WO2002008457A3 - Verfahren und vorrichtung zum analysieren von chemischen oder biologischen proben - Google Patents

Verfahren und vorrichtung zum analysieren von chemischen oder biologischen proben Download PDF

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Publication number
WO2002008457A3
WO2002008457A3 PCT/EP2001/008618 EP0108618W WO0208457A3 WO 2002008457 A3 WO2002008457 A3 WO 2002008457A3 EP 0108618 W EP0108618 W EP 0108618W WO 0208457 A3 WO0208457 A3 WO 0208457A3
Authority
WO
WIPO (PCT)
Prior art keywords
chemical
biological samples
carrier
lateral area
bore holes
Prior art date
Application number
PCT/EP2001/008618
Other languages
English (en)
French (fr)
Other versions
WO2002008457A2 (de
Inventor
Ralph Mueller
Original Assignee
Basf Lynx Bioscience Ag
Ralph Mueller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Lynx Bioscience Ag, Ralph Mueller filed Critical Basf Lynx Bioscience Ag
Priority to AU2001289754A priority Critical patent/AU2001289754A1/en
Priority to US10/333,884 priority patent/US7455967B2/en
Priority to CA002424806A priority patent/CA2424806A1/en
Priority to EP01969514A priority patent/EP1303353B1/de
Priority to DE50113601T priority patent/DE50113601D1/de
Publication of WO2002008457A2 publication Critical patent/WO2002008457A2/de
Publication of WO2002008457A3 publication Critical patent/WO2002008457A3/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00513—Essentially linear supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00513—Essentially linear supports
    • B01J2219/0052—Essentially linear supports in the shape of elongated tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00657—One-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products

Abstract

Die vorliegende Erfindung betrifft ein Verfahren und eine entsprechende Vorrichtung zum Analysieren von chemischen oder biologischen Proben, bei dem man chemische oder biologische Proben und/oder Targets (Sonden) in Form von einzelnen definierten Spots auf eine äussere zylindrische Mantelfläche eines Trägers aufbringt oder in Form von Fluidtröpfchen in Bohrungen füllt, die in der Mantelfläche des Trägers ausgespart sind. Man führt den Träger in eine zu der zylindrischen Mantelfläche im wesentlichen komplementäre Ausnehmung eines Halters ein, beeinflusst die Proben und/oder Targets über physikalische und/oder chemische Wechselwirkungen und analysiert dann die entsprechend modifizierten Spots. Die Erfindung betrifft demnach die Verwendung eines neuartigen Trägersystems zur Untersuchung von chemischen oder biologischen Proben, das sich - im Gegensatz zu herkömlichen planaren Biochips - durch eine zylindrische Geometrie auszeichnet, wobei auf der funktionalisierten Mantelfläche des Zylinders bzw. in in dem Zylindermantel ausgesparte radiale Bohrungen Substanzen aufgebracht, beispielsweise immobilisert werden können. Durch Zusammenwirken mit einem komplementäre Halter wird ein Analysesystem mit eindeutig definierten Reaktionsvolumina realisiert, das einfach standardisierbar und hochgradig automatisierbar ist.
PCT/EP2001/008618 2000-07-25 2001-07-25 Verfahren und vorrichtung zum analysieren von chemischen oder biologischen proben WO2002008457A2 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2001289754A AU2001289754A1 (en) 2000-07-25 2001-07-25 Method and device for analysing chemical or biological samples
US10/333,884 US7455967B2 (en) 2000-07-25 2001-07-25 Device for analyzing chemical or biological samples
CA002424806A CA2424806A1 (en) 2000-07-25 2001-07-25 Method and device for analysing chemical or biological samples
EP01969514A EP1303353B1 (de) 2000-07-25 2001-07-25 Verfahren und vorrichtung zum analysieren von chemischen oder biologischen proben
DE50113601T DE50113601D1 (de) 2000-07-25 2001-07-25 Verfahren und vorrichtung zum analysieren von chemischen oder biologischen proben

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10036174A DE10036174B4 (de) 2000-07-25 2000-07-25 Verfahren und Vorrichtung zum Analysieren von chemischen oder biologischen Proben
DE10036174.9 2000-07-25

Publications (2)

Publication Number Publication Date
WO2002008457A2 WO2002008457A2 (de) 2002-01-31
WO2002008457A3 true WO2002008457A3 (de) 2002-11-21

Family

ID=7650132

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/008618 WO2002008457A2 (de) 2000-07-25 2001-07-25 Verfahren und vorrichtung zum analysieren von chemischen oder biologischen proben

Country Status (7)

