WO2002032404A3 - Nanoparticles - Google Patents

Nanoparticles Download PDF

Info

Publication number
WO2002032404A3
WO2002032404A3 PCT/GB2001/004633 GB0104633W WO0232404A3 WO 2002032404 A3 WO2002032404 A3 WO 2002032404A3 GB 0104633 W GB0104633 W GB 0104633W WO 0232404 A3 WO0232404 A3 WO 0232404A3
Authority
WO
WIPO (PCT)
Prior art keywords
carbohydrate
nanoparticles
immobilising
therapeutics
studying
Prior art date
Application number
PCT/GB2001/004633
Other languages
French (fr)
Other versions
WO2002032404A2 (en
Inventor
Soledad Penades
Javier Rojo
Manuel Martin-Lomas
Original Assignee
Consejo Superior Investigacion
Soledad Penades
Javier Rojo
Manuel Martin-Lomas
Kiddle Simon John
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9901442&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2002032404(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to EP01974554A priority Critical patent/EP1326589B1/en
Priority to AU9406801A priority patent/AU9406801A/en
Priority to CA2424734A priority patent/CA2424734C/en
Priority to AU2001294068A priority patent/AU2001294068B2/en
Priority to JP2002535642A priority patent/JP4467882B2/en
Application filed by Consejo Superior Investigacion, Soledad Penades, Javier Rojo, Manuel Martin-Lomas, Kiddle Simon John filed Critical Consejo Superior Investigacion
Priority to DE60117828T priority patent/DE60117828T2/en
Priority to US10/399,284 priority patent/US7364919B2/en
Publication of WO2002032404A2 publication Critical patent/WO2002032404A2/en
Publication of WO2002032404A3 publication Critical patent/WO2002032404A3/en
Priority to US12/040,594 priority patent/US8080431B2/en
Priority to US13/306,924 priority patent/US8790934B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5115—Inorganic compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6923—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y10/00—Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/588—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with semiconductor nanocrystal label, e.g. quantum dots
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/80—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types or red blood cells
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Abstract

Materials and methods for studying and modulating the interaction of carbohydrate-containing moieties with other species are described, in particular, small particles, e.g. clusters of metal or semiconductor atoms, which can be employed as a substrate for immobilising a plurality of ligands comprising carbohydrate groups. These "nanoparticles" can then be used to study carbohydrate mediated interactions, e.g. with other carbohydrates or proteins, and as therapeutics and diagnostic reagents.
PCT/GB2001/004633 2000-10-16 2001-10-16 Nanoparticles WO2002032404A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
US10/399,284 US7364919B2 (en) 2000-10-16 2001-10-16 Nanoparticles
AU9406801A AU9406801A (en) 2000-10-16 2001-10-16 Nanoparticles
CA2424734A CA2424734C (en) 2000-10-16 2001-10-16 Nanoparticles comprising a metallic or semiconductor core which is covalently bound to a plurality of carbohydrate ligands
AU2001294068A AU2001294068B2 (en) 2000-10-16 2001-10-16 Nanoparticles
JP2002535642A JP4467882B2 (en) 2000-10-16 2001-10-16 Nanoparticles
EP01974554A EP1326589B1 (en) 2000-10-16 2001-10-16 Nanoparticles
DE60117828T DE60117828T2 (en) 2000-10-16 2001-10-16 Nanoparticles
US12/040,594 US8080431B2 (en) 2000-10-16 2008-02-29 Nanoparticles
US13/306,924 US8790934B2 (en) 2000-10-16 2011-11-29 Nanoparticles

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0025414.4A GB0025414D0 (en) 2000-10-16 2000-10-16 Nanoparticles
GB0025414.4 2000-10-16

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US10/399,284 A-371-Of-International US7364919B2 (en) 2000-10-16 2001-10-16 Nanoparticles
US10399284 A-371-Of-International 2001-10-16
US12/040,594 Continuation US8080431B2 (en) 2000-10-16 2008-02-29 Nanoparticles

