WO2002002084A8 - Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufacture - Google Patents

Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufacture

Info

Publication number
WO2002002084A8
WO2002002084A8 PCT/US2001/020319 US0120319W WO0202084A8 WO 2002002084 A8 WO2002002084 A8 WO 2002002084A8 US 0120319 W US0120319 W US 0120319W WO 0202084 A8 WO0202084 A8 WO 0202084A8
Authority
WO
WIPO (PCT)
Prior art keywords
cross
amylose starch
high amylose
linked high
controlled
Prior art date
Application number
PCT/US2001/020319
Other languages
French (fr)
Other versions
WO2002002084A1 (en
Inventor
Vincent Lenaerts
Roland Herwig Friedrich Beck
Elsie Van Bogaert
Francois Chouinard
Reiner Hopcke
Cyril Desevaux
Original Assignee
Vincent Lenaerts
Roland Herwig Friedrich Beck
Elsie Van Bogaert
Francois Chouinard
Reiner Hopcke
Cyril Desevaux
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24427807&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2002002084(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to AU7148101A priority Critical patent/AU7148101A/en
Priority to NZ523644A priority patent/NZ523644A/en
Priority to EP01950498A priority patent/EP1305009B1/en
Priority to BRPI0112140A priority patent/BRPI0112140B8/en
Priority to HU0301302A priority patent/HUP0301302A2/en
Priority to PL365634A priority patent/PL202177B1/en
Priority to DE60120413T priority patent/DE60120413T2/en
Priority to JP2002506706A priority patent/JP5025066B2/en
Priority to KR1020027018039A priority patent/KR100840393B1/en
Priority to AU2001271481A priority patent/AU2001271481B2/en
Priority to SI200130611T priority patent/SI1305009T1/en
Priority to MXPA03000035A priority patent/MXPA03000035A/en
Priority to IL15365401A priority patent/IL153654A0/en
Priority to CA002414349A priority patent/CA2414349C/en
Application filed by Vincent Lenaerts, Roland Herwig Friedrich Beck, Elsie Van Bogaert, Francois Chouinard, Reiner Hopcke, Cyril Desevaux filed Critical Vincent Lenaerts
Publication of WO2002002084A1 publication Critical patent/WO2002002084A1/en
Publication of WO2002002084A8 publication Critical patent/WO2002002084A8/en
Priority to IL153654A priority patent/IL153654A/en
Priority to NO20026254A priority patent/NO20026254L/en
Priority to HK04102459A priority patent/HK1059574A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B33/00—Preparation of derivatives of amylose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue

Abstract

The present invention relates to a novel form of cross-linked high amylose starch and process for its manufacture. Such cross-linked high amylose starch is useful as an excipient in a controlled-release pharmaceutical formulation when compressed with a pharmaceutical agent(s) in a tablet. Such cross-linked high amylose starch is prepared by (a) cross-linking and chemical modification of high amylose starch, (b) gelatinization, and (c) drying to obtain a powder of said controlled release excipient. In a preferred embodiment, such cross-linked high amylose starch is prepared in following steps: (1) granular cross-linking and additionally chemical modification (e.g., hydroxypropylation) of high- amylose starch; (2) thermal gelatinization of the starch from step (1); and (3) drying the starch from step (2) to yield a powder capable of being used as a controlled release excipient.
PCT/US2001/020319 2000-06-29 2001-06-26 Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufacture WO2002002084A1 (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
KR1020027018039A KR100840393B1 (en) 2000-06-29 2001-06-26 Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufactures
CA002414349A CA2414349C (en) 2000-06-29 2001-06-26 Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufacture
EP01950498A EP1305009B1 (en) 2000-06-29 2001-06-26 Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufacture
BRPI0112140A BRPI0112140B8 (en) 2000-06-29 2001-06-26 controlled release tablet, process for the manufacture, in an aqueous medium, of a controlled release excipient and cross-linked high amylose starch.
HU0301302A HUP0301302A2 (en) 2000-06-29 2001-06-26 Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and process for its manufacture
PL365634A PL202177B1 (en) 2000-06-29 2001-06-26 Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufacture
DE60120413T DE60120413T2 (en) 2000-06-29 2001-06-26 CROSS-LINKED STRONG AMYLOSE-CONTAINING STARCH FOR USE IN PHARMACEUTICAL FORMULATIONS WITH CONTROLLED RELEASE AND METHOD FOR THE PRODUCTION THEREOF
SI200130611T SI1305009T1 (en) 2000-06-29 2001-06-26 Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufacture
AU2001271481A AU2001271481B2 (en) 2000-06-29 2001-06-26 Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufacture
AU7148101A AU7148101A (en) 2000-06-29 2001-06-26 Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufacture
JP2002506706A JP5025066B2 (en) 2000-06-29 2001-06-26 Cross-linked high amylose starch used in sustained-release pharmaceutical preparations and method for producing the same
MXPA03000035A MXPA03000035A (en) 2000-06-29 2001-06-26 Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufacture.
IL15365401A IL153654A0 (en) 2000-06-29 2001-06-26 Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufacture
NZ523644A NZ523644A (en) 2000-06-29 2001-06-26 Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufacture
IL153654A IL153654A (en) 2000-06-29 2002-12-25 Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufacture
NO20026254A NO20026254L (en) 2000-06-29 2002-12-27 Controlled Release Tablet, Controlled Release Excipient Preparation, and Cross-linked Hoyamylose Starch.
HK04102459A HK1059574A1 (en) 2000-06-29 2004-04-06 Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufacture

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/606,399 US6607748B1 (en) 2000-06-29 2000-06-29 Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufacture
US09/606,399 2000-06-29

Publications (2)

Publication Number Publication Date
WO2002002084A1 WO2002002084A1 (en) 2002-01-10
WO2002002084A8 true WO2002002084A8 (en) 2002-04-04

Family

ID=24427807

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/020319 WO2002002084A1 (en) 2000-06-29 2001-06-26 Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufacture

Country Status (27)

Country Link
US (2) US6607748B1 (en)
EP (1) EP1305009B1 (en)
JP (1) JP5025066B2 (en)
KR (1) KR100840393B1 (en)
CN (1) CN100352509C (en)
AR (1) AR029549A1 (en)
AT (1) ATE328585T1 (en)
AU (2) AU2001271481B2 (en)
BR (1) BRPI0112140B8 (en)
CA (1) CA2414349C (en)
CZ (1) CZ300152B6 (en)
DE (1) DE60120413T2 (en)
DK (1) DK1305009T3 (en)
ES (1) ES2272499T3 (en)
HK (1) HK1059574A1 (en)
HU (1) HUP0301302A2 (en)
IL (2) IL153654A0 (en)
MX (1) MXPA03000035A (en)
MY (1) MY128308A (en)
NO (1) NO20026254L (en)
NZ (1) NZ523644A (en)
PL (1) PL202177B1 (en)
PT (1) PT1305009E (en)
RU (1) RU2274443C2 (en)
SI (1) SI1305009T1 (en)
TW (1) TWI289460B (en)
WO (1) WO2002002084A1 (en)

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US8962019B2 (en) 2005-09-09 2015-02-24 Angelini Pharma, Inc. Sustained drug release composition
WO2010028489A1 (en) * 2008-09-15 2010-03-18 Labopharm Inc. Starch-based microparticles for the release of agents disposed therein

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