WO2001078893A3 - Fluidic impedances in microfluidic system - Google Patents

Fluidic impedances in microfluidic system Download PDF

Info

Publication number
WO2001078893A3
WO2001078893A3 PCT/US2001/012244 US0112244W WO0178893A3 WO 2001078893 A3 WO2001078893 A3 WO 2001078893A3 US 0112244 W US0112244 W US 0112244W WO 0178893 A3 WO0178893 A3 WO 0178893A3
Authority
WO
WIPO (PCT)
Prior art keywords
impedances
differential pressure
fluidic
samples
microfluidic system
Prior art date
Application number
PCT/US2001/012244
Other languages
French (fr)
Other versions
WO2001078893A2 (en
WO2001078893A9 (en
Inventor
Stephen D O'connor
Gene Dantsker
Marci Pezzuto
Original Assignee
Nanostream Inc
Connor Stephen D O
Gene Dantsker
Marci Pezzuto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanostream Inc, Connor Stephen D O, Gene Dantsker, Marci Pezzuto filed Critical Nanostream Inc
Priority to JP2001576184A priority Critical patent/JP2003531018A/en
Priority to EP01930519A priority patent/EP1276565A2/en
Priority to AU2001257047A priority patent/AU2001257047A1/en
Priority to PCT/US2001/031790 priority patent/WO2002083310A2/en
Priority to AU2002213115A priority patent/AU2002213115A1/en
Publication of WO2001078893A2 publication Critical patent/WO2001078893A2/en
Publication of WO2001078893A3 publication Critical patent/WO2001078893A3/en
Publication of WO2001078893A9 publication Critical patent/WO2001078893A9/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F15—FLUID-PRESSURE ACTUATORS; HYDRAULICS OR PNEUMATICS IN GENERAL
    • F15C—FLUID-CIRCUIT ELEMENTS PREDOMINANTLY USED FOR COMPUTING OR CONTROL PURPOSES
    • F15C1/00—Circuit elements having no moving parts
    • F15C1/02—Details, e.g. special constructional devices for circuits with fluid elements, such as resistances, capacitive circuit elements; devices preventing reaction coupling in composite elements ; Switch boards; Programme devices
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F15—FLUID-PRESSURE ACTUATORS; HYDRAULICS OR PNEUMATICS IN GENERAL
    • F15D—FLUID DYNAMICS, i.e. METHODS OR MEANS FOR INFLUENCING THE FLOW OF GASES OR LIQUIDS
    • F15D1/00—Influencing flow of fluids
    • F15D1/02—Influencing flow of fluids in pipes or conduits
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0017—Capillary or surface tension valves, e.g. using electro-wetting or electro-capillarity effects
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0028—Valves having multiple inlets or outlets
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0042—Electric operating means therefor
    • F16K99/0049—Electric operating means therefor using an electroactive polymer [EAP]
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0055—Operating means specially adapted for microvalves actuated by fluids
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0055—Operating means specially adapted for microvalves actuated by fluids
    • F16K99/0057—Operating means specially adapted for microvalves actuated by fluids the fluid being the circulating fluid itself, e.g. check valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0621—Control of the sequence of chambers filled or emptied
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0874—Three dimensional network
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0073—Fabrication methods specifically adapted for microvalves
    • F16K2099/008—Multi-layer fabrications
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/0318—Processes
    • Y10T137/0402—Cleaning, repairing, or assembling
    • Y10T137/0491—Valve or valve element assembling, disassembling, or replacing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/206—Flow affected by fluid contact, energy field or coanda effect [e.g., pure fluid device or system]
    • Y10T137/218—Means to regulate or vary operation of device
    • Y10T137/2191—By non-fluid energy field affecting input [e.g., transducer]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/206—Flow affected by fluid contact, energy field or coanda effect [e.g., pure fluid device or system]
    • Y10T137/2224—Structure of body of device
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/598—With repair, tapping, assembly, or disassembly means
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/8158—With indicator, register, recorder, alarm or inspection means
    • Y10T137/8225—Position or extent of motion indicator
    • Y10T137/8242—Electrical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/8593—Systems
    • Y10T137/85978—With pump
    • Y10T137/86035—Combined with fluid receiver

Landscapes

  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Analytical Chemistry (AREA)
  • Theoretical Computer Science (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)