Publications (2)

Publication Number Publication Date
WO2002032404A2 WO2002032404A2 (en) 2002-04-25
WO2002032404A3 true WO2002032404A3 (en) 2002-08-22

Family

ID=9901442

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2001/004633 WO2002032404A2 (en) 2000-10-16 2001-10-16 Nanoparticles

Country Status (10)

Country Link
US (3) US7364919B2 (en)
EP (2) EP1671625B2 (en)
JP (2) JP4467882B2 (en)
AT (2) ATE319436T1 (en)
AU (2) AU2001294068B2 (en)
CA (1) CA2424734C (en)
DE (2) DE60117828T2 (en)
ES (2) ES2262684T3 (en)
GB (1) GB0025414D0 (en)
WO (1) WO2002032404A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110755640B (en) * 2019-10-21 2022-06-10 浙江师范大学 Preparation method and application of gold-platinum composite nano diagnosis and treatment agent

Families Citing this family (125)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7871597B2 (en) 1999-04-09 2011-01-18 Amag Pharmaceuticals, Inc. Polyol and polyether iron oxide complexes as pharmacological and/or MRI contrast agents
GB0025414D0 (en) 2000-10-16 2000-11-29 Consejo Superior Investigacion Nanoparticles
FI118061B (en) * 2001-09-24 2007-06-15 Beanor Oy Procedure and bio donor for analysis
FI115166B (en) * 2001-12-31 2005-03-15 Biofons Oy Diagnostic procedures
US7361821B2 (en) * 2002-09-20 2008-04-22 Intel Corporation Controlled alignment of nanobarcodes encoding specific information for scanning probe microscopy (SPM) reading
CN1682237B (en) 2002-09-20 2010-05-26 英特尔公司 Method and instrument for detecting biological molecule by coding probe
US7695738B2 (en) * 2003-02-19 2010-04-13 Academia Sinica Carbohydrate encapsulated nanoparticles
WO2005010481A2 (en) * 2003-06-03 2005-02-03 The Regents Of The University Of California Preparation and use of gold glyconanoparticles
GB0313259D0 (en) * 2003-06-09 2003-07-16 Consejo Superior Investigacion Magnetic nanoparticles
WO2005044861A1 (en) * 2003-10-31 2005-05-19 Wyeth Holdings Corporation Polysaccharides of helicobacter pylori
CA2545276C (en) * 2003-11-05 2016-05-31 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Carbohydrate antigen-nanoparticle conjugates and uses thereof as antimetastatic agents in treating cancer
ES2242528B1 (en) 2004-03-25 2006-12-01 Consejo Sup. Investig. Cientificas MAGNETIC NANOPARTICLES OF NOBLE METALS.
EP2330208B1 (en) 2004-05-24 2017-10-18 Midatech Ltd. Nanoparticles comprising RNA ligands
GB0411537D0 (en) * 2004-05-24 2004-06-23 Midatech Ltd Nanoparticles comprising rna ligands
US20070249063A1 (en) * 2004-08-30 2007-10-25 Deshong Philip R Biosensors
CA2582668C (en) * 2004-10-01 2013-10-01 Midatech Ltd Nanoparticles comprising antigens and adjuvants, and immunogenic structures
JP4550555B2 (en) * 2004-11-17 2010-09-22 国立大学法人 東京医科歯科大学 Preparation of quantum dot (Qdot) -nanogel composite
JP2006182673A (en) * 2004-12-27 2006-07-13 Kenji Yamamoto Medicine attached with marker
JP4484151B2 (en) * 2005-03-28 2010-06-16 国立大学法人滋賀大学 Human blood group reagent
US8845927B2 (en) * 2006-06-02 2014-09-30 Qd Vision, Inc. Functionalized nanoparticles and method
US9297092B2 (en) 2005-06-05 2016-03-29 Qd Vision, Inc. Compositions, optical component, system including an optical component, devices, and other products
US9410889B2 (en) * 2005-06-10 2016-08-09 Applied Biosystem, Llc Method and system for multiplex genetic analysis
US8252756B2 (en) 2005-06-14 2012-08-28 Northwestern University Nucleic acid functionalized nanoparticles for therapeutic applications
CA2617869C (en) * 2005-08-04 2017-02-14 Thomas William Rademacher Nanoparticles comprising antibacterial ligands
