WO2001091720A3 - Preparation of injectable suspensions having improved injectability - Google Patents

Preparation of injectable suspensions having improved injectability Download PDF

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Publication number
WO2001091720A3
WO2001091720A3 PCT/US2001/012652 US0112652W WO0191720A3 WO 2001091720 A3 WO2001091720 A3 WO 2001091720A3 US 0112652 W US0112652 W US 0112652W WO 0191720 A3 WO0191720 A3 WO 0191720A3
Authority
WO
WIPO (PCT)
Prior art keywords
suspension
viscosity
injectability
preparation
improved injectability
Prior art date
Application number
PCT/US2001/012652
Other languages
French (fr)
Other versions
WO2001091720A2 (en
Inventor
J Michael Ramstack
M Gary I Riley
Stephen E Zale
Joyce M Hotz
Olufunmi L Johnson
Original Assignee
Alkermes Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24310496&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2001091720(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to CA002406536A priority Critical patent/CA2406536C/en
Priority to PL365195A priority patent/PL204298B1/en
Priority to DE60128798T priority patent/DE60128798T2/en
Priority to NZ522335A priority patent/NZ522335A/en
Priority to KR1020027015892A priority patent/KR100810480B1/en
Priority to EP16161468.0A priority patent/EP3095442B1/en
Priority to MXPA02011543A priority patent/MXPA02011543A/en
Priority to AU5546301A priority patent/AU5546301A/en
Priority to IL152767A priority patent/IL152767A/en
Application filed by Alkermes Inc filed Critical Alkermes Inc
Priority to SI200130755T priority patent/SI1283699T1/en
Priority to AU2001255463A priority patent/AU2001255463B2/en
Priority to HU0302283A priority patent/HU228587B1/en
Priority to DK01928628T priority patent/DK1283699T3/en
Priority to EP01928628A priority patent/EP1283699B1/en
Priority to BR0111060A priority patent/BRPI0111060B8/en
Priority to JP2001587736A priority patent/JP4502355B2/en
Publication of WO2001091720A2 publication Critical patent/WO2001091720A2/en
Publication of WO2001091720A3 publication Critical patent/WO2001091720A3/en
Priority to NO20025164A priority patent/NO334660B1/en
Priority to IS6595A priority patent/IS2471B/en
Priority to BG107288A priority patent/BG66023B1/en
Priority to HK03105214A priority patent/HK1054319A1/en
Priority to HK03108656.5A priority patent/HK1056321A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Abstract

Injectable compositions having improved injectability. The injectable compositions include microparticles in an aqueous injection vehicle having a viscosity of at least 20 cp at 20 °C. The increased viscosity of the injection vehicle that constitutes the fluid phase of the suspension significantly reduces in vivo injectability failures. The injectable compositions can be made by mixing dry microparticles with an aqueous injection vehicle to form a suspension, and then mixing the suspension with a viscosity enhancing agent to increase the viscosity of the fluid phase of the suspension to the desired level for improved injectability.
PCT/US2001/012652 2000-05-25 2001-04-19 Preparation of injectable suspensions having improved injectability WO2001091720A2 (en)

Priority Applications (21)

Application Number Priority Date Filing Date Title
SI200130755T SI1283699T1 (en) 2000-05-25 2001-04-19 Injectable suspensions having improved injectability properties
AU2001255463A AU2001255463B2 (en) 2000-05-25 2001-04-19 Preparation of injectable suspensions having improved injectability
DE60128798T DE60128798T2 (en) 2000-05-25 2001-04-19 INJECTABLE SUSPENSIONS WITH IMPROVED INJECTION PROPERTIES
NZ522335A NZ522335A (en) 2000-05-25 2001-04-19 Preparation of injectable suspensions having improved injectability
KR1020027015892A KR100810480B1 (en) 2000-05-25 2001-04-19 Preparation of injectable suspensions having improved injectability
EP16161468.0A EP3095442B1 (en) 2000-05-25 2001-04-19 Injectable suspensions having improved injectability properties
MXPA02011543A MXPA02011543A (en) 2000-05-25 2001-04-19 Preparation of injectable suspensions having improved injectability.
AU5546301A AU5546301A (en) 2000-05-25 2001-04-19 Preparation of injectable suspensions having improved injectability
IL152767A IL152767A (en) 2000-05-25 2001-04-19 Composition comprising suspended microparticles for injection through a needle
PL365195A PL204298B1 (en) 2000-05-25 2001-04-19 Preparation of injectable suspensions having improved injectability
JP2001587736A JP4502355B2 (en) 2000-05-25 2001-04-19 Preparation of injectable suspensions with improved injectability
CA002406536A CA2406536C (en) 2000-05-25 2001-04-19 Preparation of injectable suspensions having improved injectability
EP01928628A EP1283699B1 (en) 2000-05-25 2001-04-19 Injectable suspensions having improved injectability properties
DK01928628T DK1283699T3 (en) 2000-05-25 2001-04-19 Preparation of injectable suspensions with improved injection properties
HU0302283A HU228587B1 (en) 2000-05-25 2001-04-19 Preparation of injectable suspensions having improved injectability
BR0111060A BRPI0111060B8 (en) 2000-05-25 2001-04-19 composition suitable for injection through a needle into a host and methods for its preparation
IS6595A IS2471B (en) 2000-05-25 2002-10-28 Injectable suspension with enhanced injection properties
NO20025164A NO334660B1 (en) 2000-05-25 2002-10-28 Preparation of injectable suspensions with improved injectability
BG107288A BG66023B1 (en) 2000-05-25 2002-11-19 Preparation of injectable suspensions having improved injectability
HK03105214A HK1054319A1 (en) 2000-05-25 2003-07-18 Injectable suspensions having improved injectability properties
HK03108656.5A HK1056321A1 (en) 2000-05-25 2003-11-27 Preparation of injectable suspensions having improved injectability

