WO2002024111A2 - Stent with optimal strength and radio-opacity characteristics - Google Patents
Stent with optimal strength and radio-opacity characteristics Download PDFInfo
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- WO2002024111A2 WO2002024111A2 PCT/US2001/029082 US0129082W WO0224111A2 WO 2002024111 A2 WO2002024111 A2 WO 2002024111A2 US 0129082 W US0129082 W US 0129082W WO 0224111 A2 WO0224111 A2 WO 0224111A2
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- strut members
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M29/00—Dilators with or without means for introducing media, e.g. remedies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
- A61F2002/91525—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other within the whole structure different bands showing different meander characteristics, e.g. frequency or amplitude
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
- A61F2002/91533—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other characterised by the phase between adjacent bands
- A61F2002/91541—Adjacent bands are arranged out of phase
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
- A61F2002/9155—Adjacent bands being connected to each other
- A61F2002/91558—Adjacent bands being connected to each other connected peak to peak
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
- A61F2002/9155—Adjacent bands being connected to each other
- A61F2002/91583—Adjacent bands being connected to each other by a bridge, whereby at least one of its ends is connected along the length of a strut between two consecutive apices within a band
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0076—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof multilayered, e.g. laminated structures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0004—Rounded shapes, e.g. with rounded corners
- A61F2230/0013—Horseshoe-shaped, e.g. crescent-shaped, C-shaped, U-shaped
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0032—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in radiographic density
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0036—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in thickness
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0096—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers
- A61F2250/0098—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers radio-opaque, e.g. radio-opaque markers
Definitions
- This invention is in the field of stents for implantation into a vessel of a human body.
- Stents are well known medical devices that are used for maintaining the patency of a large variety of vessels of the human body. A more frequent use is for implantation into the coronary vasculature. Although stents have been used for this purpose for more than ten years, and some current stent designs such as the CORDIS BX Velocity ® stent, Cordis Corporation, Miami Lakes, FL, have the required flexibility and radial rigidity to provide an excellent clinical result, they are not always clearly seen under standard fluoroscopy.
- Many current tubular stents use a multiplicity of circumferential sets of strut members connected by either straight longitudinal connecting links or undulating longitudinal connecting links.
- the circumferential sets of strut members are typically formed from a series of diagonal sections connected to curved sections forming a closed-ring, zig-zag structure. This structure opens up as the stent expands to form the element in the stent that provides structural support for the arterial wall.
- a single strut member can be thought of as a diagonal section connected to a curved section within one of the circumferential sets of strut members.
- these sets of strut members are formed from a single piece of metal having a uniform wall thickness and generally uniform strut width. Although a stent with uniform width of the strut members will function, if the width is increased to add strength or radio-opacity, the sets of strut members will experience increased strain upon expansion. High strain can cause cracking of the metal and potential fatigue failure of the stent under the cyclic stress of a beating heart.
- Fischell et al in US Patent No. 6,086,604, discloses a stent with the end sets of strut members being gold plated. Such a stent would have ideal radio- opacity but may be subject to the corrosive effects incurred through placement of dissimilar in an electrolytic solution such as blood. There has also been significant evidence that gold is a poor surface material for stents because it may increase the risk of subacute thrombosis or restenosis. Further, Fischell et al, US Patent No. 5,697,971 discloses in its FIG. 7, a stainless steel stent with increased width diagonal sections in all the circumferential sets of strut members.
- An ideally radio-opaque stent would have end sets of strut members that are highly radio-opaque so that they can be readily seen, even using low power fluoroscopy, and would further contain a central section that is visible but not too bright so as to obscure the lumen when high power cine film angiograms are taken.
- the stent should also have only one material on its outside surface to avoid potential corrosion; that material should not promote subacute thrombosis or restenosis.
- the present invention is a stent that is designed to have optimal strength and radio-opacity with good biocompatibility.
- the choices of appropriate biocompatible metals available as thin wall tubing for stent construction are somewhat limited.
- the stent design of the present invention is adjusted to the specific radio-opacity and strength characteristics of the metal from which the stent is fabricated. What is more, coatings such as parylene may be needed to avoid corrosion from stents with less biocompatible materials and/or dissimilar metals on the stent's outer surface.
