WO2002030464A1 - Nouveaux medicaments pour maladies du foie - Google Patents
Nouveaux medicaments pour maladies du foie Download PDFInfo
- Publication number
- WO2002030464A1 WO2002030464A1 PCT/JP2001/008552 JP0108552W WO0230464A1 WO 2002030464 A1 WO2002030464 A1 WO 2002030464A1 JP 0108552 W JP0108552 W JP 0108552W WO 0230464 A1 WO0230464 A1 WO 0230464A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- mcp
- gene
- liver
- liver disease
- treating
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/195—Chemokines, e.g. RANTES
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002533903A JPWO2002030464A1 (ja) | 2000-10-11 | 2001-09-28 | 新規肝疾患用薬 |
CA002425765A CA2425765A1 (en) | 2000-10-11 | 2001-09-28 | Novel drugs for liver diseases |
EP01972593A EP1325751A4 (en) | 2000-10-11 | 2001-09-28 | NEW MEDICAMENTS FOR THE TREATMENT OF LIVER DISEASES |
US10/398,285 US7335647B2 (en) | 2000-10-11 | 2001-09-28 | Drugs for liver diseases |
AU2001292301A AU2001292301A1 (en) | 2000-10-11 | 2001-09-28 | Novel drugs for liver diseases |
NO20031650A NO20031650L (no) | 2000-10-11 | 2003-04-10 | Nye legemidler for leversykdommer |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000310604 | 2000-10-11 | ||
JP2000-310604 | 2000-10-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2002030464A1 true WO2002030464A1 (fr) | 2002-04-18 |
Family
ID=18790533
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2001/008552 WO2002030464A1 (fr) | 2000-10-11 | 2001-09-28 | Nouveaux medicaments pour maladies du foie |
Country Status (8)
Country | Link |
---|---|
US (1) | US7335647B2 (ja) |
EP (1) | EP1325751A4 (ja) |
JP (1) | JPWO2002030464A1 (ja) |
CN (1) | CN1469756A (ja) |
AU (1) | AU2001292301A1 (ja) |
CA (1) | CA2425765A1 (ja) |
NO (1) | NO20031650L (ja) |
WO (1) | WO2002030464A1 (ja) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1447095A1 (en) * | 2001-11-02 | 2004-08-18 | Kensuke Egashira | Preventives and/or remedies for post-transplant arteriosclerosis as rejection of organ transplant |
WO2004062688A3 (en) * | 2002-12-23 | 2004-09-16 | Applied Research Systems | Use of cc-chemokine mutants against liver diseases |
US7666413B2 (en) | 2000-10-12 | 2010-02-23 | Genetech, Inc. | Method of reducing viscosity of high concentration protein formulations |
US8318161B2 (en) | 2009-03-06 | 2012-11-27 | Genentech, Inc. | Anti-oxidized LDL antibody formulation |
US8961964B2 (en) | 2003-04-04 | 2015-02-24 | Genentech, Inc. | High concentration antibody and protein formulations |
US10166293B2 (en) | 2000-10-12 | 2019-01-01 | Genentech, Inc. | Reduced-viscosity concentrated protein formulations |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA200970350A1 (ru) * | 2006-10-05 | 2009-12-30 | Сентокор Орто Байотек, Инк. | Антагонисты ccr2 для лечения фиброза |
BRPI0719189A2 (pt) * | 2006-10-12 | 2018-08-14 | Univ Kyushu Nat Univ Corp | uso de ciclosporinas modificadas |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995013295A1 (en) * | 1993-11-12 | 1995-05-18 | Dana Farber Cancer Institute | Human monocyte chemoattractant protein-1 (mcp-1) derivatives |
JPH08119934A (ja) * | 1994-10-21 | 1996-05-14 | Teijin Ltd | プロスタグランジン類およびその製造法 |
WO1996023068A1 (en) * | 1995-01-27 | 1996-08-01 | Glaxo Group Limited | A chemokine receptor able to bind to mcp-1, mip-1 alpha and/or rantes. its uses |
WO1996038559A1 (en) * | 1995-05-31 | 1996-12-05 | Dana Farber Cancer Institute | Chemokine n-terminal deletion mutations |
JPH0967399A (ja) * | 1995-08-30 | 1997-03-11 | Mitsui Toatsu Chem Inc | 抗mcp−1ヒトモノクローナル抗体 |
WO1998006703A1 (en) * | 1996-08-14 | 1998-02-19 | Warner-Lambert Company | 2-phenyl benzimidazole derivatives as mcp-1 antagonists |
WO1999007678A1 (en) * | 1997-08-07 | 1999-02-18 | Zeneca Limited | Indole derivatives as mcp-1 receptor antagonists |
JPH1160502A (ja) * | 1997-08-12 | 1999-03-02 | Teijin Ltd | 脳梗塞症治療薬もしくは予防薬 |
JP2000239182A (ja) * | 1999-02-19 | 2000-09-05 | Mitsubishi Chemicals Corp | 抗炎症剤 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5399346A (en) * | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
-
2001
- 2001-09-28 US US10/398,285 patent/US7335647B2/en not_active Expired - Lifetime