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/577,875 2000-05-25
US09/577,875 US6495164B1 (en) 2000-05-25 2000-05-25 Preparation of injectable suspensions having improved injectability

Publications (2)

Publication Number Publication Date
WO2001091720A2 WO2001091720A2 (en) 2001-12-06
WO2001091720A3 true WO2001091720A3 (en) 2002-05-23

Family

ID=24310496

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/012652 WO2001091720A2 (en) 2000-05-25 2001-04-19 Preparation of injectable suspensions having improved injectability

Country Status (27)

Country Link
US (7) US6495164B1 (en)
EP (4) EP2269577B1 (en)
JP (1) JP4502355B2 (en)
KR (1) KR100810480B1 (en)
CN (1) CN100453067C (en)
AT (1) ATE363891T1 (en)
AU (2) AU2001255463B2 (en)
BG (1) BG66023B1 (en)
BR (1) BRPI0111060B8 (en)
CA (1) CA2406536C (en)
CY (3) CY1107441T1 (en)
CZ (1) CZ301359B6 (en)
DE (1) DE60128798T2 (en)
DK (3) DK2269577T3 (en)
ES (3) ES2574823T3 (en)
HK (4) HK1103346A1 (en)
HU (1) HU228587B1 (en)
IL (1) IL152767A (en)
IS (1) IS2471B (en)
MX (1) MXPA02011543A (en)
NO (1) NO334660B1 (en)
NZ (1) NZ522335A (en)
PL (1) PL204298B1 (en)
PT (2) PT1283699E (en)
RU (1) RU2002135641A (en)
SI (2) SI2269577T1 (en)
WO (1) WO2001091720A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4331570A1 (en) 2015-09-21 2024-03-06 Teva Pharmaceuticals International GmbH Sustained release olanzapine formulations

