WO2001076655A9 - Method and apparatus for regulating patient temperature by irrigating the bladder with a fluid - Google Patents
Method and apparatus for regulating patient temperature by irrigating the bladder with a fluidInfo
- Publication number
- WO2001076655A9 WO2001076655A9 PCT/US2001/011176 US0111176W WO0176655A9 WO 2001076655 A9 WO2001076655 A9 WO 2001076655A9 US 0111176 W US0111176 W US 0111176W WO 0176655 A9 WO0176655 A9 WO 0176655A9
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- fluid
- bladder
- catheter
- heated
- flow rate
- Prior art date
Links
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Classifications
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- A61B2017/22051—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation
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- A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
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- A61M2205/00—General characteristics of the apparatus
- A61M2205/36—General characteristics of the apparatus related to heating or cooling
- A61M2205/366—General characteristics of the apparatus related to heating or cooling by liquid heat exchangers
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- A61M2210/00—Anatomical parts of the body
- A61M2210/10—Trunk
- A61M2210/1078—Urinary tract
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Definitions
- Cooling for Total Body Therapeutic Hypothermia filed in the United States Patent and Trademark Office on April 6, 2000, and U.S. Patent Application Serial No. 60/ , filed , entitled "METHOD AND APPARATUS FOR REGULATING PATIENT TEMPERATURE BY IRRIGATING THE BLADDER WITH A FLUID” .
- the present invention relates generally to the modification and control of the temperature of the body. More particularly, the invention relates to a method for controlling body temperature by irrigating the bladder with a working fluid.
- Organs in the human body such as the brain, kidney and heart, are maintained at a constant temperature of approximately 37° C.
- Hypothermia can be clinically defined as a core body temperature of 35° C or less.
- hypothermia is sometimes characterized further according to its severity.
- a body core temperature in the range of 33° C to 35° C is described as mild hypothermia.
- a body temperature of 28° C to 32° C is described as moderate hypothermia.
- a body core temperature in the range of 24°C to 28 °C is described as severe hypothermia.
- U.S. Patent No. 3,425,419 to Dato describes a method and apparatus of lowering and raising the temperature of the human body.
- the Dato invention is directed towards a method of inducing moderate hypothermia in a patient using a metallic catheter.
- the metallic catheter has an inner passageway through which a fluid, such as water, can be circulated.
- the catheter is inserted through the femoral vein and then through the inferior vena cava as far as the right atrium and the superior vena cava.
- the Dato catheter has an elongated cylindrical shape and is constructed from stainless steel .
- a heat transfer element such as disclosed in U.S. Patent No. 6,096,068, incorporated herein by reference in its entirety, may be placed in the feeding artery of an organ to absorb or deliver the heat from or to the blood flowing into the organ. The transfer of heat may cause either a cooling or a heating of the selected organ.
- the heat transfer element is small enough to fit within the feeding artery while still allowing a sufficient blood flow to reach the organ in order to avoid ischemic organ damage .
- the temperature of the organ can be controlled with less of an effect on the temperature of the remaining parts of the body.
- a similar heat transfer device which is employed for whole body cooling and is disposed in the venous vasculature, is disclosed in U.S. Appl . Serial No. 09/373,112, also incorporated by reference in its entirety.
- the present invention provides a method and apparatus for heating or cooling at least a selected portion of a patient's body.
- the method begins by inserting a catheter through the. urethra and into the bladder of the patient .
- a heated or chilled fluid is conducted through a supply lumen of the catheter and into the bladder.
- the fluid is evacuated from the bladder through a return lumen of the catheter.
- a quantity of urine is monitored which flows out of the bladder and through the return lumen of the catheter.
- the rate of fluid flowing through the supply lumen of the catheter is adjusted in a manner that is based at least in part on the monitored quantity of urine flowing out of the bladder.
- the fluid is conducted into the supply lumen at a substantially constant flow rate, or alternatively, at a periodically interrupted rate.
- the flow rate is less than a flow rate that would substantially prevent fluid from flowing from the kidneys to the bladder.
- the flow rate of fluid conducted into the supply lumen is substantially equal to a flow rate of fluid being evacuated from the bladder.
- the pressure of the fluid flowing into the supply lumen is monitored.
- the pressure of the fluid flowing through the return lumen may be monitored as well.
