WO2002024700A3 - SUBSTITUTED AZEPINO[4,5b]INDOLINE DERIVATIVES - Google Patents
SUBSTITUTED AZEPINO[4,5b]INDOLINE DERIVATIVES Download PDFInfo
- Publication number
- WO2002024700A3 WO2002024700A3 PCT/US2001/029447 US0129447W WO0224700A3 WO 2002024700 A3 WO2002024700 A3 WO 2002024700A3 US 0129447 W US0129447 W US 0129447W WO 0224700 A3 WO0224700 A3 WO 0224700A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- salts
- compounds
- indoline derivatives
- azepino
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002529110A JP2004509893A (en) | 2000-09-20 | 2001-09-20 | Substituted azepino [4,5b] indoline derivatives |
AU2001294606A AU2001294606A1 (en) | 2000-09-20 | 2001-09-20 | Substituted azepino(4,5b)indoline derivatives |
EP01975267A EP1319005A2 (en) | 2000-09-20 | 2001-09-20 | Substituted azepino[4,5-b]indoline derivatives |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23437600P | 2000-09-20 | 2000-09-20 | |
US60/234,376 | 2000-09-25 | ||
US26604701P | 2001-02-01 | 2001-02-01 | |
US60/266,047 | 2001-02-01 | ||
US30196401P | 2001-06-29 | 2001-06-29 | |
US60/301,964 | 2001-06-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002024700A2 WO2002024700A2 (en) | 2002-03-28 |
WO2002024700A3 true WO2002024700A3 (en) | 2002-06-13 |
Family
ID=27398561
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/029535 WO2002024701A2 (en) | 2000-09-20 | 2001-09-20 | Substituted azepino[4,5b)indole derivatives |
PCT/US2001/029447 WO2002024700A2 (en) | 2000-09-20 | 2001-09-20 | SUBSTITUTED AZEPINO[4,5b]INDOLINE DERIVATIVES |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/029535 WO2002024701A2 (en) | 2000-09-20 | 2001-09-20 | Substituted azepino[4,5b)indole derivatives |
Country Status (7)
Country | Link |
---|---|
US (4) | US6586421B2 (en) |
EP (2) | EP1319005A2 (en) |
JP (2) | JP2004509894A (en) |
AR (2) | AR035493A1 (en) |
AU (2) | AU2001294606A1 (en) |
PE (2) | PE20020510A1 (en) |
WO (2) | WO2002024701A2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9409910B2 (en) | 2008-10-31 | 2016-08-09 | Medivation Technologies, Inc. | Azepino[4,5-B]indoles and methods of use |
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EP1575984A4 (en) * | 2001-02-16 | 2006-09-06 | Bristol Myers Squibb Co | Identification and cloning of a novel human gene, ret16, involved in the intracellular signaling cascade |
EP1281700A1 (en) * | 2001-07-31 | 2003-02-05 | Resolution Research Nederland B.V. | Manufacturing process for the preparation of alpha, alpha-branched alkane carboxylic acids providing esters with an improved softness |
JP2005526691A (en) * | 2001-08-08 | 2005-09-08 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | Therapeutic agent 1H-pyrido [4,3-b] indole |
US7595311B2 (en) * | 2002-05-24 | 2009-09-29 | Exelixis, Inc. | Azepinoindole derivatives as pharmaceutical agents |
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AU2002950217A0 (en) * | 2002-07-16 | 2002-09-12 | Prana Biotechnology Limited | 8- Hydroxy Quinoline Derivatives |
US7592454B2 (en) * | 2004-04-14 | 2009-09-22 | Bristol-Myers Squibb Company | Substituted hexahydro-pyridoindole derivatives as serotonin receptor agonists and antagonists |