Country Link
US (1) US7455967B2 (de)
EP (1) EP1303353B1 (de)
AT (1) ATE386263T1 (de)
AU (1) AU2001289754A1 (de)
CA (1) CA2424806A1 (de)
DE (2) DE10036174B4 (de)
WO (1) WO2002008457A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7351471B2 (en) 2000-12-06 2008-04-01 3M Innovative Properties Company Fluoropolymer coating compositions with multifunctional fluoroalkyl crosslinkers for anti-reflective polymer films
AT500427B1 (de) * 2002-05-29 2009-02-15 Anagnostics Bioanalysis Gmbh Vorrichtung zur analyse von bestandteilen einer probe
JP2005283304A (ja) * 2004-03-29 2005-10-13 Lintec Corp プローブアレイ
AT502549B1 (de) * 2005-10-07 2007-06-15 Anagnostics Bioanalysis Gmbh Vorrichtung zur analyse von flüssigen proben
US9642723B2 (en) 2014-02-27 2017-05-09 Alphatec Spine, Inc. Spinal implants and insertion instruments
US9603718B2 (en) * 2014-02-27 2017-03-28 Alphatec Spine, Inc. Spacer with temporary fixation plate
US10578094B2 (en) 2016-05-04 2020-03-03 Curium Us Llc Pump for operation in radioactive environment
US10845291B2 (en) * 2017-05-16 2020-11-24 King Fahd University Of Petroleum And Minerals Radial core flooding apparatus and method for analysis of static and/or dynamic properties of reservoir rock
CN108220128B (zh) * 2018-04-02 2021-07-20 苏州艾博生物科技有限公司 一种药品微生物鉴定方法
CN108587892B (zh) * 2018-05-11 2021-12-21 徐州旋光生物科技有限公司 一种微生物鉴定检测仪

Citations (8)

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Publication number Priority date Publication date Assignee Title
US3932131A (en) * 1974-02-07 1976-01-13 Monega Anstalt Method and device (analysis machine) for simultaneous performance of a number of analyses, especially microanalyses, of standard type on chemical objects
US4090848A (en) * 1975-03-20 1978-05-23 Nihon Denshi Kabushiki Kaisha Automatic analyzing apparatus
US4144452A (en) * 1976-07-08 1979-03-13 International Diagnostic Technology, Inc. Fluorometric system, method and test article
JPS6269164A (ja) * 1985-09-20 1987-03-30 Nitsuteku:Kk Ｅｉａ分析装置のビ−ズ供給装置
WO1987007384A1 (en) * 1986-05-30 1987-12-03 Quidel Enzyme immunoassay device
US4740313A (en) * 1985-08-12 1988-04-26 Baxter Travenol Laboratories, Inc. Method of filtering using a rotating and oscillating spinner
DE19852835A1 (de) * 1998-11-17 2000-05-18 Stratec Biomedical Systems Ag Probenträger
WO2000040334A1 (en) * 1999-01-08 2000-07-13 Pe Corporation (Ny) Fiber array for contacting chemical species and methods for using and making same

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US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
AU6886791A (en) 1989-11-13 1991-06-13 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
DE4139211C2 (de) * 1990-11-30 1994-03-24 Hitachi Ltd Elektrophoresegerät
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JPH06504997A (ja) 1990-12-06 1994-06-09 アフィメトリックス，　インコーポレイテッド 非常に大きい規模の固定化されたポリマーの合成
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JP3322595B2 (ja) * 1996-03-28 2002-09-09 テルモ株式会社 フィルター装置および生体微細組織の分離・回収方法
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Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3932131A (en) * 1974-02-07 1976-01-13 Monega Anstalt Method and device (analysis machine) for simultaneous performance of a number of analyses, especially microanalyses, of standard type on chemical objects
US4090848A (en) * 1975-03-20 1978-05-23 Nihon Denshi Kabushiki Kaisha Automatic analyzing apparatus
US4144452A (en) * 1976-07-08 1979-03-13 International Diagnostic Technology, Inc. Fluorometric system, method and test article
US4740313A (en) * 1985-08-12 1988-04-26 Baxter Travenol Laboratories, Inc. Method of filtering using a rotating and oscillating spinner
JPS6269164A (ja) * 1985-09-20 1987-03-30 Nitsuteku:Kk Ｅｉａ分析装置のビ−ズ供給装置
WO1987007384A1 (en) * 1986-05-30 1987-12-03 Quidel Enzyme immunoassay device
DE19852835A1 (de) * 1998-11-17 2000-05-18 Stratec Biomedical Systems Ag Probenträger
WO2000040334A1 (en) * 1999-01-08 2000-07-13 Pe Corporation (Ny) Fiber array for contacting chemical species and methods for using and making same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
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Also Published As

Publication number Publication date
EP1303353B1 (de) 2008-02-13
CA2424806A1 (en) 2003-01-24
ATE386263T1 (de) 2008-03-15
AU2001289754A1 (en) 2002-02-05
US20040053327A1 (en) 2004-03-18
US7455967B2 (en) 2008-11-25
DE10036174B4 (de) 2006-12-07
DE10036174A1 (de) 2002-02-21
EP1303353A2 (de) 2003-04-23
DE50113601D1 (de) 2008-03-27
WO2002008457A2 (de) 2002-01-31

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