WO2001087264A3 - Rapidly disintegrating solid oral dosage form - Google Patents

Rapidly disintegrating solid oral dosage form Download PDF

Info

Publication number
WO2001087264A3
WO2001087264A3 PCT/US2001/015983 US0115983W WO0187264A3 WO 2001087264 A3 WO2001087264 A3 WO 2001087264A3 US 0115983 W US0115983 W US 0115983W WO 0187264 A3 WO0187264 A3 WO 0187264A3
Authority
WO
WIPO (PCT)
Prior art keywords
dosage form
solid oral
rapidly disintegrating
oral dosage
disintegrating solid
Prior art date
Application number
PCT/US2001/015983
Other languages
French (fr)
Other versions
WO2001087264A2 (en
Inventor
Rajeev A Jain
Stephen B Ruddy
Kenneth Iain Cumming
Maurice Joseph Anthony Clancy
Janet Elizabeth Codd
Original Assignee
Elan Pharma Int Ltd
Rajeev A Jain
Stephen B Ruddy
Kenneth Iain Cumming
Maurice Joseph Anthony Clancy
Janet Elizabeth Codd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE60121570T priority Critical patent/DE60121570T2/en
Priority to AU2001263228A priority patent/AU2001263228A1/en
Priority to US10/276,400 priority patent/US20040013613A1/en
Priority to EP01937497A priority patent/EP1282399B1/en
Priority to CA002408848A priority patent/CA2408848C/en
Priority to JP2001583733A priority patent/JP2003533465A/en
Application filed by Elan Pharma Int Ltd, Rajeev A Jain, Stephen B Ruddy, Kenneth Iain Cumming, Maurice Joseph Anthony Clancy, Janet Elizabeth Codd filed Critical Elan Pharma Int Ltd
Publication of WO2001087264A2 publication Critical patent/WO2001087264A2/en
Publication of WO2001087264A3 publication Critical patent/WO2001087264A3/en
Priority to US10/701,064 priority patent/US8236352B2/en
Priority to US11/979,240 priority patent/US20090130213A1/en
Priority to US11/980,720 priority patent/US20090047209A1/en
Priority to US12/068,706 priority patent/US20080213371A1/en
Priority to US12/292,395 priority patent/US20090104273A1/en
Priority to US13/291,873 priority patent/US20120114754A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery

Abstract

Disclosed is a rapidly disintegrating solid oral dosage form of a poorly soluble active ingredient and at least one pharmaceutically acceptable water-soluble or water dispersible excipient, wherein the poorly soluble active ingredient particles have an average diameter, prior to inclusion in the dosage form, of less than about 2000 nm. The dosage form of the invention has the advantage of combining rapid presentation and rapid dissolution of the active ingredient in the oral cavity.
PCT/US2001/015983 1998-10-01 2001-05-18 Rapidly disintegrating solid oral dosage form WO2001087264A2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
JP2001583733A JP2003533465A (en) 2000-05-18 2001-05-18 Rapidly disintegrating solid oral dosage form
AU2001263228A AU2001263228A1 (en) 2000-05-18 2001-05-18 Rapidly disintegrating solid oral dosage form
US10/276,400 US20040013613A1 (en) 2001-05-18 2001-05-18 Rapidly disintegrating solid oral dosage form
EP01937497A EP1282399B1 (en) 2000-05-18 2001-05-18 Rapidly disintegrating solid oral dosage form
CA002408848A CA2408848C (en) 2000-05-18 2001-05-18 Rapidly disintegrating solid oral dosage form
DE60121570T DE60121570T2 (en) 2000-05-18 2001-05-18 ORAL FASCINATING, FIXED PHARMACEUTICAL FORMS TO BE APPLIED ORIGINALLY
US10/701,064 US8236352B2 (en) 1998-10-01 2003-11-05 Glipizide compositions
US11/979,240 US20090130213A1 (en) 2000-05-18 2007-10-31 Rapidly disintegrating solid oral dosage form
US11/980,720 US20090047209A1 (en) 1999-06-22 2007-10-31 Novel nifedipine compositions
US12/068,706 US20080213371A1 (en) 2000-05-18 2008-02-11 Rapidly disintegrating solid oral dosage form
US12/292,395 US20090104273A1 (en) 1999-06-22 2008-11-18 Novel nifedipine compositions
US13/291,873 US20120114754A1 (en) 2001-05-18 2011-11-08 Rapidly disintegrating solid oral dosage form

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/572,961 2000-05-18
US09/572,961 US6316029B1 (en) 2000-05-18 2000-05-18 Rapidly disintegrating solid oral dosage form

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US09/572,961 Continuation-In-Part US6316029B1 (en) 2000-05-18 2000-05-18 Rapidly disintegrating solid oral dosage form

Related Child Applications (6)

Application Number Title Priority Date Filing Date
US10/276,400 A-371-Of-International US20040013613A1 (en) 1998-10-01 2001-05-18 Rapidly disintegrating solid oral dosage form
US10276400 A-371-Of-International 2001-05-18
US10/667,470 Continuation US20040057993A1 (en) 2000-05-18 2003-09-23 Rapidly disintegrating solid oral dosage form
US10/701,064 Continuation-In-Part US8236352B2 (en) 1998-10-01 2003-11-05 Glipizide compositions
US10/712,259 Continuation-In-Part US20040115134A1 (en) 1999-06-22 2003-11-14 Novel nifedipine compositions
US12/068,706 Continuation US20080213371A1 (en) 2000-05-18 2008-02-11 Rapidly disintegrating solid oral dosage form

Publications (2)

Publication Number Publication Date
WO2001087264A2 WO2001087264A2 (en) 2001-11-22
WO2001087264A3 true WO2001087264A3 (en) 2002-06-20

Family

ID=24290082

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/015983 WO2001087264A2 (en) 1998-10-01 2001-05-18 Rapidly disintegrating solid oral dosage form

Country Status (8)

Country Link
US (1) US6316029B1 (en)
EP (1) EP1282399B1 (en)
JP (2) JP2003533465A (en)
AT (1) ATE333265T1 (en)
AU (1) AU2001263228A1 (en)
CA (1) CA2408848C (en)
DE (1) DE60121570T2 (en)
WO (1) WO2001087264A2 (en)

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CA2408848C (en) 2009-07-21
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WO2001087264A2 (en) 2001-11-22
DE60121570T2 (en) 2007-07-05
AU2001263228A1 (en) 2001-11-26
EP1282399B1 (en) 2006-07-19
JP2003533465A (en) 2003-11-11
ATE333265T1 (en) 2006-08-15
CA2408848A1 (en) 2001-11-22
EP1282399A2 (en) 2003-02-12

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