GB0517077D0 (en) * 2005-08-19 2005-09-28 Isis Innovation Imaging agent
JP4670659B2 (en) * 2006-01-25 2011-04-13 住友電気工業株式会社 Fluorescently labeled metal powder, anisotropic conductive film containing the fluorescently labeled metal powder, and mounted product
WO2008123844A2 (en) * 2006-02-08 2008-10-16 University Of Toledo System for detecting nanoparticles using modulated surface plasmon resonance (mspr)
US8849087B2 (en) * 2006-03-07 2014-09-30 Qd Vision, Inc. Compositions, optical component, system including an optical component, devices, and other products
TW200806315A (en) * 2006-04-26 2008-02-01 Wyeth Corp Novel formulations which stabilize and inhibit precipitation of immunogenic compositions
US9212056B2 (en) 2006-06-02 2015-12-15 Qd Vision, Inc. Nanoparticle including multi-functional ligand and method
US8329635B2 (en) * 2006-06-20 2012-12-11 Bracco Imaging S.P.A. Method for the preparation of specific antibodies against saccharidic antigens
WO2008063662A2 (en) * 2006-11-21 2008-05-29 Black Lion Pharmaceuticals Gold (iii) chloride compositions for cancer
US9239329B2 (en) 2006-12-18 2016-01-19 Japan Science And Technology Agency Method of measuring interaction between biomaterial and sugar chain, method of evaluating biomaterial in sugar chain selectivity, method of screening biomaterial, method of patterning biomaterials, and kits for performing these methods
US20080317768A1 (en) 2007-06-21 2008-12-25 Boeing Company Bioconjugated nanoparticles
ES2320837B1 (en) 2007-07-26 2010-03-04 Consejo Superior De Investigaciones Cientificas HYPERTHERMIA DEVICE AND ITS USE WITH NANOPARTICLES.
WO2009026540A1 (en) 2007-08-22 2009-02-26 Colorado School Of Mines Lanthanide nanoparticle conjugates and uses thereof
EP2033660A1 (en) * 2007-09-05 2009-03-11 Freie Universität Berlin Functionalized nanoparticles for the inhibition of selectin-mediated cell adhesion
GB0718843D0 (en) 2007-09-26 2007-11-07 Cancer Rec Tech Ltd Materials and methods relating to modifying the binding of antibodies
DE102007055386B4 (en) * 2007-11-20 2015-07-16 Boehringer Ingelheim Vetmedica Gmbh Method for calibrating a sensor element
JP5397862B2 (en) * 2007-12-28 2014-01-22 国立大学法人滋賀医科大学 Gold nanoparticle composition, DNA chip, near-infrared absorbing material, drug carrier for drug delivery system (DDS), colorant, biosensor, cosmetics, in vivo diagnostic composition and therapeutic composition
EP2123269A1 (en) * 2008-05-21 2009-11-25 Freie Universität Berlin Nanoparticles functionalized with sulfated amino alcohols for the inhibition of selectin-mediated cell adhesion
WO2010096464A1 (en) 2009-02-18 2010-08-26 Boyes Stephen G Gold/lanthanide nanoparticle conjugates and uses thereof
US20110280914A1 (en) * 2009-01-30 2011-11-17 University Of Utah Research Foundation Hydrogels crosslinked with gold nanoparticles and methods of making and using thereof
EA201890311A1 (en) 2009-05-27 2018-10-31 Селекта Байосайенсиз, Инк. POLYMERIC COMPOUNDS - IMMUNE MODULATING REMEDIES
KR20120059572A (en) 2009-08-26 2012-06-08 셀렉타 바이오사이언시즈, 인크. Compositions that induce t cell help
WO2011133504A2 (en) 2010-04-20 2011-10-27 University Of Florida Research Foundation, Inc. Nanozymes, methods of making nanozymes, and methods of using nanozymes
US8962345B2 (en) * 2010-05-21 2015-02-24 The United States Of America As Represented By The Secretary Of Commerce Method of characterizing glycans attached to glycoproteins
