WO2002022849A3 - Enzymatic resolution of aryl- and thio-substituted acids - Google Patents

Enzymatic resolution of aryl- and thio-substituted acids Download PDF

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Publication number
WO2002022849A3
WO2002022849A3 PCT/US2001/028409 US0128409W WO0222849A3 WO 2002022849 A3 WO2002022849 A3 WO 2002022849A3 US 0128409 W US0128409 W US 0128409W WO 0222849 A3 WO0222849 A3 WO 0222849A3
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WO
WIPO (PCT)
Prior art keywords
alkyl
compound
thio
aryl
enzymatic resolution
Prior art date
Application number
PCT/US2001/028409
Other languages
French (fr)
Other versions
WO2002022849A2 (en
Inventor
Jingyang Zhu
Li You
Brenda J White
Shannon X Zhao
Paul M Skonezny
Original Assignee
Bristol Myers Squibb Co
Jingyang Zhu
Li You
Brenda J White
Shannon X Zhao
Paul M Skonezny
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co, Jingyang Zhu, Li You, Brenda J White, Shannon X Zhao, Paul M Skonezny filed Critical Bristol Myers Squibb Co
Priority to AU2001290774A priority Critical patent/AU2001290774B2/en
Priority to MXPA03002260A priority patent/MXPA03002260A/en
Priority to CA002422466A priority patent/CA2422466A1/en
Priority to AU9077401A priority patent/AU9077401A/en
Priority to JP2002527291A priority patent/JP2004530405A/en
Priority to EP01970810A priority patent/EP1328655A2/en
Priority to IL15492901A priority patent/IL154929A0/en
Publication of WO2002022849A2 publication Critical patent/WO2002022849A2/en
Publication of WO2002022849A3 publication Critical patent/WO2002022849A3/en

