WO2002028851A1 - Dérivés de 7-carboxy-flavones, procédé de préparation et application en thérapeutique - Google Patents
Dérivés de 7-carboxy-flavones, procédé de préparation et application en thérapeutique Download PDFInfo
- Publication number
- WO2002028851A1 WO2002028851A1 PCT/FR2001/003075 FR0103075W WO0228851A1 WO 2002028851 A1 WO2002028851 A1 WO 2002028851A1 FR 0103075 W FR0103075 W FR 0103075W WO 0228851 A1 WO0228851 A1 WO 0228851A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- group
- hydroxy
- derivatives
- flavone
- oxo
- Prior art date
Links
- 0 ***(CCC=C1)C=C1C(Os1cc(*)cc(*)c11)=CC1=O Chemical compound ***(CCC=C1)C=C1C(Os1cc(*)cc(*)c11)=CC1=O 0.000 description 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
- C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
- C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/34—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only
- C07D311/36—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only not hydrogenated in the hetero ring, e.g. isoflavones
Abstract
Description
Claims
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK01974441T DK1212313T3 (da) | 2000-10-06 | 2001-10-05 | Derivater af 7-carboxyflavoner, fremstillingsmetode og terapeutisk anvendelse |
MXPA03002986A MXPA03002986A (es) | 2000-10-06 | 2001-10-05 | Derivados de 7-carboxiflavona, procedimiento de preparacion y aplicacion terapeutica. |
SI200130022T SI1212313T1 (en) | 2000-10-06 | 2001-10-05 | 7-carboxy-flavone derivatives, preparation method and therapeutic use |
BR0114457-0A BR0114457A (pt) | 2000-10-06 | 2001-10-05 | Derivados de flavonas e de isoflavonas, processo para sua preparação, composição famacêutica, e utilização de um derivado de flavona ou de isoflavona |
DE60100314T DE60100314T2 (de) | 2000-10-06 | 2001-10-05 | 7-carboxylatische flavon derivate, verfahren zur herstellung und verwendung als heilmittel |
US10/398,187 US6965039B2 (en) | 2000-10-06 | 2001-10-05 | 7-carboxy-flavone derivatives preparation method and therapeutic use |
AU2001293956A AU2001293956A1 (en) | 2000-10-06 | 2001-10-05 | 7-carboxy-flavone derivatives, preparation method and therapeutic use |
AT01974441T ATE241609T1 (de) | 2000-10-06 | 2001-10-05 | 7-carboxylatische flavon derivate, verfahren zur herstellung und verwendung als heilmittel |
EP01974441A EP1212313B1 (fr) | 2000-10-06 | 2001-10-05 | Derives de 7-carboxy-flavones, procede de preparation et application en therapeutique |
CA002424993A CA2424993A1 (fr) | 2000-10-06 | 2001-10-05 | Derives de 7-carboxy-flavones, procede de preparation et application en therapeutique |
JP2002532436A JP2004510770A (ja) | 2000-10-06 | 2001-10-05 | 7−カルボキシフラボン誘導体、調製法および治療適用 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0012846A FR2815033B1 (fr) | 2000-10-06 | 2000-10-06 | Derives de 7-carboxy-flavones, porcede pour leur preparation et leur application en therapeutique |
FR00/12846 | 2000-10-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2002028851A1 true WO2002028851A1 (fr) | 2002-04-11 |