Families Citing this family (134)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA72189C2 (en) 1997-11-17 2005-02-15 Янссен Фармацевтика Н.В. Aqueous suspensions of 9-hydroxy-risperidone fatty acid esters provided in submicron form
US6770478B2 (en) * 2000-02-10 2004-08-03 The Regents Of The University Of California Erythrocytic cells and method for preserving cells
US6495164B1 (en) 2000-05-25 2002-12-17 Alkermes Controlled Therapeutics, Inc. I Preparation of injectable suspensions having improved injectability
US6824822B2 (en) * 2001-08-31 2004-11-30 Alkermes Controlled Therapeutics Inc. Ii Residual solvent extraction method and microparticles produced thereby
US7758890B2 (en) 2001-06-23 2010-07-20 Lyotropic Therapeutics, Inc. Treatment using dantrolene
KR100525189B1 (en) * 2002-10-10 2005-10-31 메디칸(주) Injectable solid material for human soft tissue volume replacement
US7731947B2 (en) 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
WO2004057959A2 (en) 2002-12-20 2004-07-15 Generipharm, Inc. Intracutaneous injection
US7658998B2 (en) * 2003-01-22 2010-02-09 Alkermes Controlled Therapeutics, Inc. Method of preparing sustained release microparticles
EP1603513B1 (en) * 2003-03-04 2020-12-30 Lyotropic Therapeutics, Inc. Dantrolene compositions
US20040247672A1 (en) * 2003-05-16 2004-12-09 Alkermes Controlled Therapeutics, Inc. Injectable sustained release compositions
US20050032811A1 (en) * 2003-08-06 2005-02-10 Josiah Brown Methods for administering aripiprazole
US7169180B2 (en) * 2003-09-03 2007-01-30 Brennan William A System and method for breast augmentation
US8092527B2 (en) * 2003-09-03 2012-01-10 Brennan William A System and method for breast augmentation
BRPI0413200A (en) 2003-09-03 2006-10-03 Miscon Trading S A method for treating endometriosis
US20050064045A1 (en) * 2003-09-18 2005-03-24 Sheng-Ping Zhong Injectable therapeutic formulations
US7906125B2 (en) * 2003-09-18 2011-03-15 Boston Scientific Scimed, Inc. Solid or semi-solid therapeutic formulations
SI1675573T2 (en) * 2003-10-23 2012-08-31 Otsuka Pharma Co Ltd Controlled release sterile injectable aripiprazole formulation and method
JP4947977B2 (en) * 2003-10-31 2012-06-06 わかもと製薬株式会社 Reversible thermogelling aqueous composition
US20060110423A1 (en) * 2004-04-15 2006-05-25 Wright Steven G Polymer-based sustained release device
US7456254B2 (en) 2004-04-15 2008-11-25 Alkermes, Inc. Polymer-based sustained release device
MXPA06011924A (en) * 2004-04-15 2007-06-11 Alkermes Inc Polymer-based sustained release device.
US20050260272A1 (en) * 2004-05-05 2005-11-24 Alkermes Controlled Therapeutics, Inc. Method of forming microparticles that include a bisphosphonate and a polymer
SG173326A1 (en) * 2004-06-04 2011-08-29 Camurus Ab Liquid depot formulations
ITMI20041245A1 (en) * 2004-06-22 2004-09-22 Ibsa Inst Biochimique Sa INJECTABLE PHARMACEUTICAL COMPOSITIONS INCLUDING DICLOFENAC SODIUM AND B-CYCLODESTRINE
EP1679065A1 (en) * 2005-01-07 2006-07-12 OctoPlus Sciences B.V. Controlled release compositions for interferon based on PEGT/PBT block copolymers
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
WO2006083761A2 (en) 2005-02-03 2006-08-10 Alza Corporation Solvent/polymer solutions as suspension vehicles
US8318210B2 (en) * 2005-02-28 2012-11-27 Neos Therapeutics, Lp Compositions and methods of making sustained release liquid formulations
US20060251581A1 (en) * 2005-05-09 2006-11-09 Mcintyre Jon T Method for treatment of uterine fibroid tumors
US7862552B2 (en) 2005-05-09 2011-01-04 Boston Scientific Scimed, Inc. Medical devices for treating urological and uterine conditions
US8263109B2 (en) 2005-05-09 2012-09-11 Boston Scientific Scimed, Inc. Injectable bulking compositions
JP5693817B2 (en) 2005-08-19 2015-04-01 アミリン・ファーマシューティカルズ, リミテッド・ライアビリティ・カンパニーAmylin Pharmaceuticals, Llc Diabetes treatment and weight loss
US8852638B2 (en) 2005-09-30 2014-10-07 Durect Corporation Sustained release small molecule drug formulation
CA2629300C (en) 2005-11-17 2014-07-08 Zogenix, Inc. Delivery of viscous formulations by needle-free injection
US20090038701A1 (en) 2006-01-17 2009-02-12 Baxter International Inc. Device, system and method for mixing
CN101453982B (en) 2006-05-30 2011-05-04 精达制药公司 Two-piece, internal-channel osmotic delivery system flow modulator