Abstract

The invention provides microfluidic devices with embedded fluidic impedances. Such impedancesdo not allow fluid to pass at a low differential pressure, but allow fluid to flow at a higher differential pressure. Impedances are formed by the three dimensional overlap of two or more channels contained within layers of the device. Such devices can be rapidly protyped and can be assembled to contain multiple fluidic impedances to perform complex fluid handling tasks, including metering defined volumes of samples and dividing samples into aliquots.
PCT/US2001/012244 2000-04-14 2001-04-13 Fluidic impedances in microfluidic system WO2001078893A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2001576184A JP2003531018A (en) 2000-04-14 2001-04-13 Fluid impedance in microfluidic systems
EP01930519A EP1276565A2 (en) 2000-04-14 2001-04-13 Fluidic impedances in microfluidic system
AU2001257047A AU2001257047A1 (en) 2000-04-14 2001-04-13 Fluidic impedances in microfluidic system
PCT/US2001/031790 WO2002083310A2 (en) 2001-04-13 2001-10-12 Microfluidic metering systems and methods
AU2002213115A AU2002213115A1 (en) 2001-04-13 2001-10-12 Microfluidic metering systems and methods

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/550,184 US6561208B1 (en) 2000-04-14 2000-04-14 Fluidic impedances in microfluidic system
US09/550,184 2000-04-14

Publications (3)

Publication Number Publication Date
WO2001078893A2 WO2001078893A2 (en) 2001-10-25
WO2001078893A3 true WO2001078893A3 (en) 2002-05-30
WO2001078893A9 WO2001078893A9 (en) 2002-07-04

Family

ID=24196093

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/012244 WO2001078893A2 (en) 2000-04-14 2001-04-13 Fluidic impedances in microfluidic system

Country Status (5)

Country Link
US (2) US6561208B1 (en)
EP (1) EP1276565A2 (en)
JP (1) JP2003531018A (en)
AU (1) AU2001257047A1 (en)
WO (1) WO2001078893A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9118042B2 (en) 2007-03-21 2015-08-25 Intelligent Energy Limited Fluidic distribution system and related methods