KR20180099900A (en) 2010-05-26 2018-09-05 셀렉타 바이오사이언시즈, 인크. Dose selection of adjuvanted synthetic nanocarriers
CN103209681B (en) 2010-06-10 2017-05-24 Mida科技有限公司 Nanoparticle film delivery systems
CA2802031C (en) * 2010-06-10 2015-05-12 Midatech Limited Peptide-carrying nanoparticles
US9994443B2 (en) 2010-11-05 2018-06-12 Selecta Biosciences, Inc. Modified nicotinic compounds and related methods
US9289476B2 (en) 2011-04-29 2016-03-22 Selecta Biosciences, Inc. Tolerogenic synthetic nanocarriers for allergy therapy
US20130039954A1 (en) 2011-07-29 2013-02-14 Selecta Biosciences, Inc. Control of antibody responses to synthetic nanocarriers
JP5754309B2 (en) * 2011-09-02 2015-07-29 コニカミノルタ株式会社 Quantitative analysis method for measuring fluorescence using surface plasmon excitation enhanced fluorescence spectroscopy, and quantitative analysis kit and analyte dissociation inhibitor used therefor
KR20140084020A (en) 2011-09-07 2014-07-04 미다테크 리미티드 Nanoparticle Tumour Vaccines
IN2014MN00433A (en) 2011-09-07 2015-06-19 Midatech Ltd
US9772305B2 (en) 2011-09-15 2017-09-26 Arizona Board Of Regents On Behalf Of Arizona State University System and method for small molecule detection
GB201301991D0 (en) 2013-02-05 2013-03-20 Midatech Ltd Permeation enhanced active-carrying nanoparticles
GB201302427D0 (en) 2013-02-12 2013-03-27 Midatech Ltd Nanoparticle delivery compositions
GB201303771D0 (en) 2013-03-04 2013-04-17 Midatech Ltd Nanoparticles peptide compositions
GB201303787D0 (en) 2013-03-04 2013-04-17 Midatech Ltd Nanoparticle peptide compositions
WO2014145205A2 (en) 2013-03-15 2014-09-18 St. Jude Children's Research Hospital Methods and compositions of p27kip1 transcription modulators
KR101329646B1 (en) 2013-05-02 2013-11-14 주식회사 지니스 Targeting-enhancing anticancer nanoparticles and preparation method the same
WO2014179772A2 (en) 2013-05-03 2014-11-06 Selecta Biosciences, Inc. Tolerogenic synthetic nanocarriers to reduce or prevent anaphylaxis in response to a non-allergenic antigen
CN112933218A (en) 2013-06-04 2021-06-11 西莱克塔生物科技公司 Repeated administration of non-immunosuppressive antigen-specific immunotherapeutics
WO2015023715A1 (en) 2013-08-14 2015-02-19 The University Of Florida Research Foundation, Inc. Nanozymes, methods of making nanozymes, and methods of using nanozymes
AU2014324535B2 (en) 2013-09-29 2017-03-30 St. Jude Children's Research Hospital, Inc. Aryl substituted aminomethyl spectinomycin analogs as antibacterial agents
GB201401706D0 (en) 2014-01-31 2014-03-19 Midatech Ltd Nanoparticle-insulin and insulin analogue compositions
CA2945945C (en) 2014-04-15 2023-10-03 The Regents Of The University Of California Bi-terminal pegylated integrin-binding peptides and methods of use thereof
WO2015200728A1 (en) 2014-06-25 2015-12-30 Selecta Biosciences, Inc. Methods and compositions for treatment with synthetic nanocarriers and immune checkpoint inhibitors
US9910035B1 (en) 2014-07-16 2018-03-06 Verily Life Sciences Llc Polyvalent functionalized nanoparticle-based in vivo diagnostic system
WO2016037165A1 (en) 2014-09-07 2016-03-10 Selecta Biosciences, Inc. Methods and compositions for attenuating exon skipping anti-viral transfer vector immune responses
US10688125B2 (en) 2014-12-23 2020-06-23 Midatech Ltd. Nanoparticles and their use in cancer therapy
CN107529760B (en) * 2015-05-18 2021-05-07 柿原秀己 Antibacterial substance, liquid antibacterial agent, and method for producing liquid antibacterial agent
WO2016205806A1 (en) 2015-06-18 2016-12-22 St. Jude Children's Research Hospital Methods and compositions for the prevention and treatment of hearing loss