US7718647B2 (en) * | 2004-06-30 | 2010-05-18 | Athersys, Inc. | Substituted azepine derivatives as serotonin receptor modulators |
US8685924B2 (en) | 2004-08-25 | 2014-04-01 | Takeda Pharmaceutical Company Limited | Preventives/remedies for stress urinary incontinence and method of screening the same |
EP1747779A1 (en) * | 2005-07-28 | 2007-01-31 | Laboratorios Del Dr. Esteve, S.A. | Tetrahydro-b-carbolin-sulfonamide derivatives as 5-HT6 ligands |
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US20100209960A1 (en) * | 2007-09-10 | 2010-08-19 | Merck Sharp & Dohme Corp. | Method for measuring mitochondrial membrane potential in vertebrate cells |
US7816435B2 (en) * | 2007-10-31 | 2010-10-19 | Momentive Performance Materials Inc. | Halo-functional silane, process for its preparation, rubber composition containing same and articles manufactured therefrom |
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JP5501251B2 (en) | 2008-01-11 | 2014-05-21 | アルバニー モレキュラー リサーチ, インコーポレイテッド | (1-Azinone) substituted pyridoindoles as MCH antagonists |
US9625475B2 (en) | 2008-09-29 | 2017-04-18 | Abbvie Inc. | Indole and indoline derivatives and methods of use thereof |
WO2010036998A2 (en) | 2008-09-29 | 2010-04-01 | Abbott Laboratories | Indole and indoline derivatives and methods of use thereof |
JP5588991B2 (en) | 2008-10-31 | 2014-09-10 | メディベイション テクノロジーズ, インコーポレイテッド | Pyrido [4,3-b] indole with rigid part |
US8637501B2 (en) | 2009-07-01 | 2014-01-28 | Albany Molecular Research, Inc. | Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine MCH-1 antagonists, methods of making, and use thereof |
WO2011003012A1 (en) | 2009-07-01 | 2011-01-06 | Albany Molecular Research, Inc. | Azinone-substituted azapolycycle mch-1 antagonists, methods of making, and use thereof |
US8629158B2 (en) | 2009-07-01 | 2014-01-14 | Albany Molecular Research, Inc. | Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof |
WO2011003021A1 (en) | 2009-07-01 | 2011-01-06 | Albany Molecular Research, Inc. | Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof |
JPWO2011071136A1 (en) | 2009-12-11 | 2013-04-22 | アステラス製薬株式会社 | Fibromyalgia treatment |
WO2011103485A1 (en) | 2010-02-18 | 2011-08-25 | Medivation Technologies, Inc. | Fused tetracyclic pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use |
WO2011103460A1 (en) | 2010-02-18 | 2011-08-25 | Medivation Technologies, Inc. | Fused tetracyclic pyrido[4,3-b]indole and pyrido[3,4-b]ondole derivatives and methods of use |
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US9187471B2 (en) | 2010-02-19 | 2015-11-17 | Medivation Technologies, Inc. | Pyrido [4,3-b] indole and pyrido [3,4-b] indole derivatives and methods of use |
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US8993765B2 (en) | 2010-12-21 | 2015-03-31 | Albany Molecular Research, Inc. | Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof |
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US20130178618A1 (en) * | 2012-01-10 | 2013-07-11 | William Allen Boulanger | Novel pharmaceutical intermediates and methods for preparing the same |