- coatings such as parylene may be needed to avoid corrosion from stents with less biocompatible materials and/or dissimilar metals on the stent's outer surface.
- Of extreme importance to the present invention is the achievement of optimal radio-opacity in a stent that ideally is only 0.004 inches wall thickness or less.
- Such a stent would have a pre-deployment outer diameter (profile) that would be at least 0.003 inches less than currently marketed stents.
- the stent described herein would have a wall thickness between 0.0025 inches and 0.004 inches.
- a highly radio-opaque metal such as tantalum
- tapeered strut width for stents formed from highly radio-opaque metals. Although reducing the width of the longitudinally diagonal section alone will reduce radio-opacity without significantly affecting radial strength, by having a taper on the curved sections of the circumferential sets of strut members, a greatly reduced level of strain upon stent expansion can be achieved without sacrificing radial strength. This is extremely important, as it allows a stent to be made much stronger than a stent with uniform width of the strut members while staying within the same strain limit for the material.
- Tantalum is a metal that used in stents, which is highly radio-opaque.
- the optimal radio-opacity for a stent design using tantalum could have uniform width for the circumferential sets of strut members and a wall thickness of about 0.0025 inches.
- a wall thickness of about 0.003 inches to 0.035 inches would be highly desirable.
- a 0.035 inches wall thickness tantalum stent would be too bright under cine angiography.
- the present invention envisions curved sections and diagonal sections, either or both of which could have a variable or tapered width.
- the curved sections should be tapered (wider at the center compared to the ends) to reduce strain as previously described.
- the longitudinally diagonal sections can be thinner in the center than at the ends, to reduce radio-opacity for the central sets of strut members.
- novel stent described herein might have wider diagonal sections for the end sets of strut members as compared to the central sets of strut members. This feature would enhance the radio-opacity of the end sets of strut members while retaining a moderate level of radio-opacity for the central sets of strut members. It is also envisioned to have both reduced width diagonals and/or reduced wall thickness for the central sets of strut members. It should be remembered that it is fluoroscopic visualization of the end sets of strut members that is most important for visualizing stents placed inside a coronary artery.)
- the cobalt/tungsten alloy L605 is a stronger and more radio-opaque metal compared to stainless steel.
- the wall thickness is optimally equal to or greater than 0.0045 inches.
- the present invention envisions wider diagonal sections in the sets of strut members.
- the tapered diagonal sections would be wider than the curved sections.
- the tapered curved section design for reduced strain may also be highly desirable for stents made from the L605 alloy.
- End sets of strut members with thinner curved sections Stent deliverability into curved coronary arteries is improved when the longitudinally diagonal sections of the end sets of strut members have a decreased length as compared to the length of the diagonal sections of the central sets of strut members. A shorter length of the diagonal sections will also reduce outward flaring upon expansion of the stent. Decreasing end flaring of the deployed stent is of particular importance for stents having very thin walls.
- the stents described herein are typically closed cell stents, having a curved section of a central set of strut members connected to an adjacent set of strut members by a longitudinally extending link.
- the circumferential sets of strut members are joined by undulating longitudinal connecting links with each link having a multiplicity of curved segments so as to increase the perimeter of the stent's closed cells.
- One aspect of the present invention is that the perimeter of each of the stent's closed cells should be at least 9 mm long. This design parameter allows each cell of the stent to be expanded to a circular diameter of approximately 3 mm (i.e., 9/? mm ⁇ 3 mm).
- This feature allows the "unjailing" of side branches of the artery into which the stent is placed.
- the ideal design to be radially strong, prevent plaque prolapse and still allow sidebranch access will have a maximum deployed cell area of less than 0.005 in. 2 while having a cell perimeter that is at least 9 mm in length, so as to allow unjailing of side branches.
- a good cell for side branch access should have a perimeter length between 9 mm and 11 mm. (i.e. an expandable circular diameter between 2.86 mm and 3.5 mm). Cell perimeters between 9.5 and 10 mm are optimal.
- flexible undulating longitudinal links with good support between adjacent sets of strut members.
- the flexible undulating longitudinal connecting links should have nearly equal extension in the circumferential direction on each side of a line drawn between the attachment points of the flexible undulating longitudinal connecting link to the curved sections of adjacent sets of strut members.
- "N" and inverted “N” shapes for the connecting links inherently have equal circumferential displacement on each side of the line connecting their attachment points.