Family
ID=8855113
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR2001/003075 WO2002028851A1 (fr) | 2000-10-06 | 2001-10-05 | Dérivés de 7-carboxy-flavones, procédé de préparation et application en thérapeutique |
Country Status (15)
Country | Link |
---|---|
US (1) | US6965039B2 (fr) |
EP (1) | EP1212313B1 (fr) |
JP (1) | JP2004510770A (fr) |
CN (1) | CN1301987C (fr) |
AT (1) | ATE241609T1 (fr) |
AU (1) | AU2001293956A1 (fr) |
BR (1) | BR0114457A (fr) |
CA (1) | CA2424993A1 (fr) |
DE (1) | DE60100314T2 (fr) |
DK (1) | DK1212313T3 (fr) |
ES (1) | ES2199213T3 (fr) |
FR (1) | FR2815033B1 (fr) |
MX (1) | MXPA03002986A (fr) |
PT (1) | PT1212313E (fr) |
WO (1) | WO2002028851A1 (fr) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005121116A1 (fr) * | 2004-06-08 | 2005-12-22 | Novartis Ag | Derives de chromone utiles en tant qu'antagonistes de vanilloide |
US7960399B2 (en) | 2004-06-08 | 2011-06-14 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100841901B1 (ko) * | 2002-03-18 | 2008-06-27 | 동화약품공업주식회사 | 플라보노이드 계열 화합물 또는 이를 포함하는 강진향추출물을 함유한 매트릭스 메탈로프로테이나제 활성저해제 및 기능성 식품 |
MX2010001141A (es) * | 2007-07-31 | 2010-03-01 | Limerick Biopharma Inc | Analogos fosforiladosde pirona y metodos. |
AU2008282273A1 (en) * | 2007-07-31 | 2009-02-05 | Limerick Biopharma, Inc. | Pyrone analog compositions and methods |
US20100297020A1 (en) * | 2008-10-10 | 2010-11-25 | Limerick Biopharma, Inc. | Phosphorylated and phosphonated pyrone analogs for therapeutic treatment |
WO2010129138A2 (fr) * | 2009-04-27 | 2010-11-11 | Limerick Biopharma | Analogues de pyrone phosphorylée et phospholatée pour traitement thérapeutique |
CN108329287B (zh) * | 2018-02-24 | 2020-06-16 | 海南师范大学 | 大果榕中带有环氧基的化合物及其制备方法和应用 |
CN111388464A (zh) * | 2020-04-28 | 2020-07-10 | 滨州医学院 | 芒柄花素磺酸钠在制备治疗类风湿性关节炎药物中的应用 |
CN111875571A (zh) * | 2020-07-23 | 2020-11-03 | 长沙理工大学 | 一种从酱油渣中提取大豆异黄酮的方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4157334A (en) * | 1974-12-26 | 1979-06-05 | Carlo Erba S. P. A. | 6-Carboxy-flavone derivatives and process for their preparation |
FR2543140B1 (fr) | 1983-03-24 | 1985-06-21 | Cortial | Nouveaux acides flavone-carboxyliques-4', leur methode de preparation et leur application en therapeutique |
JPS62215581A (ja) | 1986-03-18 | 1987-09-22 | Koichi Shiyudo | フラボンカルボン酸誘導体 |
DE3715779A1 (de) | 1987-05-12 | 1988-11-24 | Kali Chemie Pharma Gmbh | Flavon-3-carbonsaeure-verbindungen sowie verfahren, zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
FR2689127B1 (fr) | 1992-03-31 | 1994-05-06 | Adir Cie | Nouvelles 3', 5' -ditertbutyl-4'-hydroxy flavones, leur procede de preparation et les compositions pharmaceutiques les renfermant. |
US5399584A (en) * | 1992-05-05 | 1995-03-21 | The Procter & Gamble Company | Use of flavone derivatives for gastroprotection |
AUPO203996A0 (en) * | 1996-08-30 | 1996-09-26 | Novogen Research Pty Ltd | Therapeutic uses |
JP3957795B2 (ja) * | 1996-10-04 | 2007-08-15 | 興和株式会社 | フラボン誘導体及びこれを含有する医薬 |
-
2000
