WO2002036518A1 - Porous calcium phosphate cement - Google Patents
Porous calcium phosphate cement Download PDFInfo
- Publication number
- WO2002036518A1 WO2002036518A1 PCT/US2001/031480 US0131480W WO0236518A1 WO 2002036518 A1 WO2002036518 A1 WO 2002036518A1 US 0131480 W US0131480 W US 0131480W WO 0236518 A1 WO0236518 A1 WO 0236518A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- acid
- carbonate
- set forth
- treatment material
- calcium
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B28/00—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements
- C04B28/34—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing cold phosphate binders
- C04B28/344—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing cold phosphate binders the phosphate binder being present in the starting composition solely as one or more phosphates
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B38/00—Porous mortars, concrete, artificial stone or ceramic ware; Preparation thereof
- C04B38/02—Porous mortars, concrete, artificial stone or ceramic ware; Preparation thereof by adding chemical blowing agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B2111/00—Mortars, concrete or artificial stone or mixtures to prepare them, characterised by specific function, property or use
- C04B2111/00474—Uses not provided for elsewhere in C04B2111/00
- C04B2111/00836—Uses not provided for elsewhere in C04B2111/00 for medical or dental applications
Definitions
- This invention relates to calcium phosphate cements which set after the mixing of a powdered calcium and phosphate source in an aqueous solution to form hydroxyapatite (HA). More particularly, it relates to the addition of citric acid and sodium bicarbonate to produce carbon dioxide during the setting of a calcium phosphate cement, thereby introducing macroporosity into the structure.
- bone cements and bone filler materials which harden or set have an interconnected porosity (macroporosity) throughout their structure after hardening.
- This interconnected porosity if of sufficient pore size, allows for vascularization and tissue ingrowth to occur into the structure. Pores greater than 70 microns in diameter have been found to allow tissue ingrowth. This tissue ingrowth can be encouraged by coating or filling the pores with osteoinductive or osteoconductive factors such as bone morphogenic proteins (BMPs). Such factors are well known to those skilled in the art.
- Other therapeutic agents such as antibiotics or chemo-therapeutic agents may be introduced into the porosity by adding them to the liquid or powder.
- porosity has been generated by including fillers which are soluble in physiological fluids or which are resorbed after implantation. These systems have the disadvantage that the porosity only occurs after implantation and thus the pores cannot be filled with growth factors or other therapeutic agents prior to implantation.
- up to 50 volume percent of resorbable filler must be added to the calcium and phosphate source precursor powdered material. This sometimes adversely affects material properties and reduces the amount of hydroxyapatite formed in the reaction of the calcium and phosphate precursors.
- foaming agents such as citrimide BP which reduce the surface tension of the water have been used.
- U.S. patent 5,820,632 to Constantz et al. relates to a calcium phosphate cement wherein when a porous structure is desired, various additives may be included which may be leached out so as to provide for porosity in the cement. This porosity is in addition to any porosities achieved with a release of gas formed during the reaction to produce the product. Constantz et al. teaches including aggregates of soluble materials generally above 25 volume percent to develop sufficient interconnected porosity to foster bony ingrowth with the volume of aggregate normally being less than 50 volume percent. Specifically, Constantz et al. suggests the addition of calcium chloride and sodium or potassium hydroxide which are water soluble and will be leached out to provide the porosity.
- U.S. patent 5,525,148 to Chow et al. teaches the use of pore forming agents that are preferably, substantially insoluble in the cement itself and can be removed by either resorbtion into body tissue, dissolution into physiological solutions, dissolution in solvents or heating after the cement has hardened.
- the pore forming agents taught by Chow et al. include sugar, sodium bicarbonate and phosphate salts.
- a method for making a porous cement which sets to hydroxyapatite at ambient temperatures comprising mixing a powder comprising a calcium source, a phosphate source and a base with a liquid comprising an aqueous solution containing an acid wherein the calcium source and the phosphate source mix with the liquid component to form hydroxyapatite and the acid and base react to form carbon dioxide producing an interconnected porosity in the material.
- the base is a carbonate selected from the group consisting of sodium carbonate, sodium bicarbonate, calcium carbonate and calcium bicarbonate or a combination thereof.
- the preferred acid is selected from the group consisting of citric acid, malic acid, fumaric acid, lactic acid, succinic acid and orthophosphoric acid or a combination thereof.
- the preferred calcium and phosphate sources may be selected from the group consisting of terra-calcium phosphate, dicalcium phosphate, tricalcium phosphate and monocalcium phosphate.
- the preferred ratio of acid to carbonate to produce a neutral pH has been found to be about 0.7 grams of acid to about 1.0 grams of carbonate.
- the preferred ratio of the acid and carbonate to the combined powdered and liquid components forming the calcium phosphate cement is. about 10 to 20% by weight.