ES2422864T3 (en) 2006-08-09 2013-09-16 Intarcia Therapeutics, Inc Osmotic release systems and piston units
JP4941977B2 (en) * 2007-04-11 2012-05-30 大蔵製薬株式会社 Oral jelly-like pharmaceutical composition of benzisoxazole derivative
RU2440097C2 (en) 2007-04-23 2012-01-20 Интарсия Терапьютикс, Инк. Method of treating insulin-independent diabetes and obesity, osmotic delivery system and method for making it
MX337286B (en) 2007-05-25 2016-02-22 Indivior Uk Ltd Sustained delivery formulations of risperidone compounds.
US10092524B2 (en) 2008-06-11 2018-10-09 Edge Therapeutics, Inc. Compositions and their use to treat complications of aneurysmal subarachnoid hemorrhage
WO2009014441A2 (en) * 2007-07-26 2009-01-29 Aqtis Ip Bv Microparticles comprising pcl and uses thereof
HUE036214T2 (en) * 2007-07-31 2018-06-28 Otsuka Pharma Co Ltd Methods for producing aripiprazole suspension and freeze-dried formulation
US20090061005A1 (en) * 2007-08-21 2009-03-05 Actavis Group Ptc Ehf Paliperidone Polymorphs
US9987221B2 (en) * 2007-08-23 2018-06-05 Boston Scientific Scimed, Inc. Injectable hydrogel compositions
KR20100067684A (en) * 2007-11-05 2010-06-21 보오슈 앤드 롬 인코포레이팃드 Water-immiscible materials as vehicles for drug delivery
EP2240155B1 (en) 2008-02-13 2012-06-06 Intarcia Therapeutics, Inc Devices, formulations, and methods for delivery of multiple beneficial agents
ES2563061T3 (en) 2008-04-28 2016-03-10 Zogenix, Inc. New formulations for the treatment of migraine
US20110263496A1 (en) 2008-05-21 2011-10-27 Amylin Pharmaceuticals, Inc. Exendins to lower cholesterol and triglycerides
ES2721850T3 (en) 2008-06-16 2019-08-05 Pfizer Therapeutic polymeric nanoparticles comprising vinca alkaloids and methods of manufacturing and using them
CA2728176C (en) 2008-06-16 2017-07-04 Bind Biosciences, Inc. Drug loaded polymeric nanoparticles and methods of making and using same
US8613951B2 (en) * 2008-06-16 2013-12-24 Bind Therapeutics, Inc. Therapeutic polymeric nanoparticles with mTor inhibitors and methods of making and using same
US9216152B2 (en) * 2008-06-27 2015-12-22 Tepha, Inc. Injectable delivery of microparticles and compositions therefore
KR101760953B1 (en) * 2008-09-04 2017-07-24 아밀린 파마슈티칼스, 엘엘씨. Sustained release formulations using non-aqueous carriers
US20100063879A1 (en) * 2008-09-05 2010-03-11 Yellowpages.Com Llc Systems and Methods to Selectively Provide Information Based on User Interest
US8563041B2 (en) * 2008-12-12 2013-10-22 Bind Therapeutics, Inc. Therapeutic particles suitable for parenteral administration and methods of making and using same
JP2012512175A (en) 2008-12-15 2012-05-31 バインド バイオサイエンシズ インコーポレイテッド Long-circulating nanoparticles for sustained release of therapeutic agents
EP3323423B1 (en) 2009-09-28 2020-06-17 Intarcia Therapeutics, Inc Rapid establishment and/or termination of substantial steady-state drug delivery
TR201906255T4 (en) 2009-12-11 2019-05-21 Pfizer Stable formulations for lyophilizing therapeutic particles.
EP2515942B1 (en) 2009-12-15 2020-02-12 Pfizer Inc. Therapeutic polymeric nanoparticle compositions with high glass transition temperature or high molecular weight copolymers
WO2011106702A2 (en) 2010-02-25 2011-09-01 The Johns Hopkins University Sustained delivery of therapeutic agents to an eye compartment
WO2012012460A1 (en) 2010-07-19 2012-01-26 Xeris Pharmaceuticals, Inc. Stable glucagon formulations for the treatment of hypoglycemia
US10307372B2 (en) 2010-09-10 2019-06-04 The Johns Hopkins University Rapid diffusion of large polymeric nanoparticles in the mammalian brain
US9469630B2 (en) 2010-10-18 2016-10-18 Sumitomo Dainippon Pharma Co., Ltd. Sustained-release formulation for injection
US9327037B2 (en) 2011-02-08 2016-05-03 The Johns Hopkins University Mucus penetrating gene carriers
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
CN105853348B (en) 2011-03-10 2019-08-30 Xeris药物公司 Parenteral injection stablizing solution
EP2773331B1 (en) 2011-10-31 2016-02-10 Xeris Pharmaceuticals, Inc. Formulations for the treatment of diabetes
AU2013209452B2 (en) 2012-01-19 2015-11-05 The Johns Hopkins University Nanoparticle formulations with enhanced mucosal penetration
CA2867381C (en) 2012-03-16 2016-09-20 The Johns Hopkins University Controlled release formulations for the delivery of hif-1 inhibitors