Families Citing this family (132)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001216645A (en) * 1999-11-22 2001-08-10 Sanyo Electric Co Ltd Controller
JP3754288B2 (en) * 1999-12-27 2006-03-08 三洋電機株式会社 Control device
JP2001250329A (en) * 1999-12-27 2001-09-14 Sanyo Electric Co Ltd Data recorder
CA2399199A1 (en) * 2000-02-23 2001-08-30 Ring-Ling Chien Multi-reservoir pressure control system
US6561208B1 (en) * 2000-04-14 2003-05-13 Nanostream, Inc. Fluidic impedances in microfluidic system
US6890093B2 (en) 2000-08-07 2005-05-10 Nanostream, Inc. Multi-stream microfludic mixers
AU2001281076A1 (en) * 2000-08-07 2002-02-18 Nanostream, Inc. Fluidic mixer in microfluidic system
US6561479B1 (en) * 2000-08-23 2003-05-13 Micron Technology, Inc. Small scale actuators and methods for their formation and use
CA2430651C (en) * 2001-02-09 2010-10-12 Wisconsin Alumni Research Foundation Method and structure for microfluidic flow guiding
WO2002075312A1 (en) 2001-03-19 2002-09-26 Gyros Ab Characterization of reaction variables
US7601286B2 (en) * 2001-03-26 2009-10-13 Lawrence Livermore National Security, Llc Polymer-based platform for microfluidic systems
US20050199299A1 (en) * 2001-05-25 2005-09-15 Schick Hans G. Methods and apparatus for micro-fluidic analytical chemistry
US6919046B2 (en) * 2001-06-07 2005-07-19 Nanostream, Inc. Microfluidic analytical devices and methods
US6880576B2 (en) * 2001-06-07 2005-04-19 Nanostream, Inc. Microfluidic devices for methods development
US7189368B2 (en) * 2001-09-17 2007-03-13 Gyros Patent Ab Functional unit enabling controlled flow in a microfluidic device
US20030168936A1 (en) * 2001-11-08 2003-09-11 Everingham Gary M. Electro-active polymer as a fuel vapor control valve actuator
US20030098661A1 (en) * 2001-11-29 2003-05-29 Ken Stewart-Smith Control system for vehicle seats
JP3896840B2 (en) * 2001-12-13 2007-03-22 ソニー株式会社 COOLING DEVICE, ELECTRONIC DEVICE DEVICE, AND COOLING DEVICE MANUFACTURING METHOD
US6877892B2 (en) 2002-01-11 2005-04-12 Nanostream, Inc. Multi-stream microfluidic aperture mixers
US20040109793A1 (en) * 2002-02-07 2004-06-10 Mcneely Michael R Three-dimensional microfluidics incorporating passive fluid control structures
GB0208766D0 (en) * 2002-04-02 2002-05-29 Univ Surrey Liquid-liquid separation
WO2003085395A1 (en) * 2002-04-09 2003-10-16 Humboldt-Universität Zu Berlin Automatic sample collector
GB0215879D0 (en) * 2002-07-09 2002-08-14 Univ Cambridge Tech Monitoring of cells
US7235164B2 (en) 2002-10-18 2007-06-26 Eksigent Technologies, Llc Electrokinetic pump having capacitive electrodes
US7364647B2 (en) * 2002-07-17 2008-04-29 Eksigent Technologies Llc Laminated flow device
US7517440B2 (en) 2002-07-17 2009-04-14 Eksigent Technologies Llc Electrokinetic delivery systems, devices and methods
US6969505B2 (en) 2002-08-15 2005-11-29 Velocys, Inc. Process for conducting an equilibrium limited chemical reaction in a single stage process channel
US6622519B1 (en) * 2002-08-15 2003-09-23 Velocys, Inc. Process for cooling a product in a heat exchanger employing microchannels for the flow of refrigerant and product
US7014835B2 (en) * 2002-08-15 2006-03-21 Velocys, Inc. Multi-stream microchannel device
US20040115830A1 (en) * 2002-09-25 2004-06-17 Igor Touzov Components for nano-scale Reactor
US8220494B2 (en) * 2002-09-25 2012-07-17 California Institute Of Technology Microfluidic large scale integration
US7143785B2 (en) 2002-09-25 2006-12-05 California Institute Of Technology Microfluidic large scale integration
JP5695287B2 (en) 2002-10-02 2015-04-01 カリフォルニア インスティテュート オブ テクノロジー Nucleic acid analysis of microfluids
DE10302721A1 (en) * 2003-01-23 2004-08-05 Steag Microparts Gmbh Microfluidic arrangement for dosing liquids
JP4136969B2 (en) 2003-03-03 2008-08-20 キヤノン株式会社 Fluid transfer device
