WO2002013785A3 - Drug delivery system with burst electrode - Google Patents

Drug delivery system with burst electrode Download PDF

Info

Publication number
WO2002013785A3
WO2002013785A3 PCT/US2001/025405 US0125405W WO0213785A3 WO 2002013785 A3 WO2002013785 A3 WO 2002013785A3 US 0125405 W US0125405 W US 0125405W WO 0213785 A3 WO0213785 A3 WO 0213785A3
Authority
WO
WIPO (PCT)
Prior art keywords
polypyrrole
electroactive polymer
burst
delivery system
drug delivery
Prior art date
Application number
PCT/US2001/025405
Other languages
French (fr)
Other versions
WO2002013785A2 (en
Inventor
John R Reynolds
Hiep Ly
Patrick John Kinlen
Original Assignee
Pharmacia Corp
Univ Florida
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp, Univ Florida filed Critical Pharmacia Corp
Priority to AU2001283358A priority Critical patent/AU2001283358A1/en
Publication of WO2002013785A2 publication Critical patent/WO2002013785A2/en
Publication of WO2002013785A3 publication Critical patent/WO2002013785A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis

Abstract

A burst electrode system is provided that comprises an electroactive polymer having thereon either a polyanionic or polycationic dopant, and a biologically active ingredient that is releasable from said electroactive polymer, whereby said burst electrode system exhibits a release profile greater in quantity and faster than a standard Faradaic profile. The biologically active ingredient preferably is a drug. The electroactive polymer preferably is a polypyrrole or a polypyrrole polyelectrolyte complex such as polypyrrole poly(styrene sulfonate), heparin or polyacrylic acid.
PCT/US2001/025405 2000-08-14 2001-08-14 Drug delivery system with burst electrode WO2002013785A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001283358A AU2001283358A1 (en) 2000-08-14 2001-08-14 Drug delivery system with burst electrode

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22508400P 2000-08-14 2000-08-14
US60/225,084 2000-08-14

Publications (2)

Publication Number Publication Date
WO2002013785A2 WO2002013785A2 (en) 2002-02-21
WO2002013785A3 true WO2002013785A3 (en) 2002-10-17

Family

ID=22843455

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/025405 WO2002013785A2 (en) 2000-08-14 2001-08-14 Drug delivery system with burst electrode

Country Status (3)

Country Link
US (1) US20020022826A1 (en)
AU (1) AU2001283358A1 (en)
WO (1) WO2002013785A2 (en)

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ATE323470T1 (en) * 1999-12-10 2006-05-15 Massachusetts Inst Technology MICROCHIP DRUG DELIVERY SYSTEMS AND METHODS OF MANUFACTURING
ATE499988T1 (en) * 2000-03-02 2011-03-15 Microchips Inc MICROMECHANICAL DEVICES AND METHODS FOR STORAGE AND SELECTIVE EXPOSURE OF CHEMICALS
US7013182B1 (en) * 2000-05-04 2006-03-14 Cardiac Pacemakers, Inc. Conductive polymer sheath on defibrillator shocking coils
CA2432438C (en) 2001-01-09 2011-04-26 Microchips, Inc. Flexible microchip devices for ophthalmic and other applications
ATE285756T1 (en) * 2001-06-28 2005-01-15 Microchips Inc METHOD FOR HERMETIC SEALING MICROCHIP RESERVOIR DEVICES
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US8354066B2 (en) 2004-03-24 2013-01-15 Technion Research & Development Foundation Ltd. Artificial receptors
WO2008035343A2 (en) * 2006-09-21 2008-03-27 Technion Research & Development Foundation Ltd. Artificial receptors
US20050267440A1 (en) * 2004-06-01 2005-12-01 Herman Stephen J Devices and methods for measuring and enhancing drug or analyte transport to/from medical implant
WO2006015299A2 (en) * 2004-07-30 2006-02-09 Microchips, Inc. Multi-reservoir device for transdermal drug delivery and sensing
WO2006026768A1 (en) 2004-09-01 2006-03-09 Microchips, Inc. Multi-cap reservoir devices for controlled release or exposure of reservoir contents
US7488316B2 (en) * 2005-01-25 2009-02-10 Microchips, Inc. Control of drug release by transient modification of local microenvironments
US7850645B2 (en) 2005-02-11 2010-12-14 Boston Scientific Scimed, Inc. Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power
US20070175768A1 (en) * 2005-06-30 2007-08-02 Applera Corporation Microfluidic systems including porous polymer electrodes
CN101243316A (en) * 2005-06-30 2008-08-13 阿普尔拉股份有限公司 Porous composite electrode comprising conductive polymer
US7778684B2 (en) * 2005-08-08 2010-08-17 Boston Scientific Scimed, Inc. MRI resonator system with stent implant
US8036738B2 (en) 2006-03-14 2011-10-11 New Jersey Institute Of Technology Iontophoretic transdermal drug delivery system based on conductive polyaniline membrane
US20070239256A1 (en) * 2006-03-22 2007-10-11 Jan Weber Medical devices having electrical circuits with multilayer regions
US7881808B2 (en) * 2006-03-29 2011-02-01 Cardiac Pacemakers, Inc. Conductive polymeric coating with optional biobeneficial topcoat for a medical lead
EP1997952B1 (en) * 2007-05-29 2013-08-07 Textilforschungsinstitut Thüringen-Vogtland e.V. Textile structure for a transdermal active ingredient reservoir
DE102008025525A1 (en) * 2007-05-29 2008-12-18 Textilforschungsinstitut Thüringen-Vogtland e.V. Electrically conductive thread for active ingredient storage and release, involves metallizing electrical nonconductive thread filament, and applying loading on metallized thread filament
US20090012446A1 (en) * 2007-07-03 2009-01-08 Xinyan Cui Devices, systems and methods for release of chemical agents
EP2197537A1 (en) * 2007-10-15 2010-06-23 Cardiac Pacemakers, Inc. Conductive composite electrode material
EP2205312B1 (en) * 2007-10-19 2015-12-02 Cardiac Pacemakers, Inc. Fibrous electrode material
JP5638003B2 (en) 2009-01-12 2014-12-10 ユニバーシティ オブ マサチューセッツ ローウェル Polyisobutylene polyurethane
JP5602859B2 (en) 2009-08-21 2014-10-08 カーディアック ペースメイカーズ， インコーポレイテッド POLYISOBUTYLENE-BASED CROSSLINKABLE POLYMER AND MEDICAL DEVICE CONTAINING THE SAME
US8374704B2 (en) 2009-09-02 2013-02-12 Cardiac Pacemakers, Inc. Polyisobutylene urethane, urea and urethane/urea copolymers and medical leads containing the same
US8753708B2 (en) 2009-09-02 2014-06-17 Cardiac Pacemakers, Inc. Solventless method for forming a coating on a medical electrical lead body
US8644952B2 (en) 2009-09-02 2014-02-04 Cardiac Pacemakers, Inc. Medical devices including polyisobutylene based polymers and derivatives thereof
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Non-Patent Citations (3)

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Title
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ZHOU Q-X ET AL.: "Electrochemically controlled binding and release of protonated dimethyldopamine and other cations from poly(N-methylpyrrole)/ polyanion composite redox polymers", JOURNAL OF ELECTROANALYTICAL CHEMISTRY, vol. 261, 1989, ISSN: 0022-0728, pages 147 - 164, XP000109287 *

Also Published As

Publication number Publication date
AU2001283358A1 (en) 2002-02-25
US20020022826A1 (en) 2002-02-21
WO2002013785A2 (en) 2002-02-21

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