- a temperature differential is monitored between the fluid conducted into the supply lumen and the fluid flowing through the return lumen.
- FIG. 1 is a partially perspective and partially schematic view of a catheter system including a circulation set constructed in accordance with the present invention.
- FIG. 2 is a schematic illustration of the circulation set depicted in FIG. 1, showing in particular the flow of the working fluid.
- FIG. 3 shows the distal end of the catheter depicted in FIGs. 1 and 2 inserted into the bladder.
- FIGs. 4-8 show different arrangements of the distal end of the catheter depicted in FIGs . 1 and 2 inserted into the bladder.
- FIG. 9 shows a cross-section of the catheter at a point proximal of the balloon.
- FIGs. 10-12 show various optional dispersion tips located on the supply orifice of the catheter for distributing fluid throughout the bladder.
- FIG. 13 shows a cross-section of the dispersion tip of FIG. 12.
- FIG. 14A shows a prior art heat exchange system.
- FIG. 14B shows a heat exchange system constructed in accordance with an embodiment of the invention.
- the present invention provides a relatively non- intrusive method and apparatus for heating or cooling all or part of a patient's body.
- the invention achieves this result by circulating a heat transfer fluid through the patient's bladder 11 (see FIG. 3) .
- Heat transfer via the bladder 11 is advantageous because the bladder 11 is located in the abdominal cavity, surrounded by a variety of organs, and in addition the bladder walls are highly perfused with blood.
- the abdominal cavity volume includes a substantial portion of the high blood flow vessels the aorta 17 and the inferior vena cava 19.
- the fluid absorbs heat from or delivers heat through the wall of the bladder 11 and into the abdominal cavity and the arterial and venous vessels populating this area, thereby regulating the temperature of a patient's whole body or one or more selected organs.
- the bladder 11 is supplied with blood by the superior, middle and inferior vesical arteries, which arise from the auterior trunk of the intereal iliac artery.
- cooling of the internal organs and a considerable amount of blood can be accomplished without the invasive step of inserting a catheter directly into the vascular system.
- insertion of a catheter into the bladder to monitor urine output is a common procedure .
- Such urethral catheters are commonly termed "Foley" catheters.
- a common Foley-type catheter may be the basis for the design and construction of a catheter according to the invention. As described below, however, significant modifications may be made to a common Foley catheter in order to make the same optimum for the present methods .
- FIG. 1 shows one embodiment of the bladder thermal control system 20 constructed in accordance with the present invention.
- the system includes a catheter 100, control system 26, and a circulation set 28 partially housed by the control unit system 26.
- the control system 26 may be equipped with an output display 36 and input keys 40 to facilitate user interaction with the control system 26.
- FIG. 1 shows a fairly large and relatively complex control system 26, the complexity of the same depends on the application to which the same is put.
- the control system 26 may be a simple Mallinkrodt Blood and Fluid Warmer, as manufactured by Mallinkrodt Medical of St. Louis, MO.
- the nature of the heat exchanger used within the control system may be simple, such as a simple resistive heat exchanger or thermo-electric heat exchanger .
- the catheter 100 which may employ a design similar to that of a Foley catheter, for example, is configured for insertion into the urethra.
- the proximal end of the catheter 100 includes a manifold 105 having an inlet port 102 and an outlet port 104 on its proximal end.
- a supply lumen 106 and a return lumen 108 are connected to a port located on the distal end of the manifold 105.
- the supply and return lumens 106 and 108 respectively terminate in supply and return orifices 110 and 112.
- the catheter may have a diameter of, e.g., 18 F or another size as dictated by the requirements of the user.
- the supply orifice 110 may include an optional dispersion tip. In FIG. 3, both a supply orifice 115 and a dispersion tip 116 are shown, although in practice typically only one or the other would be used.
- the supply orifice 110 may cause the fluid to emerge in a direction parallel to the axis of the catheter (supply orifice 110) or perpendicular to the same (supply orifice 115) . These aspects are discussed in more . detail below in connection with FIGS. 4-8.
- the distal tip or supply orifice of the catheter may be made of a very soft material so as to minimize tissue damage of the urethra upon insertion.
- the same may be coated with various materials to minimize deleterious coating of undesired biological materials on the tip during or after insertion.