JP2004317128A (en) * 2003-04-10 2004-11-11 Kanagawa Acad Of Sci & Technol Microchannel structure and microchip device
JP2004325185A (en) * 2003-04-23 2004-11-18 Arkray Inc Two-stage specimen analysis tool
US7294734B2 (en) * 2003-05-02 2007-11-13 Velocys, Inc. Process for converting a hydrocarbon to an oxygenate or a nitrile
US8580211B2 (en) * 2003-05-16 2013-11-12 Velocys, Inc. Microchannel with internal fin support for catalyst or sorption medium
CA2526965C (en) * 2003-05-16 2011-10-11 Velocys Inc. Process for forming an emulsion using microchannel process technology
US7220390B2 (en) * 2003-05-16 2007-05-22 Velocys, Inc. Microchannel with internal fin support for catalyst or sorption medium
US7485671B2 (en) * 2003-05-16 2009-02-03 Velocys, Inc. Process for forming an emulsion using microchannel process technology
SG145784A1 (en) * 2003-08-11 2008-09-29 California Inst Of Techn Microfluidic large scale integration
CA2535842C (en) * 2003-08-29 2012-07-10 Velocys Inc. Process for separating nitrogen from methane using microchannel process technology
US20050084072A1 (en) * 2003-10-17 2005-04-21 Jmp Industries, Inc., An Ohio Corporation Collimator fabrication
US8066955B2 (en) * 2003-10-17 2011-11-29 James M. Pinchot Processing apparatus fabrication
US6994245B2 (en) * 2003-10-17 2006-02-07 James M. Pinchot Micro-reactor fabrication
EP1526290A1 (en) * 2003-10-23 2005-04-27 F. Hoffmann-La Roche Ag Microchannel with a non-closing valve
EP1525917A1 (en) * 2003-10-23 2005-04-27 F. Hoffmann-La Roche Ag Microfluidic device with feed-through
GB0327094D0 (en) * 2003-11-21 2003-12-24 Inverness Medical Switzerland Laminated device
KR100613398B1 (en) * 2003-11-25 2006-08-17 한국과학기술연구원 Element detecting system using cantilever, method for fabrication of the same system and method for detecting micro element using the same system
WO2005052578A1 (en) * 2003-11-28 2005-06-09 Olympus Corporation Biosubstance testing apparatus and reaction stage thereof
KR100572207B1 (en) * 2003-12-18 2006-04-19 주식회사 디지탈바이오테크놀러지 Bonding method of plastic microchip
US7029647B2 (en) * 2004-01-27 2006-04-18 Velocys, Inc. Process for producing hydrogen peroxide using microchannel technology
US9023900B2 (en) 2004-01-28 2015-05-05 Velocys, Inc. Fischer-Tropsch synthesis using microchannel technology and novel catalyst and microchannel reactor
US7084180B2 (en) * 2004-01-28 2006-08-01 Velocys, Inc. Fischer-tropsch synthesis using microchannel technology and novel catalyst and microchannel reactor
US8747805B2 (en) 2004-02-11 2014-06-10 Velocys, Inc. Process for conducting an equilibrium limited chemical reaction using microchannel technology
US7665303B2 (en) 2004-03-31 2010-02-23 Lifescan Scotland, Ltd. Method of segregating a bolus of fluid using a pneumatic actuator in a fluid handling circuit
US7559356B2 (en) 2004-04-19 2009-07-14 Eksident Technologies, Inc. Electrokinetic pump driven heat transfer system
US7004198B1 (en) * 2004-07-20 2006-02-28 Sandia Corporation Micro-fluidic interconnect
US7168680B2 (en) * 2004-07-22 2007-01-30 Harris Corporation Embedded control valve using electroactive material
CA2574113C (en) * 2004-07-23 2014-02-18 Anna Lee Tonkovich Distillation process using microchannel technology
US7305850B2 (en) * 2004-07-23 2007-12-11 Velocys, Inc. Distillation process using microchannel technology
US7093818B2 (en) * 2004-08-03 2006-08-22 Harris Corporation Embedded control valve using homopolar motor
EP1786797B1 (en) * 2004-08-12 2014-11-26 Velocys, Inc. Process for converting ethylene to ethylene oxide using microchannel process technology
US7622509B2 (en) * 2004-10-01 2009-11-24 Velocys, Inc. Multiphase mixing process using microchannel process technology
WO2006047757A1 (en) * 2004-10-26 2006-05-04 Massachusetts Institute Of Technology Systems and methods for transferring a fluid sample