- the specially designed "M” or “W” shapes of the present invention also provide this desirable attribute. Nearly equal circumferential lengths on either side of a line drawn between the attachment points of the flexible undulating longitudinal connecting links help in preventing plaque from pushing the "M" or "W” shaped link inward when .the stent is deployed into an artery.
- the "M” and “W” shapes are of particular advantage in obtaining the desired attribute of small area cells that have good side branch access capability because of an increased perimeter length. It should also be understood that the "M” and “W” shapes each add an additional half cycle of undulating link length to the cell perimeter as compared to an "N" shaped link design, thus improving the stent's longitudinal flexibility. It should also be noted that a “W” link is simply an inverted "M” link.
- the N I ROYAL TM stent has a uniform thickness of gold plating, which makes the center too radio- opaque as compared to the radio-opacity of the end sets of strut members.
- Fischell et al. US Patent No. 6,086,604, teaches stents having gold placed at the end sets of strut members. This creates a potential for corrosion from dissimilar metals, namely, gold and stainless steel.
- the present invention envisions a gold coating that is sufficiently thick on the end sets of strut members to provide optimal radio-opacity with a thin coating of gold on the rest of the stent.
- the present invention also envisions next generation manufacturing techniques using photo-etching, whereby a stent pattern is etched into a thin-walled metal tube. These techniques already can produce variations in wall thickness as well as strut width for any stent pattern.
- the present invention envisions use of these techniques to create stents with optimal radio-opacity. In particular for a stent formed from a single metal or alloy, thicker metal at each end of the stent could increase radio-opacity there as compared to the central section of the stent. Perhaps more important is the use of multi-thickness etching techniques with a two- or three- layered tube where one of the layers is a highly radio-opaque material such as tantalum.
- a two-layer tube having one layer of stainless steel and a second layer of tantalum could be etched to provide the end sets of strut members with 0.001 inches of tantalum and 0.0025 inches of stainless steel while the remainder of the stent would have less than 0.0005 inches of tantalum with a stainless steel layer of 0.003 inches. It is also envisioned that there could be tantalum only on the end sets of strut members. Thus, one could produce a stent with enhanced radio-opacity at the ends with the stent having a uniform wall thickness.
- any of the above optimal radio-opacity stent designs may be used with plastic coatings such as parylene, antithrombogenic coatings such as heparin or phosphorylcholine, or a nti-prol iterative coatings such as taxol or rapamycin.
- a stent with tapered curved sections the center of the curved sections being wider than ends of the curved sections so as to reduce plastic strain as the stent is expanded as compared to a curved section with uniform width.
- Another object of the present invention is to have a stent with tapered diagonal sections in the sets of strut members where the center of the diagonal section is narrower than the ends to reduce the radio-opacity of central sets of strut members of the stent as compared to a stent with diagonal sections having a uniform width.
- Still another object of the invention is to have a stent with decreased wall thickness at the central struts compared to the end struts so as to have a comparatively higher radio-opacity for the end sets of strut members.
- Still another object of the present invention is to have a stent with tapered diagonal sections for one or more of the sets of strut members where the center of the diagonal section is wider than the ends to increase the radio- opacity of the end sets of strut members as compared to a stent with uniform width of the diagonal sections.
- Still another object of the present invention is to have end sets of strut members having both shorter diagonal sections and thinner width curved sections as compared to those sections in the central sets of strut members.
- Still another object of the present invention is to have a stent with a radio-opaque metal coating where the radio-opaque metal coating has greater wall thickness on the end sets of strut members as compared to thickness on the sets of strut members at the center of the stent.
- Still another object of the present invention is to have a stent etched from a multi-layer metal tube having one layer significantly more radio-opaque than at least one other layer; the etched stent being formed with increased wall thickness of the more radio-opaque layer on the end sets of strut members as compared with the sets of strut members at the center of the stent.
- Still another object of the present invention is to have the stent with optimized radio-opacity that is coated with a plastic material and an additional organic compound to prevent thrombus formation and/or restenosis.
- Still another object of the present invention is to have a stent coated with a plastic material that includes a radio-opaque filler material.
- FIG. 1 is a flat layout of a prior art stent having uniform strut width for the circumferential sets of strut members.