- the supply and return lumens 106 and 108 may be formed from a pair of concentric flexible tubes so that the supply lumen 106 may be concentrically located within the annular return lumen 108. Of course, the same may also be non-coaxial as dictated by the requirements of the user.
- FIG. 3 when the catheter 100 is properly inserted into the urethra its distal end is located in the bladder. Fluid is conducted into the bladder from the supply lumen 106 via supply orifice 110. Fluid is conducted out of the bladder 11 via at least one return orifice 112 and into return lumen or lumens 108.
- the supply orifice 110 is spatially separated from the return orifices 112 so that fluid has an opportunity to thoroughly irrigate the bladder 11 before returning through the return orifice 112.
- the catheter 100 may include a balloon 14 (see FIGs. 3 and 4) near its tip to prevent its expulsion from the urethra.
- the balloon 14 may also serve the purpose of anchoring the catheter against movement caused by a pulsating working fluid supply, as may be the case if certain types of pumps are employed to drive the working fluid.
- the balloon 14 may be inflated by a single inflation lumen, a dual inflation lumen, or other such lumen as is known.
- FIG. 9 one embodiment of a catheter shaft is shown in cross-section.
- the catheter shaft 123 includes a supply lumen 106 and a return lumen 108.
- a lumen 122 is also shown for providing a space through which to deliver cabling to pressure monitor 77; however, cabling for pressure monitor 77 may also be provided through a microcatheter or capillary catheter disposed within the supply lumen 106 or the return lumen 108.
- a separate lumen 125 is also shown for use in inflating and deflating balloon 11 .
- a separate lumen 125 is also shown for use in delivering various drugs. While four separate lumens are shown in FIG. 9, more or less may be provided depending on the requirements of the user. With reference to Figures 1 and 2, an embodiment of the circulation set 28 will now be described.
- the circulation set 28 may include one or more of the following: a fluid reservoir 60, a pump 64, a filter 68, a heat exchanger 72, a temperature and pressure sensor assembly 76, supply line 80, and a return line 84.
- the supply line 80 and return line 84 are preferably comprised of one or more pieces of tubing, connectors, etc. joining the aforementioned components of the circulation set 28.
- the circulation set 28 supplies, filters, circulates, and monitors the temperature and pressure of the heat transfer fluid for the catheter 24.
- the fluid reservoir 60 is a modified IV bag made of PVC filled with saline. Since the typical bladder volume is about 500-750 cc , the volume of the fluid reservoir 60 should be greater than about 1000 cc . In this way the entire working fluid, as well as urine produced during the procedure, can be contained within the reservoir 60.
- Other working fluids besides saline such as, but not limited to, isotonic solutions, Ringer solution, and the like may be used. Various other solutions may be employed, including those that act to neutralize the proteins inherent in urine. In this way, when the combination of working fluid and urine is recirculated back into the bladder, the danger of infection is minimized.
- the fluid reservoir 60 is used to prime the lines
- the fluid reservoir 60 includes a supply or inlet tube 90 that communicates at an inlet 91 with the return line 84 outside of the reservoir 60 and communicates at an opposite end or outlet 92 with an inside 94 of the reservoir 60.
- the fluid reservoir 60 also includes a return or outlet tube 96 that communicates at one end with the supply line 80 outside of the reservoir 60 and communicates at an opposite end, i.e., at an inlet 98, with the inside 94 of the reservoir 60.
- the reservoir 60 may typically have a pressure of about 75 mm Hg (1.4 psi) , although the same may be pressurized to achieve higher pressures, e.g., 300 mm Hg (5.6 psi) .
- the filter 68 is preferably a 5-micron filter carried by male and female housing members .
- the filter 68 removes impurities from the circulating heat transfer fluid.
- the circulation set 28 may include more than one filter 68, the circulation set 28 may include no filters 68, or the filter 68 may be a part of one or more components of the circulation set .
- the heat exchanger 72 which is used to heat or chill the fluid supplied to the catheter, may be any of a variety of conventionally designed heat exchangers. As noted above, the heat exchanger 72 may employ a resistive heater, a microwave heater, a thermoelectric device, a closed-circuit temperature control system, etc.
- a height differential h' may be employed between an additional fluid reservoir, such as an elevated IV bag, and the catheter.
- the purpose of the pump would then be to pump the combination working fluid and urine up to the additional fluid reservoir.