EP1817102A1 (en) * 2004-11-12 2007-08-15 Velocys, Inc. Process using microchannel technology for conducting alkylation or acylation reaction
KR100965032B1 (en) 2004-11-16 2010-06-21 벨로시스, 인코포레이티드 Multiphase reaction process using microchannel technology
CA2587412C (en) * 2004-11-17 2013-03-26 Velocys Inc. Emulsion process using microchannel process technology
WO2006056236A1 (en) * 2004-11-25 2006-06-01 Agilent Technologies, Inc. Microfluidic arrangement with coupling device having a selectable optical detection portion
EP1827693B1 (en) * 2004-12-09 2010-03-24 Scandinavian Micro Biodevices ApS A micro fluidic device and methods for producing a micro fluidic device
EP1843849A2 (en) * 2005-01-12 2007-10-17 Inverness Medical Switzerland GmbH A method of producing a microfluidic device and microfluidic devices
JP4153496B2 (en) * 2005-02-04 2008-09-24 セイコーインスツル株式会社 Section sample processing container, section sample processing method, and section sample processing apparatus
DE102005008224B3 (en) * 2005-02-23 2006-06-14 Directif Gmbh Apparatus for automatically activating microfluid device, for carrying out biochemical purifications and assays, having activator controlled on the basis of measurements of exerted force
US7507274B2 (en) * 2005-03-02 2009-03-24 Velocys, Inc. Separation process using microchannel technology
GB0505294D0 (en) * 2005-03-15 2005-04-20 Riso Nat Lab Transferring materials to polymer surfaces
EP1868714A1 (en) * 2005-03-23 2007-12-26 Velocys, Inc. Surface features in microprocess technology
US7331655B2 (en) * 2005-05-19 2008-02-19 Xerox Corporation Fluid coupler and a device arranged with the same
WO2006127889A2 (en) * 2005-05-25 2006-11-30 Velocys Inc. Support for use in microchannel processing
US20060280029A1 (en) * 2005-06-13 2006-12-14 President And Fellows Of Harvard College Microfluidic mixer
US20070004810A1 (en) * 2005-06-30 2007-01-04 Yong Wang Novel catalyst and fischer-tropsch synthesis process using same
JP5551871B2 (en) * 2005-07-08 2014-07-16 ヴェロシス，インク． Catalytic reaction process using microchannel technology
JP4657867B2 (en) * 2005-09-27 2011-03-23 セイコーインスツル株式会社 Microreactor and microreactor system
DK1957794T3 (en) * 2005-11-23 2014-08-11 Eksigent Technologies Llc Electrokinetic pump designs and drug delivery systems
ES2389382T3 (en) 2006-02-21 2012-10-25 Universal Biosensors Pty Limited Fluid transfer mechanism
JPWO2007122785A1 (en) * 2006-04-18 2009-08-27 日本碍子株式会社 Reaction apparatus, reaction module for reaction apparatus, and liquid feeding apparatus for reaction apparatus
WO2007122819A1 (en) * 2006-04-18 2007-11-01 Ngk Insulators, Ltd. Device for reactions with liquid media
US20080032390A1 (en) * 2006-08-04 2008-02-07 Ivar Meyvantsson Method and Device for Control of Diffusive Transport
GB0617035D0 (en) 2006-08-30 2006-10-11 Inverness Medical Switzerland Fluidic indicator device
GB0621520D0 (en) * 2006-10-28 2006-12-06 P2I Ltd Novel products
US8877484B2 (en) * 2007-01-10 2014-11-04 Scandinavian Micro Biodevices Aps Microfluidic device and a microfluidic system and a method of performing a test
US7867592B2 (en) 2007-01-30 2011-01-11 Eksigent Technologies, Inc. Methods, compositions and devices, including electroosmotic pumps, comprising coated porous surfaces
US8367397B2 (en) * 2007-02-15 2013-02-05 Honeywell International Inc. Active biochip for nucleic acid analysis
US7863035B2 (en) * 2007-02-15 2011-01-04 Osmetech Technology Inc. Fluidics devices
EP2800187B1 (en) * 2007-03-21 2017-12-20 Intelligent Energy Limited Electrochemical system comprising a fluid manifold
US8679694B2 (en) * 2007-03-21 2014-03-25 Societe Bic Fluidic control system and method of manufacture
KR20090030084A (en) * 2007-09-19 2009-03-24 삼성전자주식회사 Microfluidic device
JP4509167B2 (en) * 2007-11-05 2010-07-21 ソニー株式会社 Channel structure, channel substrate having the same, and fluid control method