- FIG. 2 is a flat layout of a prior art stent design having "M” and “W” flexible connecting links.
- FIG. 3 is an enlargement of the "M” link of the stent design of FIG. 2.
- FIG. 4 is an enlargement of the improved "M" link design of the present invention.
- FIG. 5 is a flat layout of the present invention stent design for a highly radio-opaque metal.
- FIG. 6 is a flat layout of part of the present invention stent design of FIG. 5.
- FIG. 7 is a flat layout of an alternate embodiment of part of the present invention stent design of FIG. 5.
- FIG. 8 is a flat layout of the present invention stent design for a 5 somewhat radio-opaque metal.
- FIG. 9 is a flat layout of the present invention stent design for a stent coated with a radio-opaque metal.
- FIG. 10 is a flat layout of an alternate embodiment of the present invention stent including an "N" shaped flexible connecting link.
- FIG. 11 is a flat layout of the present invention stent design as photo- etched from a tube.
- FIG. 12A is an enlargement of a section of the photo-etched stent of FIG. 11.
- FIG. 12B is a longitudinal cross section at 12-12 of the enlarged section of FIG. 11 shown in FIG. 12A, the stent having a radio-opaque coating that is thickest on the end sets of strut members.
- FIG. 12C is a longitudinal cross section at 12-12 of the enlarged section of FIG. 11 shown in FIG. 12A, as etched from a two-layer tube where one of the tube layers is a moderately radio-opaque metal and the other layer is a highly radio-opaque metal.
- FIG. 1 shows a flat layout of an embodiment of a prior art stent described by Fischell et al in US Patent Application S/N 09/192,101 , incorporated herein by reference.
- the stent 5 of FIG. 1 is shown in its crimped, pre-deployed state as it would appear if it were cut longitudinally and then laid out into a flat, 2-dimensional configuration.
- the stent 5 comprises end sets of strut members 2 located at each end of the stent 5 and three central sets of strut members 6 connected each to the other by sets of longitudinally extending undulating "N" links 4.
- the end sets of strut members 2 consist of alternating curved sections 7 and diagonal sections 9.
- the central sets of strut members 6 located longitudinally between the end sets of strut members 2 consist of alternating curved sections 3 and diagonal sections 8.
- the longitudinally diagonal sections 9 of the end sets of strut members 2 are shorter in length than the longitudinally diagonal sections 8 of the central sets of strut members 6.
- the shorter diagonal sections 9 will reduce the stiff longitudinal length of metal at the ends of the stent 5 to improve deliverability (by reducing "fish-scaling") and will also increase the post- expansion strength of the end sets of strut members 2 as compared with the central sets of strut members 6.
- the width of the curved sections 3 and 7 and the diagonal sections 8 and 9 are all the same.
- the stent 5 is a design well suited to stainless steel having a wall thickness of 0.0045" or greater, such as found in the CORDIS BX Velocity ® stent.
- the stent 5 were formed from a highly radio-opaque metal such as tantalum with wall thickness of 0.0030 to 0.0035 inches and with sets of strut members 6 having widths of greater than the 0.005 inches that is necessary for good radial strength, then the stent would be too radio-opaque.
- the end sets of strut members 2 might have a tendency to flare outwardly into the vessel wall upon expansion.
- the central sets of strut members 6 with longer diagonal sections 8 will not have maximized radial strength assuming the same strut width for both central sets of strut members 6 and end sets of strut members 2.
- Optimized strength at the longitudinal center of a stent is important as it is that region that must typically hold back a larger amount of plaque than at the ends of the stent.
- each set of strut members should have maximized radial strength rather than having the central sets of strut members 6 being less strong than the end sets of strut members as previously described.
- This design would be similar to the stent 5 of FIG. 1 with the novel improvement being that the width of the curved sections 3 of the central sets of strut members 6 would be greater than the width of the curved sections 7 of the end sets of strut members 2. The greater width of the curved sections 3 will increase the strength of the central sets of strut members 6 compensating for loss of radial strength because of the longer diagonal sections 8.
- the stent 60 shown in FIG. 2 is a flat layout of a prior art stent design having "N", “M” and “W” flexible connecting links.
