WO2002036266A3 - Fluid separation devices, systems and methods - Google Patents

Fluid separation devices, systems and methods Download PDF

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Publication number
WO2002036266A3
WO2002036266A3 PCT/US2001/046953 US0146953W WO0236266A3 WO 2002036266 A3 WO2002036266 A3 WO 2002036266A3 US 0146953 W US0146953 W US 0146953W WO 0236266 A3 WO0236266 A3 WO 0236266A3
Authority
WO
WIPO (PCT)
Prior art keywords
fluid
separated
rotor
channel
centrifugal
Prior art date
Application number
PCT/US2001/046953
Other languages
French (fr)
Other versions
WO2002036266A2 (en
Inventor
Thomas J Felt
Dennis J Hlavinka
Original Assignee
Gambro Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gambro Inc filed Critical Gambro Inc
Priority to EP01990890A priority Critical patent/EP1458488B1/en
Priority to AT01990890T priority patent/ATE537907T1/en
Priority to AU2002230652A priority patent/AU2002230652A1/en
Publication of WO2002036266A2 publication Critical patent/WO2002036266A2/en
Publication of WO2002036266A3 publication Critical patent/WO2002036266A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/0209—Multiple bag systems for separating or storing blood components
    • A61M1/0231—Multiple bag systems for separating or storing blood components with gas separating means, e.g. air outlet through microporous membrane or gas bag
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A61M1/3696—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0407—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles
    • B04B5/0428—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles with flexible receptacles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B7/00—Elements of centrifuges
    • B04B7/08—Rotary bowls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B9/00—Drives specially designed for centrifuges; Arrangement or disposition of transmission gearing; Suspending or balancing rotary bowls
    • B04B9/08—Arrangement or disposition of transmission gearing ; Couplings; Brakes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/38—Removing constituents from donor blood and storing or returning remainder to body, e.g. for transfusion
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B04B2005/045—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation having annular separation channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B04B2005/0464—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation with hollow or massive core in centrifuge bowl
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B9/00—Drives specially designed for centrifuges; Arrangement or disposition of transmission gearing; Suspending or balancing rotary bowls
    • B04B9/14—Balancing rotary bowls ; Schrappers
    • B04B2009/143—Balancing rotary bowls ; Schrappers by weight compensation with liquids

Abstract

A centrifugal separation device (10) for use in a fluid separation system to centrifugally separate a composite fluid into the composite components thereof. This centrifugal separation device includes a centrifugal rotor housing (30) and a rotor (40) which is disposed in a freely rotatable disposition within the housing, the rotor having a fluid receiving area (42) and several fluid flow channels defined therein. A composite fluid to be separated is delivered to the fluid receiving area from which it travels through a radial fluid transport channel (44) to a circumferential fluid separation channel (46) where it is subjected to substantial centrifugal forces which separate the composite fluid into components which each then travel to distinct first and second separated fluid outlet channels (52, 54). The separated fluids then exit from these outlet channels and are then moved from the separation device to a collection bag for storage or may then be returned to the donor. The first and second fluid outlet channels also have respective first and second lengths which are related to each other so as to provide a substantial hydraulic pressure balance for the respective separated fluids flowing therethrough. Such a pressure balance controls the interface of the separated fluid components within the circumferential separation channel. The preferred relationship of the respective first and second lengths of said first and second separated fluid outlet channels to each other which provides the hydraulic balance is ρ3gh3 = ρ3gh3 wherein the first length of the first outlet channel is h3, and the second length of the second outlet channel is h3, wherein g is a gravitational acceleration value and ρ3 represents the density of the fluids in the first outlet channel and ρ3 represents the density of the fluids in the second outlet channel. The preferred centrifugal drive motor used here produces a rotating magnetic field, which co-acts with a magnetically reactive material disposed in the rotor to rotate the rotor with the rotating magnetic field. A loopless, sealless continuous flow centrifuge is thus useful herein.
PCT/US2001/046953 2000-11-02 2001-11-02 Fluid separation devices, systems and methods WO2002036266A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP01990890A EP1458488B1 (en) 2000-11-02 2001-11-02 Fluid separation devices, systems and methods
AT01990890T ATE537907T1 (en) 2000-11-02 2001-11-02 DEVICES, SYSTEMS AND METHODS FOR FLUID SEPARATION
AU2002230652A AU2002230652A1 (en) 2000-11-02 2001-11-02 Fluid separation devices, systems and methods

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24528200P 2000-11-02 2000-11-02
US60/245,282 2000-11-02

Publications (2)

Publication Number Publication Date
WO2002036266A2 WO2002036266A2 (en) 2002-05-10
WO2002036266A3 true WO2002036266A3 (en) 2004-06-24

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2001/046953 WO2002036266A2 (en) 2000-11-02 2001-11-02 Fluid separation devices, systems and methods
PCT/US2001/046940 WO2002062482A2 (en) 2000-11-02 2001-11-02 Fluid separation devices, systems and methods

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2001/046940 WO2002062482A2 (en) 2000-11-02 2001-11-02 Fluid separation devices, systems and methods

Country Status (5)

Country Link
US (4) US6773389B2 (en)
EP (2) EP1363739B1 (en)
AT (2) ATE537906T1 (en)
AU (2) AU2002253801A1 (en)
WO (2) WO2002036266A2 (en)

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