WO2009076134A1 (en) * 2007-12-11 2009-06-18 Eksigent Technologies, Llc Electrokinetic pump with fixed stroke volume
EP2280905B1 (en) * 2008-04-11 2016-07-06 Fluidigm Corporation Multilevel microfluidic systems and methods
US8063236B2 (en) * 2008-05-08 2011-11-22 University Of Florida Research Foundation, Inc. Method for transferring N-atoms from metal complexes to organic and inorganic substrates
US9017946B2 (en) 2008-06-23 2015-04-28 Canon U.S. Life Sciences, Inc. Systems and methods for monitoring the amplification of DNA
US8122901B2 (en) 2008-06-30 2012-02-28 Canon U.S. Life Sciences, Inc. System and method for microfluidic flow control
WO2010013704A1 (en) * 2008-07-29 2010-02-04 シャープ株式会社 Microdevice, microchip device, and analysis method utilizing same
WO2010059351A2 (en) * 2008-10-30 2010-05-27 University Of Washington Substrate for manufacturing disposable microfluidic devices
CN102307665A (en) * 2008-12-04 2012-01-04 全技术联合公司 Methods and apparatus for moving aliquot samples of fluid
JP2010210118A (en) * 2009-03-09 2010-09-24 Jamco Corp Passenger plane mounted steam oven including safety valve for water leakage prevention purposes
BRPI1008513A2 (en) * 2009-03-20 2016-03-08 Avantium Holding B V flow control unit for microfluidized applications, and system for performing a plurality of parallel experiments
JP5250574B2 (en) * 2010-02-10 2013-07-31 富士フイルム株式会社 Microchannel device
DE102010003642A1 (en) * 2010-03-15 2011-09-15 Fresenius Medical Care Deutschland Gmbh Cassette with a sensor for determining the difference between a first and a second liquid flow
EP2558203A1 (en) * 2010-04-16 2013-02-20 Opko Diagnostics, LLC Systems and devices for analysis of samples
USD869308S1 (en) 2010-04-29 2019-12-10 Sony Corporation Micro flow channel chip
USD673287S1 (en) 2010-11-24 2012-12-25 Sony Corporation Micro flow channel chip
USD673286S1 (en) * 2010-04-29 2012-12-25 Sony Corporation Micro flow channel chip
KR101190142B1 (en) 2010-09-09 2012-10-12 아주대학교산학협력단 Lateral Flow Assay Device Providing Pre-treatment of Blood
US20130288292A1 (en) * 2011-01-11 2013-10-31 Ivar Meyvantsson Surface-tension based flow guidance in a microstructure environment
CA2830010A1 (en) * 2011-03-15 2012-09-20 Carclo Technical Plastics Limited Sample metering
JP2014519570A (en) 2011-05-05 2014-08-14 エクシジェント テクノロジーズ， エルエルシー Gel coupling for electrokinetic delivery system
US8852693B2 (en) 2011-05-19 2014-10-07 Liquipel Ip Llc Coated electronic devices and associated methods
GB201109203D0 (en) * 2011-06-01 2011-07-13 Carclo Technical Plastics Ltd Fluid flow control
DE102011079698B4 (en) * 2011-07-25 2022-08-04 Robert Bosch Gmbh Microfluidic device having a chamber for storing a liquid
GB201214122D0 (en) 2012-08-07 2012-09-19 Oxford Catalysts Ltd Treating of catalyst support
CN102886280B (en) * 2012-08-28 2014-06-11 博奥生物有限公司 Microfluidic chip and application thereof
US11209102B2 (en) * 2014-01-29 2021-12-28 Hewlett-Packard Development Company, L.P. Microfluidic valve
WO2016201218A2 (en) 2015-06-12 2016-12-15 Velocys, Inc. Synthesis gas conversion process
USD812766S1 (en) * 2016-07-12 2018-03-13 EMULATE, Inc. Microfluidic chip for use with a fluid perfusion module
USD842493S1 (en) * 2016-09-07 2019-03-05 EMULATE, Inc. Microfluidic chip without pressure features for use with a fluid perfusion module
USD838864S1 (en) * 2016-09-07 2019-01-22 EMULATE, Inc. Opaque microfluidic chip without pressure features for use with a fluid perfusion module
USD816861S1 (en) * 2016-09-07 2018-05-01 EMULATE, Inc. Transparent microfluidic chip without pressure features for use with a fluid perfusion module
US11192103B2 (en) 2017-05-04 2021-12-07 University Of Utah Research Foundation Micro-fluidic device for rapid PCR
CN211905402U (en) * 2019-11-22 2020-11-10 京东方科技集团股份有限公司 Detection chip and detection system