- the stent 60 is shown in its crimped pre-deployed state as it would appear if it were cut longitudinally and then laid out into a flat, 2-dimensional configuration. It should be clearly understood that the stent 60 is in fact cylindrical in shape, which cylindrical shape would be obtained by rolling the flat configuration of FIG. 2 into a cylinder with the top points "G" joined to the bottom points "H”.
- the stent 60 is typically fabricated by laser machining of a cylindrical, stainless steel tube.
- a central set of strut members 62 is a cylindrical, closed, ring-like section of the stent 60 consisting of a multiplicity of curved sections 63 connected to diagonal sections 68. Every curved section 63 of each central set of strut members 62 is attached to a connecting link which is either a flexible "N" link 44, "M” link 64 or a "W” link 84.
- the stent 60 also has two end sets of strut members 72 consisting of a multiplicity of curved sections 73 connected to diagonal sections 78. In this embodiment, half of the curved sections 73 of the end set of strut members 72 are attached to "N" links 44 with the other half of the curved sections 73 situated at the extreme ends of the stent 60.
- the diagonal sections 78 of the end sets of strut members 72 are shorter than the diagonal sections 68 of the central sets of strut members 62. Shorter diagonal sections enhance the post-expansion radial strength of the end sets of strut members 72 as compared to the central sets of strut members 62.
- FIG. 3 is an enlargement of the "M" link 64 of the prior art stent of FIG. 2.
- One disadvantage of this design relates to the circumferential extent of the "M” link 64 with respect to a line 65 that could be drawn between the two attachment points 68 where the "M” link 64 attaches to the curved sections 63. Because almost all of the "M” link 64 lies above the line 65, pressure on the top of the "M” link 64 from plaque in an artery could bend the top of the "M” link 64 inward into the arterial lumen. This would be highly undesirable.
- an "M" or “W” link should have an equal circumferential extent on either side of a line drawn between the attachment points to adjacent sets of strut members as shown in FIG. 4.
- the "M” link 14 has a circumferential extent (i.e., length) L' above and L" below the line 15.
- the line 15 is drawn between the attachment points 18 where the "M" link 14 attaches to adjacent curved sections 13.
- Such a balanced design would diminish any likelihood of the flexible connecting link 14 from expanding into the arterial lumen.
- FIG. 5 is a flat layout view of a stent 20 that includes some embodiments of the present invention.
- the design of FIG. 5 is particularly applicable to stents made from a highly radio-opaque metal such as tantalum.
- the stent 20 of FIG. 5 is shown in flat, layout view based on its pre-deployed state, as it would appear before it is crimped onto a balloon catheter.
- the stent 20 comprises end sets of strut members 22 located at each end of the stent 20 and central sets of strut members 26 connected each to the other by sets of individual flexible "M" links 24.
- the "M" links 24 are similar to the "M" Iink14 of FIG. 4.
- the end sets of strut members 22 consist of a multiplicity of curved sections 27 connected to diagonal sections 29.
- the central sets of strut members 26 located longitudinally between the end sets of strut members 22 consist of a multiplicity of curved sections 23 connected to diagonal sections 28.
- a strut element 25 as being composed of one adjacent curved section 23 joined to a diagonal section 28.
- a central set of strut members 26 as being a closed, circumferential, ring-like structure comprising a multiplicity of connected strut elements 25.
- An end set of strut members could be likewise defined as being a multiplicity of connected strut elements 17.
- the stent 20 is a closed cell stent having cells 19 formed from portions of adjacent sets of strut members connected by "M" links 24.
- M strut members
- An important aspect of stent design is to be able to place a guidewire through the expanded cell 19, into a side branch vessel.
- a balloon angioplasty catheter can then be advanced over the guidewire and inflated to enlarge and circularize the opening of the cell 19 to "unjail" the side branch vessel.
- unjailing is meant removing metal from the ostium of the side branch vessel, thus improving blood flow to that side branch.
- the cell 19 has an interior length of the perimeter that is at least 9 mm. Since balloon dilatation of the cell 19 would cause it to be near circular, a perimeter length of the cell 19 would provide a diameter of 9/?, which is approximately 3 mm.
- a good cell design for side branch access should have a perimeter between 9 mm and 11 mm. (i.e., an expanded circular diameter between 2.86 and 3.5 mm) where cell perimeters between 9.5 and 10 mm are optimal and would be suitable for essentially any side branch of a coronary artery.