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    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01M—PROCESSES OR MEANS, e.g. BATTERIES, FOR THE DIRECT CONVERSION OF CHEMICAL ENERGY INTO ELECTRICAL ENERGY
    • H01M4/00—Electrodes
    • H01M4/02—Electrodes composed of, or comprising, active material
    • H01M4/13—Electrodes for accumulators with non-aqueous electrolyte, e.g. for lithium-accumulators; Processes of manufacture thereof
    • H01M4/136—Electrodes based on inorganic compounds other than oxides or hydroxides, e.g. sulfides, selenides, tellurides, halogenides or LiCoFy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P11/00—Preparation of sulfur-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01M—PROCESSES OR MEANS, e.g. BATTERIES, FOR THE DIRECT CONVERSION OF CHEMICAL ENERGY INTO ELECTRICAL ENERGY
    • H01M4/00—Electrodes
    • H01M4/02—Electrodes composed of, or comprising, active material
    • H01M4/36—Selection of substances as active materials, active masses, active liquids
    • H01M4/362—Composites
    • H01M4/366—Composites as layered products
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01M—PROCESSES OR MEANS, e.g. BATTERIES, FOR THE DIRECT CONVERSION OF CHEMICAL ENERGY INTO ELECTRICAL ENERGY
    • H01M4/00—Electrodes
    • H01M4/02—Electrodes composed of, or comprising, active material
    • H01M4/36—Selection of substances as active materials, active masses, active liquids
    • H01M4/58—Selection of substances as active materials, active masses, active liquids of inorganic compounds other than oxides or hydroxides, e.g. sulfides, selenides, tellurides, halogenides or LiCoFy; of polyanionic structures, e.g. phosphates, silicates or borates
    • H01M4/5825—Oxygenated metallic salts or polyanionic structures, e.g. borates, phosphates, silicates, olivines
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01M—PROCESSES OR MEANS, e.g. BATTERIES, FOR THE DIRECT CONVERSION OF CHEMICAL ENERGY INTO ELECTRICAL ENERGY
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    • H01M4/62—Selection of inactive substances as ingredients for active masses, e.g. binders, fillers
    • H01M4/624—Electric conductive fillers
    • H01M4/625—Carbon or graphite
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01M—PROCESSES OR MEANS, e.g. BATTERIES, FOR THE DIRECT CONVERSION OF CHEMICAL ENERGY INTO ELECTRICAL ENERGY
    • H01M10/00—Secondary cells; Manufacture thereof
    • H01M10/05—Accumulators with non-aqueous electrolyte
    • H01M10/052—Li-accumulators
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01M—PROCESSES OR MEANS, e.g. BATTERIES, FOR THE DIRECT CONVERSION OF CHEMICAL ENERGY INTO ELECTRICAL ENERGY
    • H01M10/00—Secondary cells; Manufacture thereof
    • H01M10/05—Accumulators with non-aqueous electrolyte
    • H01M10/052—Li-accumulators
    • H01M10/0525—Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodes; Lithium-ion batteries
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01M—PROCESSES OR MEANS, e.g. BATTERIES, FOR THE DIRECT CONVERSION OF CHEMICAL ENERGY INTO ELECTRICAL ENERGY
    • H01M4/00—Electrodes
    • H01M4/02—Electrodes composed of, or comprising, active material
    • H01M2004/026—Electrodes composed of, or comprising, active material characterised by the polarity
    • H01M2004/027—Negative electrodes
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01M—PROCESSES OR MEANS, e.g. BATTERIES, FOR THE DIRECT CONVERSION OF CHEMICAL ENERGY INTO ELECTRICAL ENERGY
    • H01M4/00—Electrodes
    • H01M4/02—Electrodes composed of, or comprising, active material
    • H01M4/36—Selection of substances as active materials, active masses, active liquids
    • H01M4/48—Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides
    • H01M4/485—Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of mixed oxides or hydroxides for inserting or intercalating light metals, e.g. LiTi2O4 or LiTi2OxFy
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01M—PROCESSES OR MEANS, e.g. BATTERIES, FOR THE DIRECT CONVERSION OF CHEMICAL ENERGY INTO ELECTRICAL ENERGY
    • H01M4/00—Electrodes
    • H01M4/02—Electrodes composed of, or comprising, active material
    • H01M4/36—Selection of substances as active materials, active masses, active liquids
    • H01M4/48—Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides
    • H01M4/52—Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of nickel, cobalt or iron
    • H01M4/525—Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of nickel, cobalt or iron of mixed oxides or hydroxides containing iron, cobalt or nickel for inserting or intercalating light metals, e.g. LiNiO2, LiCoO2 or LiCoOxFy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E60/00—Enabling technologies; Technologies with a potential or indirect contribution to GHG emissions mitigation
    • Y02E60/10—Energy storage using batteries

Abstract

Provided is a method of resolving a racemic mixture of a compound of formula I to obtain a desired enantiomer, (I), wherein Ar is C6 or C10 aromatic group that can be substituted with H, C1 to C6 alkyl, trifluoromethyl or halo, R5 is halo or -S-R1, wherein R1 is H or acetyl, and R2 is H or C1 to C6 alkyl, the method comprising: reacting a compound of formula (I) wherein the compound is an ester whereby R2 is C1 to C6 alkyl with a lipase derived from Mucor meihei to stereoselectively hydrolyze the ester bond to produce an acid; and isolating the acid, wherein the reaction is conducted in a solvent comprising 80 % to 98% v/v % organic phase and a residue of water phase (which can be buffered).
PCT/US2001/028409 2000-09-15 2001-09-12 Enzymatic resolution of aryl- and thio-substituted acids WO2002022849A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
AU2001290774A AU2001290774B2 (en) 2000-09-15 2001-09-12 Enzymatic resolution of aryl- and thio-substituted acids
MXPA03002260A MXPA03002260A (en) 2000-09-15 2001-09-12 Enzymatic resolution of aryl- and thio-substituted acids.
CA002422466A CA2422466A1 (en) 2000-09-15 2001-09-12 Enzymatic resolution of aryl- and thio-substituted acids
AU9077401A AU9077401A (en) 2000-09-15 2001-09-12 Enzymatic resolution of aryl and thio-substituted acids
JP2002527291A JP2004530405A (en) 2000-09-15 2001-09-12 Enzymatic resolution of aryl and thio substituted acids
EP01970810A EP1328655A2 (en) 2000-09-15 2001-09-12 Enzymatic resolution of aryl- and thio-substituted acids
IL15492901A IL154929A0 (en) 2000-09-15 2001-09-12 Enzymatic resolution of aryl and thio-substituted acids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23319300P 2000-09-15 2000-09-15
US60/233,193 2000-09-15