GB2541166A (en) 2015-07-24 2017-02-15 Midatech Ltd Nanoparticle-based liver-targeting therapy and imaging
US20170157215A1 (en) 2015-12-04 2017-06-08 Jomoco, Corp. Compositions and methods to mitigate or prevent an immune response to an immunogenic therapeutic molecule in non-human primates
KR20220123332A (en) 2016-03-11 2022-09-06 셀렉타 바이오사이언시즈, 인크. Formulations and doses of pegylated uricase
EP3448364B1 (en) 2016-04-29 2022-02-09 Icahn School of Medicine at Mount Sinai Targeting the innate immune system to induce long-term tolerance and to resolve macrophage accumulation in atherosclerosis
US20180085319A1 (en) 2016-09-27 2018-03-29 Takashi Kei Kishimoto Methods and compositions for treating cancer
AU2018206291A1 (en) 2017-01-03 2019-07-25 Emergex Vaccines Holding Limited Universal influenza vaccine compositions
CA3049384A1 (en) 2017-01-07 2018-07-12 Selecta Biosciences, Inc. Patterned dosing of immunosuppressants coupled to synthetic nanocarriers
GB201701745D0 (en) 2017-02-02 2017-03-22 Midatech Ltd Nanoparticle-based liver-targeting therapy and imaging
KR20190124295A (en) 2017-03-11 2019-11-04 셀렉타 바이오사이언시즈, 인크. Methods and compositions related to combination treatment with synthetic nanocarriers comprising anti-inflammatory agents and immunosuppressants
US10543231B2 (en) 2017-05-19 2020-01-28 Mayo Foundation For Medical Education And Research Methods and materials for treating cancer
GB2563602B (en) 2017-06-19 2022-06-08 Middlesex Univ Higher Education Corporation Method and apparatus for imaging
US11426457B2 (en) 2017-09-21 2022-08-30 Emergex Vaccines Holding Limited MHC class I associated peptides for prevention and treatment of zika virus
CN111542336A (en) 2017-10-13 2020-08-14 西莱克塔生物科技公司 Methods and compositions for attenuating antiviral transfer vector IGM response
JP2021509400A (en) 2018-01-06 2021-03-25 イマージェクス ヴァクシンズ ホールディング リミテッドＥｍｅｒｇｅｘ Ｖａｃｃｉｎｅｓ Ｈｏｌｄｉｎｇ Ｌｉｍｉｔｅｄ MHC class I-related peptides for the prevention and treatment of multiple flaviviruses
US20210093708A1 (en) 2018-03-29 2021-04-01 Emergex Vaccines Holding Limited Vaccine compositions
US20210283237A1 (en) 2018-03-29 2021-09-16 Emergex Vaccines Holding Limited Vaccine compositions
AU2019270582A1 (en) 2018-05-18 2020-11-26 Emergex Vaccines Holding Limited Reverse peptide vaccine
WO2020018583A1 (en) 2018-07-16 2020-01-23 Selecta Biosciences, Inc. Methods and compositions of otc constructs and vectors
MX2021000638A (en) 2018-07-16 2021-06-23 Selecta Biosciences Inc Methods and compositions of mma constructs and vectors.
GB201819430D0 (en) 2018-11-29 2019-01-16 Midatech Ltd Therapeutic compounds, nanoparticles and uses thereof
GB201820471D0 (en) 2018-12-14 2019-01-30 Midatech Ltd Nanoparticle-based therapy of inflammatory disorders
GB201820470D0 (en) 2018-12-14 2019-01-30 Midatech Ltd Antifolate-carrying nanoparticles and their use in medicine
EP3962537A1 (en) 2019-04-28 2022-03-09 Selecta Biosciences, Inc. Methods for treatment of subjects with preexisting immunity to viral transfer vectors
EP3976802A1 (en) 2019-05-28 2022-04-06 Selecta Biosciences, Inc. Methods and compositions for attenuated anti-viral transfer vector immune response
US20200399628A1 (en) 2019-06-04 2020-12-24 Selecta Biosciences, Inc. Formulations and doses of pegylated uricase
US11890299B2 (en) 2019-06-27 2024-02-06 Hologic, Inc. Ablation agent and methods of use
JP2022553345A (en) 2019-10-21 2022-12-22 セレクタ バイオサイエンシーズ インコーポレーテッド Methods and compositions for treating liver disease and disorders