JP6138904B2 (en) 2012-03-16 2017-05-31 ザ・ジョンズ・ホプキンス・ユニバーシティー Nonlinear multiblock copolymer drug conjugates for delivery of active agents
CA2871778C (en) 2012-05-03 2022-09-13 Kala Pharmaceuticals, Inc. Pharmaceutical nanoparticles showing improved mucosal transport
US9827191B2 (en) 2012-05-03 2017-11-28 The Johns Hopkins University Compositions and methods for ophthalmic and/or other applications
US11596599B2 (en) 2012-05-03 2023-03-07 The Johns Hopkins University Compositions and methods for ophthalmic and/or other applications
EP2844227B1 (en) 2012-05-03 2020-11-18 Kala Pharmaceuticals, Inc. Pharmaceutical nanoparticles showing improved mucosal transport
WO2013166498A1 (en) 2012-05-04 2013-11-07 The Johns Hopkins University Lipid-based drug carriers for rapid penetration through mucus linings
US9125805B2 (en) 2012-06-27 2015-09-08 Xeris Pharmaceuticals, Inc. Stable formulations for parenteral injection of small molecule drugs
EP2877155B1 (en) 2012-07-26 2020-10-28 Camurus AB Opioid formulations
EA032943B1 (en) 2012-09-17 2019-08-30 Пфайзер Инк. Process for preparing therapeutic nanoparticles (embodiments) and therapeutic nanoparticle (embodiments)
WO2014124006A1 (en) 2013-02-05 2014-08-14 The Johns Hopkins University Nanoparticles for magnetic resonance imaging tracking and methods of making and using thereof
US9018162B2 (en) 2013-02-06 2015-04-28 Xeris Pharmaceuticals, Inc. Methods for rapidly treating severe hypoglycemia
RU2016136430A (en) * 2014-02-11 2018-03-15 Др. Редди'С Лабораторис Лтд. Parenteral compositions of celecoxib
WO2015127389A1 (en) 2014-02-23 2015-08-27 The Johns Hopkins University Hypotonic enema formulations and methods of use
TWI636798B (en) 2014-03-14 2018-10-01 輝瑞大藥廠 Therapeutic nanoparticles comprising a therapeutic agent and methods of making and using same
WO2016022831A1 (en) 2014-08-06 2016-02-11 Xeris Pharmaceuticals, Inc. Syringes, kits, and methods for intracutaneous and/or subcutaneous injection of pastes
US11471401B2 (en) 2014-08-28 2022-10-18 The General Hospital Corporation Injectable slurries and methods of manufacturing the same
US11504322B2 (en) 2014-08-28 2022-11-22 The General Hospital Corporation Injectable slurries and methods of manufacturing the same
EP4176885A1 (en) * 2014-08-28 2023-05-10 The General Hospital Corporation Compositions and methods for treatment of neurological disorders
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
WO2016100392A1 (en) 2014-12-15 2016-06-23 The Johns Hopkins University Sunitinib formulations and methods for use thereof in treatment of ocular disorders
JP6846351B2 (en) 2015-01-27 2021-03-24 ザ・ジョンズ・ホプキンス・ユニバーシティー Hypotonic hydrogel formulation for enhanced transport of active agents on mucosal surfaces
US20160303281A1 (en) 2015-04-17 2016-10-20 Rochal Industries, Llc Composition and kits for pseudoplastic microgel matrices
HUE055728T2 (en) 2015-05-22 2021-12-28 Univ Leland Stanford Junior Treatment of post-bariatric hypoglycemia with exendin(9-39)
EP3302354B1 (en) 2015-06-03 2023-10-04 i2o Therapeutics, Inc. Implant placement systems
US9649364B2 (en) 2015-09-25 2017-05-16 Xeris Pharmaceuticals, Inc. Methods for producing stable therapeutic formulations in aprotic polar solvents
KR20180016732A (en) 2015-06-10 2018-02-19 에보니크 룀 게엠베하 Process for preparing a powder comprising a human coagulation factor protein and a lactic acid polymer
AR106018A1 (en) 2015-08-26 2017-12-06 Achillion Pharmaceuticals Inc ARYL, HETEROARYL AND HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF MEDICAL DISORDERS
EP3340982B1 (en) 2015-08-26 2021-12-15 Achillion Pharmaceuticals, Inc. Compounds for treatment of immune and inflammatory disorders
US11590205B2 (en) 2015-09-25 2023-02-28 Xeris Pharmaceuticals, Inc. Methods for producing stable therapeutic glucagon formulations in aprotic polar solvents
CN105310980A (en) * 2015-10-09 2016-02-10 北京万全德众医药生物技术有限公司 Paliperidone controlled-release suspension oral liquid and its preparation method
MX2018005932A (en) 2015-11-12 2019-05-20 Graybug Vision Inc Aggregating microparticles for therapy.
HRP20231453T1 (en) 2015-11-16 2024-03-01 Medincell S.A. A method for morselizing and/or targeting pharmaceutically active principles to synovial tissue
CN114576893A (en) 2016-02-26 2022-06-03 通用医疗公司 Medical ice slurry production and delivery system and method