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946795A (en) * 1987-08-27 1990-08-07 Biotrack, Inc. Apparatus and method for dilution and mixing of liquid samples
WO1998055852A1 (en) * 1997-06-06 1998-12-10 Caliper Technologies Corp. Microfabricated structures for facilitating fluid introduction into microfluidic devices
US5958344A (en) * 1995-11-09 1999-09-28 Sarnoff Corporation System for liquid distribution
WO1999060397A1 (en) * 1998-05-18 1999-11-25 University Of Washington Liquid analysis cartridge
WO2001004909A1 (en) * 1999-07-09 2001-01-18 Orchid Biosciences, Inc. Fluid delivery system for a microfluidic device using a pressure pulse

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3568692A (en) 1967-11-27 1971-03-09 Bowles Eng Corp Optical machining process
US3587615A (en) 1969-10-30 1971-06-28 Bell Telephone Labor Inc Electrically responsive fluid logic device
US3680576A (en) 1970-09-02 1972-08-01 Bendix Corp Bonded metal structure having intricate passages formed therein, and a method of making said structures
US4426451A (en) 1981-01-28 1984-01-17 Eastman Kodak Company Multi-zoned reaction vessel having pressure-actuatable control means between zones
US4606375A (en) * 1985-06-04 1986-08-19 United Technologies Corporation Fluidic device
US6176962B1 (en) 1990-02-28 2001-01-23 Aclara Biosciences, Inc. Methods for fabricating enclosed microchannel structures
US5858188A (en) 1990-02-28 1999-01-12 Aclara Biosciences, Inc. Acrylic microchannels and their use in electrophoretic applications
US5770029A (en) 1996-07-30 1998-06-23 Soane Biosciences Integrated electrophoretic microdevices
GB2244135B (en) 1990-05-04 1994-07-13 Gen Electric Co Plc Sensor devices
SE470347B (en) 1990-05-10 1994-01-31 Pharmacia Lkb Biotech Microstructure for fluid flow systems and process for manufacturing such a system
SE9100392D0 (en) 1991-02-08 1991-02-08 Pharmacia Biosensor Ab A METHOD OF PRODUCING A SEALING MEANS IN A MICROFLUIDIC STRUCTURE AND A MICROFLUIDIC STRUCTURE COMPRISING SUCH SEALING MEANS
US5698299A (en) 1991-02-28 1997-12-16 Dyconex Patente Ag Thin laminated microstructure with precisely aligned openings
US5230866A (en) 1991-03-01 1993-07-27 Biotrack, Inc. Capillary stop-flow junction having improved stability against accidental fluid flow
US5262127A (en) 1992-02-12 1993-11-16 The Regents Of The University Of Michigan Solid state chemical micro-reservoirs
US5545367A (en) 1992-04-15 1996-08-13 Soane Technologies, Inc. Rapid prototype three dimensional stereolithography
US5744366A (en) 1992-05-01 1998-04-28 Trustees Of The University Of Pennsylvania Mesoscale devices and methods for analysis of motile cells
US5300370A (en) 1992-11-13 1994-04-05 Ballard Power Systems Inc. Laminated fluid flow field assembly for electrochemical fuel cells
DE69413012T2 (en) 1993-03-19 1999-03-25 Du Pont INTEGRATED DEVICE FOR CHEMICAL PROCESS STEPS AND MANUFACTURING METHOD THEREFOR
DE4405005A1 (en) * 1994-02-17 1995-08-24 Rossendorf Forschzent Micro fluid diode
US5595712A (en) 1994-07-25 1997-01-21 E. I. Du Pont De Nemours And Company Chemical mixing and reaction apparatus
US6129973A (en) 1994-07-29 2000-10-10 Battelle Memorial Institute Microchannel laminated mass exchanger and method of making
US5658413A (en) 1994-10-19 1997-08-19 Hewlett-Packard Company Miniaturized planar columns in novel support media for liquid phase analysis
US5858193A (en) 1995-06-06 1999-01-12 Sarnoff Corporation Electrokinetic pumping
CA2204912C (en) 1994-11-10 2005-01-04 David Sarnoff Research Center, Inc. Liquid distribution system
US5640995A (en) 1995-03-14 1997-06-24 Baxter International Inc. Electrofluidic standard module and custom circuit board assembly
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US5872010A (en) 1995-07-21 1999-02-16 Northeastern University Microscale fluid handling system
US5849208A (en) 1995-09-07 1998-12-15 Microfab Technoologies, Inc. Making apparatus for conducting biochemical analyses
US5658515A (en) 1995-09-25 1997-08-19 Lee; Abraham P. Polymer micromold and fabrication process
DE19536856C2 (en) 1995-10-03 1997-08-21 Danfoss As Micromixer and mixing process
US5755026A (en) * 1996-08-15 1998-05-26 Delco Electronics Corporation Method of preventing condensation on a surface housing an electronic apparatus
US6123316A (en) 1996-11-27 2000-09-26 Xerox Corporation Conduit system for a valve array
US5971355A (en) 1996-11-27 1999-10-26 Xerox Corporation Microdevice valve structures to fluid control
US5904824A (en) 1997-03-07 1999-05-18 Beckman Instruments, Inc. Microfluidic electrophoresis device
US5932315A (en) 1997-04-30 1999-08-03 Hewlett-Packard Company Microfluidic structure assembly with mating microfeatures
US6154226A (en) 1997-05-13 2000-11-28 Sarnoff Corporation Parallel print array
US6106685A (en) 1997-05-13 2000-08-22 Sarnoff Corporation Electrode combinations for pumping fluids
US5882465A (en) 1997-06-18 1999-03-16 Caliper Technologies Corp. Method of manufacturing microfluidic devices
US6073482A (en) 1997-07-21 2000-06-13 Ysi Incorporated Fluid flow module
US5932799A (en) 1997-07-21 1999-08-03 Ysi Incorporated Microfluidic analyzer module
WO1999015888A1 (en) 1997-09-19 1999-04-01 Aclara Biosciences, Inc. Capillary electroflow apparatus and method
US5945203A (en) 1997-10-14 1999-08-31 Zms Llc Stratified composite dielectric and method of fabrication
AU1517999A (en) 1997-10-15 1999-05-03 Aclara Biosciences, Inc. Laminate microstructure device and method for making same
US6074725A (en) 1997-12-10 2000-06-13 Caliper Technologies Corp. Fabrication of microfluidic circuits by printing techniques
EP1179585B1 (en) 1997-12-24 2008-07-09 Cepheid Device and method for lysis
GB9800220D0 (en) 1998-01-06 1998-03-04 Central Research Lab Ltd Method of forming interconnections between channels and chambers
US6167910B1 (en) * 1998-01-20 2001-01-02 Caliper Technologies Corp. Multi-layer microfluidic devices
US6117396A (en) 1998-02-18 2000-09-12 Orchid Biocomputer, Inc. Device for delivering defined volumes
DE69917761T2 (en) 1998-03-23 2005-08-11 Amalgamated Research, Inc. FRACTAL STRUCTURE FOR THE MEASUREMENT AND DISTRIBUTION OF FLUIDS
ATE530891T1 (en) 1998-05-22 2011-11-15 California Inst Of Techn MINIATURIZED CELL SORTER
US6494614B1 (en) 1998-07-27 2002-12-17 Battelle Memorial Institute Laminated microchannel devices, mixing units and method of making same
US6572830B1 (en) 1998-10-09 2003-06-03 Motorola, Inc. Integrated multilayered microfludic devices and methods for making the same
AU763497B2 (en) 1998-10-13 2003-07-24 Biomicro Systems, Inc. Fluid circuit components based upon passive fluid dynamics
EP1127611A3 (en) 1999-03-03 2001-11-07 Symyx Technologies, Inc. Chemical processing microsystems with integrated, separation-based reaction product analysis
ES1045001Y (en) * 1999-12-30 2000-12-16 Aparellaje Electrico Sa RETAINING DEVICE FOR CONDUCTORS OF AN ELECTRICAL DUCTING.
US6537506B1 (en) 2000-02-03 2003-03-25 Cellular Process Chemistry, Inc. Miniaturized reaction apparatus
US6561208B1 (en) * 2000-04-14 2003-05-13 Nanostream, Inc. Fluidic impedances in microfluidic system
AU2001259770A1 (en) 2000-05-15 2001-11-26 Biomicro Systems, Inc. Air flow regulation in microfluidic circuits for pressure control and gaseous exchange
US6557575B1 (en) * 2001-11-19 2003-05-06 Waters Investments Limited Fluid flow control freeze/thaw valve for narrow bore capillaries or microfluidic devices

