WO2001076469A3 - Method for measuring baroreflex sensitivity and therapy optimization in heart failure patients - Google Patents

Method for measuring baroreflex sensitivity and therapy optimization in heart failure patients Download PDF

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Publication number
WO2001076469A3
WO2001076469A3 PCT/US2001/010676 US0110676W WO0176469A3 WO 2001076469 A3 WO2001076469 A3 WO 2001076469A3 US 0110676 W US0110676 W US 0110676W WO 0176469 A3 WO0176469 A3 WO 0176469A3
Authority
WO
WIPO (PCT)
Prior art keywords
heart failure
baroreflex sensitivity
chronic heart
series
failure patients
Prior art date
Application number
PCT/US2001/010676
Other languages
French (fr)
Other versions
WO2001076469A2 (en
Inventor
Lawrence S Baumann
Veerichetty A Kadhiresan
Original Assignee
Cardiac Pacemakers Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cardiac Pacemakers Inc filed Critical Cardiac Pacemakers Inc
Priority to AU2001249784A priority Critical patent/AU2001249784A1/en
Publication of WO2001076469A2 publication Critical patent/WO2001076469A2/en
Publication of WO2001076469A3 publication Critical patent/WO2001076469A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362—Heart stimulators
    • A61N1/37—Monitoring; Protecting
    • A61N1/3702—Physiological parameters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362—Heart stimulators
    • A61N1/365—Heart stimulators controlled by a physiological parameter, e.g. heart potential
    • A61N1/36514—Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure
    • A61N1/36564—Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by blood pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362—Heart stimulators
    • A61N1/3627—Heart stimulators for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy

Abstract

A method and apparatus for determining the baroreflex sensitivity in a chronic heart failure patient and a method for chronic heart therapy evaluation. The method including providing a series of pacing stimuli to the heart of a chronic heart failure patient and measuring the change in pulse pressure and the change in cycle length incident to each pacing series. The changes being plotted to produce a line indicative of baroreflex sensitivity. The apparatus including a pacemaker having sensors for monitoring both cycle length and pulse pressure wherein the sensors may be integral or separate from the pacemaker. The method for evaluating chronic heart failure therapies including administering a series of therapies and evaluating each therapy based on the resultant increase of the patient's baroreflex sensitivity.
PCT/US2001/010676 2000-04-07 2001-04-03 Method for measuring baroreflex sensitivity and therapy optimization in heart failure patients WO2001076469A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001249784A AU2001249784A1 (en) 2000-04-07 2001-04-03 Method for measuring baroreflex sensitivity and therapy optimization in heart failure patients

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/545,362 US6371922B1 (en) 2000-04-07 2000-04-07 Method for measuring baroreflex sensitivity and therapy optimization in heart failure patients
US09/545,362 2000-04-07

Publications (2)

Publication Number Publication Date
WO2001076469A2 WO2001076469A2 (en) 2001-10-18
WO2001076469A3 true WO2001076469A3 (en) 2002-02-07

Family

ID=24175919

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/010676 WO2001076469A2 (en) 2000-04-07 2001-04-03 Method for measuring baroreflex sensitivity and therapy optimization in heart failure patients

Country Status (3)

Country Link
US (2) US6371922B1 (en)
AU (1) AU2001249784A1 (en)
WO (1) WO2001076469A2 (en)

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