU2001236586A1 (en) | Method and apparatus for determining chemical properties | |
AU2001252807A1 (en) | Method and apparatus for collecting and transporting liquids, specifically blood | |
AU2002249206A1 (en) | Device and method for detecting the presence of an analyte | |
AU2001266950A1 (en) | Method and apparatus for processing metals, and the metals so produced | |
AU2001217357A1 (en) | Sequence analysis method and sequence analysis apparatus | |
EP1136817A3 (en) | Method and apparatus for detecting concentration of solution, and apparatus for diluting and preparing agents | |
GB2358817B (en) | Trace-level gas analysis apparatus and method | |
AUPR808001A0 (en) | Method and apparatus for determining concentration of a chemical substance in a solution | |
WO2002046475A3 (en) | Method of detecting and treating tuberous sclerosis complex associated disorders | |
AU2001272578A1 (en) | Precalendering method, finishing method and apparatus for implementing the methods | |
AU2002219009A1 (en) | Method for the selective detection of gases using laser spectroscopy | |
AU2002317672A1 (en) | Method for the biochemical detection of analytes | |
AU2002332942A1 (en) | Device and method for determining an analyte |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
AK | Designated states |
Kind code of ref document: A3 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A3 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2001918488 Country of ref document: EP |
|
ENP | Entry into the national phase |
Ref country code: JP Ref document number: 2001 568062 Kind code of ref document: A Format of ref document f/p: F |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2402189 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2001245558 Country of ref document: AU |
|
WWP | Wipo information: published in national office |
Ref document number: 2001918488 Country of ref document: EP |
|
WWG | Wipo information: grant in national office |
Ref document number: 2001918488 Country of ref document: EP |