- 2000-10-06 FR FR0012846A patent/FR2815033B1/fr not_active Expired - Fee Related
-
2001
- 2001-10-05 CN CNB018169449A patent/CN1301987C/zh not_active Expired - Fee Related
- 2001-10-05 AU AU2001293956A patent/AU2001293956A1/en not_active Abandoned
- 2001-10-05 JP JP2002532436A patent/JP2004510770A/ja active Pending
- 2001-10-05 BR BR0114457-0A patent/BR0114457A/pt not_active IP Right Cessation
- 2001-10-05 DK DK01974441T patent/DK1212313T3/da active
- 2001-10-05 PT PT01974441T patent/PT1212313E/pt unknown
- 2001-10-05 EP EP01974441A patent/EP1212313B1/fr not_active Expired - Lifetime
- 2001-10-05 ES ES01974441T patent/ES2199213T3/es not_active Expired - Lifetime
- 2001-10-05 US US10/398,187 patent/US6965039B2/en not_active Expired - Fee Related
- 2001-10-05 CA CA002424993A patent/CA2424993A1/fr not_active Abandoned
- 2001-10-05 DE DE60100314T patent/DE60100314T2/de not_active Expired - Fee Related
- 2001-10-05 MX MXPA03002986A patent/MXPA03002986A/es active IP Right Grant
- 2001-10-05 AT AT01974441T patent/ATE241609T1/de not_active IP Right Cessation
- 2001-10-05 WO PCT/FR2001/003075 patent/WO2002028851A1/fr active Application Filing
Non-Patent Citations (4)
Title |
---|
CHEMICAL ABSTRACTS, vol. 119, no. 17, 25 October 1993, Columbus, Ohio, US; abstract no. 173825b, ABAD,M. ET AL.: "ANTI-INFLAMMATORY ACTIVITY OF TWO FLAVONOIDS FROM TANCETUM MICROPHYLLUM." page 48; XP002056027 * |
CHEMICAL ABSTRACTS, vol. 128, no. 22, 1998, Columbus, Ohio, US; abstract no. 274942d, ANA MARIA SILVAN: "EFFECTS OF COMPOUNDS EXTRACTED FROM TANACETUM MICROPHYLLUM" page 974; column 1; XP002170500 * |
J. NAT. PROD., vol. 56, no. 7, 1993, pages 1164 - 7 * |
PLANTA MED., vol. 64, no. 3, 1998, ENGL, pages 200 - 3 * |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005121116A1 (fr) * | 2004-06-08 | 2005-12-22 | Novartis Ag | Derives de chromone utiles en tant qu'antagonistes de vanilloide |
US7960399B2 (en) | 2004-06-08 | 2011-06-14 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
US8211902B2 (en) | 2004-06-08 | 2012-07-03 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
US8809528B2 (en) | 2004-06-08 | 2014-08-19 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
US9102653B2 (en) | 2004-06-08 | 2015-08-11 | Novartis Ag | Substituted quinazolinones as vanilloid antagonists |
Also Published As
Publication number | Publication date |
---|---|
JP2004510770A (ja) | 2004-04-08 |
US20040059136A1 (en) | 2004-03-25 |
FR2815033B1 (fr) | 2003-09-05 |
CA2424993A1 (fr) | 2002-04-11 |
BR0114457A (pt) | 2003-10-21 |
DE60100314T2 (de) | 2004-04-01 |
MXPA03002986A (es) | 2004-05-24 |
FR2815033A1 (fr) | 2002-04-12 |
DK1212313T3 (da) | 2003-09-22 |
DE60100314D1 (de) | 2003-07-03 |
AU2001293956A1 (en) | 2002-04-15 |
CN1301987C (zh) | 2007-02-28 |
ATE241609T1 (de) | 2003-06-15 |
EP1212313B1 (fr) | 2003-05-28 |
ES2199213T3 (es) | 2004-02-16 |
PT1212313E (pt) | 2003-10-31 |
US6965039B2 (en) | 2005-11-15 |
CN1468228A (zh) | 2004-01-14 |
EP1212313A1 (fr) | 2002-06-12 |
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