- 2001-09-28 CN CNA01817244XA patent/CN1469756A/zh active Pending
- 2001-09-28 JP JP2002533903A patent/JPWO2002030464A1/ja active Pending
- 2001-09-28 CA CA002425765A patent/CA2425765A1/en not_active Abandoned
- 2001-09-28 EP EP01972593A patent/EP1325751A4/en not_active Withdrawn
- 2001-09-28 AU AU2001292301A patent/AU2001292301A1/en not_active Abandoned
- 2001-09-28 WO PCT/JP2001/008552 patent/WO2002030464A1/ja active Application Filing
-
2003
- 2003-04-10 NO NO20031650A patent/NO20031650L/no not_active Application Discontinuation
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995013295A1 (en) * | 1993-11-12 | 1995-05-18 | Dana Farber Cancer Institute | Human monocyte chemoattractant protein-1 (mcp-1) derivatives |
JPH08119934A (ja) * | 1994-10-21 | 1996-05-14 | Teijin Ltd | プロスタグランジン類およびその製造法 |
WO1996023068A1 (en) * | 1995-01-27 | 1996-08-01 | Glaxo Group Limited | A chemokine receptor able to bind to mcp-1, mip-1 alpha and/or rantes. its uses |
WO1996038559A1 (en) * | 1995-05-31 | 1996-12-05 | Dana Farber Cancer Institute | Chemokine n-terminal deletion mutations |
JPH0967399A (ja) * | 1995-08-30 | 1997-03-11 | Mitsui Toatsu Chem Inc | 抗mcp−1ヒトモノクローナル抗体 |
WO1998006703A1 (en) * | 1996-08-14 | 1998-02-19 | Warner-Lambert Company | 2-phenyl benzimidazole derivatives as mcp-1 antagonists |
WO1999007678A1 (en) * | 1997-08-07 | 1999-02-18 | Zeneca Limited | Indole derivatives as mcp-1 receptor antagonists |
JPH1160502A (ja) * | 1997-08-12 | 1999-03-02 | Teijin Ltd | 脳梗塞症治療薬もしくは予防薬 |
JP2000239182A (ja) * | 1999-02-19 | 2000-09-05 | Mitsubishi Chemicals Corp | 抗炎症剤 |
Non-Patent Citations (4)
Title |
---|
CZAJA M.J. ET AL.: "Monocyte chemoattractant protein 1 (MCP-1) expression occurs in toxic rat liver injury and human liver disease", JOURNAL OF LEUKOCYTE BIOLOGY, vol. 55, no. 1, 1994, pages 120 - 126, XP002907286 * |
MARRA F. ET AL.: "Increased expression of monocyte chemotactic protein-1 during active hepatic fibrogenesis: correlation with monocyte infiltration", AMERICAN JOURNAL OF PATHOLOGY, vol. 152, no. 2, 1998, pages 423 - 430, XP002907288 * |
MARRA F. ET AL.: "Monocyte chemotactic protein-1 as a chemoattractant for human hepatic stellate cells", HEPATOLOGY, vol. 29, no. 1, pages 140 - 148, XP002907287 * |
See also references of EP1325751A4 * |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7666413B2 (en) | 2000-10-12 | 2010-02-23 | Genetech, Inc. | Method of reducing viscosity of high concentration protein formulations |
US8142776B2 (en) | 2000-10-12 | 2012-03-27 | Genentech, Inc. | Reduced-viscosity concentrated protein formulations |
US10166293B2 (en) | 2000-10-12 | 2019-01-01 | Genentech, Inc. | Reduced-viscosity concentrated protein formulations |
EP1447095A1 (en) * | 2001-11-02 | 2004-08-18 | Kensuke Egashira | Preventives and/or remedies for post-transplant arteriosclerosis as rejection of organ transplant |
EP1447095A4 (en) * | 2001-11-02 | 2009-08-05 | Kensuke Egashira | MEANS FOR THE PREVENTION AND / OR TREATMENT OF ARTERIOSCLEROSIS AFTER TRANSPLANTATION AS A DISPOSAL OF THE TRANSPLANTED ORGAN |
WO2004062688A3 (en) * | 2002-12-23 | 2004-09-16 | Applied Research Systems | Use of cc-chemokine mutants against liver diseases |
US7476381B2 (en) | 2002-12-23 | 2009-01-13 | Laboratoires Serono Sa | Methods of reducing serum alanine transferase levels in a subject with hepatitis |
US8961964B2 (en) | 2003-04-04 | 2015-02-24 | Genentech, Inc. | High concentration antibody and protein formulations |
US10034940B2 (en) | 2003-04-04 | 2018-07-31 | Genentech, Inc. | High concentration antibody and protein formulations |
US8318161B2 (en) | 2009-03-06 | 2012-11-27 | Genentech, Inc. | Anti-oxidized LDL antibody formulation |
Also Published As
Publication number | Publication date |
---|---|
CN1469756A (zh) | 2004-01-21 |
JPWO2002030464A1 (ja) | 2004-02-19 |
US20050053603A1 (en) | 2005-03-10 |
EP1325751A4 (en) | 2005-05-04 |
AU2001292301A1 (en) | 2002-04-22 |
NO20031650D0 (no) | 2003-04-10 |
EP1325751A1 (en) | 2003-07-09 |
US7335647B2 (en) | 2008-02-26 |
CA2425765A1 (en) | 2003-04-11 |
NO20031650L (no) | 2003-06-05 |
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