US10653753B2 (en) 2016-03-04 2020-05-19 Eiger Biopharmaceuticals, Inc. Treatment of hyperinsulinemic hypoglycemia with exendin-4 derivatives
WO2017197055A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Heterocyclic degronimers for target protein degradation
CN109641874A (en) 2016-05-10 2019-04-16 C4医药公司 C for target protein degradation3The glutarimide degron body of carbon connection
WO2017197036A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Spirocyclic degronimers for target protein degradation
WO2017200943A1 (en) 2016-05-16 2017-11-23 Intarcia Therapeutics, Inc. Glucagon-receptor selective polypeptides and methods of use thereof
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
CA3029262A1 (en) 2016-06-27 2018-01-04 Achillion Pharmaceuticals, Inc. Quinazoline and indole compounds to treat medical disorders
RU2019102647A (en) 2016-07-01 2020-08-03 Г1 Терапьютикс, Инк. PYRIMIDINE-BASED ANTIPROLIFERATING AGENTS
WO2018057977A1 (en) 2016-09-23 2018-03-29 Delpor, Inc. Stable compositions for incretin mimetic compounds
JP2019535734A (en) 2016-11-21 2019-12-12 アイガー・バイオファーマシューティカルズ・インコーポレイテッドＥｉｇｅｒ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Buffered formulation of exendin (9-39)
KR20190104039A (en) 2017-01-03 2019-09-05 인타르시아 세라퓨틱스 인코포레이티드 Methods Including Continuous Administration of GLP-1 Receptor Agonists and Co-administration of Drugs
US10350200B2 (en) * 2017-01-23 2019-07-16 Southwest Research Institute Aqueous suspensions of oximes for autoinjectors
US20180235899A1 (en) 2017-02-17 2018-08-23 Privo Technologies, Inc. Particle-based multi-layer therapeutic delivery device and method
CA3057438A1 (en) 2017-03-20 2018-09-27 Teva Pharmaceuticals International Gmbh Sustained release olanzapine formulaitons
BR112019019452A2 (en) 2017-03-23 2020-04-14 Graybug Vision Inc compound, and, use of a compound
RU2019139817A (en) 2017-05-10 2021-06-10 Грейбуг Вижн, Инк. DELAYED RELEASE MICROPARTICLES AND THEIR SUSPENSIONS FOR DRUG THERAPY
KR20240036128A (en) 2017-06-02 2024-03-19 엑스에리스 파머수티클스, 인크. Precipitation resistant small molecule drug formulations
US10568842B2 (en) * 2017-08-18 2020-02-25 Lance L. Gooberman Anti-inflammatory pharmaceutical compositions and methods of administration
CN109589304A (en) * 2017-10-01 2019-04-09 万特制药(海南)有限公司 Risperidone oral administration solution and preparation method thereof
JP2021519337A (en) 2018-03-26 2021-08-10 シー４ セラピューティクス， インコーポレイテッド Cereblon binder for the degradation of Ikaras
US20230022157A1 (en) 2018-08-20 2023-01-26 Achillion Pharmaceuticals, Inc. Pharmaceutical compounds for the treatment of complement factor d medical disorders
CN113164395A (en) * 2018-10-15 2021-07-23 株式会社钟根堂 Long-acting naltrexone microparticle composition for injection
EP3866773A4 (en) 2018-10-16 2022-10-26 Georgia State University Research Foundation, Inc. Carbon monoxide prodrugs for the treatment of medical disorders
WO2021138646A1 (en) * 2020-01-03 2021-07-08 Privo Technologies, Inc. Systems and pharmaceutical compositions for treatment by direct injection of a targeted population of cells
BE1028769B1 (en) * 2020-11-02 2022-05-31 Flanders Color Nv WATER BASED LIQUID RINSE LACQUER
US20240100012A1 (en) 2021-01-18 2024-03-28 Mark Hasleton Pharmaceutical dosage form
US11241330B1 (en) 2021-04-02 2022-02-08 Brixton Biosciences, Inc. Apparatus for creation of injectable slurry
CA3227324A1 (en) 2021-07-06 2023-01-12 Mark Hasleton Treatment of serotonin reuptake inhibitor withdrawal syndrome
CN114146020B (en) * 2022-02-10 2022-04-29 中国远大集团有限责任公司 Injection beauty product and preparation method and application thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994025460A1 (en) * 1993-04-28 1994-11-10 Janssen Pharmaceutica N.V. Risperidone pamoate
WO1995013799A1 (en) * 1993-11-19 1995-05-26 Alkermes Controlled Therapeutics Inc. Ii Preparation of biodegradable microparticles containing a biologically active agent
WO1996001652A1 (en) * 1994-07-11 1996-01-25 Janssen Pharmaceutica N.V. Aqueous risperidone formulations
WO1997044039A1 (en) * 1996-05-20 1997-11-27 Janssen Pharmaceutica N.V. Aqueous suspensions of 9-hydroxyrisperidone fatty acid esters
WO1999025354A2 (en) * 1997-11-17 1999-05-27 Janssen Pharmaceutica N.V. Aqueous suspensions of submicron 9-hydroxyrisperidone fatty acid esters