- FIG. 1 is a cross-sectional micrograph of the porous bone cement of the present invention formed at liquid to powder ratio of .25 and an acid/base weight percent of 10%; and FIG. 2 is a cross-sectional micrograph of the porous bone cement of the present invention made from a liquid to powder ratio of .35 and an weight percent of acid to base of 20%.
- This invention relates to calcium phosphate cements of the type taught in Brown and Chow, U.S. reissued patents RE 33,161 and RE 33,221 and in Chow and Takagi U.S. patent 5,525,148 and in Constantz U.S. patent 4,880,610, the teachings of which are incorporated herein by reference.
- the method for porosity generation of the present invention is the addition of citric acid monohydrate in an aqueous mixture and sodium bicarbonate in powder form into the calcium phosphate powder mixture taught by the patents referred to above in which tetra-calcium phosphate and dicalcium phosphate powders are mixed with a liquid component which may be dionized water or a sodium phosphate solution.
- the ratio of acid to base is 1 gram of a base such as sodium bicarbonate to 0.7 grams of an acid such as citric acid.
- the sodium bicarbonate powder is mixed with the tetra-calcium phosphate and dicalcium phosphate powders with the resultant mixture then being combined with an aqueous liquid into which the citric acid has been added as a liquid.
- the preferred liquid to powder ratio is between about .25 to .35.
- the preferred weight percent of the acid/base to the liquid and powder combination is between about 10 to about 20 weight percent.
- the ratio of acid to base was determined by reacting various ratios of each component in 10ml of water. The ratio that left the pH of the water unchanged after completion of the reaction was chosen to be mixed with the powdered tetra- calcium phosphate and dicalcium phosphate combination. It was determined that the ratio of 0.7 grams of citric acid to 1.0 grams of sodium bicarbonate produced a neutral pH.
- Sodium bicarbonate was mixed as a powder into the powdered tetra-calcium phosphate and dicalcium phosphate.
- Citric acid monohydrate was mixed into the deionized water liquid component.
- the acid/base ratio (A/B) was 0.7 grams of citric acid to 1.0 grams of sodium bicarbonate.
- a series of tests were performed in which the citric acid was added to deionized water and also was added to a .25 M sodium phosphate solution.
- Various liquid/powder (1/p) ratios were evaluated. Although the acid used was in solution, the invention would work equally well if an acid in dry form (free of uncombined water) was used as part of the powdered component.
- specimen number 10 and specimen number 11 produced the most acceptable levels of hydroxyapatite of 67 and 69%, respectively and greater than 35% porosity.
- the pore sizes were between 440 and 580 microns. Pore sizes of at least 70 microns are desirable.
- Specimen 10 include a liquid to powder to ratio of .35 and 20% by weight of the citric acid and sodium bicarbonate added in with the aforementioned ratio of .7 grams of the citric acid to every gram of sodium bicarbonate and had a 35% porosity with 67% HA.
- specimen 11 which utilized a .25 liquid to powder ratio and a 10% acid base weight ratio produced a 47% porosity with 69% HA.
- the method of producing a porous structure in a bone cement or filler could be utilized on any bone cement type such as a glass ionomer cement, poly (propylene fumarate) or a methacrylate cement where liquid and powdered components are mixed.
- a methacrylate cement is made by reacting a liquid methacrylate monomer with a powdered methacrylate polymer. Again, the powdered sodium bicarbonate is added to the powdered component and an acid source, such as citric acid, is added to the liquid component.
- any gas producing chemical reaction could be used to form the pores.
- the acid in the liquid component it is possible to add the acid in a crystalline form as a solid component.
- An example of such an acid material is phosphoric acid free of uncombined water.
- the calcium phosphate materials mixed without the gas forming citric acid and sodium bicarbonate components had a macroporosity of only 4%.
- the pore size can be controlled by using less liquid in the liquid to powder ratio and/or less of the acid-base mixture to obtain smaller pore sizes. Conversely, more liquid or a higher weight percent of acid-base results in more porosity and larger pores.
- FIGS. 1 and 2 show the porous bone cements of Examples 11 and 10 respectively, showing average pore sizes greater than 70 microns.