JP2023501457A (en) 2019-11-08 2023-01-18 セレクタ バイオサイエンシーズ インコーポレーテッド Formulation and dosage of pegylated uricase
JP2023506891A (en) 2019-12-18 2023-02-20 エフ． ホフマン－ラ ロシュ エージー． Sequencing-by-synthesis methods using sequential labeling schemes
EP4110334A1 (en) 2020-02-26 2023-01-04 Selecta Biosciences, Inc. Methods and compositions using synthetic nanocarriers comprising immunosuppressant
US20230147052A1 (en) 2020-04-14 2023-05-11 Selecta Biosciences, Inc. Methods and compositions for inducing autophagy
GB202008250D0 (en) 2020-06-02 2020-07-15 Emergex Vaccines Holding Ltd Diagnosis, prevention and treatment of coronavirus infection
CN111590087B (en) * 2020-06-04 2023-04-18 安徽医科大学 Preparation method of fluorescent gold nanocluster, prepared fluorescent gold nanocluster and application thereof
US20220133864A1 (en) 2020-11-04 2022-05-05 Selecta Biosciences, Inc. Methods and compositions for reducing immune responses against immunoglobulin proteases
CA3207247A1 (en) 2021-01-05 2022-07-14 Selecta Biosciences, Inc. Viral vector dosing protocols
EP4294435A1 (en) 2021-02-16 2023-12-27 Emergex Vaccines Holding Limited Reverse peptides from coronavirus for immunogenic purposes
CN113059177A (en) * 2021-03-05 2021-07-02 江苏师范大学 Nano particle with gold/silver/gold core-shell structure and synthesis method thereof
US11859021B2 (en) 2021-03-19 2024-01-02 Icahn School Of Medicine At Mount Sinai Compounds for regulating trained immunity, and their methods of use
JP2024514577A (en) 2021-04-09 2024-04-02 セレクタ バイオサイエンシーズ インコーポレーテッド Synthetic nanocarriers containing immunosuppressants in combination with high affinity IL-2 receptor agonists to enhance immune tolerance
WO2022253917A1 (en) 2021-06-02 2022-12-08 Emergex Vaccines Holding Limited Human coronavirus 229e derived peptides
CN113500199B (en) * 2021-06-10 2022-11-08 浙江大学 Preparation method of gold-platinum-based bimetallic active oxygen self-generating nano material, product and application thereof
US20230141563A1 (en) 2021-10-12 2023-05-11 Selecta Biosciences, Inc. Methods and compositions for attenuating anti-viral transfer vector igm responses
WO2023064350A1 (en) 2021-10-12 2023-04-20 Selecta Biosciences, Inc. Viral vector dosing protocols
WO2023086615A1 (en) 2021-11-14 2023-05-19 Selecta Biosciences, Inc. Multiple dosing with viral vectors
US20230263906A1 (en) 2022-01-10 2023-08-24 Selecta Biosciences, Inc. High affinity il-2 receptor agonists and synthetic nanocarrier dose sparing
US20230357437A1 (en) 2022-03-09 2023-11-09 Selecta Biosciences, Inc. Immunosuppressants in combination with anti-igm agents and related dosing
WO2023172628A1 (en) 2022-03-09 2023-09-14 Selecta Biosciences, Inc. Immunosuppressant in combination with high affinity il-2 receptor agonists and related dosing
US20230372535A1 (en) 2022-03-25 2023-11-23 Selecta Biosciences, Inc. Synthetic nanocarriers comprising an immunosuppressant in combination with high affinity il-2 receptor agonists and anti-igm agents
WO2023196566A1 (en) 2022-04-08 2023-10-12 Selecta Biosciences, Inc. High affinity il-2 receptor agonists and immunosuppressants to enhance immune tolerance
WO2024036324A1 (en) 2022-08-11 2024-02-15 Selecta Biosciences, Inc. Compositions and methods related to immunoglobulin proteases and fusions thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999061911A2 (en) * 1998-04-20 1999-12-02 University Of North Carolina At Chapel Hill Nanometer particles containing a reactive monolayer