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Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0466548A1 (en) * | 1990-06-27 | 1992-01-15 | Adir Et Compagnie | 1,2,3,4,5,6-Hexahydroazepino[4,5-b]indole and 1,2,3,4-tetrahydro-beta-carbolines, processes for their preparation, and pharmaceutical compositions containing them |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR6699E (en) | 1905-09-25 | 1907-01-31 | Maurice Honore Firmin Muraire | Silkworm cocoon threading machine |
DE1062840B (en) | 1953-03-03 | 1959-08-06 | Siemens Reiniger Werke Ag | Device for making visible, or for strengthening visible, images caused by corpuscular or wave radiation, in particular for x-ray fluoroscopy |
CH445508A (en) * | 1964-12-03 | 1967-10-31 | Geigy Ag J R | Process for the production of new indole derivatives |
US3839357A (en) | 1966-05-10 | 1974-10-01 | Upjohn Co | 1,2,3,4,5,6-hexahydroazepino(4,5-b)indoles |
GR35044B (en) | 1966-05-10 | 1968-07-31 | The Upjohn Company | METHOD OF PREPARATION OF ORGANIC COMPOUNDS. |
US3525750A (en) | 1966-05-31 | 1970-08-25 | Geigy Chem Corp | 1,2,3,4,5,6-hexahydro-azepino(4,5-b) indole derivatives |
US3553232A (en) | 1967-08-25 | 1971-01-05 | Upjohn Co | 4-(1,4,5,6-tetrahydroazepine(4,5-b)indole-3(2h)-yl)butyrophenones |
US3622673A (en) | 1968-11-14 | 1971-11-23 | Upjohn Co | 4-(1,4,5,6-TETRAHYDROZEPINO 4,5-b INDOL-3(2H)-YL-BUTYROPHENON COMPOSITIONS AND PROCESS OF TREATMENT MENTAL OR EMOTIONAL DISORDERS |
US3652588A (en) | 1969-10-23 | 1972-03-28 | Upjohn Co | 6-alkyl-1 2 3 4 5 6-hexahydroazepino(4 5-b)indoles |
US3676558A (en) | 1970-08-28 | 1972-07-11 | Upjohn Co | Anorexigenic compositions comprising 6-alkyl-1,2,3,4,5,6-hexahydroazepino 4,5-indoles as active ingredient and process of treatment |
US3776922A (en) * | 1972-03-24 | 1973-12-04 | J Epstein | Indole carboxaldehydes |
EP0028381B1 (en) * | 1979-11-02 | 1985-04-10 | Sandoz Ag | Azepinoindoles, process for their production and pharmaceutical compositions containing them |
CH649553A5 (en) * | 1982-05-06 | 1985-05-31 | Sandoz Ag | AZEPINOINDOLS AND METHOD FOR THE PRODUCTION THEREOF. |
JPS63163347A (en) | 1986-12-25 | 1988-07-06 | Konica Corp | Method for preventing photodiscoloration of organic coloring substance |
EP0377238A1 (en) | 1988-12-22 | 1990-07-11 | Duphar International Research B.V | New annelated indolo (3,2-c)-lactams |
AR023574A1 (en) | 1999-04-23 | 2002-09-04 | Pharmacia & Upjohn Co Llc | TETRACICLIC AZEPININDOL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND THE USE OF SUCH COMPOUNDS TO PREPARE A MEDICINAL PRODUCT, AND INTERMEDIARIES |
MXPA01012914A (en) | 1999-06-15 | 2004-04-21 | Bristol Myers Squibb Co | Substituted heterocycle fused gamma-carbolines. |
DE19929076A1 (en) | 1999-06-25 | 2000-12-28 | Aventis Pharma Gmbh | New indanyl-substituted benzenesulfonamide derivatives, as potassium channel blockers useful as safe antiarrhythmic agents, e.g. for treating atrial fibrillation or flutter |
MY122278A (en) | 1999-07-19 | 2006-04-29 | Upjohn Co | 1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position |
WO2002004456A1 (en) * | 2000-07-06 | 2002-01-17 | Pharmacia & Upjohn Company | SUBSTITUTED 2,3,7,8,9,10,11,12-OCTAHYDROAZEPINO[4,5-b]PYRANO[3,2-e]INDOLES |
-
2001
- 2001-09-20 JP JP2002529111A patent/JP2004509894A/en not_active Withdrawn
- 2001-09-20 AU AU2001294606A patent/AU2001294606A1/en not_active Abandoned
- 2001-09-20 AR ARP010104449A patent/AR035493A1/en not_active Application Discontinuation