- the diagonal sections 29 of the end sets of strut members 22 are shorter in length than the diagonal sections 28 of the central sets of strut members 26.
- the shorter diagonal sections 29 will reduce the longitudinal extent of the metal strut at the end of the stent to improve deliverability into a vessel of the human body by decreasing fish-scaling.
- the width of the curved sections 23 and 27 and the diagonal sections 28 and 29 are different as compared to the prior art stents 5 and 6 of FIGURES 1 and 2.
- FIG. 6 shows that the curved sections 23 (of the central sets of strut members 26 of FIG. 5) have a width at the center of the curve W c .
- the width of the curved sections 23 taper down as one moves away from the center of the curve until a minimum width W d is reached at the center of the section 28.
- the inside arc of the curved section 23 has a center that is longitudinally displaced from the center of the outside arc. This tapered shape for the curved section 23 provides a significant reduction in metal strain with little effect on the radial strength of the expanded stent as compared to a stent having sets of strut members with a uniform strut width.
- This reduced strain design has several advantages. First, it can allow the present invention design to have a much greater usable range of radial expansion as compared to a stent with a uniform strut width. Second, it can allow the width at the center of the curve to be increased which increases radial strength without greatly increasing the metal strain (i.e. one can make a stronger stent). Finally, the taper reduces the amount of metal in the stent and that should improve the stent thrombogenicity.
- FIG. 6 also shows a unique design for the end sets of strut members 22,
- the diagonal sections of the end sets of strut members 22 have a length L en ⁇ that is shorter than the length L of the. diagonal sections 28 of the central sets of strut members 26.
- each set of strut members should just reach the maximum allowable plastic strain for the metal being used at the largest allowable expanded diameter of the stent.
- the curved sections 7 of the end sets of strut members 2 and the curved sections 3 of the central sets of strut members 6 have the same widths.
- the end sets of strut members 2 (which have shorter diagonal sections 9) will reach the maximum allowable diameter at a level of strain that is greater than the level of strain experienced by the central sets of strut members 6.
- the present invention teaches a design with the width at the center of the curve W c end of the curved section 27 being less than the width W c of the curved sections 23 of the central sets of strut members 26. This reduced width for the
- curved sections 23 compensates for the shorter length L end of the end diagonal sections 29 so that there is the same strain in both the central and end sets of strut members 22 and 26 respectively as the stent 20 is expanded to its maximum allowable diameter.
- the end sets of strut members 22 can also be tapered like the central sets of strut members 26 where the width of the strut tapers down as one moves away from the center of the curve of the curved sections 27 until a minimum width W d end is reached at the diagonal section 29.
- the curved sections 23, 27 each have an inside (concave) arc and an outside (convex) arc. Each arc has a center that is longitudinally displaced from the other center.
- the tapered strut design shown in FIGS. 5 and 6 also has an advantage for stents made from highly radio-opaque metals such as tantalum. If one uses uniform strut width as seen with the stent 5 of FIG. 1 , then a properly designed thin-walled (0.0025 inches to 0.035 inches) wall tantalum stent may be too radio-opaque. The reduced metal from the thinner diagonal sections 28 and 29 will decrease the radio-opacity without affecting radial strength. Nominal dimensions and dimension ranges (all in inches) for a tantalum stent produced using the design of FIG. 5 are as follows:
- FIG. 7 is an alternative embodiment 21' of section 21 shown in FIG. 6 of the present invention stent 20 of FIG. 5. In this embodiment, the only difference is the shape of the diagonal sections 28'.
- the diagonal sections 28 of FIG. 6 have uniform thickness.
- a preferred embodiment of the present invention is as seen in FIG. 7 to have tapered diagonal sections 28' in the central sets of strut members 26 and uniform thickness diagonal sections 29 (having a greater average width) for the end sets of strut members 22.
- an alternate embodiment may use straight links connecting only half of the curved sections of the sets of strut members. Such a design, would also have the advantages of the reduce strain strut designs as shown in FIGS. 5, 6 and 7.
- the wall thickness of the central set of strut members 26 could be thinner that the wall thickness of the end set of strut members 22.
- the "M" links 24 also have a much narrower width as compared to the width of any strut member of the end set of strut members. Both these attributes of the stent 20 create the following desirable radio-opacity characteristics: highly radio-opaque end sets of strut members and decreased radio-opacity at the central region of the stent 20.