- This has a benefit in that many physicians, such as urologists, are more comfortable reading bladder pressure as centimeters of water. For example, many urologists use, as a rule of thumb, about 10-20 centimeters of water as a safe bladder pressure.
- the height of the top of the water in the IV bag referenced to the approximate height of the bladder, can then be easily visually used as a measure of bladder inflation pressure.
- the control of the speed of pump 64 may be primarily given to control circuit 126, and a primary determinant of the pump speed may be the core body temperature as determined by a temperature monitor 128.
- the temperature monitor 128 may be an esophageal monitor, a tympanic monitor, or any other type of temperature monitor as is known in the art with which core body temperature may be monitored.
- the measured patient temperature may be the primary parameter on which depends the speed of pump 64.
- ⁇ T and the internal bladder pressure may determine the pump speed and the level of "valving" of a pinch valve 65.
- a “span” may be defined which corresponds to a ⁇ T small enough that very close control by control circuit 26 must occur in order to prevent overshoot. If ⁇ T > the span, i.e., the target temperature is relatively far from the core temperature, then the pump speed is maximized and the pinch valve 65 actuated to maintain the pressure of working fluid in the bladder 11. In this mode, the maximum amount of heating (or cooling) would occur.
- the pinch valve 65 is actuated to ensure that the bladder is not over-pressurized, as may be measured directly or inferred by a technique described below.
- the pump speed may be set proportional to ⁇ T, and / or the pinch valve 65 may be regulated to maintain the pressure of the working fluid in the bladder 11.
- the pinch valve 65 may require significant opening in order to maintain the pressure of the working fluid in the bladder 11. This is because it has been noted that the pressure of the working fluid in the bladder must be maintained in order to maintain a satisfactory heat transfer rate.
- a pressure sensor 77 may be employed to measure the pressure of the working fluid in the bladder 11. This pressure sensor 77 may be provided through a throughlumen in either the supply / inlet lumen or the return / outlet lumen, and may comprise a standard medical-grade pressure transducer.
- This pressure sensor 77 may be referenced to a core pressure monitor 127 (the transducer of which is not shown in FIG. 2) and both may provide signals to the control circuit 126.
- the measured bladder pressure may be employed, when ⁇ T is less than the span, to control the level of valving of pinch valve 65 in order to maintain the bladder pressure at as high a level as is safe and effective for heat transfer to occur.
- a typical operating pressure for safe use in the bladder has been quoted in some sources as being in the range of 0.2 to 0.3 psi.
- a typical ureter transport pressure i.e., the maximum bladder pressure which would allow an influx of urine from the ureters, has been suggested to be about 20-60 cm H 2 0 or about 0.28 - 0.85 psi.
- this value if properly assessed and measured, may also be used as a maximum pressure.
- a conservative approach may be to use the lesser of the allowed pressures as a maximum.
- the pressure sensor 77 and the control circuit 126 may be designed such that if a pressure higher than a predetermined value is encountered in the bladder, the pump 64 shuts down or the valve 65 completely closes or both. Other failsafe procedures may also be employed.
- the pressure sensor 77 may be referenced to an internal pressure measured at another location, such as the heart line, etc. In abdominal surgery, such a reference pressure may be neglected. As shown in FIGS. 4-8, the pressure sensor 77 may be located in various locations with respect to the supply orifice 110. In FIG. 4, the pressure sensor 77 and the supply orifice 110 are shown in roughly the same location at the distal tip of the catheter. The pressure sensor 77 may also be proximal of the distal tip, as shown in FIG. 5. The same could be true in the case where a side supply orifice 115 is employed (FIG. 6) . Alternatively, where a side supply orifice 115 is employed, the pressure sensor 77 may be located at the distal tip of the catheter (FIG.
- the pressure sensor 77 may be located at the distal tip of the catheter or proximal of the distal tip of the catheter.
- a specified flux of working fluid may be supplied to the bladder.
- Valve 65' can be actuated to obtained the desired bladder pressure and volume. If the supply flux is less than the drain flux, when the valve 65' is completely open, then for p bla _ der ⁇ raax i mum the system will not overpressure the bladder.