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE634668A (en) 1962-07-11
BE744162A (en) 1969-01-16 1970-06-15 Fuji Photo Film Co Ltd ENCAPSULATION PROCESS
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
DE2010115A1 (en) 1970-03-04 1971-09-16 Farbenfabriken Bayer Ag, 5090 Leverkusen Process for the production of micro-granules
US3700215A (en) * 1970-10-21 1972-10-24 Hardman Inc Mixing and dispensing device
JPS523342B2 (en) 1972-01-26 1977-01-27
GB1413186A (en) 1973-06-27 1975-11-12 Toyo Jozo Kk Process for encapsulation of medicaments
US4029782A (en) * 1975-04-28 1977-06-14 Eli Lilly And Company Cefazolin suspension for parenteral administration
JPS523653A (en) 1975-06-27 1977-01-12 Fuji Photo Film Co Ltd Process for producing fine polymer particles
IL51791A0 (en) * 1976-04-14 1977-05-31 Exxon Research Engineering Co New injectable medicinal compositions
US4384975A (en) 1980-06-13 1983-05-24 Sandoz, Inc. Process for preparation of microspheres
US4389330A (en) 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
US4530840A (en) 1982-07-29 1985-07-23 The Stolle Research And Development Corporation Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
US5385738A (en) 1983-10-14 1995-01-31 Sumitomo Pharmaceuticals Company, Ltd. Sustained-release injection
JPS60112713A (en) * 1983-11-21 1985-06-19 Sumitomo Chem Co Ltd Useful slow-releasing injection
JPH0657658B2 (en) * 1985-04-11 1994-08-03 住友製薬株式会社 Sustained release formulation
JPS60100516A (en) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd Preparation of sustained release microcapsule
IE58110B1 (en) 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
US4804663A (en) 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
IE59361B1 (en) 1986-01-24 1994-02-09 Akzo Nv Pharmaceutical preparation for obtaining a highly viscous hydrogel or suspension
US4803075A (en) * 1986-06-25 1989-02-07 Collagen Corporation Injectable implant composition having improved intrudability
WO1989003678A1 (en) 1987-10-30 1989-05-05 Stolle Research & Development Corporation Low residual solvent microspheres and microencapsulation process
US5158952A (en) 1988-11-07 1992-10-27 Janssen Pharmaceutica N.V. 3-[2-[4-(6-fluoro-1,2-benzisoxozol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9 tetrahydro-9-hydroxy-2-methyl-4H-pyrido [1,2-a]pyrimidin-4-one, compositions and method of use
IL92344A0 (en) 1989-01-04 1990-07-26 Gist Brocades Nv Microencapsulation of bioactive substances in biocompatible polymers,microcapsules obtained and pharmaceutical preparation comprising said microcapsules
US5019400A (en) 1989-05-01 1991-05-28 Enzytech, Inc. Very low temperature casting of controlled release microspheres
DE69024953T3 (en) 1989-05-04 2005-01-27 Southern Research Institute, Birmingham encapsulation
US5478564A (en) 1990-02-22 1995-12-26 Teva Pharmaceutical Industries, Ltd. Preparation of microparticles for controlled release of water-soluble substances
US5271941A (en) * 1990-11-02 1993-12-21 Cho Chung Yoon S Antisense oligonucleotides of human regulatory subunit RI.sub.α of cAMP-dependent protein kinases
IT1243390B (en) 1990-11-22 1994-06-10 Vectorpharma Int PHARMACEUTICAL COMPOSITIONS IN THE FORM OF PARTICLES SUITABLE FOR THE CONTROLLED RELEASE OF PHARMACOLOGICALLY ACTIVE SUBSTANCES AND PROCEDURE FOR THEIR PREPARATION.
US5486362A (en) * 1991-05-07 1996-01-23 Dynagen, Inc. Controlled, sustained release delivery system for treating drug dependency
HU222501B1 (en) 1991-06-28 2003-07-28 Endorecherche Inc. Controlled release pharmaceutical composition containing mpa or mga and process for its preparation
US20020009443A1 (en) * 1991-12-02 2002-01-24 Vanitha Ramakrishman Inhibitory immunoglobulin polypeptides to human pdgf beta receptor
US5658593A (en) 1992-01-16 1997-08-19 Coletica Injectable compositions containing collagen microcapsules
US6537574B1 (en) * 1992-02-11 2003-03-25 Bioform, Inc. Soft tissue augmentation material
DK0632820T3 (en) 1992-02-28 2000-10-02 Collagen Corp Highly concentrated, homogenized collagen compositions
US5656297A (en) 1992-03-12 1997-08-12 Alkermes Controlled Therapeutics, Incorporated Modulated release from biocompatible polymers