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946795A (en) * 1987-08-27 1990-08-07 Biotrack, Inc. Apparatus and method for dilution and mixing of liquid samples
US5958344A (en) * 1995-11-09 1999-09-28 Sarnoff Corporation System for liquid distribution
WO1998055852A1 (en) * 1997-06-06 1998-12-10 Caliper Technologies Corp. Microfabricated structures for facilitating fluid introduction into microfluidic devices
WO1999060397A1 (en) * 1998-05-18 1999-11-25 University Of Washington Liquid analysis cartridge
WO2001004909A1 (en) * 1999-07-09 2001-01-18 Orchid Biosciences, Inc. Fluid delivery system for a microfluidic device using a pressure pulse

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9118042B2 (en) 2007-03-21 2015-08-25 Intelligent Energy Limited Fluidic distribution system and related methods

Also Published As

Publication number Publication date
JP2003531018A (en) 2003-10-21
AU2001257047A1 (en) 2001-10-30
WO2001078893A2 (en) 2001-10-25
US6561208B1 (en) 2003-05-13
WO2001078893A9 (en) 2002-07-04
US6755211B1 (en) 2004-06-29
EP1276565A2 (en) 2003-01-22

Similar Documents

Publication Publication Date Title
WO2001078893A3 (en) Fluidic impedances in microfluidic system
DE60112812D1 (en) POROUS MICRO VALVE
WO2001089695A3 (en) Valve for use in microfluidic structures
WO2002030560A3 (en) Fluidic couplers and modular microfluidic systems
WO2002081934A3 (en) Pneumatic valve interface for use in microfluidic structures
EP1928571A4 (en) Device and method for microfluidic control of a first fluid in contact with a second fluid, wherein the first and second fluids are immiscible
WO2001002093A3 (en) Detection article having fluid control film with capillary channels
AU2002310501A1 (en) Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system
AU2019268197A1 (en) Backflush methods and devices for chromatography
WO2003068670A3 (en) Microfluidic valve and system therefor
WO2003065976A3 (en) Microfluidics apparatus and methods of use therefor
WO2004007080A3 (en) Flow device
AU2000277079A8 (en)
WO2006060770A3 (en) Pressure regulated continuously variable volume container for fluid delivery
WO2008049083A3 (en) Lateral flow and flow-through bioassay based on patterned porous media, methods of making same, and methods of using same
EP1992402A4 (en) Micro fluid device and trace liquid diluting method
WO2006020555A3 (en) Connector with check valve and method of use
WO2007024485A8 (en) Microfluidic reduction of diffusion and complience effect in a fluid mixing region
WO2007021480A3 (en) System for aerodynamic flows and associated method
WO2004091795A3 (en) Manipulation of polymers in a microchannel
WO2008002462A3 (en) Methods and devices for microfluidic point-of-care immunoassays
AU2002327550A1 (en) Multi-channel microfluidic system design with balanced fluid flow distribution
AU2001297572A1 (en) Microfabricated fluidic circuit elements and applications
WO2007021907A3 (en) Resonant sensor systems and methods with reduced gas interference
WO2007016339A3 (en) Drainage devices and methods

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

AK Designated states

Kind code of ref document: C2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: C2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

COP Corrected version of pamphlet

Free format text: PAGES 30-34, AMENDED CLAIMS, ADDED

ENP Entry into the national phase

Ref country code: JP

Ref document number: 2001 576184

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 2001930519

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2001930519

Country of ref document: EP