- the temperature and pressure sensor assembly 76 is used in one embodiment for measuring the temperature and the pressure of the heat transfer fluid in the supply line 80 before it enters the catheter 24, and measuring the temperature and the pressure of the heat transfer fluid in the return line 84, after it leaves the catheter 24. As described in more detail below, one or both of these measurements are important for determining not only the heating or cooling efficiency that can be achieved with the catheter 100, but also to ensure that the patient's bladder 11 is not irrigated at such a high rate, or subjected to such a high pressure, that renal failure occurs.
- the temperature and pressure sensor assembly 76 includes thermocouples and pressure transducers for respectively measuring the temperature and pressure of the fluid, and may also include associated electronics.
- Signals from the temperature and pressure assembly 76 are provided to control the control circuit 126 within control unit 26 (FIGs. 1 AND 2) . As noted above, this information is used by control unit 26 as feedback to control the throughput of pump 64 (if included in circulation set 28) , which in turn determines the flow rate of the fluid based on input parameters supplied to the control unit 26 via user input keys 40. The control unit 26 may also determine the rate of heat transferred to and from the working fluid by the heat exchanger 72.
- the temperature and pressure sensor assembly 76 may include alarms that shut down the system if a dangerous situation arises. For example, a maximum safe temperature of working fluid has been quoted as being about 45°C. If this temperature were exceeded, the system may be designed to shut itself down or even turn itself off. Alternatively, a high temperature may be allowed, but only for a short predetermined period of time.
- the mucosa in the bladder lining has been noted as being damaged after exposure to 43°C working fluid for four hours.
- the "pain threshold” has been noted as 42.5°C.
- a "mixed fluid" temperature may be defined as that which exits the bladder, and corresponds to the temperature of fluid after the effect of mixing with existing fluid in the bladder as well as with the urine.
- another suitable procedure may be to set the temperature of the working fluid as high as possible, without damaging tissue, for its entry into the bladder. This would correspond to a maximum heat transfer condition. That is, the effect of mixing can only be to lower the temperature and lessen the heat transfer.
- a typical flow rate may be, e.g., about 4-5 cubic centimeters of working fluid per second. Animal experiments have shown that such flow rates may lead to about 100-120 Watts of cooling, at 2 /_ to 3 % °C per hour, for an animal of 40 kg. Animal experiments have also shown that such flow rates may lead to about 40 Watts of heating for an animal of 40 kg.
- a suitable range of extreme low temperatures may be about 10-12 °C. In particular, these temperatures would be for the temperature of the working fluid as it enters the bladder. In this regime, the temperature may be chosen to be high enough so as to not cause uric acid crystallization, etc.
- the circulation set 28 depicted in FIGs. 1 and 2 recirculates the heat transfer fluid so that it flows through the bladder 11 a multiple of times.
- the heat transfer fluid would include urine that has accumulated in the bladder 11 and been conducted through the return lumen of the catheter.
- the circulation set 28 may continuously replenish the supply of heat transfer fluid so that the bladder 11 is irrigated with fresh heat transfer fluid.
- the heat transfer fluid is disposed of after being flushed from the bladder 11 by the catheter.
- the typical urine output from a 70 kg patient has been measured to be about 70 ml/hour up to about a liter per day (0.6 cc/hr/kg) .
- these numbers may vary according to the patient . Accordingly, during the procedure the volume of fluid returning from the bladder 11 in the circulation set should be monitored to ensure that it increases at the expected rate. If the volume of urine does not increase as expected, the patient may be undergoing renal failure and the procedure should be stopped so that appropriate action can be taken.
- the urine output volume may be measured in a number of different ways.
- the urine output may be monitored simply by observing the change in fluid level in the fluid reservoir 60.
- the fluid level may be electronically or optically detected by a sensor so that it can be monitored by the control unit 26.
- control unit 26 can determine the quantity or rate of urine output simply by measuring the differential between the quantity or rate of fluid flowing into the bladder 11 and flowing out of the bladder 11 once the bladder 11 has been initially filled.
- control unit may automatically adjust the fluid flow rate in response to the measured urine volume .
- the volume of fluid supplied by the catheter and residing in the bladder 11 must not be so great that it upsets the physiologic balance in the bladder 11.
- the volume of fluid should not be so great that it exerts a pressure on the walls of the bladder 11 that prevents the flow of urine from the ureters 13 (FIG. 3) into the bladder 11. This pressure should typically be less than about 0.28-0.85 psi.