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7807532A (en) * 1978-07-13 1980-01-15 Akzo Nv METAL IMMUNO TEST.
WO1983000173A1 (en) 1981-07-02 1983-01-20 Eynon, David, Leslie Flow box
EP0093757A1 (en) * 1981-11-12 1983-11-16 Ulf SCHRÖDER Intravascularly administrable, magnetically responsive nanosphere or nanoparticle, a process for the production thereof, and the use thereof
SE8704157L (en) * 1987-10-26 1989-04-27 Carbomatrix Ab C O Ulf Schroed SUPERPARAMAGNETIC PARTICLES AND PROCEDURES FOR PREPARING THEREOF AND APPLICATION
US5178882A (en) * 1990-06-22 1993-01-12 The Regents Of The University Of California Viral decoy vaccine
US5248772A (en) * 1992-01-29 1993-09-28 Coulter Corporation Formation of colloidal metal dispersions using aminodextrans as reductants and protective agents
DK0656368T4 (en) * 1992-08-05 2003-09-29 Meito Sangyo Kk Small diameter composite material containing a water-soluble carboxypolysaccharide and magnetic iron oxide
WO1995031220A1 (en) * 1994-05-12 1995-11-23 Otsuka Pharmaceutical Co., Ltd. Contrast medium for magnetic resonance imaging
FR2777193B1 (en) * 1998-04-14 2001-06-08 Coletica PARTICLE WITH A CHELATING HYDROXAMIC GROUP OF METAL IONS AND THEIR USE IN COSMETICS OR PHARMACY
WO2001073123A2 (en) 2000-03-28 2001-10-04 Nanosphere Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
GB0025414D0 (en) 2000-10-16 2000-11-29 Consejo Superior Investigacion Nanoparticles