- FIG. 8 is a flat layout view of another embodiment of the present invention showing a stent 30 made from a moderately radio-opaque metal such as the cobalt-tungsten alloy L605.
- the alloy L605 has great radial strength and is approximately 20% to 30% more radio-opaque than stainless steel. Therefore, with L605, the same level of radio-opacity is achieved with a stent wall thickness that is 20% to 30% less than a stent made from stainless steel.
- One goal in the use of L605 would be to reduce the wall thickness by 30% but end up with a stent that is still more radio-opaque than an equivalent stainless steel stent such as the stent 5 shown in FIG. 1.
- the stent 30 comprises end sets of strut members 32 located at each end of the stent 30 and central sets of strut members 36 connected each to the other by sets of flexible "M" links 34.
- the "M" links 34 are similar to the "M" links 14 of FIG. 4.
- Each end set of strut members 32 comprises alternating curved sections 37 and diagonal sections 39 connected together to form a closed circumferential structure.
- the central sets of strut members 36 located longitudinally between the end sets of strut members 32 comprises curved sections 33 and diagonal sections 38 connected together to form a closed circumferential ring-like structure.
- the diagonal sections 39 of the end sets of strut members 32 are shorter in length than the diagonal sections 38 of the central sets of strut members 36.
- the shorter diagonal sections 39 will reduce the longitudinal length of metal at the end of the stent to improve deliverability into a vessel of the human body.
- the widths of the diagonal sections 38 and 39 are different as compared to the prior art stents 5 and 60 of FIGS. 1 and 2.
- FIG. 9 it can be seen that the diagonal sections 38 of the central sets of strut members 36 have a width at the center T c and a width at the end T e where the width in the center T c is larger than the width at the end T e .
- the curved sections 33 and 37 shown in FIG. 9 are tapered similar to the curved sections 23 and 27 of FIG. 6. It is also envisioned that the curved sections 33 and 37 could have uniform width similar to the curved sections 3 and 7 of FIG. 1.
- the diagonal sections 39 of the end sets of strut members 32 also have a tapered shape.
- the diagonal sections 37 have a width in the center T c end and a width at the end T e end where the width in the center T c end is larger than the width at the end T e end .
- the diagonal section 39 center width T c end of the end sets of strut members 32 is shown in FIG. 9 to be wider than the width T c of the diagonal section 38. A wider piece of metal will be more radio-opaque.
- the stent has curved sections with a single bend connecting the diagonal sections of its sets of strut members, and flexible connecting links connecting the curved sections of its circumferential sets of strut members.
- the stent of FIG. 10 is an alternate embodiment of the present invention showing central sets of strut members 46 having curved sections 43 and diagonal sections 48 with tapered shapes similar in design to the curved sections 23' and diagonal sections 28' of the stent section 21' shown in FIG. 7.
- the stent 40 of FIG. 10 is shown in a layout view in its pre-deployed state as it would appear before it is crimped onto a balloon catheter.
- the stent 40 comprises end sets of strut members 42 located at each end of the stent 40 and central sets of strut members 46.
- the sets of strut members 42 and 46 are connected each to the other by sets of individual flexible "N" links 44.
- the "N" links 44 are similar in shape but slightly longer than the "N" links 4 of FIG. 1.
- the end sets of strut members 42 consist of curved sections 47 and diagonal sections 49.
- the central sets of strut members 46 located longitudinally between the end sets of strut members 42 consist of curved sections 43 and diagonal sections 48.
- the stent 40 is a closed cell stent having cells 45 formed from portions of adjacent sets of strut members connected by "N" links 44. Prolapse of plaque through the closed cells 45 is minimized if the expanded area of the cell 45 is less than about 0.005 in. 2 at any diameter up to the maximum deployment diameter of the stent 40. It is also important for an optimum stent design that a guidewire can be placed through the expanded cell 45 into a side branch vessel. A balloon angioplasty catheter would then be advanced over the guidewire, through the cell 45 and inflated to "unjail" the side branch, i.e. remove any stent strut that is blocking blood flow into that side branch.
- FIG. 11 is a flat layout view of another embodiment of the present invention in the form of a stent 50 that is photo-etched from a metal tube.