- One way of ensuring that this does not occur is to monitor the urine flow in the manner previously described.
- P S ⁇ p Pr ⁇ y is the supply pressure
- P RETORU is the return pressure
- P B _ ADDER is the bladder pressure
- Q is the supply and return heat flux (in the steady state)
- ⁇ p SUP p Ly (Q) is the pressure drop on the supply lumen
- ⁇ p EETDHN (Q) is the pressure drop on the return lumen.
- the fluid may be provided to the supply lumen in a continuous, constant flow or as a pulsed flow of fluid.
- the pulsed flow may be a flow that is either intermittently interrupted or simply reduced in rate on an intermittent basis. A pulsed flow rate will allow urine that has accumulated in the bladder 11 to be flushed out.
- the flow rate may be pulsed so that the bladder 11 is flushed at a regular interval, e.g., every few minutes.
- the present invention also contemplates more complex flow rate patterns such as periodic and aperiodic oscillatory patterns, for example. If a constant flow is used, it should be sufficiently low to ensure that the pressure in the bladder 11 is not so great that urine cannot be flushed from the bladder 11. That is, the bladder 11 pressure should be less than the pressure in the ureter 13 so that urine flow from the kidneys 15 to the bladder 11 is not prevented. Of course, in many cases it will be desirable to maintain as great a flow of fluid as possible to maximize the rate of heat exchange.
- the pressure exerted upon the bladder 11 by each pulse may exceed the pressure that can be used in a continuous flow.
- the duration between the pulses should be sufficiently great so that urine flows out of the bladder 11 to allow drainage of the kidneys 15.
- the flow rate can be controlled by control unit 26 based on the information received from the temperature and / or pressure assembly 76, the values of the user input parameters received via user input keys 40, the value of pressure in the bladder measured by pressure monitor 77, or the volume or rate of urine flow out of the bladder 11.
- tip 116a may be a diffuser that distributes the fluid in substantially all directions.
- the diffusing tip 116a may be formed, for example, from a porous material or an impermeable material having a series of orifices distributed over its surface.
- FIG. 11 shows another tip design that employs a floating ball valve 116b.
- Floating ball valve 116b includes a slidable ball 117 whose movement is constrained by cage 118, which extends outward from the supply orifice 110.
- cage 118 which extends outward from the supply orifice 110.
- the floating ball valve 116b advantageously prevents substantial amounts of fluid from flowing back into the supply orifice 110 when no fluid is flowing up through the catheter.
- FIG. 12 shows yet another embodiment of the invention that employs a deflector tip 116c that has a surface 119 opposing the plane of the supply orifice 110, which deflects the fluid as it exits the orifice 110 so that it is distributed over a complete 360° region.
- the deflector tip 116c which is preferably formed from a pliable material, is fixed to an insert (not shown) positioned in the supply orifice 110.
- FIG. 13 illustrates a cross-section of the tip of FIG. 12, and shows four roughly perpendicular fluid paths 165 emerging from four supply lumens 166.
- the four supply lumens 166 may all emerge themselves from supply lumen 106.
- supply lumen 106 may be split into four separate lumens 166 to allow four mutually perpendicular or independent flows 165 to emerge.
- the insertion of a Foley-type catheter is generally uncomplicated, and can be performed by nurses or emergency personnel, embodiments of the invention may be implemented on an emergency vehicle such as an ambulance.
- a prior art refrigeration system 200 is shown. Such a system is exceedingly well-known, and includes a pump 202, a heat exchanger 204, a restriction valve 208, and an apparatus 206 to exhaust heat to a temperature bath.
- a liquid to gas heat exchanger transfers heat from the working fluid to the cold side of an evaporative chiller.
- FIG. 14B A system 201 according to an embodiment of the present invention is shown in FIG. 14B .
- a source of compressed gas 218 is valvably coupled via valve 220 to an optional restriction valve 222 to a heat exchanger 224.
- a working fluid output for, e.g., cold working fluid, is labeled by outlet 214.
- a working fluid input for, e.g., hot working fluid, is labeled by inlet 216.
- An exhaust to the environment is shown as exhaust 226.
- a compressed gas from source 218 is expanded adiabatically through a valve.
- the expansion results in a reduced temperature gas that absorbs heat from the working fluid in the liquid-to-gas heat exchanger 224.