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999061911A2 (en) * 1998-04-20 1999-12-02 University Of North Carolina At Chapel Hill Nanometer particles containing a reactive monolayer

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; LIU, JIAN ET AL: "Cyclodextrin-Modified Gold Nanospheres. Host-Guest Interactions at Work to Control Colloidal Properties", XP002200177, retrieved from STN Database accession no. 131:23964 CA *
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (1999), 121(17), 4304-4305, 1999 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110755640B (en) * 2019-10-21 2022-06-10 浙江师范大学 Preparation method and application of gold-platinum composite nano diagnosis and treatment agent

Also Published As

Publication number Publication date
EP1671625B1 (en) 2010-05-19
US20120071443A1 (en) 2012-03-22
EP1326589B1 (en) 2006-03-08
ES2346319T3 (en) 2010-10-14
ES2262684T3 (en) 2006-12-01
CA2424734C (en) 2011-10-11
WO2002032404A2 (en) 2002-04-25
DE60142192D1 (en) 2010-07-01
JP2009242418A (en) 2009-10-22
AU9406801A (en) 2002-04-29
JP2004511511A (en) 2004-04-15
AU2001294068B2 (en) 2005-12-22
EP1671625B2 (en) 2013-12-25
CA2424734A1 (en) 2002-04-25
US20080145441A1 (en) 2008-06-19
JP4467882B2 (en) 2010-05-26
DE60117828D1 (en) 2006-05-04
US20040052729A1 (en) 2004-03-18
GB0025414D0 (en) 2000-11-29
ATE319436T1 (en) 2006-03-15
EP1671625A1 (en) 2006-06-21
EP1326589A2 (en) 2003-07-16
ATE468112T1 (en) 2010-06-15
DE60117828T2 (en) 2006-11-16
US8080431B2 (en) 2011-12-20
US8790934B2 (en) 2014-07-29
US7364919B2 (en) 2008-04-29
ES2346319T5 (en) 2014-03-18

Similar Documents

Publication Publication Date Title
WO2002032404A3 (en) Nanoparticles
EP2277548A3 (en) Magnetic nanoparticles linked to a ligand
CA2521007A1 (en) Particulate material containing thermoplastic elastomer and methods for making and using same
ATE236656T1 (en) LIMITED MULTIFUNCTIONAL SURFACE MODIFICATION REAGENT
WO2002068932A3 (en) Methods for providing extended dynamic range in analyte assays
CY1111863T1 (en) OPTIONS AGAINST DEATH RECEPTOR 4 (DR4) AND THEIR USES
WO2005033158A3 (en) Attachment of molecules to surfaces
HUP0204499A2 (en) Biomedical assay device
WO2002061090A3 (en) Prokaryotically produced antibodies and uses thereof
EP1978081A3 (en) Stabilized liquid compositions
WO2003031977A3 (en) Binding assay using a magnetic field
ATE378399T1 (en) MAGNETIC MANIPULATION OF BIOLOGICAL SAMPLES
WO2001035100A3 (en) Binding acceleration techniques for the detection of analytes
JP2005513440A5 (en)
WO2000043783A3 (en) Assays involving colloids and non-colloidal structures
DE60226437D1 (en) WATER-SOLUBLE POLYMERIC COMPOSITIONS WITH AFFINITY FOR METALIONS AND METHOD FOR THEIR APPLICATION
WO2002086452A3 (en) Selective deposition of materials on contoured surfaces
WO2006105409A3 (en) Multiplex assay systems
WO2004090506A3 (en) Surfaces that selectively bind to moieties
EP1585986B8 (en) Surface layer affinity-chromatography
AU6085201A (en) Separation of glyco-containing entities
WO2002060583A8 (en) Microarrayer
WO2004096156A3 (en) Toll-like receptor 9 effector agents and uses thereof
EP1375678A3 (en) Methods and compositions for performing array based assays
ATE157283T1 (en) APPLIED MICRO BALLS

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2001974554

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2424734

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2001294068

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2002535642

Country of ref document: JP

WWP Wipo information: published in national office

Ref document number: 2001974554

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWE Wipo information: entry into national phase

Ref document number: 10399284

Country of ref document: US

WWG Wipo information: grant in national office

Ref document number: 2001974554

Country of ref document: EP

WWG Wipo information: grant in national office

Ref document number: 2001294068

Country of ref document: AU