Publications (2)

Publication Number Publication Date
WO2002022849A2 WO2002022849A2 (en) 2002-03-21
WO2002022849A3 true WO2002022849A3 (en) 2002-08-29

Family

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Family Applications (1)

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PCT/US2001/028409 WO2002022849A2 (en) 2000-09-15 2001-09-12 Enzymatic resolution of aryl- and thio-substituted acids

Country Status (8)

Country Link
US (3) US6620600B2 (en)
EP (1) EP1328655A2 (en)
JP (1) JP2004530405A (en)
AU (2) AU2001290774B2 (en)
CA (1) CA2422466A1 (en)
IL (1) IL154929A0 (en)
MX (1) MXPA03002260A (en)
WO (1) WO2002022849A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040092494A9 (en) * 2000-08-30 2004-05-13 Dudley Robert E. Method of increasing testosterone and related steroid concentrations in women
US20050009158A1 (en) * 2003-03-07 2005-01-13 Arindam Roy Process for enzymatically resolving an enantiomeric mixture of alpha-hydroxy acids
CN110483290B (en) * 2019-08-09 2022-05-31 上海应用技术大学 Method for synthesizing beta-keto ester by copper catalysis

Citations (3)

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WO1993025704A1 (en) * 1992-06-08 1993-12-23 Laboratorios Menarini S.A. A process for the preparation of s-(+)-2-(3-benzoylphenyl)propionic acid by enzyme-catalysed enantioselective transesterification in an organic solvent
JP2000023693A (en) * 1998-07-10 2000-01-25 Mitsubishi Chemicals Corp Production of optically active 2-acetylthio-3- phenylpropionic acid

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US5508272A (en) 1993-06-15 1996-04-16 Bristol-Myers Squibb Company Compounds containing a fused bicycle ring and processes therefor
JPH10295392A (en) 1997-04-22 1998-11-10 Kanegafuchi Chem Ind Co Ltd Production of l-allysine acetal
NL1007113C2 (en) 1997-09-25 1999-03-26 Dsm Nv Process for the preparation of optically active 2-amino-omega-oxoalkanoic acid derivatives.
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EP0249859A2 (en) * 1986-06-20 1987-12-23 Bayer Ag Process for the preparation of (1R,4S)-4-hydroxy-2-cyclopentenyl esters
WO1993025704A1 (en) * 1992-06-08 1993-12-23 Laboratorios Menarini S.A. A process for the preparation of s-(+)-2-(3-benzoylphenyl)propionic acid by enzyme-catalysed enantioselective transesterification in an organic solvent
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Also Published As

Publication number Publication date
EP1328655A2 (en) 2003-07-23
AU2001290774B2 (en) 2005-12-15
MXPA03002260A (en) 2003-09-10
US7141694B2 (en) 2006-11-28
JP2004530405A (en) 2004-10-07
IL154929A0 (en) 2003-10-31
US7026143B2 (en) 2006-04-11
WO2002022849A2 (en) 2002-03-21
US20040072310A1 (en) 2004-04-15
US20040077061A1 (en) 2004-04-22
US6620600B2 (en) 2003-09-16
CA2422466A1 (en) 2002-03-21
US20020061565A1 (en) 2002-05-23
AU9077401A (en) 2002-03-26

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