- the heated, expanded gas is then discarded to the environment via exhaust 226.
- a additional temperature reduction in the expanded gas may be achieved by the phase change from the storage pressure to the expanded pressure .
- Gases which may be useful in embodiments of the invention employing adiabatic expansion include nitrogen, carbon dioxide, etc.
- Gases which may be useful in embodiments of the invention employing adiabatic expansion with a phase change include nitrous oxide .
- the above portable heat exchange system may be employed not only in the above bladder cooling embodiment but may also be employed as a heat exchange system for various other heat exchange catheters, including that disclosed in U.S. Patent No. 6,096,068, incorporated above by reference in its entirety, or that disclosed in U.S. Appl . Serial No. 09/373,112, also incorporated by reference in its entirety.
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
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JP2001574170A JP2003530159A (en) | 2000-04-06 | 2001-04-06 | Method and apparatus for regulating patient temperature by irrigating the bladder with fluid |
EP01924744A EP1267739A2 (en) | 2000-04-06 | 2001-04-06 | Method and apparatus for regulating patient temperature by irrigating the bladder with a fluid |
AU2001251369A AU2001251369A1 (en) | 2000-04-06 | 2001-04-06 | Method and apparatus for regulating patient temperature by irrigating the bladder with a fluid |
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
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US19560900P | 2000-04-06 | 2000-04-06 | |
US60/195,609 | 2000-04-06 | ||
US09/586,000 US6383210B1 (en) | 2000-06-02 | 2000-06-02 | Method for determining the effective thermal mass of a body or organ using cooling catheter |
US09/586,000 | 2000-06-02 | ||
US27052501P | 2001-02-21 | 2001-02-21 | |
US60/270,525 | 2001-02-21 | ||
US09/827,010 US6648906B2 (en) | 2000-04-06 | 2001-04-05 | Method and apparatus for regulating patient temperature by irrigating the bladder with a fluid |
US09/827,010 | 2001-04-05 |
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WO2001076655A2 WO2001076655A2 (en) | 2001-10-18 |
WO2001076655A3 WO2001076655A3 (en) | 2002-02-28 |
WO2001076655A9 true WO2001076655A9 (en) | 2002-03-28 |
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PCT/US2001/011176 WO2001076655A2 (en) | 2000-04-06 | 2001-04-06 | Method and apparatus for regulating patient temperature by irrigating the bladder with a fluid |
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US (2) | US6648906B2 (en) |
EP (1) | EP1267739A2 (en) |
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-
2001
- 2001-04-05 US US09/827,010 patent/US6648906B2/en not_active Expired - Lifetime
- 2001-04-06 JP JP2001574170A patent/JP2003530159A/en active Pending
- 2001-04-06 WO PCT/US2001/011176 patent/WO2001076655A2/en not_active Application Discontinuation
- 2001-04-06 EP EP01924744A patent/EP1267739A2/en not_active Withdrawn
- 2001-04-06 AU AU2001251369A patent/AU2001251369A1/en not_active Abandoned
-
2003
- 2003-11-17 US US10/716,205 patent/US6918924B2/en not_active Expired - Fee Related
Cited By (3)
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US9132250B2 (en) | 2009-09-03 | 2015-09-15 | Breathe Technologies, Inc. | Methods, systems and devices for non-invasive ventilation including a non-sealing ventilation interface with an entrainment port and/or pressure feature |
US9358358B2 (en) | 2010-09-30 | 2016-06-07 | Breathe Technologies, Inc. | Methods, systems and devices for humidifying a respiratory tract |
US9320644B2 (en) | 2011-07-25 | 2016-04-26 | Neurosave, Inc. | Non-invasive systems, devices, and methods for selective brain cooling |
Also Published As
Publication number | Publication date |
---|---|
US20010039440A1 (en) | 2001-11-08 |
US6918924B2 (en) | 2005-07-19 |
EP1267739A2 (en) | 2003-01-02 |
WO2001076655A3 (en) | 2002-02-28 |
US6648906B2 (en) | 2003-11-18 |
AU2001251369A1 (en) | 2001-10-23 |
JP2003530159A (en) | 2003-10-14 |
WO2001076655A2 (en) | 2001-10-18 |
US20040102826A1 (en) | 2004-05-27 |
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