AU3941493A (en) * 1992-03-30 1993-11-08 Alza Corporation Viscous suspensions of controlled-release drug particles
GB9211268D0 (en) * 1992-05-28 1992-07-15 Ici Plc Salts of basic peptides with carboxyterminated polyesters
WO1994010982A1 (en) 1992-11-17 1994-05-26 Yoshitomi Pharmaceutical Industries, Ltd. Sustained-release microsphere containing antipsychotic and process for producing the same
EP0674506B1 (en) 1992-12-02 2000-08-23 Alkermes Controlled Therapeutics, Inc. Controlled release growth hormone containing microspheres
US5429824A (en) * 1992-12-15 1995-07-04 Eastman Kodak Company Use of tyloxapole as a nanoparticle stabilizer and dispersant
MY113268A (en) * 1992-12-29 2002-01-31 Insite Vision Incorporated Plasticized bioerodible controlled delivery system
US5650173A (en) 1993-11-19 1997-07-22 Alkermes Controlled Therapeutics Inc. Ii Preparation of biodegradable microparticles containing a biologically active agent
NZ276088A (en) 1993-11-19 1999-07-29 Janssen Pharmaceutica Nv [(1,2-benzisoxazol-3-yl)-1-piperidinyl-alkyl-6,7,8,9-tetrahydro-4h- pyrido[1,2-a]-pyrimidin-4-one derivatives (ie risperidone)
DE4440337A1 (en) * 1994-11-11 1996-05-15 Dds Drug Delivery Services Ges Pharmaceutical nanosuspensions for drug application as systems with increased saturation solubility and dissolution rate
US5922253A (en) 1995-05-18 1999-07-13 Alkermes Controlled Therapeutics, Inc. Production scale method of forming microparticles
US5904935A (en) 1995-06-07 1999-05-18 Alza Corporation Peptide/protein suspending formulations
US5747058A (en) 1995-06-07 1998-05-05 Southern Biosystems, Inc. High viscosity liquid controlled delivery system
CA2195119C (en) * 1995-06-09 2001-09-11 Mark Chasin Formulations and methods for providing prolonged local anesthesia
US5942253A (en) 1995-10-12 1999-08-24 Immunex Corporation Prolonged release of GM-CSF
SE505146C2 (en) * 1995-10-19 1997-06-30 Biogram Ab Particles for delayed release
DK0885002T3 (en) * 1996-03-04 2011-08-22 Penn State Res Found Materials and methods for enhancing cellular internalization
US5792477A (en) * 1996-05-07 1998-08-11 Alkermes Controlled Therapeutics, Inc. Ii Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent
BR9815499A (en) 1997-07-02 2001-01-02 Euro Celtique Sa Prolonged anesthesia in joints and body spaces.
GB9718986D0 (en) 1997-09-09 1997-11-12 Danbiosyst Uk Controlled release microsphere delivery system
JP2000039867A (en) * 1998-05-18 2000-02-08 Fujitsu Ltd Plasma display device and driving method of plasma display panel
US6143314A (en) * 1998-10-28 2000-11-07 Atrix Laboratories, Inc. Controlled release liquid delivery compositions with low initial drug burst
US6194006B1 (en) * 1998-12-30 2001-02-27 Alkermes Controlled Therapeutics Inc. Ii Preparation of microparticles having a selected release profile
US6306425B1 (en) * 1999-04-09 2001-10-23 Southern Research Institute Injectable naltrexone microsphere compositions and their use in reducing consumption of heroin and alcohol
ES2230154T3 (en) 1999-08-27 2005-05-01 Southern Research Institute INJECTABLE COMPOSITIONS OF BUPRENORFINE AND ITS USE FOR REDUCTION OF HEROIN AND ALCOHOL CONSUMPTION.
US6495164B1 (en) * 2000-05-25 2002-12-17 Alkermes Controlled Therapeutics, Inc. I Preparation of injectable suspensions having improved injectability

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994025460A1 (en) * 1993-04-28 1994-11-10 Janssen Pharmaceutica N.V. Risperidone pamoate
WO1995013799A1 (en) * 1993-11-19 1995-05-26 Alkermes Controlled Therapeutics Inc. Ii Preparation of biodegradable microparticles containing a biologically active agent
WO1996001652A1 (en) * 1994-07-11 1996-01-25 Janssen Pharmaceutica N.V. Aqueous risperidone formulations
WO1997044039A1 (en) * 1996-05-20 1997-11-27 Janssen Pharmaceutica N.V. Aqueous suspensions of 9-hydroxyrisperidone fatty acid esters
WO1999025354A2 (en) * 1997-11-17 1999-05-27 Janssen Pharmaceutica N.V. Aqueous suspensions of submicron 9-hydroxyrisperidone fatty acid esters

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4331570A1 (en) 2015-09-21 2024-03-06 Teva Pharmaceuticals International GmbH Sustained release olanzapine formulations

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