- 2001-09-20 AR ARP010104450A patent/AR034264A1/en unknown
- 2001-09-20 WO PCT/US2001/029535 patent/WO2002024701A2/en not_active Application Discontinuation
- 2001-09-20 US US09/957,319 patent/US6586421B2/en not_active Expired - Fee Related
- 2001-09-20 AU AU2001292898A patent/AU2001292898A1/en not_active Abandoned
- 2001-09-20 PE PE2001000944A patent/PE20020510A1/en not_active Application Discontinuation
- 2001-09-20 PE PE2001000945A patent/PE20020443A1/en not_active Application Discontinuation
- 2001-09-20 EP EP01975267A patent/EP1319005A2/en not_active Withdrawn
- 2001-09-20 US US09/957,625 patent/US6583135B2/en not_active Expired - Fee Related
- 2001-09-20 EP EP01973304A patent/EP1319004A2/en not_active Withdrawn
- 2001-09-20 JP JP2002529110A patent/JP2004509893A/en active Pending
- 2001-09-20 WO PCT/US2001/029447 patent/WO2002024700A2/en not_active Application Discontinuation
-
2003
- 2003-03-20 US US10/394,676 patent/US6828314B2/en not_active Expired - Fee Related
- 2003-03-20 US US10/393,968 patent/US6903090B2/en not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0466548A1 (en) * | 1990-06-27 | 1992-01-15 | Adir Et Compagnie | 1,2,3,4,5,6-Hexahydroazepino[4,5-b]indole and 1,2,3,4-tetrahydro-beta-carbolines, processes for their preparation, and pharmaceutical compositions containing them |
Non-Patent Citations (5)
Title |
---|
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; BARKOV, N. K. ET AL: "Pharmacological properties of carazedine", XP002195043, retrieved from STN Database accession no. 121:49905 * |
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KUCHEROVA, N. F. ET AL: "3,9-Dimethyl-1,2,3,4,5,5a,6,10b-octahydroazepino[4,5-b]indole", XP002195045, retrieved from STN Database accession no. 69:59212 * |
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; SHARKOVA, N. M. ET AL: "Indole derivatives. XXVIV. Synthesis of some new polycondensed indole systems", XP002195044, retrieved from STN Database accession no. 70:115036 * |
EKSP. KLIN. FARMAKOL. (1994), 57(2), 4-6 * |
KHIM. GETEROTSIKL. SOEDIN. (1969), (1), 88-90 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9409910B2 (en) | 2008-10-31 | 2016-08-09 | Medivation Technologies, Inc. | Azepino[4,5-B]indoles and methods of use |
US9481676B2 (en) | 2008-10-31 | 2016-11-01 | Medivation Technologies, Inc. | Azepino[4,5-B]indoles and methods of use |
Also Published As
Publication number | Publication date |
---|---|
US20020077318A1 (en) | 2002-06-20 |
AU2001294606A1 (en) | 2002-04-02 |
AR034264A1 (en) | 2004-02-18 |
EP1319005A2 (en) | 2003-06-18 |
US6586421B2 (en) | 2003-07-01 |
US20020107278A1 (en) | 2002-08-08 |
JP2004509894A (en) | 2004-04-02 |
WO2002024701A2 (en) | 2002-03-28 |
AU2001292898A1 (en) | 2002-04-02 |
WO2002024701A3 (en) | 2002-06-13 |
US6583135B2 (en) | 2003-06-24 |
EP1319004A2 (en) | 2003-06-18 |
US20030220321A1 (en) | 2003-11-27 |
US6828314B2 (en) | 2004-12-07 |
PE20020510A1 (en) | 2002-06-12 |
AR035493A1 (en) | 2004-06-02 |
US6903090B2 (en) | 2005-06-07 |
WO2002024700A2 (en) | 2002-03-28 |
PE20020443A1 (en) | 2002-05-16 |
US20030225058A1 (en) | 2003-12-04 |
JP2004509893A (en) | 2004-04-02 |
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