- the stent 50 is shown in its pre-deployed state as it would appear before it is crimped onto a balloon catheter.
- the stent 50 comprises end sets of strut members 52P and 52D located respectively at the proximal and distal ends of the stent 50.
- the stent 50 also has central sets of strut members 56 connected each to the other by sets of flexible "M" links 54.
- the "M” links 54 are similar to the "M” links 14 of FIG. 4.
- the end sets of strut members 52P and 52D each consists of curved sections 57 and diagonal sections 59.
- the central sets of strut members 56 located longitudinally between the end sets of strut members 52 consist of curved sections 53 and diagonal sections 58.
- FIG. 12A The section 55 of the photo-etched stent 50 is shown enlarged in FIG. 12A.
- FIGS. 12B and 12C show two embodiments of the present invention that can provide a stent with enhanced radio-opacity at the stent ends.
- FIG. 12A shows diagonal sections 58 and 59 and an "M" link 54 connecting the curved sections 53 and 57.
- FIG. 12B is a longitudinal cross section at 12-12 of the stent section 55 shown in FIG. 12A.
- the stent design shown in FIG. 12B has a highly radio- opaque coating that is thicker on the end sets of strut members 52 as compared to the thickness on either the flex links 54 or the central sets of strut members 56.
- FIG. 12B shows the coating 57C on the curved section 57 of the end set of strut members 52 being thicker than the coating 54C on the flex link 54 and also thicker than the coating 53C on the curved section 53.
- the most likely coating for the stent 50 would be gold plating although platinum, tantalum or any other highly radio-opaque metal could be used.
- the present invention has the entire stent coated to provide an exterior surface for the stent 50 that is formed from a single metal. This reduces the potential for corrosion that can occur with dissimilar metals on the stent's exterior surface when placed in a saline solution such as the blood.
- an additional coating of a flexible plastic such as parylene may be desirable.
- a flexible plastic such as parylene
- Such an organic coating has the additional advantage of allowing the attachment of drugs such as taxol or rapamycin to reduce restenosis.
- FIG. 12C is the longitudinal cross section at 12-12 of yet another alternate embodiment of the enlarged section 55 of FIG. 11 shown in FIG. 12A.
- the stent design shown in FIG. 12C is etched from a two-layer tube where one of the tube layers is a metal of conventional radio-opacity such as stainless steel and the other layer is a highly radio-opaque metal such as tantalum.
- the end sets of strut members 52' have a thicker layer of the radio- opaque metal than the flex links 54' or the central sets of strut members 56'.
- the curved section 57' of the end set of strut members 52' has conventional metal layer 57N' and radio-opaque metal layer 57R'.
- the flex link 54' has a standard metal layer 54N' and a radio-opaque metal layer 54R'.
- the central sets of strut members 56' have curved sections 53' with conventional metal layers 53N' and radio-opaque metal layers 53R'.
- the radio-opaque metal layer 57R' of the end sets of strut members 52' is thicker than the radio-opaque metal layers 54R' and 53R'.
- multi-layer photo-etching processes for metals that can control the thickness of individual layers have been developed so that the embodiment of FIG. 12C can be produced within the current state of the art of photo-etching.
- two and three layer tubing is now available from several manufacturers and can be photo-etched to make a stent with optimal high radio-opacity for the end set of strut members and reduced radio-opacity for the central sets of strut members.
Abstract
Description
Claims
Priority Applications (7)
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MXPA02005126A MXPA02005126A (en) | 2000-09-22 | 2001-09-18 | Stent with optimal strength and radio-opacity characteristics. |
JP2002528151A JP2004522463A (en) | 2000-09-22 | 2001-09-18 | Stent |
AU89128/01A AU782021B2 (en) | 2000-09-22 | 2001-09-18 | Stent with optimal strength and radio-opacity characteristics |
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EP01968924.9A EP1399091B1 (en) | 2000-09-22 | 2001-09-18 | Stent with optimal strength and radio-opacity characteristics |
AU2005201815A AU2005201815B9 (en) | 2000-09-22 | 2005-04-29 | Stent with optimal strength and radio-opacity characteristics |
AU2005205781A AU2005205781B2 (en) | 2000-09-22 | 2005-09-01 | Stent with optimal strength and radio-opacity characteristics |
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US09/899,147 | 2001-07-06 |
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