WO2001072323A3 - Use of insulin for the treatment of cartilagenous disorders - Google Patents

Use of insulin for the treatment of cartilagenous disorders Download PDF

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Publication number
WO2001072323A3
WO2001072323A3 PCT/US2001/009230 US0109230W WO0172323A3 WO 2001072323 A3 WO2001072323 A3 WO 2001072323A3 US 0109230 W US0109230 W US 0109230W WO 0172323 A3 WO0172323 A3 WO 0172323A3
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WO
WIPO (PCT)
Prior art keywords
insulin
treatment
administration
cartilage
injury
Prior art date
Application number
PCT/US2001/009230
Other languages
French (fr)
Other versions
WO2001072323A2 (en
Inventor
Ellen H Filvaroff
Franklin W Okumu
Original Assignee
Genentech Inc
Ellen H Filvaroff
Franklin W Okumu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc, Ellen H Filvaroff, Franklin W Okumu filed Critical Genentech Inc
Priority to EP01922571A priority Critical patent/EP1265630B1/en
Priority to AU4935701A priority patent/AU4935701A/en
Priority to DE60120372T priority patent/DE60120372T2/en
Priority to CA2402191A priority patent/CA2402191C/en
Priority to JP2001570284A priority patent/JP2003528149A/en
Publication of WO2001072323A2 publication Critical patent/WO2001072323A2/en
Publication of WO2001072323A3 publication Critical patent/WO2001072323A3/en
Priority to IL151408A priority patent/IL151408A/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/30—Insulin-like growth factors (Somatomedins), e.g. IGF-1, IGF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
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    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

The present invention relates to methods for the treatment and repair of cartilage, including cartilage damaged by injury or cartilagenous disorders, including arthritis, comprising the administration of insulin and/or insulin variants. Optionally, the administration may be in combination with a cartilage agent (e.g., peptide growth factor, catabolism antagonist, osteo-, synovial, anti-inflammatory factor), in an extended- or sustained-release form. Alternatively, the method provides for the treatment and repair of cartilage damaged by injury or cartilagenous disorders comprising the administration of insulin and/or insulin in combination with standard surgical techniques. Alternatively, the method provides for the treatment and repair of cartilage damaged by injury or cartilagenous disorders comprising the administration of chondrocytes previously treated with an effective amount of insulin and/or insulin variant.
PCT/US2001/009230 2000-03-24 2001-03-22 Use of insulin for the treatment of cartilagenous disorders WO2001072323A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP01922571A EP1265630B1 (en) 2000-03-24 2001-03-22 Use of insulin for the treatment of cartilagenous disorders
AU4935701A AU4935701A (en) 2000-03-24 2001-03-22 Use of insulin for the treatment of cartilagenous disorders
DE60120372T DE60120372T2 (en) 2000-03-24 2001-03-22 USE OF INSULIN FOR THE TREATMENT OF CORTICAL DISEASES
CA2402191A CA2402191C (en) 2000-03-24 2001-03-22 Use of insulin for the treatment of cartilagenous disorders
JP2001570284A JP2003528149A (en) 2000-03-24 2001-03-22 Use of insulin for the treatment of cartilage disorders
IL151408A IL151408A (en) 2000-03-24 2002-08-21 Use of insulin for the preparation of medicaments for the treatment of cartilagenous disorders

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19210300P 2000-03-24 2000-03-24
US60/192,103 2000-03-24

Publications (2)

Publication Number Publication Date
WO2001072323A2 WO2001072323A2 (en) 2001-10-04
WO2001072323A3 true WO2001072323A3 (en) 2002-06-06

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/009230 WO2001072323A2 (en) 2000-03-24 2001-03-22 Use of insulin for the treatment of cartilagenous disorders

Country Status (11)

Country Link
US (4) US6689747B2 (en)
EP (1) EP1265630B1 (en)
JP (2) JP2003528149A (en)
AT (1) ATE328605T1 (en)
AU (1) AU4935701A (en)
CA (1) CA2402191C (en)
DE (1) DE60120372T2 (en)
DK (1) DK1265630T3 (en)
ES (1) ES2266187T3 (en)
IL (1) IL151408A (en)
WO (1) WO2001072323A2 (en)

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US20040138101A1 (en) 2004-07-15
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