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE60115703T DE60115703T2 (en) | 2000-10-30 | 2001-10-10 | POROUS CALCIUM PHOSPHATE CEMENT |
JP2002539282A JP2004512880A (en) | 2000-10-30 | 2001-10-10 | Porous calcium phosphate cement |
CA002394100A CA2394100C (en) | 2000-10-30 | 2001-10-10 | Porous calcium phosphate cement |
AU96730/01A AU777599B2 (en) | 2000-10-30 | 2001-10-10 | Porous calcium phosphate cement |
EP01977625A EP1335757B1 (en) | 2000-10-30 | 2001-10-10 | Porous calcium phosphate cement |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/699,662 US6547866B1 (en) | 2000-10-30 | 2000-10-30 | Porous calcium phosphate cement |
US09/699,662 | 2000-10-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2002036518A1 true WO2002036518A1 (en) | 2002-05-10 |
Family
ID=24810331
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/031480 WO2002036518A1 (en) | 2000-10-30 | 2001-10-10 | Porous calcium phosphate cement |
Country Status (7)
Country | Link |
---|---|
US (2) | US6547866B1 (en) |
EP (1) | EP1335757B1 (en) |
JP (1) | JP2004512880A (en) |
AU (1) | AU777599B2 (en) |
CA (1) | CA2394100C (en) |
DE (1) | DE60115703T2 (en) |
WO (1) | WO2002036518A1 (en) |
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FR2841897A1 (en) * | 2002-07-08 | 2004-01-09 | Rousselot Sas | Production of apatitic cement useful for trapping pollutants comprises reacting dicalcium phosphate dihydrate with calcium carbonate in the presence of an activator |
WO2006014886A2 (en) | 2004-07-26 | 2006-02-09 | Skeletal Kinetics Llc | Calcium phosphate cements and methods for using the same |
EP1761472A2 (en) * | 2004-02-10 | 2007-03-14 | New York University | Macroporous, resorbable and injectible calcium phosphate-based cements (mcpc) for bone repair, augmentation, regeneration, and osteoporosis treatment |
WO2008089019A2 (en) * | 2007-01-12 | 2008-07-24 | Warsaw Orthopedic, Inc. | System and method for forming porous bone filling material |
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US7651701B2 (en) | 2005-08-29 | 2010-01-26 | Sanatis Gmbh | Bone cement composition and method of making the same |
US7754005B2 (en) | 2006-05-02 | 2010-07-13 | Kyphon Sarl | Bone cement compositions comprising an indicator agent and related methods thereof |
US7758693B2 (en) | 2002-06-07 | 2010-07-20 | Kyphon Sarl | Strontium-apatite cement preparations, cements formed therefrom, and uses thereof |
US7968616B2 (en) | 2008-04-22 | 2011-06-28 | Kyphon Sarl | Bone cement composition and method |
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- 2001-10-10 EP EP01977625A patent/EP1335757B1/en not_active Expired - Lifetime
- 2001-10-10 WO PCT/US2001/031480 patent/WO2002036518A1/en active IP Right Grant
- 2001-10-10 JP JP2002539282A patent/JP2004512880A/en active Pending
- 2001-10-10 CA CA002394100A patent/CA2394100C/en not_active Expired - Fee Related
- 2001-10-10 AU AU96730/01A patent/AU777599B2/en not_active Ceased
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2002
- 2002-09-09 US US10/237,499 patent/US6670293B2/en not_active Expired - Fee Related
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Cited By (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7758693B2 (en) | 2002-06-07 | 2010-07-20 | Kyphon Sarl | Strontium-apatite cement preparations, cements formed therefrom, and uses thereof |
US8715410B2 (en) | 2002-06-07 | 2014-05-06 | Warsaw Orthopedic, Inc. | Strontium-apatite cement preparation cements formed therefrom, and use thereof |
FR2841897A1 (en) * | 2002-07-08 | 2004-01-09 | Rousselot Sas | Production of apatitic cement useful for trapping pollutants comprises reacting dicalcium phosphate dihydrate with calcium carbonate in the presence of an activator |
EP1761472A2 (en) * | 2004-02-10 | 2007-03-14 | New York University | Macroporous, resorbable and injectible calcium phosphate-based cements (mcpc) for bone repair, augmentation, regeneration, and osteoporosis treatment |
EP1761472A4 (en) * | 2004-02-10 | 2010-01-20 | Univ New York | Macroporous, resorbable and injectible calcium phosphate-based cements (mcpc) for bone repair, augmentation, regeneration, and osteoporosis treatment |
US8168692B2 (en) | 2004-04-27 | 2012-05-01 | Kyphon Sarl | Bone substitute compositions and method of use |
WO2006014886A2 (en) | 2004-07-26 | 2006-02-09 | Skeletal Kinetics Llc | Calcium phosphate cements and methods for using the same |
EP1771184A2 (en) * | 2004-07-26 | 2007-04-11 | Skeletal Kinetics LLC | Calcium phosphate cements and methods for using the same |
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Also Published As
Publication number | Publication date |
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DE60115703T2 (en) | 2006-10-05 |
AU777599B2 (en) | 2004-10-21 |
JP2004512880A (en) | 2004-04-30 |
US6670293B2 (en) | 2003-12-30 |
CA2394100A1 (en) | 2002-05-10 |
US6547866B1 (en) | 2003-04-15 |
US20030019396A1 (en) | 2003-01-30 |
AU9673001A (en) | 2002-05-15 |
DE60115703D1 (en) | 2006-01-12 |
EP1335757B1 (en) | 2005-12-07 |
EP1335757A1 (en) | 2003-08-20 |
CA2394100C (en) | 2007-12-11 |
EP1335757A4 (en) | 2003-08-20 |
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